Rede social académica

O processo de Bolonha apresenta directivas para a construção de um espaço europeu de ensino superior. A adopção destas directivas requer uma abordagem que favoreça, na prática, a mobilidade dos estudantes que têm dificuldades em compreenderem as oportunidades que lhes são oferecidas. Neste contexto, esta dissertação explora a hipótese de utilização de uma rede social para apoiar a mobilidade de estudantes no espaço europeu. No âmbito desta dissertação propõe-se um modelo de conhecimento para representar os membros de uma rede social vocacionada para apoiar cenários de mobilidade, designada por rede social académica. Este modelo foi obtido pela fusão da ontologia Academic Ontology to Support the Bologna Mobility Process com a ontologia Friend of a Friend Ontology. Para efeitos de avaliação experimental, foi criado um demonstrador numa rede social disponível publicamente na Internet que utiliza uma versão simplificada do modelo proposto. Os cenários usados nas experiências representam situações reais às quais foi aplicado um processo rudimentar de descoberta de conhecimentoThe Bologna Process aimed to build a European Higher Education Area and has the objective to promote students mobility. The adoption of the Bologna Process requires an approach that facilitates, in practice, the mobility of students who have difficulties to understand the opportunities offered to them. In this context, this thesis explores the possibility of using a social network to support the mobility of students within the European Higher Education Area. This thesis proposes a knowledge model to represent members of a social network dedicated to supporting mobility scenarios, known as academic social network. This model was obtained by fusion of the Ontology Academic Support to the Bologna Process Mobility with the Friend of a Friend Ontology. For experimental evaluation, a demonstrator was created in a social network available on the Internet that uses a simplified version of the model. The scenarios used in the experiments represent real situations to which was applied a rudimentary process of knowledge discovery

Cardiovascular risk and physical activity practice in children and adolescents of Muzambinho/MG: influence of gender and age

INTRODUÇÃO E OBJETIVO: A doença cardiovascular inicia na infância e está atrelada à presença de fatores de risco cardiovascular (FRC). A prevalência desses fatores varia em diferentes populações brasileiras, tendo sido estudada principalmente em cidades de médio e grande porte. Este estudo avaliou a prevalência dos FRC e da prática de atividade física (AF) em crianças e adolescentes de Muzambinho, uma cidade de pequeno porte. MÉTODO: Foram avaliados 205 sujeitos (entre sete e 18 anos - 108 do gênero masculino). Foram medidos: peso, estatura, glicemia, colesterolemia, pressão arterial (PA) e prática de AF. As comparações foram realizadas pelo teste do Qui-quadrado. RESULTADOS: A prevalência de sobrepeso foi de 19% e de valores alterados de PA, glicemia e colesterolemia foram de, respectivamente, 11, 5 e 15%. Não houve diferença na prevalência dos FRC entre os sexos. O tabagismo, o alcoolismo, a PA alterada e a insuficiência de AF aumentaram com a idade. Setenta e nove por cento dos sujeitos praticavam AF de locomoção, 10% ocupacional, 97% nas aulas de educação física, 72% no recreio e 90% de lazer. Noventa e dois por cento foram considerados ativos. A prática de AF ocupacional foi maior nas meninas e aumentou nos meninos com a idade. A prevalência de AF de lazer e recreio diminuiu com a idade nos dois sexos. CONCLUSÃO: A prevalência de FRC, exceto do sedentarismo, foi expressiva, não diferiu entre os sexos e aumentou com a idade. A prática de AF de todos os tipos foi alta, diferenciou-se entre os sexos e diminuiu com a idade.INTRODUCTION AND OBJECTIVE: Cardiovascular disease begins at infancy and it has been linked to the presence of cardiovascular risk factors (CRF). Prevalence of these factors varies a lot among different Brazilian populations and has been mostly studied in big and medium size cities. Thus, this study assessed the prevalence of CRF and physical activity (PA) in children and adolescents from Muzambinho, a small city in the state of Minas Gerais. METHODS: 205 subjects (7 to 18 years - 108 males) were studied. Body weight and height, glycemia, cholesterolemia, blood pressure (BP), and PA were measured. Comparisons were made by Qui-square test. RESULTS: Obesity and altered values of BP, glycemia, and cholesterolemia were found, respectively, in 19, 11, 5 and 15% of the subjects. There was no difference between genders, while the prevalence of smokers, drinkers, altered BP, and inactivity increased with age. Seventy-nine percent of the subjects practiced community PA; 10% occupational PA; 97% physical education classes; 72% PA during school recess; and 90% leisure time PA. Ninety-two percent of them were active. Occupational PA was higher in girls, and increased with age in boys. Leisure time and during school recess PA decreased with age in both genders. CONCLUSION: Except for physical inactivity, prevalence of CRF was high, did not differ between genders, and increased with age. High levels of all kinds of PA were found; they differed between genders, and decreased with age.CNPqUSP - Pró-Reitoria de Graduaçã

