115 research outputs found
Boulder size and shape distributions on asteroid Ryugu
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/10/2019
- Field of study
In 2018, the Japanese spacecraft Hayabusa2, arrived at the small asteroid Ryugu. The surface of this C-type asteroid is covered with numerous boulders whose size and shape distributions are investigated in this study. Using a few hundred Optical Navigation Camera (ONC) images with a pixel scale of approximately 0.65 m, we focus on boulders greater than 5m in diameter. Smaller boulders are also considered using five arbitrarily chosen ONC close-up images with pixel scales ranging from 0.7 to 6 cm. Across the entire surface area (~2.7 km2) of Ryugu, nearly 4400 boulders larger than 5m were identified. Boulders appear to be uniformly distributed across the entire surface, with some slight differences in latitude and longitude. At ~50 kmâ2, the number density of boulders larger than 20m is twice as large as on asteroid Itokawa (or Bennu). The apparent shapes of Ryugu's boulders resemble laboratory impact fragments, with larger boulders being more elongated. The ratio of the total volume of boulders larger than 5m to the total excavated volume of craters larger than 20m on Ryugu can be estimated to be ~94%, which is comparatively high. These observations strongly support the hypothesis that most boulders found on Ryugu resulted from the catastrophic disruption of Ryugu's larger parent body, as described in previous papers (Watanabe et al., 2019; Sugita et al.,2019). The cumulative size distribution of boulders larger than 5âŻm has a power-index of â2.65âŻÂ±âŻ0.05, which is comparatively shallow compared with other asteroids visited by spacecraft. For boulders smaller than 4âŻm, the power-index is even shallower and ranges from â1.65âŻÂ±âŻ0.05 to â2.01âŻÂ±âŻ0.06. This particularly shallow power-index implies that some boulders are buried in Ryugu's regolith. Based on our observations, we suggest that boulders near the equator might have been buried by the migration of finer material and, as a result, the number density of boulders larger than 5âŻm in the equatorial region is lower than at higher latitudes
Genetic Characterization of Coronaviruses from Domestic Ferrets, Japan
- Author
- Publication venue
- 'Centers for Disease Control and Prevention (CDC)'
- Publication date
- 01/02/2014
- Field of study
We detected ferret coronaviruses in 44 (55.7%) of 79 pet ferrets tested in Japan and classified the viruses into 2 genotypes on the basis of genotype-specific PCR. Our results show that 2 ferret coronaviruses that cause feline infectious peritonitisâlike disease and epizootic catarrhal enteritis are enzootic among ferrets in Japan
Visualization of walking speed variation-induced synchronized dynamic changes in lower limb joint angles and activity of trunk and lower limb muscles with a newly developed gait analysis system
- Author
- Publication venue
- 'SAGE Publications'
- Publication date
- 01/10/2018
- Field of study
Purpose:To evaluate a newly developed system for dynamic analysis of gait kinematics and muscle activity.Methods:We recruited 10 healthy men into this study. Analyses of three-dimensional motion and wireless surface electromyogram (EMG) were integrated to achieve synchronous measurement. The participants walked continuously for 10 min under two conditions: comfortable and quick pace. Outcome measures were joint angles of the lower limbs determined from reflective markers and myoelectric activity of trunk and lower limbs determined from EMG sensors, comparing comfortable and quick gait pace.Results:Lower limb joint angle was significantly greater at the quick pace (maximum flexion of the hip joint: 4.1°, maximum extension of hip joint: 2.3°, and maximum flexion of the knee joint while standing: 7.4°). The period of maximum flexion of the ankle joint during a walking cycle was 2.5% longer at a quick pace. EMG amplitudes of all trunk muscles significantly increased during the period of support by two legs (cervical paraspinal: 55.1%, latissimus dorsi: 31.3%, and erector spinae: 32.6%). EMG amplitudes of quadriceps, femoral biceps, and tibialis anterior increased significantly by 223%, 60.9%, and 67.4%, respectively, between the periods of heel contact and loading response. EMG amplitude of the gastrocnemius significantly increased by 102% during the heel-off period.Conclusion:Our gait analysis synchronizing three-dimensional motion and wireless surface EMG successfully visualized dynamic changes in lower limb joint angles and activity of trunk and lower limb muscles induced by various walking speeds
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force
- Author
- Abe Ryuzo
- Abe Shinji
- Adachi Tomohiro
- Adachi Yuichi
- Ai Masumi
- Amishima Masaru
- Amiya Saori
- Anan Ryusuke
- Ando Akira
- Anzai Tatsuhiko
- Arai Daisuke
- Arai Ryosuke
- Arai Sawako
- Arakawa Kenichi
- Arimura Ken
- Asakura Takanori
- Asano Koichiro
- Awano Nobuyasu
- Azuma Masanori
- Baba Hiroaki
- Baba Rie
- Baba Tomoya
- Beppu Satoru
- Chiba Shigeru
- Chihara Yusuke
- Chubachi Shotaro
- Edahiro Ryuya
- Egi Moritoki
- Endo Akifumi
- Endo Mayu
- Enomoto Takatoshi
- Eriguchi Yoshihiro
- Fuchimoto Yasuko
- Fujii Kazuhiko
- Fujimoto Nobukazu
- Fujita Kazue
- Fujitani Shigeki
- Fujiwara Akiko
- Fuke Satoshi
- Fukui Takahiro
- Fukui Yasutaka
- Fukunaga Koichi
- Fukuta Tetsuya
- Fukuyama Satoru
- Funatsu Yohei
- Gon Yasuhiro
- Hagihara Masao
- Hagimoto Satoshi
- Hagiwara Eri
- Hagiwara Shigehiro
- Hanada Satoko
- Hara Reina
- Harada Masahiro
- Harada Norihiro
- Harada Sonoko
- Harada Yuko
- Haruta Yuki
- Hase Isano
- Hasegawa Naoki
- Hasegawa Takanori
- Hasegawa Yoshinori
- Hashiguchi Mizuha
- Hashimoto Naozumi
- Hashimoto Satoru
- Hashino Takuya
- Hattori Takeshi
- Hayashi Kentaro
- Hayashi Reina
- Hayashi Shinichi
- Hida Naoya
- Hiki Makoto
- Hirai Yoshihiro
- Hiramatsu Yuji
- Hirano Toshiyuki
- Hiranuma Hisato
- Hirata Haruhiko
- Hirouchi Takatomo
- Honda Takayuki
- Horinouchi Hirohisa
- Hoshino Kota
- Hosoda Chiaki
- Hyugaji Takayoshi
- Ichikado Kazuya
- Ichikawa Masako
- Ichimura Naoya
- Igarashi Akira
- Ihara Shoichi
- Ikemura Shinnosuke
- Imamura Tomonori
- Imoto Seiya
- Inomata Minoru
- Inoue Sumito
- Inoue Takashi
- Inoue Takuya
- Inoue Yoshiaki
- Ishiguro Takashri
- Ishihara Sayoko
- Ishihara Shoichiro
- Ishii Makoto
- Ishii Tomoo
- Ishikawa Motonao
- Ishikura Hiroyasu
- Ishioka Kota
- Isogai Susumu
- Isono Taisuke
- Ito Akihiro
- Ito Fumimaro
- Ito Kazuto
- Ito Satoshi
- Ito Yoko
- Iwagoe Hajime
- Iwamura Hiromu
- Izumi Namiki
- Izumo Takehiro
- Kabata Hiroki
- Kagaya Takashi
- Kagyo Junko
- Kai Hirayasu
- Kamata Hirofumi
- Kamimaki Isamu
- Kamiya Akane
- Kan-o Keiko
- Kanai Masahiro
- Kanai Masayuki
- Kanai Takanori
- Kanaoka Kensuke
- Kanayama Syuji
- Kanda Hidenori
- Kanehiro Arihiko
- Kaneko Yutaro
- Kaneyama Yasunari
- Kasamatsu Yu
- Kashiwada Takeru
- Katayama Kazuhiko
- Katayama Kotoe
- Kato Kazuto
- Kato Yasuhiro
- Kawada Miki
- Kawamura Kodai
- Kawana Akihiko
- Kawana Masatoshi
- Kawashima Hidetoshi
- Kikuchi Ryota
- Kimizuka Yoshifumi
- Kimura Akinori
- Kimura Nozomu
- Kimura Tomoki
- Kimura Tomoyuki
- Kimura Yasuhiro
- Kishi Hiroto
- Kita Toshiyuki
- Kitagawa Yuichiro
- Kitagawa Yuko
- Kitamura Hideya
- Kobayashi Keigo
- Kobayashi Yoichi
- Kodaka Norio
- Kodama Nobuhiro
- Koh Hidefumi
- Kohashi Sumiko
- Koike Ryuji
- Koji Sakamoto
- Kojima Mitsuaki
- Kokuto Hiroyuki
- Komase Yuko
- Komuta Kiyoshi
- Konishi Shunichiro
- Kono Yuta
- Koshida Kiyoshi
- Kozu Yutaka
- Kuge Tomoki
- Kumanogoh Atsushi
- Kuraki Takashige
- Kuramochi Mizuki
- Kurihara Yuko
- Kusaka Yu
- Kuse Naoyuki
- Kuwahara Naota
- Lee Ho
- Maeda Shunsuke
- Maeno Toshitaka
- Makino Shohei
- Makino Yasushi
- Manabe Tadashi
- Maruyama Junichi
- Maruyama Shuhei
- Masaki Katsunori
- Mashimo Shuko
- Masuda Makoto
- Masuzawa Keita
- Matsui Yuma
- Matsumoto Kinnosuke
- Matsumoto Koichiro
- Matsumoto Shuichiro
- Matsumoto Takemasa
- Matsunaga Tomohiro
- Matsuse Hiroto
- Matsushita Yasushi
- Minemura Hiroyuki
- Mitamura Keiko
- Miyagawa Kazuya
- Miyake Takahito
- Miyano Satoru
- Miyawaki Masayoshi
- Miyazaki Masatoshi
- Miyazaki Yasunari
- Miyazaki Yoshimune
- Miyazawa Naoki
- Mochimaru Takao
- Mori Nobuaki
- Morikawa Daiki
- Morisaki Hiroshi
- Morita Atsuho
- Morita Takayoshi
- Motegi Mitsuru
- Murakami Koji
- Murakami Teruaki
- Muranaka Hiroyuki
- Murohashi Kota
- Mutoh Yoshikazu
- Nagai Hideaki
- Nagao Genta
- Nagasaka Tomoki
- Nagasaki Tadao
- Nagasaki Yoji
- Nagata Kaoru
- Naito Tatsuhiko
- Naito Toshio
- Nakachi Ichiro
- Nakada Taka-Aki
- Nakajima Jun
- Nakajima Yukiko
- Nakamori Yasushi
- Nakamura Ai
- Nakamura Kazunori
- Nakamura Morio
- Nakamura Yoshihiko
- Nakano Chihiro
- Nakano Yasushi
- Nakatsumi Hiroki
- Nakayama Sohei
- Namba Shinichi
- Namkoong Ho
- Nanki Kosaku
- Nannya Yasuhito
- Narita Atsuya
- Narumoto Osamu
- Niitsu Takayuki
- Nikaido Takefumi
- Nishi Koichi
- Nishida Takashi
- Nishikawa Masanori
- Nishimura Tomoyasu
- Nishio Kazumi
- Nishitsuji Masaru
- Nishiyama Kei
- Nishiyama Kenta
- Niwa Kazuki
- Noda Yoshimi
- Noguchi Yoichiro
- Nukaga Shigenari
- Ochi Junichi
- Odani Toshio
- Odate Mitsuru
- Ogata Hideo
- Ogata Tomouki
- Ogawa Aki
- Ogawa Seishi
- Ogawa Shinichi
- Oguma Tsuyoshi
- Ogura Shinji
- Ogura Takashi
- Ogura Takayuki
- Ohba Takehiko
- Ohira Yoshiyuki
- Ohta Kazuhide
- Ohta Ken
- Ohta Shin
- Okabayashi Hiroko
- Okada Takenori
- Okada Yukinori
- Okamori Satoshi
- Okamoto Masaki
- Omae Yosuke
- Omote Norihito
- Ono Akihiro
- Ono Hiroshi
- Ono Yoshinao
- Onoi Keisuke
- Ooshima Nobuharu
- Osawa Takeshi
- Oshima Taku
- Oshio Takeshi
- Ota Sho
- Oyama Baku
- Oyamada Yoshitaka
- Ozaki Shinji
- Sado Reiko
- Sado Toshikatsu
- Sagara Hironori
- Sageshima Hisako
- Saiki Ryunosuke
- Saito Fukuki
- Saito Fumitake
- Saito Hiroshi
- Saito Ryuichi
- Saito Yoshinobu
- Sakagami Satoru
- Sakurai Toshihiro
- Sandhu Yuuki
- Sano Hirohito
- Sano Tomoya
- Sasa Noah
- Sasaki Junichi
- Sasaki Kana
- Sasano Hajime
- Sassa Chihiro Tani
- Sato Masamichi
- Sato Ryuichi
- Sato Tomonori
- Sato Toshiro
- Sato Yoko
- Sato Yuki
- Satomi Ryosuke
- Seike Masahiro
- Sekikawa Yoshiyuki
- Shibata Shun
- Shibata Yoko
- Shibusawa Takayuki
- Shichinohe Yasuo
- Shimada Hisato
- Shimada Tadanaga
- Shimizu Eigo
- Shimizu Tetsuo
- Shimo Masatoshi
- Shimoda Masafumi
- Shinoki Masato
- Shinozuka Jun
- Shinozuka Keisuke
- Shiomi Tetsuya
- Shirai Yuya
- Shiroyama Takayuki
- Shoko Tomohisa
- Sonehara Kyuto
- Sonobe Kazunari
- Suematsu Ryohei
- Sueyoshi Atsushi
- Sugimoto Hideyasu
- Sugiura Hisatoshi
- Suzuki Junya
- Suzuki Shoji
- Suzuki Yusuke
- Tada Ai
- Tagaya Etsuko
- Takada Minoru
- Takagi Haruhi
- Takahashi Hidenori
- Takahashi Hiroshi
- Takahashi Kazuhisa
- Takahashi Kenichiro
- Takahashi Kunihiko
- Takahashi Mai
- Takahashi Saeko
- Takahashi Takeshi
- Takaku Yotaro
- Takano Kenji
- Takano Tomomi
- Takaoka Hatsuyo
- Takata Tohru
- Takayanagi Noboru
- Takeda Yoshito
- Takei Reoto
- Takeuchi Mayumi
- Taki Reiko
- Takita Mumon
- Takoi Hiroyuki
- Tanaka Akihiko
- Tanaka Hiromu
- Tanaka Toru
- Tanaka Yoshiaki
- Tani Mayuko
- Tanino Yoshinori
- Tateishi Tomoya
- Tateno Hiroki
- Terai Hideki
- Terashima Mariko
- Togashi Yuki
- Tohda Shuji
- Tokunaga Katsushi
- Tokunaga Yoshihisa
- Tominaga Yoshiteru
- Tomono Kazunori
- Tone Mari
- Tsuburai Takahiro
- Tsuchida Tomoya
- Uchida Sho
- Uchida Tomoyuki
- Uchimura Yuji
- Ueda Ken
- Ueda Soichiro
- Ueda Suguru
- Ueda Tetsuya
- Ueno Takafumi
- Umeda Akira
- Uno Shunsuke
- Utsugi Mitsuyoshi
- Uwamino Yoshifumi
- Wada Daiki
- Wada Sae
- Wakabayashi Aya
- Wakahara Keiko
- Wang Qingbo S.
- Watanabe Chie
- Watanabe Hiroki
- Watanabe Hiroko
- Watanabe Kazuyoshi
- Watanabe Masafumi
- Yagi Kazuma
- Yamada Mitsuhiro
- Yamada Yuichiro
- Yamagata Kunihiro
- Yamaguchi Yuta
- Yamamoto Kenichi
- Yamamoto Makoto
- Yamamoto Masaomi
- Yamamoto Yuji
- Yamano Yasuhiko
- Yamasaki Masaki
- Yamashita Tatsuya
- Yasui Yoshinori
- Yatomi Masakiyo
- Yokote Koutaro
- Yoneda Midori
- Yonekawa Akiko
- Yoshida Eriko
- Yoshida Kosuke
- Yoshida Shozo
- Yoshida Shuichi
- Yoshida Toru
- Yoshifuji Ayumi
- Yoshihara Tomoyuki
- Yoshiya Kazuhisa
- Yoshiyama Takashi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
ăăłăăć¶ć§ăżăčăŻăă©ăŒăčăCOVID-19æŁè
ç±æ„ăźèĄæ¶Č现èă«ăăăéșäŒćçșçŸăźç¶ČçŸ
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ćăźćäșșć·źăćœ±éżăă--. äșŹéœć€§ćŠăăŹăčăȘăȘăŒăč. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection
DOCK2 is involved in the host genetics and biology of severe COVID-19
- Author
- Abe Ryuzo
- Abe Shinji
- Adachi Tomohiro
- Adachi Yuichi
- Ai Masumi
- Amishima Masaru
- Amiya Saori
- Anan Ryusuke
- Ando Akira
- Anzai Tatsuhiko
- Aoki Ryousuke
- Arai Daisuke
- Arai Ryosuke
- Arai Sawako
- Arakawa Kenichi
- Arimura Ken
- Asai Satoshi
- Asakura Takanori
- Asano Koichiro
- Awano Nobuyasu
- Azekawa Shuhei
- Azuma Masanori
- Baba Hiroaki
- Baba Rie
- Baba Tomoya
- Beppu Satoru
- Chiba Shigeru
- Chihara Yusuke
- Chubachi Shotaro
- Edahiro Ryuya
- Egi Moritoki
- Eguchi Hirotaka
- Endo Akifumi
- Endo Mayu
- Enomoto Takatoshi
- Eriguchi Yoshihiro
- Fuchimoto Yasuko
- Fujii Kazuhiko
- Fujimoto Nobukazu
- Fujita Kazue
- Fujitani Shigeki
- Fujiwara Akiko
- Fuke Satoshi
- Fukui Takahiro
- Fukui Yasutaka
- Fukui Yoshinori
- Fukunaga Koichi
- Fukushima Munehisa
- Fukusumi Takahito
- Fukuta Tetsuya
- Fukuyama Satoru
- Funatsu Yohei
- Furukawa Yoichi
- Gon Yasuhiro
- Hagihara Masao
- Hagimoto Satoshi
- Hagiwara Eri
- Hagiwara Shigehiro
- Hamamoto Junko
- Hanada Satoko
- Hara Reina
- Harada Masahiro
- Harada Norihiro
- Harada Sonoko
- Harada Yuko
- Haruta Yuki
- Hase Isano
- Hasegawa Naoki
- Hasegawa Takanori
- Hasegawa Yoshinori
- Hashiguchi Mizuha
- Hashimoto Naozumi
- Hashimoto Satoru
- Hashino Takuya
- Hattori Takeshi
- Hayashi Hiroyuki
- Hayashi Kentaro
- Hayashi Reina
- Hayashi Shinichi
- Hida Naoya
- Higashiyama Masahiko
- Hiki Makoto
- Hirai Yoshihiro
- Hiramatsu Yuji
- Hirano Toshiyuki
- Hiranuma Hisato
- Hirata Haruhiko
- Hirouchi Takatomo
- Hizawa Nobuyuki
- Honda Takayuki
- Horinouchi Hirohisa
- Hoshino Kota
- Hosoda Chiaki
- Hyugaji Takayoshi
- Ichikado Kazuya
- Ichimura Naoya
- Igarashi Akira
- Ihara Shoichi
- Ikemura Shinnosuke
- Imai Takao
- Imamura Tomonori
- Imoto Seiya
- Inohara Hidenori
- Inomata Minoru
- Inoue Sumito
- Inoue Takashi
- Inoue Takuya
- Inoue Yoshiaki
- Ishiguro Takashi
- Ishihara Rino
- Ishihara Sayoko
- Ishihara Shoichiro
- Ishii Makoto
- Ishii Tomoo
- Ishikawa Motonao
- Ishikura Hiroyasu
- Ishioka Kota
- Isogai Susumu
- Isono Taisuke
- Ito Akihiro
- Ito Fumimaro
- Ito Kazuto
- Ito Satoshi
- Ito Yoko
- Iwagoe Hajime
- Iwamura Hiromu
- Izumi Namiki
- Izumo Takehiro
- Kabata Hiroki
- Kagaya Takashi
- Kagyo Junko
- Kai Hirayasu
- Kamata Hirofumi
- Kamatani Yoichiro
- Kamimaki Isamu
- Kamiya Akane
- Kan-o Keiko
- Kanai Masahiro
- Kanai Masayuki
- Kanai Takanori
- Kanaoka Kensuke
- Kanayama Syuji
- Kanda Hidenori
- Kanehiro Arihiko
- Kaneko Yutaro
- Kaneyama Yasunari
- Kasamatsu Yu
- Kashiwada Takeru
- Katayama Kazuhiko
- Katayama Kotoe
- Kato Kazuto
- Kato Yasuhiro
- Kawabata Shuhei
- Kawada Miki
- Kawamura Kodai
- Kawamura Yusuke
- Kawana Akihiko
- Kawana Masatoshi
- Kawashima Hidetoshi
- Kijima Noriyuki
- Kikuchi Ryota
- Kimizuka Yoshifumi
- Kimura Akinori
- Kimura Nozomu
- Kimura Tomoki
- Kimura Tomoyuki
- Kimura Yasuhiro
- Kishi Hiroto
- Kishikawa Toshihiro
- Kishima Haruhiko
- Kita Toshiyuki
- Kitagawa Yuichiro
- Kitagawa Yuko
- Kitamura Hideya
- Kobayashi Keigo
- Kobayashi Yoichi
- Kodaka Norio
- Kodama Nobuhiro
- Koh Hidefumi
- Kohashi Sumiko
- Koike Ryuji
- Koji Sakamoto
- Kojima Mitsuaki
- Kokuto Hiroyuki
- Komase Yuko
- Komuta Kiyoshi
- Konishi Shunichiro
- Kono Yuta
- Koretsune Yukihiro
- Koshida Kiyoshi
- Kozu Yutaka
- Kuge Tomoki
- Kumanogoh Atsushi
- Kuraki Takashige
- Kuramochi Mizuki
- Kurihara Yuko
- Kusaka Yu
- Kuse Naoyuki
- Kuwahara Naota
- Lee Ho
- Liu Yu-Chen
- Maeda Shunsuke
- Maeda Yuichi
- Maeno Toshitaka
- Makino Shohei
- Makino Yasushi
- Manabe Tadashi
- Maruyama Junichi
- Maruyama Shuhei
- Masaki Katsunori
- Mashimo Shuko
- Masuda Makoto
- Masumoto Akihide
- Masuzawa Keita
- Matsubara Yuta
- Matsuda Fumihiko
- Matsuda Koichi
- Matsui Yuma
- Matsumoto Kinnosuke
- Matsumoto Koichiro
- Matsumoto Shuichiro
- Matsumoto Takemasa
- Matsunaga Tomohiro
- Matsuo Hirotaka
- Matsuse Hiroto
- Matsushita Yasushi
- Mikami Yohei
- Minami Shiro
- Minemura Hiroyuki
- Mitamura Keiko
- Miyagawa Kazuya
- Miyake Takahito
- Miyano Satoru
- Miyawaki Masayoshi
- Miyawaki Satoru
- Miyazaki Masatoshi
- Miyazaki Yasunari
- Miyazaki Yoshimune
- Miyazawa Naoki
- Mochimaru Takao
- Mori Nobuaki
- Morikawa Daiki
- Morisaki Hiroshi
- Morisaki Takayuki
- Morita Atsuho
- Morita Takayoshi
- Motegi Mitsuru
- Motooka Daisuke
- Murakami Koji
- Murakami Teruaki
- Murakami Yoshinori
- Muranaka Hiroyuki
- Murayama Shigeo
- Murohashi Kota
- Muto Kaori
- Mutoh Yoshikazu
- Nagai Akiko
- Nagai Hideaki
- Nagao Genta
- Nagasaka Tomoki
- Nagasaki Tadao
- Nagasaki Yoji
- Nagata Kaoru
- Nagayama Satoshi
- Naito Tatsuhiko
- Naito Toshio
- Naito Yoko
- Nakachi Ichiro
- Nakada Taka-Aki
- Nakajima Jun
- Nakajima Yukiko
- Nakamori Yasushi
- Nakamura Ai
- Nakamura Kazunori
- Nakamura Morio
- Nakamura Yoshihiko
- Nakano Chihiro
- Nakano Yasushi
- Nakatsumi Hiroki
- Nakayama Akiyoshi
- Nakayama Sohei
- Namba Shinichi
- Namkoong Ho
- Nanki Kosaku
- Nannya Yasuhito
- Narita Atsuya
- Narumoto Osamu
- Nii Takuro
- Niitsu Takayuki
- Nikaido Takefumi
- Nishi Koichi
- Nishida Takashi
- Nishihara Hiroshi
- Nishikawa Masanori
- Nishimura Tomoyasu
- Nishio Kazumi
- Nishitsuji Masaru
- Nishiyama Kei
- Nishiyama Kenta
- Niwa Kazuki
- Noda Yoshimi
- Noguchi Yoichiro
- Nukaga Shigenari
- Obara Wataru
- Obata Daisuke
- Ochi Junichi
- Odani Toshio
- Odate Mitsuru
- Ogata Hideo
- Ogata Tomouki
- Ogawa Aki
- Ogawa Seishi
- Ogawa Shinichi
- Oguma Tsuyoshi
- Ogura Shinji
- Ogura Takashi
- Ogura Takayuki
- Ohba Takehiko
- Ohira Yoshiyuki
- Ohta Kazuhide
- Ohta Ken
- Ohta Shin
- Okabayashi Hiroko
- Okada Takenori
- Okada Yukinori
- Okamori Satoshi
- Okamoto Masaki
- Okudela Koji
- Okuzaki Daisuke
- Omae Yosuke
- Omote Norihito
- Ono Akihiro
- Ono Hiroshi
- Ono Yoshinao
- Onoi Keisuke
- Ooshima Nobuharu
- Osawa Takeshi
- Oshima Taku
- Oshio Takeshi
- Ota Sho
- Oyama Baku
- Oyamada Yoshitaka
- Ozaki Shinji
- Sado Reiko
- Sado Toshikatsu
- Sagara Hironori
- Sageshima Hisako
- Saiki Ryunosuke
- Saito Fukuki
- Saito Fumitake
- Saito Hiroshi
- Saito Ryuichi
- Saito Yoshinobu
- Sakagami Satoru
- Sakakibara Shuhei
- Sakurai Toshihiro
- Sano Hirohito
- Sano Tomoya
- Sasa Noah
- Sasaki Junichi
- Sasaki Kana
- Sasano Hajime
- Sasano Hitoshi
- Sassa Chihiro Tani
- Sato Masamichi
- Sato Ryuichi
- Sato Tomonori
- Sato Toshiro
- Sato Yoko
- Sato Yuki
- Satomi Ryosuke
- Seike Masahiro
- Sekikawa Yoshiyuki
- Shibata Shun
- Shibata Yoko
- Shibusawa Takayuki
- Shichinohe Yasuo
- Shimada Hisato
- Shimada Tadanaga
- Shimizu Eigo
- Shimizu Tetsuo
- Shimo Masatoshi
- Shimoda Masafumi
- Shinoki Masato
- Shinozuka Jun
- Shinozuka Keisuke
- Shiomi Tetsuya
- Shirai Yuya
- Shiroyama Takayuki
- Shoko Tomohisa
- Sinozaki Nobuaki
- Sonehara Kyuto
- Sonobe Kazunari
- Suematsu Ryohei
- Sueyoshi Atsushi
- Sugihara Fuminori
- Sugimoto Hideyasu
- Sugiura Hisatoshi
- Suzuki Junya
- Suzuki Ken
- Suzuki Motoyuki
- Suzuki Shoji
- Suzuki Takao
- Suzuki Yusuke
- Tachikawa Natsuo
- Tada Ai
- Tagaya Etsuko
- Takada Minoru
- Takagaki Masatoshi
- Takagi Haruhi
- Takahashi Hidenori
- Takahashi Hiroshi
- Takahashi Kazuhisa
- Takahashi Kenichiro
- Takahashi Kunihiko
- Takahashi Mai
- Takahashi Meiko
- Takahashi Saeko
- Takahashi Takeshi
- Takahashi Yasuo
- Takaku Yotaro
- Takano Kenji
- Takano Tomomi
- Takaoka Hatsuyo
- Takata Tohru
- Takayanagi Noboru
- Takeda Yoshito
- Takei Reoto
- Takemoto Norihiko
- Takeuchi Mayumi
- Taki Reiko
- Takita Mumon
- Takoi Hiroyuki
- Takuwa Ayako
- Tanaka Akihiko
- Tanaka Hiromu
- Tanaka Toru
- Tanaka Yoshiaki
- Tani Mayuko
- Tanino Yoshinori
- Tateishi Tomoya
- Tateno Hiroki
- Terai Hideki
- Terashima Mariko
- Togashi Yuki
- Tohda Shuji
- Tokunaga Katsushi
- Tokunaga Yoshihisa
- Tominaga Yoshiteru
- Tomono Kazunori
- Tone Mari
- Tsuburai Takahiro
- Tsuchida Tomoya
- Uchida Sho
- Uchida Tomoyuki
- Uchimura Yuji
- Ueda Ken
- Ueda Soichiro
- Ueda Suguru
- Ueda Tetsuya
- Ueno Takafumi
- Ueno Yuya
- Umeda Akira
- Uno Shunsuke
- Utsugi Mitsuyoshi
- Uwamino Yoshifumi
- Wada Daiki
- Wada Sae
- Wakabayashi Aya
- Wakahara Keiko
- Wang Qingbo S.
- Watanabe Chie
- Watanabe Hiroki
- Watanabe Hiroko
- Watanabe Kazuyoshi
- Watanabe Masafumi
- Wing James B.
- Yagi Kazuma
- Yamada Mitsuhiro
- Yamada Shuhei
- Yamada Yuichiro
- Yamagata Kunihiro
- Yamaguchi Hiroki
- Yamaguchi Yuta
- Yamaji Ken
- Yamamoto Kenichi
- Yamamoto Makoto
- Yamamoto Masaomi
- Yamamoto Yuji
- Yamanashi Yuji
- Yamano Yasuhiko
- Yamasaki Masaki
- Yamashita Tatsuya
- Yanagita Emmy
- Yasui Yoshinori
- Yatomi Masakiyo
- Yokote Koutaro
- Yoneda Midori
- Yonekawa Akiko
- Yoshida Eriko
- Yoshida Kosuke
- Yoshida Shozo
- Yoshida Shuichi
- Yoshida Toru
- Yoshifuji Ayumi
- Yoshihara Tomoyuki
- Yoshimori Kozo
- Yoshimura Yukihiro
- Yoshiya Kazuhisa
- Yoshiyama Takashi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
ăăłăăć¶ć§ăżăčăŻăă©ăŒăčăCOVID-19çŸæŁæćæ§éșäŒćDOCK2ăźéçćæ©ćșăè§Łæ --ăąăžăąæ性ăźăă€ăȘăŹăăžăăȘăŒă§COVID-19ăźæČ»çæšçăçșèŠ--. äșŹéœć€§ćŠăăŹăčăȘăȘăŒăč. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (nâ=â61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target
Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).
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- A'Court C.
- Aaroe H.
- Abd El-Aziz A.
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- Xhaet O.
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- Xu R. Y.
- Xue L.
- Yagensky A.
- Yakupov E.
- Yamada T.
- Yamagishi T.
- Yamaguchi H.
- Yamamoto K.
- Yamamoto K. (Kenichi)
- Yamamoto K. (Kentaro)
- Yamamoto K. (Kunihiko)
- Yamamoto T.
- Yamasawa M.
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- Yamazoe M.
- Yan X. W.
- Yang J. S.
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- Yap S. Y.
- Yasui K.
- Yawila S.
- Ye S.
- Ye Y.
- Yeo C.
- Yeter E.
- Yildirim E.
- Yildirim R.
- Yilmaz F.
- Yilmaz M. B.
- Yilmaz O.
- Yim K. H.
- Yin Y. H.
- Yokota N.
- Yokoyama Y.
- Yong R.
- Yoo K. M.
- Yoon E. J.
- Yoon J. H.
- Yorgun H.
- Yoshida H.
- Yoshida K.
- Yoshida T. (Tetsuro)
- Yoshida T. (Tomoki)
- Yoshimura A.
- Yoshizawa N.
- Yousef G.
- Yu H. Y.
- Yu J. H.
- Yu T.
- Yuksekdag V
- Yun S. Y.
- Yunis M. E.
- Zaatout E.
- Zaidi S. M. A.
- Zaitsu R.
- Zak J.
- Zakutynska-Kowalczyk K.
- Zaluska R.
- Zaman K.
- Zanolin D.
- Zapata G.
- Zateyshchikov D.
- Zateyshchikova A.
- Zauzig H-D
- Zauzig H.
- Zecca C.
- Zemlianskaia O.
- Zhai H.
- Zhan Q.
- Zhang G. S.
- Zhang H. Q.
- Zhang Q.
- Zhang R.
- Zhang Y.
- Zhao R. P.
- Zhao Y. S.
- Zheng W. Y.
- Zhirov I
- Zhou B.
- Zhou Z. H.
- Zhu X. Y.
- Zhuravleva E.
- Zhurba S.
- Zidek M.
- Zidkova E.
- Ziefle S.
- Zika J.
- Zillo M.
- Zimmett L.
- Zimny H-H
- Zincke S.
- Zinka E.
- Zotova I
- Zrazhevskiy K.
- Zubeeva G.
- Zuber M.
- Zurbrigk F. J.
- Zutz S.
- Zyczynska-Szmon M.
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2018
- Field of study
Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and â„1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (nâ=â5069) or prospectively (nâ=â5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (â€6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; pâ=â0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)
Search for dark matter produced in association with bottom or top quarks in âs = 13 TeV pp collisions with the ATLAS detector
- Author
- Aaboud Morad
- Aad Georges
- Abbott Brad
- Abdinov Ovsat
- Abeloos Baptiste
- Abidi Syed
- AbouZeid Ossama
- Abraham Nicola
- Abramowicz Halina
- Abreu Henso
- Abreu Ricardo
- Abulaiti Yiming
- Acharya Bobby
- Adachi Shunsuke
- Adamczyk Leszek
- Adelman Jahred
- Adersberger Michael
- Adye Tim
- Affolder Tony
- Afik Yoav
- Agatonovic-Jovin Tatjana
- Agheorghiesei Catalin
- Aguilar-Saavedra Juan
- Ahlen Steven
- Ahmadov Faig
- Aielli Giulio
- Akatsuka Shunichi
- Akerstedt Henrik
- Akilli Ece
- Akimov Andrei
- Alberghi Gian
- Albert Justin
- Albicocco Pietro
- Alconada Verzini Maria
- Alderweireldt Sara
- Aleksa Martin
- Aleksandrov Igor
- Alexa Calin
- Alexander Gideon
- Alexopoulos Theodoros
- Alhroob Muhammad
- Ali Babar
- Aliev Malik
- Alimonti Gianluca
- Alison John
- Alkire Steven
- Allbrooke Benedict
- Allen Benjamin
- Allport Phillip
- Aloisio Alberto
- Alonso Alejandro
- Alonso Francisco
- Alpigiani Cristiano
- Alshehri Azzah
- Alstaty Mahmoud
- Alvarez Gonzalez Barbara
- Alviggi Mariagrazia
- Amadio Brian
- Amaral Coutinho Yara
- Amelung Christoph
- Amidei Dante
- Amor Dos Santos Susana
- Amoroso Simone
- Anastopoulos Christos
- Ancu Lucian
- Andari Nansi
- Andeen Timothy
- Anders Christoph
- Anders John
- Anderson Kelby
- Andreazza Attilio
- Andrei George
- Angelidakis Stylianos
- Angelozzi Ivan
- Angerami Aaron
- Anisenkov Alexey
- Anjos Nuno
- Annovi Alberto
- Antel Claire
- Antonelli Mario
- Antonov Alexey
- Antrim Daniel
- Anulli Fabio
- Aoki Masato
- Aperio Bella Ludovica
- Arabidze Giorgi
- Arai Yasuo
- Araque Juan
- Araujo Ferraz Victor
- Arce Ayana
- Ardell Rose
- Arduh Francisco
- Arguin Jean-Francois
- Argyropoulos Spyridon
- Arik Metin
- Armbruster Aaron
- Armitage Lewis
- Arnaez Olivier
- Arnold Hannah
- Arratia Miguel
- Arslan Ozan
- Artamonov Andrei
- Artoni Giacomo
- Artz Sebastian
- Asai Shoji
- Asbah Nedaa
- Ashkenazi Adi
- Asquith Lily
- Assamagan Ketevi
- Astalos Robert
- Atkinson Markus
- Atlay Naim
- Augsten Kamil
- Avolio Giuseppe
- Axen Bradley
- Ayoub Mohamad
- Azuelos Georges
- Baas Alessandra
- Baca Matthew
- Bachacou Henri
- Bachas Konstantinos
- Backes Moritz
- Bagnaia Paolo
- Bahmani Marzieh
- Bahrasemani Sina
- Baines John
- Bajic Milena
- Baker Oliver
- Bakker Pepijn
- Baldin Evgenii
- Balek Petr
- Balli Fabrice
- Balunas William
- Banas Elzbieta
- Bandyopadhyay Anjishnu
- Banerjee Swagato
- Bannoura Arwa
- Barak Liron
- Barberio Elisabetta
- Barberis Dario
- Barbero Marlon
- Barillari Teresa
- Barisits Martin-Stefan
- Barkeloo Jason
- Barklow Timothy
- Barlow Nick
- Barnes Sarah
- Barnett Bruce
- Barnett Michael
- Barnovska-Blenessy Zuzana
- Baroncelli Antonio
- Barone Gaetano
- Barr Alan
- Barranco Navarro Laura
- Barreiro GuimarĂŁes da Costa JoĂŁo
- Barreiro Fernando
- Barros Vale Maria
- Bartoldus Rainer
- Barton Adam
- Bartos Pavol
- Basalaev Artem
- Bassalat Ahmed
- Bates Richard
- Batista Santiago
- Batley Richard
- Battaglia Marco
- Bauce Matteo
- Bauer Florian
- Bawa Harinder
- Beacham James
- Beattie Michael
- Beau Tristan
- Beauchemin Pierre-Hugues
- Bechtle Philip
- Beck Hans~Peter
- Beck Helge
- Becker Kathrin
- Becker Maurice
- Becot Cyril
- Beddall Andrew
- Beddall Ayda
- Bednyakov Vadim
- Bedognetti Matteo
- Bee Christopher
- Beermann Thomas
- Begalli Marcia
- Begel Michael
- Behr Janna
- Bell Andrew
- Bella Gideon
- Bellagamba Lorenzo
- Bellerive Alain
- Bellomo Massimiliano
- Belotskiy Konstantin
- Beltramello Olga
- Belyaev Nikita
- Benary Odette
- Benchekroun Driss
- Bender Michael
- Benekos Nektarios
- Benhammou Yan
- Benhar Noccioli Eleonora
- Benitez Jose
- Benjamin Douglas
- Benoit Mathieu
- Bensinger James
- Bentvelsen Stan
- Beresford Lydia
- Beretta Matteo
- Berge David
- Bergeaas Kuutmann Elin
- Berger Nicolas
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- Berlendis Simon
- Bernard Nathan
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- Besjes Geert-Jan
- Bessidskaia Bylund Olga
- Bessner Martin
- Besson Nathalie
- Bethani Agni
- Bethke Siegfried
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- Bevan Adrian
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- Biedermann Dustin
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- Biglietti Michela
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- Blocker Craig
- Blue Andrew
- Blumenschein Ulrike
- Blunier Sylvain
- Bobbink Gerjan
- Bobrovnikov Victor
- Bocchetta Simona
- Bocci Andrea
- Bock Christopher
- Boehler Michael
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- Bogavac Danijela
- Bogdanchikov Alexander
- Bohm Christian
- Boisvert Veronique
- Bokan Petar
- Bold Tomasz
- Boldyrev Alexey
- Bolz Arthur
- Bomben Marco
- Bona Marcella
- Boonekamp Maarten
- Borisov Anatoly
- Borissov Guennadi
- Bortfeldt Jonathan
- Bortoletto Daniela
- Bortolotto Valerio
- Boscherini Davide
- Bosman Martine
- Bossio Sola Jonathan
- Boudreau Joseph
- Bouhova-Thacker Evelina
- Boumediene Djamel
- Bourdarios Claire
- Boutle Sarah
- Boveia Antonio
- Boyd James
- Boyko Igor
- Bozson Adam
- Bracinik Juraj
- Brandt Andrew
- Brandt Gerhard
- Brandt Oleg
- Braren Frued
- Bratzler Uwe
- Brau Benjamin
- Brau James
- Breaden Madden William
- Brendlinger Kurt
- Brennan Amelia
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- Brenner Richard
- Bressler Shikma
- Briglin Daniel
- Bristow Timothy
- Britton Dave
- Britzger Daniel
- Brochu Frederic
- Brock Ian
- Brock Raymond
- Brooijmans Gustaaf
- Brooks Timothy
- Brooks William
- Brosamer Jacquelyn
- Brost Elizabeth
- Broughton James
- Bruckman de Renstrom Pawel
- Bruncko Dusan
- Bruni Alessia
- Bruni Graziano
- Bruni Lucrezia
- Bruno Salvatore
- Brunt Benjamin
- Bruschi Marco
- Bruscino Nello
- Bryant Patrick
- Bryngemark Lene
- Buanes Trygve
- Buat Quentin
- Buchholz Peter
- Buckley Andrew
- Budagov Ioulian
- Buehrer Felix
- Bugge Magnar
- Bulekov Oleg
- Bullock Daniel
- Burch Tyler
- Burdin Sergey
- Burgard Carsten
- Burger Angela
- Burghgrave Blake
- Burka Klaudia
- Burke Stephen
- Burmeister Ingo
- Burr Jonathan
- Bussey Peter
- Butler John
- Buttar Craig
- Butterworth Jonathan
- Butti Pierfrancesco
- Buttinger William
- Buzatu Adrian
- Buzykaev Aleksey
- BĂŒscher Daniel
- BĂŒscher Volker
- C-Q Changqiao
- Cabrera UrbĂĄn Susana
- Caforio Davide
- Cai Huacheng
- Cairo Valentina
- Cakir Orhan
- Calace Noemi
- Calafiura Paolo
- Calandri Alessandro
- Calderini Giovanni
- Calfayan Philippe
- Callea Giuseppe
- Caloba Luiz
- Calvente Lopez Sergio
- Calvet David
- Calvet Samuel
- Calvet Thomas
- Camacho Toro Reina
- Camarda Stefano
- Camarri Paolo
- Cameron David
- Caminal Armadans Roger
- Camincher Clement
- Campana Simone
- Campanelli Mario
- Camplani Alessandra
- Campoverde Angel
- Canale Vincenzo
- Cano Bret Marc
- Cantero Josu
- Cao Tingting
- Capeans Garrido Maria
- Caprini Irinel
- Caprini Mihai
- Capua Marcella
- Carbone Ryne
- Cardarelli Roberto
- Cardillo Fabio
- Carli Ina
- Carli Tancredi
- Carlino Gianpaolo
- Carlson Benjamin
- Carminati Leonardo
- Carney Rebecca
- Caron Sascha
- Carquin Edson
- Carrillo-Montoya German
- CarrĂĄ Sonia
- Casadei Diego
- Casado Maria
- Casha Albert
- Casolino Mirkoantonio
- Casper David
- Castelijn Remco
- Castillo Gimenez Victoria
- Castro Nuno
- Catinaccio Andrea
- Catmore James
- Cattai Ariella
- Caudron Julien
- Cavaliere Viviana
- Cavallaro Emanuele
- Cavalli Donatella
- Cavalli-Sforza Matteo
- Cavasinni Vincenzo
- Celebi Emre
- Ceradini Filippo
- Cerda Alberich Leonor
- Cerri Alessandro
- Cerrito Lucio
- Cerutti Fabio
- Cervelli Alberto
- Cetin Serkant
- Chafaq Aziz
- Chakraborty Dhiman
- Chan Stephen
- Chan Wing
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- Chang Philip
- Chapman John
- Charlton Dave
- Chau Chav
- Chavez Barajas Carlos
- Che Siinn
- Cheatham Susan
- Chegwidden Andrew
- Chekanov Sergei
- Chekulaev Sergey
- Chelkov Gueorgui
- Chelstowska Magda
- Chen Cheng
- Chen Chunhui
- Chen Hucheng
- Chen Jing
- Chen Shenjian
- Chen Shion
- Chen Xin
- Chen Ye
- Cheng Hok
- Cheng Huajie
- Cheplakov Alexander
- Cheremushkina Evgeniya
- Cherkaoui El Moursli Rajaa
- Cheu Elliott
- Cheung Kingman
- Chevalier Laurent
- Chiarella Vitaliano
- Chiarelli Giorgio
- Chiodini Gabriele
- Chisholm Andrew
- Chitan Adrian
- Chiu Yu
- Chizhov Mihail
- Choi Kyungeon
- Chomont Arthur
- Chouridou Sofia
- Chow Yun
- Christodoulou Valentinos
- Chu Ming
- Chudoba Jiri
- Chuinard Annabelle
- Chwastowski Janusz
- Chytka Ladislav
- Ciftci Abbas
- Cinca Diane
- Cindro Vladimir
- Cioara Irina
- Ciocio Alessandra
- Cirotto Francesco
- Citron Zvi
- Citterio Mauro
- Ciubancan Mihai
- Clark Allan
- Clark Brian
- Clark Michael
- Clark Philip
- Clarke Robert
- Clement Christophe
- Coadou Yann
- Cobal Marina
- Coccaro Andrea
- Cochran James
- Colasurdo Luca
- Cole Brian
- Colijn Auke-Pieter
- Collot Johann
- Colombo Tommaso
- Conde Muiño Patricia
- Coniavitis Elias
- Connell Simon
- Connelly Ian
- Constantinescu Serban
- Conti Geraldine
- Conventi Francesco
- Cooke Mark
- Cooper-Sarkar Amanda
- Cormier Felix
- Cormier Kyle
- Corradi Massimo
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- Cortes-Gonzalez Arely
- Costa Giuseppe
- Costa MarĂa
- Costanzo Davide
- Cottin Giovanna
- Cowan Glen
- Cox Brian
- Cranmer Kyle
- Crawley Samuel
- Creager Rachael
- Cree Graham
- Crescioli Francesco
- Cribbs Wayne
- Cristinziani Markus
- Croft Vince
- Crosetti Giovanni
- Crépé-Renaudin Sabine
- Cueto Ana
- Cuhadar Donszelmann Tulay
- Cukierman Aviv
- Cummings Jane
- Curatolo Maria
- Czekierda Sabina
- Czodrowski Patrick
- CĂșth Jakub
- D'amen Gabriele
- D'Auria Saverio
- D'Eramo Louis
- D'Onofrio Monica
- Da Cunha Sargedas De Sousa Mario
- Da Via Cinzia
- Dabrowski Wladyslaw
- Dado Tomas
- Dai Tiesheng
- Dale Orjan
- Dallaire Frederick
- Dallapiccola Carlo
- Dam Mogens
- Dandoy Jeffrey
- Daneri Maria
- Dang Nguyen
- Daniells Andrew
- Dann Nicholas
- Danninger Matthias
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- Dassoulas James
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- Dawe Edmund
- Dawson Ian
- de Asmundis Riccardo
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- De Cecco Sandro
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- De Jong Paul
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- De Kaushik
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- Dehghanian Nooshin
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- della Volpe Domenico
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- Demers Sarah
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- Demilly Aurelien
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- Desch Klaus
- Deterre Cecile
- Dette Karola
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- Di Donato Camilla
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- Dimitrievska Aleksandra
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- Dobos Daniel
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- Dopke Jens
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- Dova Maria-Teresa
- Doyle Tony
- Drechsler Eric
- Dris Manolis
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- Duckeck Guenter
- Ducourthial Audrey
- Ducu Otilia
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- Dudarev Alexey
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- Duflot Laurent
- Dulsen Carsten
- Dumancic Mirta
- Dumitriu Ana
- Duncan Anna
- Dunford Monica
- Duperrin Arnaud
- Duran Yildiz Hatice
- Durglishvili Archil
- Duschinger Dirk
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- Duvnjak Damir
- Dyndal Mateusz
- Dziedzic Bartosz
- DĂez Cornell Sergio
- DĂŒhrssen Michael
- DĂŒren Michael
- Eckardt Christoph
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- Edgar Ryan
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- Einsweiler Kevin
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- El Kacimi Mohamed
- El Kosseifi Rima
- Ellajosyula Venugopal
- Ellert Mattias
- Elles Sabine
- Ellinghaus Frank
- Elliot Alison
- Ellis Nicolas
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- Emeliyanov Dmitry
- Enari Yuji
- Ennis Joseph
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- Erdmann Johannes
- Ereditato Antonio
- Ernst Michael
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- Etzion Erez
- Evans Hal
- Ezhilov Alexey
- Ezzi Mohammed
- Fabbri Federica
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- Ferrer Antonio
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- Filipuzzi Marco
- FilipÄiÄ Andrej
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- Freund Benjamin
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- Gabizon Ofir
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- Gabrielli Andrea
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- Gadatsch Stefan
- Gadomski Szymon
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- Yamatani Masahiro
- Yamazaki Tomohiro
- Yamazaki Yuji
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- Yang Hongtao
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- Yao Weiming
- Yap Yee
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- Zaidan Remi
- Zaitsev Alexander
- Zakharchuk Nataliia
- Zalieckas Justas
- Zaman Aungshuman
- Zambito Stefano
- Zanzi Daniele
- Zeitnitz Christian
- Zemaityte Gabija
- Zemla Andrzej
- Zeng Jian
- Zeng Qi
- Zenin Oleg
- Zerwas Dirk
- Zhang Dengfeng
- Zhang Dongliang
- Zhang Fangzhou
- Zhang Guangyi
- Zhang Huijun
- Zhang Jinlong
- Zhang Lei
- Zhang Liqing
- Zhang Matt
- Zhang Peng
- Zhang Rui
- Zhang Ruiqi
- Zhang Xueyao
- Zhang Yu
- Zhang Zhiqing
- Zhao Xiandong
- Zhao Yongke
- Zhao Zhengguo
- Zhemchugov Alexey
- Zhou Bing
- Zhou Chen
- Zhou Li
- Zhou Maosen
- Zhou Mingliang
- Zhou Ning
- Zhou You
- Zhu Cheng
- Zhu Hongbo
- Zhu Junjie
- Zhu Yingchun
- Zhuang Xuai
- Zhukov Konstantin
- Zibell Andre
- Zieminska Daria
- Zimine Nikolai
- Zimmermann Christoph
- Zimmermann Stephanie
- Zinonos Zinonas
- Zinser Markus
- Ziolkowski Michael
- Zobernig Georg
- Zoccoli Antonio
- Zou Rui
- zur Nedden Martin
- Zwalinski Lukasz
- Ă kesson Torsten
- Ć filigoj Tina
- ĆœeniĆĄ Tibor
- ĆœivkoviÄ Lidija
- Îlvarez Piqueras DamiĂĄn
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fbâ1 of protonâproton collision data recorded by the ATLAS experiment at âs = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements
Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.
- Author
- A. Abd El-Aziz
- A. Abdul
- A. Agakhanyan
- A. Aggarwala
- A. Agrawal
- A. Al Mulla
- A. Al Naeemi
- A. Alfieri
- A. Ali
- A. Altun
- A. Alvarez D'Amelio
- A. Andersson
- A. Argena
- A. Austria
- A. Aydinlar
- A. Babyesiza
- A. Barai
- A. Barreau
- A. Barszcz
- A. Bartes
- A. Bazzoni Ruiz
- A. Beattie
- A. Bianchi
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- Ajay K. Kakkar
- Ajay K. Kakkar
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- David Fitzmaurice
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- S. Piña Toledano
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- S. Seki
- S. Severi
- S. Shah
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- S. Silva
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- S. Suresh
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- S. Sutcliffe
- S. Tahon
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- S. Tereshchenko
- S. Testa
- S. Thng
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- S. Tohyo
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- S. Toru
- S. Tranche Iparraguirre
- S. Tsunoda
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- S. Vangel
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- S. Villarreal Umaña
- S. Vizel
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- S. Zincke
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- S.J. Connolly
- S.K. Abou Seif
- S.M.A. Zaidi
- S.P. Cao
- S.R. Jeon
- S.W. Hwang
- S.W. Park
- S.W. Wong
- S.Y. Yap
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- S.Z. Goldhaber
- Samuel Z. Goldhaber
- Samuel Z. Goldhaber
- Samuel Z. Goldhaber
- Sang Hee Kim
- Sang Hyun Kim
- Sanjay Kakkar
- Seil Oh
- Sen Adachi
- Shinya Goto
- Sho Nagai
- Shu Suzuki
- Shunichi Nagai
- Shunji Suzuki
- Stuart J. Connolly
- Susumu Adachi
- Susumu Suzuki
- Sylvia Haas
- Sylvia Haas
- T. Adachi
- T. Amano
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- T. Fooks
- T. Fudo
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- T. Gooding
- T. Gorshkova
- T. Goto
- T. Grabek
- T. Gutowski
- T. Habon
- T. Harbour
- T. Hatsuno
- T. Hicks
- T. Higashi
- T. Hole
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- T. Ido
- T. Inoue
- T. Iwao
- T. Iwase
- T. Izquierdo
- T. Kasai
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- T. Khairy
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- T. Kira
- T. Kito
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- T. Ko
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- T. Kotani
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- T. Kusumoto
- T. Kuwahata
- T. Laksomya
- T. Lincoln
- T. Loekkegaard
- T. LĂ€Ăig
- T. Mark
- T. Medvedeva
- T. Minagawa
- T. Mita
- T. Mito
- T. Mori
- T. Mueller
- T. Murayama
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- T. Nagatomo
- T. Nagoshi
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- T. Nanke
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- T. Ogawa
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- T. Ovdiienko
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- T. Patching
- T. Phan
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- T. Suetsugu
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- T. Taguchi
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- T. Tana
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- T. Washizuka
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- V. Becerra Munoz
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- V. Eissing
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- V. Hansen
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- V. Klein
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- V. LilienweiĂ
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- V. Mochonyi
- V. Nagalingam
- V. Navarre
- V. Nemtsova
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- V. O'May
- V. Olguin
- V. Oriana
- V. Palumbo
- V. Pannacci
- V. Paul
- V. Pengo
- V. Piamonte
- V. Quintern
- V. Rasanen
- V. Rios
- V. Roa Castro
- V. St Joseph
- V. Thyssen
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- V. Ueckermann
- V. Vanajakshamma
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- V. Wilson
- V. Worthy
- V. Yuksekdag
- V.A. Kothiwale
- V.A. Sinisi
- V.L. Pereira
- V.M. Ortega
- V.M. Vijan
- Veerappa A. Kothiwale
- Velam Vanajakshamma
- Vikas Bisne
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- W. Haverkamp
- W. Hermans
- W. Jetten
- W. Kunz Sebba Barroso de Souza
- W. Kurdzielewicz
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- W. Murdoch
- W. Myszka
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- W. Rogowski
- W. Smolders
- W. Suebjaksing
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- W. Szkrobka
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- W. Wongcharoen
- W. Wongtheptien
- W.H. Li
- W.J. Chi
- W.L. Liu
- W.M. Kutayli
- W.N. Guo
- W.S. Son
- W.T. Lim
- W.Y. Lee
- W.Y. Zheng
- Wael Al Mahmeed
- Werner Hacke
- X. Chen
- X. Giry
- X. Li
- X. Robiro Robiro
- X. Sheng
- X. Vandamme
- X. Viñolas
- X.A. He
- X.F. Huang
- X.J. Gao
- X.J. Shi
- X.L. Luo
- X.S. Cheng
- X.S. Hu
- X.W. Yan
- X.Y. Zhu
- Xavier Viñolas
- Y. Abe
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- Y. Balthazar
- Y. Belenkova
- Y. Campisto
- Y. Emura
- Y. Fujii
- Y. Fujisawa
- Y. Go
- Y. Gomez Perez
- Y. Gottwalles
- Y. Guo
- Y. Haraguchi
- Y. Hata
- Y. Hatori
- Y. Hayashi
- Y. Ivanova
- Y. Jiao
- Y. Kamogawa
- Y. Kato
- Y. Katsube
- Y. Katsuda
- Y. Kawada
- Y. Kelfkens
- Y. Kitami
- Y. Koretsune
- Y. Koshibu
- Y. Kumai
- Y. Maruyama
- Y. Matsuura
- Y. Mizuno
- Y. Moiseeva
- Y. Mostovoy
- Y. Niijima
- Y. Nishida
- Y. Nishihata
- Y. Oba
- Y. Onuki Pearce
- Y. Orlov
- Y. Osmolovskaya
- Y. Park
- Y. Saito
- Y. Sakamoto
- Y. Samejima
- Y. Santanakorn
- Y. Sasagawa
- Y. Sekine
- Y. Seta
- Y. Shapovalova
- Y. Shiina
- Y. Shimoyama
- Y. Shozawa
- Y. Stipp
- Y. Suzuki
- Y. Svyshchenko
- Y. Takagi
- Y. Tsuchiya
- Y. Ueyama
- Y. Vandekerckhove
- Y. Vorasettakarnkij
- Y. Wakasa
- Y. Ye
- Y. Yokoyama
- Y. Zhang
- Y.-I. Kim
- Y.H. Li
- Y.H. Sun
- Y.H. Yin
- Y.J. Yang
- Y.J. Yang
- Y.K. On
- Y.M. Chen
- Y.M. Lee
- Y.M. Sohn
- Y.R. Jeon
- Y.S. Oh
- Y.S. Son
- Y.S. Zhao
- Y.Y. Liu
- Ying Wang
- Yoichi Nakamura
- Yong Wang
- Yoshihisa Fujiura
- Yoshitake Fujiura
- Yuhei Shiga
- Yuichiro Nakamura
- Yukihiro Koretsune
- Yukio Shiga
- Z. Babjakova
- Z. Boda
- Z. Djaidani
- Z. Lajkowski
- Z. Laszlo
- Z. May
- Z. Monhart
- Z. Ongen
- Z. Radics
- Z.C. Lu
- Z.H. Zhou
- Z.M. Yang
- Publication venue
- Indian Heart J
- Publication date
- 01/01/2018
- Field of study
BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362
Efficacy of an additional flap operation in bladder-preserving surgery with radical prostatectomy and cystourethral anastomosis for rectal cancer involving the prostate
- Author
- Akihiro Kobayasi
- AR Mundy
- CJ Gannon
- DM Kecmanovic
- E Rullier
- FT Ferenschild
- GC Bannura
- H Ike
- H Katayama
- H Lepor
- H Nakamura
- HS Chen
- JA Eastham
- JN Wiig
- JN Wiig
- JT Kakuda
- K Koda
- K Renner
- K Shirouzu
- K Yamada
- Keita Noguchi
- LW Klee
- M Fujisawa
- M Nishio
- M Vermaas
- Masaaki Ito
- MB Nielsen
- MD Balbay
- N Saito
- N Saito
- N Saito
- Norio Saito
- R Chamlou
- R Schiessel
- R Stein
- RE Hautmann
- RE Jimenez
- RJ Gonzalez
- RJ Nicholls
- S Fujii
- S Hasegawa
- S Ishiguro
- S Yamamoto
- SC Campbell
- TS Domes
- TX Yang
- UE Studer
- WL Law
- Y Moriya
- Yasuyuki Sakai
- Yoshinobu Komai
- Yuji Nishizawa
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
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