373 research outputs found
Thermotomaculum hydrothermale gen. nov., sp. nov., a novel heterotrophic thermophile within the phylum Acidobacteria from a deep-sea hydrothermal vent chimney in the Southern Okinawa Trough
- Author
- A-L Reysenbach
- CM Santelli
- DA Bryant
- DB Meisinger
- DE Minnikin
- DJ Lane
- DL Swofford
- H Imachi
- H Kampe
- Hiroshi Izumi
- IH Koch
- IS Kulichevskaya
- J Sambrook
- J Tamaoka
- J Tamaoka
- J Zimmermann
- JA Baross
- JD Coates
- K Komagata
- K Takai
- Ken Takai
- KG Porter
- M Sait
- Masayuki Miyazaki
- MB Stott
- N Kishimoto
- N Saitou
- NL Ward
- P Hugenholtz
- P LĂłpez-GarcĂa
- S Kleinsteuber
- S Nakagawa
- S Nakagawa
- S Nakagawa
- S Nakagawa
- SA Eichorst
- Satoshi Nakagawa
- Sayaka Mino
- SF Altschul
- SM Barns
- SM Barns
- SM Sievert
- T Nunoura
- T Nunoura
- T Nunoura
- TA Pankratov
- Takuro Nunoura
- TH Jukes
- Tomohiro Toki
- Tomoo Sawabe
- W Liesack
- W Ludwig
- W Ludwig
- W Zillig
- WJ Brazelton
- Y Fukunaga
- Y Sako
- Yoshihiko Sako
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2012
- Field of study
http://www.godac.jamstec.go.jp/darwin/cruise/natsushima/nt08-13/
Junctional Adhesion Molecule 2 Mediates the Interaction between Hatched Blastocyst and Luminal Epithelium: Induction by Progesterone and LIF
- Author
- A Psychoyos
- AJ Wilcox
- BC Paria
- BC Paria
- Bo Jia
- C Lamagna
- C Weber
- CB Teng
- CL Stewart
- DP Lu
- H Bhatt
- H Ni
- H Pan
- Haibin Wang
- HJ Lim
- HL Franco
- Hua Ni
- JE Cartwright
- JG Cheng
- Ji-Long Liu
- JL Escary
- JR Chen
- K Siddiquee
- KG Danielsson
- KJ Mandell
- M Ernst
- M Marwood
- MM Shen
- Ren-Wei Su
- RJ Ludwig
- RJ Ludwig
- RM Bigsby
- SA Cunningham
- SA Cunningham
- Shun-Li Yue
- T Sakaguchi
- Tong-Song Wang
- TW Liang
- W Beguelin
- Wei Lei
- Weng-Bo Deng
- XH Ma
- Xu-Hui Feng
- YM Huet-Hudson
- Zeng-Ming Yang
- Zhen-Ao Zhao
- ZM Yang
- Publication venue
- Public Library of Science
- Publication date
- 12/04/2012
- Field of study
National Basic Research Program of China [2011CB944402]; National Natural Science Foundation of China [30930013, 31071276]Background: Junctional adhesion molecule 2 (Jam2) is a member of the JAM superfamily. JAMs are localized at intercellular contacts and participated in the assembly and maintenance of junctions, and control of cell permeability. Because Jam2 is highly expressed in the luminal epithelium on day 4 of pregnancy, this study was to determine whether Jam2 plays a role in uterine receptivity and blastocyst attachment in mouse uterus. Methodology/Principal Findings: Jam2 is highly expressed in the uterine luminal epithelium on days 3 and 4 of pregnancy. Progesterone induces Jam2 expression in ovariectomized mice, which is blocked by progesterone antagonist RU486. Jam2 expression on day 4 of pregnancy is also inhibited by RU486 treatment. Leukemia inhibitory factor (LIF) up-regulates Jam2 protein in isolated luminal epithelium from day 4 uterus, which is blocked by S3I-201, a cell-permeable inhibitor for Stat3 phosphorylation. Under adhesion assay, recombinant Jam2 protein increases the rate of blastocyst adhesion. Both soluble recombinant Jam2 and Jam3 can reverse this process. Conclusion: Jam2 is highly expressed in the luminal epithelium of receptive uterus and up-regulated by progesterone and LIF via tyrosine phosphorylation of Stat3. Jam2 may play a role in the interaction between hatched blastocyst and receptive uterus
Risk factors associated with non-alcoholic fatty liver disease in subjects from primary care units. A case-control study
- Author
- AJ Sanyal
- Alba AlumĂ
- Albert Tibau
- AM Diehl
- C Pagano
- Carmen Sanchez
- Dolores Miranda
- Enriqueta Alcaraz
- ES Ford
- Executive summary of the third report of the National Cholesterol Education (NCEP)
- G Bedogni
- G Bedogni
- Guillem Pera
- J CaballerĂa
- J Ludwig
- JB Dixon
- JesĂșs Bernad
- JM Clark
- Josep AubĂ
- José Dario Casas
- KG Alberti
- Laura Muñoz
- Ll CaballerĂa
- Llorenç CaballerĂa
- Ma Antonia Auladell
- Marti Birules
- Miren Maite Aizpurua
- NHO
- P Angulo
- P Angulo
- Pere TorĂĄn
- S Chitturi
- SA Hills
- Santiago Canut
- W Yourssef
- Publication venue
- BioMed Central
- Publication date
- 01/10/2008
- Field of study
<p>Abstract</p> <p>Background</p> <p>Non alcoholic fatty liver disease (NAFL) consists in the accumulation of fat vacuoles in the cytoplasm of hepatocytes. Many etiologic factors are associated with NAFL, such as, the metabolic syndrome factors, medications, bariatric surgery, nutritional disorders. However, very little information is available on the clinical relevance of this disorder as a health problem in the general population.</p> <p>Methods and design</p> <p>The aim of the study is establish the risk factors most frequently associated with NAFL in a general adult population assigned to the primary care units and to investigate the relationship between each component of the metabolic syndrome and the risk of having a NAFL.</p> <p>A population based case-control, observational and multicenter study will be carried out in 18 primary care units from the "Area de Gestión del Barcelonés Nord y Maresme" (Barcelona) attending a population of 360,000 inhabitants and will include 326 cases and 370 controls. Cases are defined as all subjects fulfilling the inclusion criteria and with evidence of fatty liver in an abdominal ultrasonography performed for any reason. One control will be randomly selected for each case from the population, matched for age, gender and primary care center. Controls with fatty liver or other liver diseases will be excluded.</p> <p>All cases and controls will be asked about previous hepatic diseases, consumption of alcohol, smoking and drugs, and a physical examination, biochemical analyses including liver function tests, the different components of the metabolic syndrome and the HAIR score will also be performed. Paired controls will also undergo an abdominal ultrasonography.</p> <p>Discussion</p> <p>This study will attempt to determine the factors most frequently associated with the presence of NAFL investigate the relationship between the metabolic syndrome and the risk of fatty liver and study the influence of the different primary care professionals in avoiding the evolution of the disease.</p
Observation of associated near-side and away-side long-range correlations in âsNN=5.02ââTeV proton-lead collisions with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdel Khalek S
- Abdelalim AA
- Abdinov O
- Aben R
- Abi B
- Abolins M
- Abouzeid OS
- Abramowicz H
- Abreu H
- Acharya BS
- Adamczyk L
- Adams DL
- Addy TN
- Adelman J
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akesson TP
- Akimoto G
- Akimov AV
- Alam MA
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Allbrooke BM
- Allison LJ
- Allport PP
- Allwood-Spiers SE
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alonso F
- Altheimer A
- Alvarez Gonzalez B
- Alviggi MG
- Amako K
- Amelung C
- Ammosov VV
- Amor Dos Santos SP
- Amorim A
- Amoroso S
- Amram N
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Anduaga XS
- Angelidakis S
- Anger P
- Angerami A
- Anghinolfi F
- Anisenkov A
- Anjos N
- Annovi A
- Antonaki A
- Antonelli M
- Antonov A
- Antos J
- Anulli F
- Aoki M
- Aperio Bella L
- Apolle R
- Arabidze G
- Aracena I
- Arai Y
- Arce AT
- Arfaoui S
- Arguin JF
- Argyropoulos S
- Arik E
- Arik M
- Armbruster AJ
- Arnaez O
- Arnal V
- Artamonov A
- Artoni G
- Arutinov D
- Asai S
- Ask S
- Asman B
- Asquith L
- Assamagan K
- Astalos R
- Astbury A
- Atkinson M
- ATLAS Collaboration The
- Auerbach B
- Auge E
- Augsten K
- Aurousseau M
- Avolio G
- Axen D
- Azuelos G
- Azuma Y
- Baak MA
- Baccaglioni G
- Bacci C
- Bach AM
- Bachacou H
- Bachas K
- Backes M
- Backhaus M
- Backus Mayes J
- Badescu E
- Bagnaia P
- Bai Y
- Bailey DC
- Bain T
- Baines JT
- Baker OK
- Baker S
- Balek P
- Balli F
- Banas E
- Banerjee P
- Banerjee S
- Banfi D
- Bangert A
- Bansal V
- Bansil HS
- Barak L
- Baranov SP
- Barber T
- Barberio EL
- Barberis D
- Barbero M
- Bardin DY
- Barillari T
- Barisonzi M
- Barklow T
- Barlow N
- Barnett BM
- Barnett RM
- Baroncelli A
- Barone G
- Barr AJ
- Barreiro GuimarĂŁes da Costa J
- Barreiro F
- Bartoldus R
- Barton AE
- Bartsch V
- Basye A
- Bates RL
- Batkova L
- Batley JR
- Battaglia A
- Battistin M
- Bauer F
- Bawa HS
- Beale S
- Beau T
- Beauchemin PH
- Beccherle R
- Bechtle P
- Beck HP
- Becker K
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- Beckingham M
- Becks KH
- Beddall A
- Beddall AJ
- Bedikian S
- Bednyakov VA
- Bee CP
- Beemster LJ
- Beermann TA
- Begel M
- Behar Harpaz S
- Belanger-Champagne C
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- Bergeaas Kuutmann E
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- Bobbink GJ
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- Butterworth JM
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- Chalupkova I
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- Chapman JD
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- Chernyatin V
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- Chilingarov A
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- Christidi IA
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- Chromek-Burckhart D
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- Cooper BD
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- Cuciuc CM
- Cuenca Almenar C
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- Flowerdew MJ
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- Formica A
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- Garay Walls FM
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- Yen AL
- Yilmaz M
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- Yorita K
- Yoshida R
- Yoshihara K
- Young C
- Young CJ
- Youssef S
- Yu D
- Yu DR
- Yu J
- Yu J
- Yuan L
- Yurkewicz A
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zambito S
- Zanello L
- Zanzi D
- Zaytsev A
- Zeitnitz C
- Zeman M
- Zemla A
- Zenin O
- ZeniĆĄ T
- Zerwas D
- Zevi Della Porta G
- Zhang D
- Zhang H
- Zhang J
- Zhang L
- Zhang X
- Zhang Z
- Zhao L
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhuravlov V
- Zibell A
- Zieminska D
- Zimin NI
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zitoun R
- ZivkoviÄ L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- Zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- American Physical Society
- Publication date
- 01/01/2012
- Field of study
Two-particle correlations in relative azimuthal angle (ÎÏ) and pseudorapidity (Îη) are measured in âsNN=5.02ââTeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1ââÎŒb-1 of data as a function of transverse momentum (pT) and the transverse energy (ÎŁETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Îη|<5) ânear-sideâ (ÎÏâŒ0) correlation that grows rapidly with increasing ÎŁETPb. A long-range âaway-sideâ (ÎÏâŒÏ) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ÎŁETPb, is found to match the near-side correlation in magnitude, shape (in Îη and ÎÏ) and ÎŁETPb dependence. The resultant ÎÏ correlation is approximately symmetric about Ï/2, and is consistent with a dominant cosâĄ2ÎÏ modulation for all ÎŁETPb ranges and particle pT
Search for R-parity-violating supersymmetry in events with four or more leptons in sqrt(s) =7 TeV pp collisions with the ATLAS detector
- Author
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- Abajyan T
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- Abdallah J
- Khalek SA
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- Wingerter-Seez I
- Winkelmann S
- Winklmeier F
- Wittgen M
- Wollstadt SJ
- Wolter MW
- Wolters H
- Wong WC
- Wooden G
- Wosiek BK
- Wotschack J
- Woudstra MJ
- Wozniak KW
- Wraight K
- Wright M
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- Wu SL
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- Wynne BM
- Xella S
- Xiao M
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- Yabsley B
- Yacoob S
- Yamada M
- Yamaguchi H
- Yamamoto A
- Yamamoto K
- Yamamoto S
- Yamamura T
- Yamanaka T
- Yamazaki T
- Yamazaki Y
- Yan Z
- Yang H
- Yang UK
- Yang Y
- Yang Z
- Yanush S
- Yao L
- Yao Y
- Yasu Y
- Smit GVY
- Ye J
- Ye S
- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Yoshihara K
- Young C
- Young CJ
- Youssef S
- Yu D
- Yu DR
- Yu J
- Yu J
- Yuan L
- Yurkewicz A
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zajacova Z
- Zanello L
- Zanzi D
- Zaytsev A
- Zeitnitz C
- Zeman M
- Zemla A
- Zendler C
- Zenin O
- Zenis T
- Zinonos Z
- Zerwas D
- della Porta GZ
- Zhang D
- Zhang H
- Zhang J
- Zhang X
- Zhang Z
- Zhao L
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhuravlov V
- Zibell A
- Zieminska D
- Zimin NI
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Collaboration ATLAS
- Publication venue
- Springer Verlag
- Publication date
- 01/01/2008
- Field of study
A search for new phenomena in final states with four or more leptons (electrons or muons) is presented. The analysis is based on 4.7 fbâ1 of sâ=7TeV proton-proton collisions delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in two signal regions: one that requires moderate values of missing transverse momentum and another that requires large effective mass. The results are interpreted in a simplified model of R-parity-violating supersymmetry in which a 95% CL exclusion region is set for charged wino masses up to 540 GeV. In an R-parity-violating MSUGRA/CMSSM model, values of m 1/2 up to 820 GeV are excluded for 10 < tan ÎČ < 40
Search for high-mass resonances decaying to dilepton final states in pp collisions at sâ=7 TeV with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Acharya BS
- Adamczyk L
- Adams DL
- Addy TN
- Adelman J
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Agustoni M
- Aharrouche M
- Ahlen SP
- Ahles R
- Ahmad A
- Ahsan M
- Aielli G
- Akesson TPA
- Akimoto G
- Akimov AV
- Alam MA
- Alam MS
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Allbrooke BMM
- Allport PP
- Allwood-Spiers SE
- Almenar CC
- Almond J
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- Alviggi MG
- Amako K
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- Castanheira MTD
- Castillo IS
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- Castro NF
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- Catinaccio A
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- Cavasinni V
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- Chalupkova I
- Chan K
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- Chapleau B
- Chapman JD
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- Chareyre E
- Charlton DG
- Chavda V
- Cheatham S
- Chekanov S
- Chekulaev SV
- Chelkov GA
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- Chernyatin V
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- Zobernig G
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- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- Springer
- Publication date
- 23/11/2012
- Field of study
The ATLAS detector at the Large Hadron Collider is used to search for high-mass resonances decaying to an electron-positron pair or a muon-antimuon pair. The search is sensitive to heavy neutral ZâČ gauge bosons, Randall-Sundrum gravitons, Z * bosons, techni-mesons, Kaluza-Klein Z/Îł bosons, and bosons predicted by Torsion models. Results are presented based on an analysis of pp collisions at a center-of-mass energy of 7 TeV corresponding to an integrated luminosity of 4.9 fbâ1 in the e + e â channel and 5.0 fbâ1 in the ÎŒ + ÎŒ âchannel. A Z âČ boson with Standard Model-like couplings is excluded at 95 % confidence level for masses below 2.22 TeV. A Randall-Sundrum graviton with coupling k/MPl=0.1 is excluded at 95 % confidence level for masses below 2.16 TeV. Limits on the other models are also presented, including Technicolor and Minimal ZâČ Models
Search for the neutral Higgs bosons of the minimal supersymmetric standard model in pp collisions at root s=7 TeV with the ATLAS detector
- Author
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- Zobernig G
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- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- Publication date
- 01/02/2013
- Field of study
A search for neutral Higgs bosons of the Minimal Supersymmetric Standard Model (MSSM) is reported. The analysis is based on a sample of proton-proton collisions at a centre-of-mass energy of 7TeV recorded with the ATLAS detector at the Large Hadron Collider. The data were recorded in 2011 and correspond to an integrated luminosity of 4.7 fb-1 to 4.8 fb-1. Higgs boson decays into oppositely-charged muon or Ï lepton pairs are considered for final states requiring either the presence or absence of b-jets. No statistically significant excess over the expected background is observed and exclusion limits at the 95% confidence level are derived. The exclusion limits are for the production cross-section of a generic neutral Higgs boson, Ï, as a function of the Higgs boson mass and for h/A/H production in the MSSM as a function of the parameters mA and tan ÎČ in the mhmax scenario for mA in the range of 90GeV to 500 GeV. Copyright CERN
Metabolically active microbial communities in marine sediment under high-CO2 and low-pH extremes
- Author
- A Boetius
- A Chao
- A Miyashita
- A Pernthaler
- A Teske
- Antje Boetius
- CJ Krebs
- D de Beer
- D de Beer
- Dirk de Beer
- E Pruesse
- EC Pielou
- EF DeLong
- F Inagaki
- F Inagaki
- F Inagaki
- F Wenzhöfer
- Fumio Inagaki
- Gregor Rehder
- H Fossing
- H Niemann
- H Sakai
- J Kallmeyer
- J Kallmeyer
- J Kallmeyer
- J Lupton
- J Lupton
- JA Frank
- JF Biddle
- JM Hall-Spencer
- JP Barry
- JR Cole
- K Grasshoff
- K Knittel
- K Knittel
- K Nauhaus
- K Shitashima
- K Yanagawa
- Katsunori Yanagawa
- KE Fabricius
- KG Lloyd
- KG Lloyd
- KH Nealson
- Ko-ichi Nakamura
- KZ House
- Matthias Haeckel
- Michinari Sunamura
- NP Revsbech
- P Jeroschewski
- PD Schloss
- R Suzuki
- RI Amann
- RI Amann
- S Kleindienst
- T Holler
- T Hoshino
- T Huber
- T Nunoura
- T Nunoura
- Taiki Futagami
- Takeshi Terada
- Tatsuhiko Hoshino
- TC Onstott
- Tetsuro Urabe
- U Konno
- V Tunnicliffe
- VJ Orphan
- W Ludwig
- W Manz
- WJ Brazelton
- Y Morono
- Y Morono
- YN Yu
- Yuki Morono
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 25/10/2012
- Field of study
Sediment-hosting hydrothermal systems in the Okinawa Trough maintain a large amount of liquid, supercritical and hydrate phases of CO2 in the seabed. The emission of CO2 may critically impact the geochemical, geophysical and ecological characteristics of the deep-sea sedimentary environment. So far it remains unclear whether microbial communities that have been detected in such high-CO2 and low-pH habitats are metabolically active, and if so, what the biogeochemical and ecological consequences for the environment are. In this study, RNA-based molecular approaches and radioactive tracer-based respiration rate assays were combined to study the density, diversity and metabolic activity of microbial communities in CO2-seep sediment at the Yonaguni Knoll IV hydrothermal field of the southern Okinawa Trough. In general, the number of microbes decreased sharply with increasing sediment depth and CO2 concentration. Phylogenetic analyses of community structure using reverse-transcribed 16S ribosomal RNA showed that the active microbial community became less diverse with increasing sediment depth and CO2 concentration, indicating that microbial activity and community structure are sensitive to CO2 venting. Analyses of RNA-based pyrosequences and catalyzed reporter deposition-fluorescence in situ hybridization data revealed that members of the SEEP-SRB2 group within the Deltaproteobacteria and anaerobic methanotrophic archaea (ANME-2a and -2c) were confined to the top seafloor, and active archaea were not detected in deeper sediments (13â30âcm in depth) characterized by high CO2. Measurement of the potential sulfate reduction rate at pH conditions of 3â9 with and without methane in the headspace indicated that acidophilic sulfate reduction possibly occurs in the presence of methane, even at very low pH of 3. These results suggest that some members of the anaerobic methanotrophs and sulfate reducers can adapt to the CO2-seep sedimentary environment; however, CO2 and pH in the deep-sea sediment were found to severely impact the activity and structure of the microbial community
Measurement of the cross-section of high transverse momentum vector bosons reconstructed as single jets and studies of jet substructure in pp collisions at âs = 7 TeV with the ATLAS detector
- Author
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2014
- Field of study
This paper presents a measurement of the cross-section for high transverse momentum W and Z bosons produced in pp collisions and decaying to all-hadronic final states. The data used in the analysis were recorded by the ATLAS detector at the CERN Large Hadron Collider at a centre-of-mass energy of âs = 7 TeV;{\rm Te}{\rm V}andcorrespondtoanintegratedluminosityof4.6\;{\rm f}{{{\rm b}}^{-1}}.ThemeasurementisperformedbyreconstructingtheboostedWorZbosonsinsinglejets.ThereconstructedjetmassisusedtoidentifytheWandZbosons,andajetsubstructuremethodbasedonenergyclusterinformationinthejetcentreâofâmassframeisusedtosuppressthelargemultiâjetbackground.ThecrossâsectionforeventswithahadronicallydecayingWorZboson,withtransversemomentum{{p}_{{\rm T}}}\gt 320\;{\rm Ge}{\rm V}andpseudorapidity|\eta |\lt 1.9,ismeasuredtobe{{\sigma }_{W+Z}}=8.5\pm 1.7$ pb and is compared to next-to-leading-order calculations. The selected events are further used to study jet grooming techniques
Strategies to reduce medication errors with reference to older adults
- Author
- Adams C
- Aufseeser Weiss MR
- Australian Council for Safety and Quality in Health Care.
- Australian Institute of Health and Welfare (AIHW).
- Australian Institute of Health and Welfare.
- Ayuthya S
- Bates DW
- Bayne T
- Bolton P
- Boyle CM
- Brent Hodgkinson
- Briggs B
- Brown HN
- Brown SJ
- Burton ME
- Casner PR
- Cerne F
- Hawkey CJ
- Heinemann D
- Hurley SF
- Khan KS
- Kim Nichols
- Kruse H
- Larrabee JH
- Leape LL
- Lengacher CA
- Ludwig Beymer P
- McNally KM
- Mungall DR
- Mutter M
- Nelson R
- NHMRC.
- Overhage JM
- Papastrat K
- Pape TM
- Ray MD
- Rhonda Nay
- Roark DC
- Roughead EE
- Schaubhut RM
- Shah NR
- Shojania KG
- Spencer DC
- Strohecker S
- Susan Koch
- Westwood M
- White RH
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2006
- Field of study
Backgroundâ In Australia, around 59% of the general population uses prescription medication with this number increasing to about 86% in those aged 65 and over and 83% of the population over 85 using two or more medications simultaneously. A recent report suggests that between 2% and 3% of all hospital admissions in Australia may be medication related with older Australians at higher risk because of higher levels of medicine intake and increased likelihood of being admitted to hospital. The most common medication errors encountered in hospitals in Australia are prescription/medication ordering errors, dispensing, administration and medication recording errors. Contributing factors to these errors have largely not been reported in the hospital environment. In the community, inappropriate drugs, prescribing errors, administration errors, and inappropriate dose errors are most common. Objectivesâ To present the best available evidence for strategies to prevent or reduce the incidence of medication errors associated with the prescribing, dispensing and administration of medicines in the older persons in the acute, subacute and residential care settings, with specific attention to persons aged 65âyears and over. Search strategyâ Bibliographic databases PubMed, Embase, Current contents, The Cochrane Library and others were searched from 1986 to present along with existing health technology websites. The reference lists of included studies and reviews were searched for any additional literature. Selection criteriaâ Systematic reviews, randomised controlled trials and other research methods such as non-randomised controlled trials, longitudinal studies, cohort or case-control studies, or descriptive studies that evaluate strategies to identify and manage medication incidents. Those people who are involved in the prescribing, dispensing or administering of medication to the older persons (aged 65âyears and older) in the acute, subacute or residential care settings were included. Where these studies were limited, evidence available on the general patient population was used. Data collection and analysisâ Study design and quality were tabulated and relative risks, odds ratios, mean differences and associated 95% confidence intervals were calculated from individual comparative studies containing count data where possible. All other data were presented in a narrative summary. Resultsâ Strategies that have some evidence for reducing medication incidents are: âąâ computerised physician ordering entry systems combined with clinical decision support systems; âąâ individual medication supply systems when compared with other dispensing systems such as ward stock approaches; âąâ use of clinical pharmacists in the inpatient setting; âąâ checking of medication orders by two nurses before dispensing medication; âąâ a Medication Administration Review and Safety committee; and âąâ providing bedside glucose monitors and educating nurses on importance of timely insulin administration. In general, the evidence for the effectiveness of intervention strategies to reduce the incidence of medication errors is weak and high-quality controlled trials are needed in all areas of medication prescription and delivery
- âŠ