Germline MUTYH (MYH) mutations in portuguese individuals with multiple colorectal adenomas

Germinal mutations in the base excision repair (BER) gene MUTYH (MYH) have recently been described in association with predisposition to multiple colorectal adenomas and cancer. In contrast to the classic dominant condition of familial adenomatous polyposis (FAP) due to germinal mutations in the APC gene, the MYH polyposis is an autosomal recessive disease. The identification of individuals affected by MYH polyposis brings new and important implications for the diagnostic, screening, genetic counseling, follow up and therapeutic options in these patients. In this study, screening for germinal mutations in the MYH gene was performed in 53 Portuguese individuals with multiple colorectal adenomas or classic adenomatous polyposis, in whom no mutation had been identified in the APC gene. The results revealed the presence of biallelic germline MYH mutations in 21 patients. In addition, we here report 3 mutations (c.340T>C [p.Y114H]; c.503G>A [p.R168H]; and c.1186_1187insGG [p.E396fsX437]) which, to our knowledge, have not been previously described. © 2004 Wiley-Liss, Incinfo:eu-repo/semantics/publishedVersio

Parecer sobre a realização de actividades Todo o Terreno nas escombreiras da Mina da Panasqueira

Parecer, elaborado em parceria, apresentado a diversas entidades, na sequência de notícia da SIC sobre actividades denominadas de radicais nas Escombreiras da Mina da Panasqueira

Identificação de Problemas e Propostas para Melhoria

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SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal

Genomic surveillance of SARS-CoV-2 in Portugal was rapidly implemented by the National Institute of Health in the early stages of the COVID-19 epidemic, in collaboration with more than 50 laboratories distributed nationwide. Methods By applying recent phylodynamic models that allow integration of individual-based travel history, we reconstructed and characterized the spatio-temporal dynamics of SARSCoV-2 introductions and early dissemination in Portugal. Results We detected at least 277 independent SARS-CoV-2 introductions, mostly from European countries (namely the United Kingdom, Spain, France, Italy, and Switzerland), which were consistent with the countries with the highest connectivity with Portugal. Although most introductions were estimated to have occurred during early March 2020, it is likely that SARS-CoV-2 was silently circulating in Portugal throughout February, before the first cases were confirmed. Conclusions Here we conclude that the earlier implementation of measures could have minimized the number of introductions and subsequent virus expansion in Portugal. This study lays the foundation for genomic epidemiology of SARS-CoV-2 in Portugal, and highlights the need for systematic and geographically-representative genomic surveillance.We gratefully acknowledge to Sara Hill and Nuno Faria (University of Oxford) and Joshua Quick and Nick Loman (University of Birmingham) for kindly providing us with the initial sets of Artic Network primers for NGS; Rafael Mamede (MRamirez team, IMM, Lisbon) for developing and sharing a bioinformatics script for sequence curation (https://github.com/rfm-targa/BioinfUtils); Philippe Lemey (KU Leuven) for providing guidance on the implementation of the phylodynamic models; Joshua L. Cherry (National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health) for providing guidance with the subsampling strategies; and all authors, originating and submitting laboratories who have contributed genome data on GISAID (https://www.gisaid.org/) on which part of this research is based. The opinions expressed in this article are those of the authors and do not reflect the view of the National Institutes of Health, the Department of Health and Human Services, or the United States government. This study is co-funded by Fundação para a Ciência e Tecnologia and Agência de Investigação Clínica e Inovação Biomédica (234_596874175) on behalf of the Research 4 COVID-19 call. Some infrastructural resources used in this study come from the GenomePT project (POCI-01-0145-FEDER-022184), supported by COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation (POCI), Lisboa Portugal Regional Operational Programme (Lisboa2020), Algarve Portugal Regional Operational Programme (CRESC Algarve2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), and by Fundação para a Ciência e a Tecnologia (FCT).info:eu-repo/semantics/publishedVersio

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements