109 research outputs found
Glycogen synthase kinase-3β inactivation inhibits tumor necrosis factor-α production in microglia by modulating nuclear factor κB and MLK3/JNK signaling cascades
- Publication venue
- BioMed Central
- Publication date
- 01/01/2010
- Field of study
<p>Abstract</p> <p>Background</p> <p>Deciphering the mechanisms that modulate the inflammatory response induced by microglial activation not only improves our insight into neuroinflammation but also provides avenues for designing novel therapies that could halt inflammation-induced neuronal degeneration. Decreasing glycogen synthase kinase-3β (GSK-3β) activity has therapeutic benefits in inflammatory diseases. However, the exact molecular mechanisms underlying GSK-3β inactivation-mediated suppression of the inflammatory response induced by microglial activation have not been completely clarified. Tumor necrosis factor-α (TNF-α) plays a central role in injury caused by neuroinflammation. We investigated the regulatory effect of GSK-3β on TNF-α production by microglia to discern the molecular mechanisms of this modulation.</p> <p>Methods</p> <p>Lipopolysaccharide (LPS) was used to induce an inflammatory response in cultured primary microglia or murine BV-2 microglial cells. Release of TNF-α was measured by ELISA. Signaling molecules were analyzed by western blotting, and activation of NF-κB and AP-1 was measured by ELISA-based DNA binding analysis and luciferase reporter assay. Protein interaction was examined by coimmunoprecipitation.</p> <p>Results</p> <p>Inhibition of GSK-3β by selective GSK-3β inhibitors or by RNA interference attenuated LPS-induced TNF-α production in cultured microglia. Exploration of the mechanisms by which GSK-3β positively regulates inflammatory response showed that LPS-induced IκB-α degradation, NF-κBp65 nuclear translocation, and p65 DNA binding activity were not affected by inhibition of GSK-3β activity. However, GSK-3β inactivation inhibited transactivation activity of p65 by deacetylating p65 at lysine 310. Furthermore, we also demonstrated a functional interaction between mixed lineage kinase 3 (MLK3) and GSK-3β during LPS-induced TNF-α production in microglia. The phosphorylated levels of MLK3, MKK4, and JNK were increased upon LPS treatment. Decreasing GSK-3β activity blocked MLK3 signaling cascades through disruption of MLK3 dimerization-induced autophosphorylation, ultimately leading to a decrease in TNF-α secretion.</p> <p>Conclusion</p> <p>These results suggest that inactivation of GSK-3β might represent a potential strategy to downregulate microglia-mediated inflammatory processes.</p
Systemic administration of urocortin after intracerebral hemorrhage reduces neurological deficits and neuroinflammation in rats
- Author
- A Abuirmeileh
- AD Mendelow
- AI Qureshi
- AJ Kastin
- AJ Kastin
- AJ Kastin
- AM Abdelrahman
- AM Abdelrahman
- B Peruzzo
- BA De Fanti
- BK Brar
- Cheng-Yoong Pang
- Chih-Wei Hsu
- CL MacLellan
- CN Liu
- D Hanggi
- DG Parkes
- DG Parkes
- DJ Torpy
- E Gonzalez-Rey
- EL Cureton
- EM Fekete
- F Esen
- GA Rosenberg
- GJ Hankey
- GY Yang
- H Kettenmann
- HK Liew
- HK Park
- Hock-Kean Liew
- Hsiao-Fen Peng
- HY Huang
- J Aronowski
- J Chen
- J Wang
- J Wang
- J Wang
- J Wu
- Jia-Yi Wang
- JL Moreau
- JM Gordon
- Jon-Son Kuo
- K Chu
- K Van Pett
- KH Jung
- KM Lawrence
- LB Morgenstern
- M Kohno
- M Torricelli
- M Xue
- Mei-Jen Wang
- MG Spina
- MH Perrin
- MJ Wang
- N Pouratian
- SL Stevens
- SM Davidson
- SM Gardiner
- SY Hsu
- Ting-Yi Li
- W Pan
- W Pan
- W Rosamond
- WA Pedersen
- X Zhao
- X Zhao
- Y Wu
- Y Xu
- Publication venue
- BioMed Central
- Publication date
- 01/01/2012
- Field of study
<p>Abstract</p> <p>Background</p> <p>Intracerebral hemorrhage (ICH) remains a serious clinical problem lacking effective treatment. Urocortin (UCN), a novel anti-inflammatory neuropeptide, protects injured cardiomyocytes and dopaminergic neurons. Our preliminary studies indicate UCN alleviates ICH-induced brain injury when administered intracerebroventricularly (ICV). The present study examines the therapeutic effect of UCN on ICH-induced neurological deficits and neuroinflammation when administered by the more convenient intraperitoneal (i.p.) route.</p> <p>Methods</p> <p>ICH was induced in male Sprague-Dawley rats by intrastriatal infusion of bacterial collagenase VII-S or autologous blood. UCN (2.5 or 25 μg/kg) was administered i.p. at 60 minutes post-ICH. Penetration of i.p. administered fluorescently labeled UCN into the striatum was examined by fluorescence microscopy. Neurological deficits were evaluated by modified neurological severity score (mNSS). Brain edema was assessed using the dry/wet method. Blood-brain barrier (BBB) disruption was assessed using the Evans blue assay. Hemorrhagic volume and lesion volume were assessed by Drabkin's method and morphometric assay, respectively. Pro-inflammatory cytokine (TNF-α, IL-1β, and IL-6) expression was evaluated by enzyme-linked immunosorbent assay (ELISA). Microglial activation and neuronal loss were evaluated by immunohistochemistry.</p> <p>Results</p> <p>Administration of UCN reduced neurological deficits from 1 to 7 days post-ICH. Surprisingly, although a higher dose (25 μg/kg, i.p.) also reduced the functional deficits associated with ICH, it is significantly less effective than the lower dose (2.5 μg/kg, i.p.). Beneficial results with the low dose of UCN included a reduction in neurological deficits from 1 to 7 days post-ICH, as well as a reduction in brain edema, BBB disruption, lesion volume, microglial activation and neuronal loss 3 days post-ICH, and suppression of TNF-α, IL-1β, and IL-6 production 1, 3 and 7 days post-ICH.</p> <p>Conclusion</p> <p>Systemic post-ICH treatment with UCN reduces striatal injury and neurological deficits, likely via suppression of microglial activation and inflammatory cytokine production. The low dose of UCN necessary and the clinically amenable peripheral route make UCN a potential candidate for development into a clinical treatment regimen.</p
Search for lepton-flavour-violating decays of the Higgs and Z bosons with the ATLAS detector
- Author
- A Arhrib
- A Azatov
- A Crivellin
- A Crivellin
- A Goudelis
- A. A. Affolder
- A. A. E. Bannoura
- A. A. Elliot
- A. A. Grillo
- A. A. J. Lesage
- A. A. Komar
- A. A. Korol
- A. A. Maier
- A. A. Minaenko
- A. A. Nepomuceno
- A. A. O’Rourke
- A. A. Snesarev
- A. A. Solodkov
- A. A. Talyshev
- A. Aloisio
- A. Alonso
- A. Amorim
- A. Andreazza
- A. Angerami
- A. Annovi
- A. Antonov
- A. Artamonov
- A. Ashkenazi
- A. B. Fenyuk
- A. B. Kowalewska
- A. Baroncelli
- A. Basalaev
- A. Bassalat
- A. Beddall
- A. Bellerive
- A. Bingul
- A. Bocci
- A. Borisov
- A. Boveia
- A. Brandt
- A. Bruni
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- A. C. Daniells
- A. C. König
- A. C. Martyniuk
- A. C. Schaffer
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- A. Calandri
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- A. Castelli
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- A. Cerri
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- W. Taylor
- W. Trischuk
- W. Van Den Wollenberg
- W. Vandelli
- W. Verkerke
- W. Wagner
- W. Walkowiak
- W. Wiedenmann
- X. Chen
- X. Ju
- X. Lei
- X. Li
- X. Lou
- X. Ruan
- X. Sun
- X. Wang
- X. Wu
- X. Zhang
- X. Zhao
- X. Zhuang
- Y. A. Kurochkin
- Y. Abulaiti
- Y. Amaral Coutinho
- Y. Arai
- Y. Bai
- Y. Benhammou
- Y. C. Yap
- Y. Chen
- Y. Cheng
- Y. Coadou
- Y. Du
- Y. Enari
- Y. F. Ryabov
- Y. Fang
- Y. Gao
- Y. Guo
- Y. Hasegawa
- Y. Heng
- Y. Hernández Jiménez
- Y. Horii
- Y. Huang
- Y. Ikegami
- Y. Ilchenko
- Y. Jiang
- Y. K. Kim
- Y. Kataoka
- Y. Komori
- Y. Kulchitsky
- Y. L. Chan
- Y. L. Liu
- Y. Li
- Y. Liu
- Y. Ma
- Y. Makida
- Y. Minami
- Y. Ming
- Y. Nagasaka
- Y. Nakahama
- Y. Ninomiya
- Y. Okumura
- Y. Oren
- Y. Qin
- Y. Rodina
- Y. Rozen
- Y. S. Gao
- Y. Sakurai
- Y. Sasaki
- Y. Smirnov
- Y. Sugaya
- Y. Takubo
- Y. Tayalati
- Y. Unno
- Y. Wu
- Y. Yamaguchi
- Y. Yamazaki
- Y. Yang
- Y. Yasu
- Y. Zhao
- Y. Zhu
- Yu. A. Tikhonov
- Z. Barnovska
- Z. D. Greenwood
- Z. Dolezal
- Z. Gecse
- Z. H. Citron
- Z. Hajduk
- Z. Hubacek
- Z. Idrissi
- Z. J. Grout
- Z. Liang
- Z. M. Karpova
- Z. Marshall
- Z. Rurikova
- Z. Vykydal
- Z. Yan
- Z. Yang
- Z. Zhang
- Z. Zhao
- Z. Zinonos
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 27/04/2016
- Field of study
Direct searches for lepton flavour violation in decays of the Higgs and Z bosons with the ATLAS detector at the LHC are presented. The following three decays are considered: H→eτ, H→μτ, and Z→μτ. The searches are based on the data sample of proton–proton collisions collected by the ATLAS detector corresponding to an integrated luminosity of 20.3 fb−1 at a centre-of-mass energy of s√=8 TeV. No significant excess is observed, and upper limits on the lepton-flavour-violating branching ratios are set at the 95 % confidence level: Br (H→eτ)<1.04%, Br (H→μτ)<1.43%, and Br (Z→μτ)<1.69×10−5
The genetic architecture of the human cerebral cortex
- Author
- Adams Hieab H H
- Adams Hieab H H
- Agartz Ingrid
- Ahlijanian Michael
- Ahmad Shahzad
- Ainscough Susan
- Aisen Paul
- Albers Colleen S
- Albert Marilyn
- Alhusaini Saud
- Allard Joanne
- Almeida Marcio A A
- Alnæs Dag
- Alvim Marina K M
- Ames David
- Ames David
- Amin Najaf
- Amlien Inge K
- Amouyel Philippe
- Ances Beau
- Anderson Karen
- Anderson Tim J
- Andersson Micael
- Andreassen Ole A
- Andreassen Ole A
- Apostolova Liana
- Ard Tyler
- Arias-Vasquez Alejandro
- Armstrong Nicola J
- Armstrong Nicola J
- Arnedo Vanessa
- Arnold Steven E
- Artiges Eric
- Artiges Eric
- Ashley-Koch Allison
- Assaly Michele
- Assareh Amelia A
- Asthana Sanjay
- Atkins Joshua R
- Aydin Semiha
- Ayesa-Arriola Rosa
- Baca Marne
- Bachman David
- Banaschewski Tobias
- Barbot Alexis
- Barker Gareth
- Barone Paolo
- Bartha Rob
- Bartzokis George
- Bastin Mark E
- Bastin Mark E
- Bates Vernice
- Baune Bernhard T
- Becerra Mauricio
- Becker Andreas
- Becker James T
- Beckett Laurel
- Beckham Jean C
- Beiser Alexa S
- Belden Christine M
- Belger Aysenil
- Bell Karen L
- Berg Daniela
- Bergman Howard
- Bernard Manon
- Bernard Manon
- Bernick Charles
- Bernstein Matthew
- Beyer Frauke
- Bezivin-Frere Pauline
- Biondo Francesca
- Bis Joshua C
- Bis Joshua C
- Bishop Courtney
- Black Sandra
- Blangero John
- Blank Karen
- Bodge Courtney
- Bokde Arun
- Bonakdarpour Borna
- Boomsma Dorret I
- Borges-Neto Salvador
- Borowski Bret
- Borrie Michael
- Bralten Janita
- Brand Connie
- Brandabur Melanie
- Brandt Christine L
- Brewer James
- Brockington John
- Brodaty Henry
- Brodaty Henry
- Bromberg Uli
- Brooks David
- Brooks William M
- Brosch Jared R
- Brouwer Rachel M
- Brown Gregory G
- Bruehl Ruediger
- Brunner Han G
- Buckholtz Neil
- Buckner Randy L
- Budson Andrew E
- Buimer Elizabeth E L
- Buitelaar Jan K
- Burke Anna
- Burns Jeffrey M
- Bustillo Juan R
- Bülow Robin
- Bülow Robin
- Bürger Christian
- Bÿchel Christian
- Cabrera Yuliana
- Cahn Wiepke
- Cairns Murray J
- Cairns Nigel J
- Calhoun Vince
- Cannon Dara M
- Capote Horacio
- Carlsson Cynthia M
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- Cavalleri Gianpiero L
- Cedarbaum Jesse
- Cellar Janet S
- Celmins Dzintra
- Cendes Fernando
- Chahine Lama
- Chakravarty Mallar
- Chalker Alison
- Chao Steven
- Chen Kewei
- Chen Qiang
- Chertkow Howard
- Cheung Joshua W
- Chiang Gloria
- Ching Christopher R K
- Chowdhury Munir
- Chowdhury Sohini
- Chu Congying
- Cichon Sven
- Clark Christopher M
- Clark David
- Coffey Christopher
- Coleman Edward
- Colodro-Conde Lucía
- Comery Thomas
- Conrad Gary
- Conrod Patricia
- Consortium CHARGE
- Consortium Enhancing NeuroImaging Genetics through Meta-Analysis
- Consortium EPIGEN
- Consortium IMAGEN
- Consortium SYS
- Correia Stephen
- Corvin Aiden
- Couvy-Duchesne Baptiste
- Crawford Karen
- Creech Mary L
- Crespo-Facorro Benedicto
- Crivello Fabrice
- Curran Joanne E
- D'Agostino Daniel
- Daedelow Laura
- Daiello Lori A
- Dale Anders M
- Dale Anders M
- Dalley Jeffrey
- Dalrymple-Alford John C
- Dalvie Shareefa
- Dang Mimi
- Dannlowski Udo
- Darin Abigail
- Davies Gareth E
- Davies Peter
- de Araujo Tânia K
- de Geus Eco J C
- de Zubicaray Greig I
- de Zwarte Sonja M C
- Deary Ian J
- Deary Ian J
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- Desrivières Sylvane
- Dietsche Bruno
- Djurovic Srdjan
- Doan Nhat Trung
- Doherty Colin P
- Dohm Katharina
- Dolen Sara
- Donohoe Gary
- Donohue Michael
- Doody Rachelle S
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- Dunlop Becky
- Egebjerg Jan
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- Fedko Iryna O
- Feldman Howard
- Fernandez Hubert
- Fernández Guillén
- Figurski Michal
- Filippi Irina
- Fillit Howard
- Fillmer Ariane
- Finger Elizabeth
- Fisher Simon E
- Flashman Laura A
- Fleisher Adam
- Fletcher Evan
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- Fontoura Paulo
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- Fornage Myriam
- Fornage Myriam
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- Gauss Katharina
- Ge Tian
- Geldmacher David
- Gessert Devon
- Ghanbari Mohsen
- Giddaluru Sudheer
- Gigliotti Christina
- Gil Yolanda
- Gillespie Nathan A
- Glahn David C
- Gloer Katherine
- Goldman Aaron L
- Goldstein Bonnie S
- Goldstein David B
- Gollub Randy L
- Gowland Penny
- Gowland Penny A
- Grabe Hans J
- Grabe Hans Jörgen
- Grachev Igor D
- Graff-Radford Neill R
- Grasby Katrina L
- Green Davis Robert C
- Green Melissa J
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- Green Robert C
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- Griffith Randall
- Grimmer Yvonne
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- Grotegerd Dominik
- Gruber Oliver
- Gudnason Vilmundur
- Gunter Jeff
- Gurholt Tiril P
- Guthrie Stephanie
- Gutman Boris A
- Hake Ann Marie
- Hansell Narelle K
- Hardy Peter
- Hariri Ahmad R
- Harlan Sherry
- Harless Kelly
- Harris Mat
- Harris Mathew A
- Harrison Marc B
- Hart David
- Hartman Catharina A
- Harvey Danielle
- Hashimoto Ryota
- Haswell Courtney C
- Hauser Michael
- Hauser Robert
- Hawkins Keith A
- Hefti Franz
- Heidebrink Judith L
- Heindel Walter
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- Heinzen Erin L
- Henskens Frans A
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- Heslenfeld Dirk J
- Hetelle Joel
- Hewitt David L
- Heyn Chris Chinthaka
- Hibar Derrek P
- Hillegers Manon H J
- Himali Jayandra J
- Ho Beng-Choon
- Ho New Fei
- Hoehn David
- Hoekstra Pieter J
- Hofer Edith
- Hofer Edith
- Hoffmann Per
- Hoffmann Wolfgang U
- Hofman Albert
- Hogarth Penelope
- Hohmann Sarah
- Holleran Laurena
- Holmes Avram J
- Holsboer Florian
- Holtzman David
- Homuth Georg
- Hong L Elliot
- Honig Lawrence S
- Hoogman Martine
- Hopkins William D
- Hosein Chris
- Hosten Norbert
- Hottenga Jouke-Jan
- Hsiao John
- Hsiung Ging-Yuek Robin
- Hu Shu-Ching
- Hulshoff Pol Hilleke E
- Hunter Christine
- Hynes Mary L
- Häusler Alexander N
- Håberg Asta K
- Ihlenfeld Albrecht
- Ikeda Masashi
- Ikram M Arfan
- Ikram M Arfan
- Ing Alex
- Initiative Alzheimer’s Disease Neuroimaging
- Initiative Parkinson’s Progression Markers
- Iranzo Alex
- Isaacson Stuart
- Isensee Corinna
- Ismail M Saleem
- Ittermann Bernd
- Jack Clifford R
- Jack Clifford R
- Jagust William
- Jahanshad Neda
- James Angela
- James Olga
- James Raymond
- Jang MiHyun
- Jankovic Joseph
- Janowitz Deborah
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- Jia Tianye
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- Johnson Kathleen
- Johnson Keith A
- Johnson Kris
- Johnson Nancy
- Johnson Patricia Lynn
- Johnson Sterling
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- Jönsson Erik G
- Kahn René S
- Kanai Ryota
- Kantarci Kejal
- Karama Sherif
- Karama Sherif
- Karlawish Jason H
- Kasperaviciute Dalia
- Kass Joseph S
- Kataki Maria
- Kaufmann Tobias
- Kaye Jeffrey A
- Kelly Sinead
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- Klein Marieke
- Knapp Michael
- Knodt Annchen R
- Knol Maria J
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- Koops Sanne
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- Korecka Magdalena
- Kowalksi Nancy
- Kowall Neil
- Kremen Sarah
- Kremen William S
- Krug Axel
- Krämer Bernd
- Kuller Lew
- Kwok John B
- Kwok John B J
- Lah James J
- Lam Max
- Lamar Melissa
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- Lancaster Thomas M
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- Leverenz James
- Levey Allan I
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- Lim Kelvin O
- Lin Honghuang
- Lin Michael
- Lind Betty
- Lind Penelope A
- Linder Carly
- Lipowski Kristine
- Loeffler Markus
- Logovinsky Veronika
- Logue Mark
- Longstreth W. T.
- Longstreth William T
- Lopes-Cendes Iscia
- Lopez Oscar L
- Lopez Oscar L
- Lord Joanne L
- Loughland Carmel M
- Love Marissa Natelson
- Lu Po H
- Luciano Michelle
- Luciano Michelle
- Luykx Jurjen J
- Lyons Michael J
- Macciardi Fabio
- Maillard Pauline
- Maingault Sophie
- Makino Kelly M
- Malferrari Giulia
- Malloy Paul
- Marek Kenneth
- Mari Zoltan
- Marquand Andre F
- Marshall Gad A
- Marson Daniel
- Martin Kim
- Martin Nicholas G
- Martinot Jean-Luc
- Martinot Jean-Luc
- Martinot Marie-Laure Paillère
- Mason Sara S
- Mathalon Daniel H
- Mather Karen A
- Mather Karen A
- Mathews Dana
- Mathias Samuel R
- Mathis Chet
- Mattay Venkata S
- Matthews Brandy R
- Matthews Sarah
- Mayoral Van Son Jaqueline
- Mazoyer Bernard
- Mazoyer Bernard
- McCoy Arita
- McDonald Colm
- McEwen Sarah C
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- Medland Sarah E
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- Mesulam Marek-Marsel
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- Nyberg Lars
- Nöthen Markus M
- O'Leary Daniel S
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- Oates Elizabeth
- Obisesan Thomas O
- Obradov Sanja
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- Rasser Paul E
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- Richer Louis
- Riedel Brandalyn C
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- Robbins Trevor
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- Roffman Joshua L
- Rogalski Emily
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- Rosen Howard J
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- Rotter Jerome I
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- Schneider Stacy
- Schofield Peter R
- Schofield Peter R
- Scholz Markus
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- Shin Jean
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- Siderowf Andrew
- Silbert Lisa C
- Silverman Daniel H S
- Silverstein Rebecca
- Sim Kang
- Simpson Donna M
- Simuni Tanya
- Singleton Andrew
- Singleton-Garvin Jamika
- Sink Kaycee M
- Sirrel Sherye A
- Sisodiya Sanjay M
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- Snyder Peter J
- Soares Holly
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- Spann Bryan M
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- Stein Jason L
- Stern Matthew
- Stern Yaakov
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- Stringaris Argyris
- Swerdlow Russell H
- Sämann Philipp G
- Sønderby Ida E
- Tanner Caroline
- Tansey Katherine E
- Tarawneh Rawan
- Tariot Pierre
- Tatsuoka Curtis
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- Thompson Paul
- Thompson Paul M
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- Toga Arthur
- Toga Arthur W
- Toga Arthur W
- Tolosa Eduardo
- Tooney Paul A
- Tordesillas-Gutiérrez Diana
- Torres Fábio R
- Tran Baochan
- Tremont Geoffrey
- Trncic Nadira
- Trojanowki John Q
- Trollor Julian
- Trollor Julian N
- Turner Jessica A
- Turner Raymond Scott
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- Veillette Suzanne
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- Vernooij Meike W
- Villena Teresa
- Villringer Arno
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- Völker Uwe
- Völzke Henry
- Walter Henrik
- Walter Henrik
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- Walton Esther
- Wang Mingyuan
- Wang Yunpeng
- Ward Chad
- Wardlaw Joanna M
- Wardlaw Joanna M
- Weber Bernd
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- Weintraub Sandra
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- Wen Wei
- Westlye Lars T
- Whelan Christopher D
- Whelan Robert
- Whelan Robert
- White Tonya
- Willeke Diana
- Williams Karen
- Williams Steve
- Wilson Renee
- Winkfield David
- Witbracht Megan
- Witt Stephanie H
- Witte A Veronica
- Wittfeld Katharina
- Wittfeld Katharina
- Wolf Christiane
- Wolfers Thomas
- Wolk David A
- Womack Kyle
- Wong Terence Z
- Woo Ellen
- Wright Margaret J
- Wright Margaret J
- Wu Chuang-Kuo
- Wu Jing Qin
- Wurster Isabel
- Xia Rui
- Yamamori Hidenaga
- Yanez Beatriz
- Yang Mia
- Yang Qiong
- Yang Qiong
- Yankey Jon
- Yasuda Clarissa L
- Yeh Randy
- Yesavage Jerome
- Zamrini Edward
- Zare Habil
- Zaremba Dario
- Zhang Zuo
- Zhou Juan
- Zhu Alyssa H
- Zimmerman Earl A
- Ziolkowski Jaimie
- Zsembik Leo C P
- Zwiers Marcel P
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/01/2020
- Field of study
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder
Discutindo a educação ambiental no cotidiano escolar: desenvolvimento de projetos na escola formação inicial e continuada de professores
- Author
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Acosta Darin
- Acosta Jhon Gabriel
- Adam Nadia
- Adam Wolfgang
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adler Volker
- Adzic Petar
- Afanasiev Serguei
- Agostino Lorenzo
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Aguilo Ernest
- Ahmad Muhammad
- Ahmed Ijaz
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Akgun Ugur
- Akin Ilina Vasileva
- Alagoz Enver
- Albajar Carmen
- Albayrak Elif Asli
- Albergo Sebastiano
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alexander James
- Aliev Takhmasib
- Almeida Nuno
- Alver Burak
- Alverson George
- Alves Gilvan
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anastassov Anton
- Anderson Jacob
- Anderson Michael
- Andrea Jeremy
- Andreev Valeri
- Andreev Vladimir
- Andreev Yuri
- Andrews Warren
- Anghel Ioana Maria
- Antonelli Louis
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Appelt Eric
- Apresyan Artur
- Aranyi Attila
- Arce Pedro
- Arcidiacono Roberta
- Arenton Michael Wayne
- Arfaei Hessamaddin
- Argiro Stefano
- Arisaka Katsushi
- Arneodo Michele
- Asaadi Jonathan
- Asghar Muhammad Irfan
- Askew Andrew
- Assran Yasser
- Ata Metin
- Atac Muzaffer
- Atramentov Oleksiy
- Attikis Alexandros
- Auffray Etiennette
- Autermann Christian Tobias
- Auzinger Georg
- Avery Paul
- Avetisyan Aram
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
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- Azzolini Virginia
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- Baarmand Marc M.
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- Wardle Nicholas
- Wardrope David
- Wasserbaech Steven
- Wayne Mitchell
- Weber Hendrik
- Weber Martin
- Weber Matthias
- Wehrli Lukas
- Weiler Thomas
- Weinberg Marc
- Weinberger Michael
- Wendland Lauri
- Weng Joanna
- Weng Yao
- Wenger Edward Allen
- Werner Jeremy Scott
- Wetzel James
- Whitbeck Andrew
- Whitmore Juliana
- Whyntie Tom
- Wickramage Nadeesha
- Widl Edmund
- Wigmans Richard
- Wilken Rachel
- Wilkinson Richard
- Williams Grayson
- Willmott Carlos
- Wimpenny Stephen
- Winn Dave
- Winstrom Lucas
- Wissing Christoph
- Wittich Peter
- Wittmer Bruno
- Womersley William John
- Won Steven
- Wood Darien
- Wood Jeffrey Scott
- Worm Steven
- Wright Douglas
- Wrochna Grzegorz
- Wu Jing-Han
- Wu Weimin
- Wulz Claudia-Elisabeth
- Wyslouch Bolek
- Würthwein Frank
- Xiao Hong
- Xie Si
- Xu Ming
- Yagil Avraham
- Yan Ming
- Yang Fan
- Yang Mingming
- Yang Yong
- Yang Zong-Chang
- Yazgan Efe
- Yelton John
- Yetkin Taylan
- Yi Kai
- Yildirim Eda
- Yilmaz Yetkin
- Yiu Chun Hin
- Yohay Rachel
- Yoo Hwi Dong
- Yoo Jaehyeok
- Yoon Sungho
- York Andrew
- Yu Intae
- Yu Shin-Shan
- Yumiceva Francisco
- Yun Jae Chul
- Zabel James
- Zabi Alexandre
- Zablocki Jakub
- Zaganidis Nicolas
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Marco
- Zang Jingjing
- Zang Shi-Lei
- Zarubin Anatoli
- Zatserklyaniy Andriy
- Zeinali Maryam
- Zeise Manuel
- Zeuner Wolfram Dietrich
- Zeyrek Mehmet
- Zhang Jinzhong
- Zhang Linlin
- Zhang Zhen
- Zheng Yu
- Zhokin Alexander
- Zhu Bo
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Ziebarth Eva Barbara
- Ziegler Jill
- Zielinski Marek
- Zito Giuseppe
- Zorbilmez Caglar
- Zotto Pierluigi
- Zou Wei
- Zumerle Gianni
- Zuranski Andrzej
- Zöller Marc Henning
- Publication venue
- Publication date
- 01/01/2011
- Field of study
A presente pesquisa buscou discutir como a Educação Ambiental (EA) vem sendo trabalhada, no Ensino Fundamental e como os docentes desta escola compreendem e vem inserindo a EA no cotidiano escolar., em uma escola estadual do município de Tangará da Serra/MT, Brasil. Para tanto, realizou-se entrevistas com os professores que fazem parte de um projeto interdisciplinar de EA na escola pesquisada. Verificou-se que o projeto da escola não vem conseguindo alcançar os objetivos propostos por: desconhecimento do mesmo, pelos professores; formação deficiente dos professores, não entendimento da EA como processo de ensino-aprendizagem, falta de recursos didáticos, planejamento inadequado das atividades. A partir dessa constatação, procurou-se debater a impossibilidade de tratar do tema fora do trabalho interdisciplinar, bem como, e principalmente, a importância de um estudo mais aprofundado de EA, vinculando teoria e prática, tanto na formação docente, como em projetos escolares, a fim de fugir do tradicional vínculo “EA e ecologia, lixo e horta”.Facultad de Humanidades y Ciencias de la Educació
stairs and fire
- Author
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Acosta Darin
- Acosta Jhon Gabriel
- Adair Antony
- Adam Nadia
- Adam Wolfgang
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adler Volker
- Adzic Petar
- Afanasiev Serguei
- Agostino Lorenzo
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Aguilo Ernest
- Ahmad Muhammad
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Akgun Ugur
- Akin Ilina Vasileva
- Alagoz Enver
- Albajar Carmen
- Albayrak Elif Asli
- Albergo Sebastiano
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Aldá Júnior Walter Luiz
- Alexander James
- Aliev Takhmasib
- Almeida Nuno
- Alver Burak
- Alverson George
- Alves Gilvan
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anastassov Anton
- Anderson Jacob
- Anderson Michael
- Andrea Jeremy
- Andreev Valeri
- Andreev Vladimir
- Andreev Yuri
- Andrews Warren
- Anghel Ioana Maria
- Antonelli Louis
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Appelt Eric
- Apresyan Artur
- Aranyi Attila
- Arce Pedro
- Arcidiacono Roberta
- Arenton Michael Wayne
- Arfaei Hessamaddin
- Argiro Stefano
- Arisaka Katsushi
- Arneodo Michele
- Arora Sanjay
- Asawatangtrakuldee Chayanit
- Asghar Muhammad Irfan
- Askew Andrew
- Assran Yasser
- Ata Metin
- Atac Muzaffer
- Atramentov Oleksiy
- Attikis Alexandros
- Auffray Etiennette
- Autermann Christian Tobias
- Auzinger Georg
- Avdeeva Ekaterina
- Avery Paul
- Avetisyan Aram
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Baarmand Marc M.
- Babb John
- Bacchetta Nicola
- Bachtis Michail
- Baden Drew
- Baesso Paolo
- Baffioni Stephanie
- Bagliesi Giuseppe
- Bai Yuting
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Bakirci Mustafa Numan
- Bakken Jon Alan
- Balazs Michael
- Ball Austin
- Ball Gordon
- Ban Yong
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Sunil
- Banzuzi Kukka
- Barbagli Giuseppe
- Barberis Emanuela
- Barbone Lucia
- Bardak Cemile
- Barfuss Anne-Fleur
- Bargassa Pedrame
- Barge Derek
- Baringer Philip
- Barker Anthony
- Barnes Virgil E.
- Barnett Bruce Arnold
- Barney David
- Barone Luciano
- Barrett Matthew
- Bartalini Paolo
- Barth Christian
- Basegmez Suzan
- Basso Lorenzo
- Battilana Carlo
- Baty Clement
- Bauer Gerry
- Bauerdick Lothar A. T.
- Baumgartel Darin
- Baur Ulrich
- Bayshev Igor
- Bazterra Victor Eduardo
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Beaupere Nicolas
- Bedjidian Marc
- Beernaert Kelly
- Behrenhoff Wolf
- Behrens Ulf
- Belforte Stefano
- Beliy Nikita
- Belknap Donald
- Bell Alan James
- Bell Ken W.
- Bellan Paolo
- Bellan Riccardo
- Bellinger James Nugent
- Belotelov Ivan
- Belyaev Alexander
- Belyaev Andrey
- Benaglia Andrea
- Bencze Gyorgy
- Bendavid Joshua
- Benedetti Daniele
- Benelli Gabriele
- Benhabib Lamia
- Beni Noemi
- Benucci Leonardo
- Benussi Luigi
- Benvenuti Alberto
- Beranek Sarah
- Beretvas Andrew
- Bergauer Thomas
- Berger Joram
- Bergholz Matthias
- Beri Suman Bala
- Bernardes Cesar Augusto
- Bernardini Jacopo
- Bernet Colin
- Berry Douglas
- Berry Edmund
- Berryhill Jeffrey
- Bertl Willi
- Berzano Umberto
- Besancon Marc
- Betchart Burton
- Bethani Agni
- Betts Russell Richard
- Beuselinck Raymond
- Bhat Pushpalatha C.
- Bhatnagar Vipin
- Bhattacharya Saptaparna
- Bhattacharya Satyaki
- Bhatti Anwar
- Bialas Wojciech
- Bialkowska Helena
- Bian Jian-Guo
- Bianchi Giovanni
- Bianchini Lorenzo
- Bianco Stefano
- Biasini Maurizio
- Biasotto Massimo
- Biino Cristina
- Bilei Gian Mario
- Bilin Bugra
- Bilinskas Mykolas Jurgis
- Bilki Burak
- Bilmis Selcuk
- Biselli Angela
- Bisello Dario
- Bitioukov Sergei
- Blekman Freya
- Blobel Volker
- Bloch Daniel
- Bloch Ingo
- Bloch Philippe
- Bloom Kenneth
- Bluj Michal
- Blumenfeld Barry
- Blyweert Stijn
- Bobrovskyi Sergei
- Boccali Tommaso
- Bocci Andrea
- Bochenek Joseph
- Bodek Arie
- Bodin David
- Boimska Bozena
- Boldizsar Laszlo
- Bolla Gino
- Bolognesi Sara
- Bolton Tim
- Bonacorsi Daniele
- Bonato Alessio
- Bondu Olivier
- Bontenackels Michael
- Boos Edouard
- Bornheim Adolf
- Borras Kerstin
- Borrello Laura
- Bortignon Pierluigi
- Bortoletto Daniela
- Bose Suvadeep
- Bose Tulika
- Bostock Francis
- Botta Cristina
- Boudoul Gaelle
- Boulahouache Chaouki
- Boumediene Djamel
- Bourilkov Dimitri
- Boutemeur Madjid
- Boutle Sarah
- Braibant-Giacomelli Sylvie
- Branca Antonio
- Branson James G.
- Breedon Richard
- Breto Guillermo
- Breuker Horst
- Brew Christopher
- Brigliadori Luca
- Brigljevic Vuko
- Brinkerhoff Andrew
- Broccolo Giuseppe
- Brochero Cifuentes Javier Andres
- Brom Jean-Marie
- Brona Grzegorz
- Brooke James John
- Broutin Clementine
- Brown Robert M.
- Brownson Eric
- Brun Hugues
- Bruno Giacomo
- Buchmann Marco-Andrea
- Buchmuller Oliver
- Bunin Pavel
- Bunkowski Karol
- Bunn Julian
- Buontempo Salvatore
- Burgmeier Armin
- Burkett Kevin
- Busson Philippe
- Busza Wit
- Butler Joel Nathan
- Butler Philip H.
- Butt Jamila
- Butz Erik
- Bylsma Ben
- Bäni Lukas
- Cabrera Andrés
- Cabrillo Iban Jose
- Caebergs Thierry
- Cakir Altan
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- Calderon De La Barca Sanchez Manuel
- Calderon Alicia
- Cali Ivan Amos
- Calligaris Luigi
- Callner Jeremy
- Calvert Brian
- Calvo Enrique
- Campagnari Claudio
- Campbell Alan
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- Cavanaugh Richard
- Ceard Ludivine
- Cepeda Maria
- Cerati Giuseppe Benedetto
- Cerci Salim
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- Cerminara Gianluca
- Cerrada Marcos
- Chabert Eric Christian
- Chadwick Matthew
- Chakaberia Irakli
- Chamizo Llatas Maria
- Chan Matthew
- Chang Paoti
- Chang Sunghyun
- Chang You-Hao
- Chang Yu-Wei
- Chang Yuan-Hann
- Chanon Nicolas
- Chao Yuan
- Charaf Otman
- Charlot Claude
- Chasco Matthew
- Chasserat Julien
- Chatrchyan Serguei
- Chatterjee Avishek
- Chauhan Sushil
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- Chen Guo-Ming
- Chen He-Sheng
- Chen Jie
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- Chen Kuan-Hsin
- Chen Mingshui
- Chen Yi
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- Cherepanov Vladimir
- Chertok Maxwell
- Chetluru Vasundhara
- Cheung Harry
- Chhibra Simranjit Singh
- Chierici Roberto
- Chiochia Vincenzo
- Chiorboli Massimiliano
- Chlebana Frank
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- Choi Minkyoo
- Choi Suyong
- Choi Young Kyu
- Choi Young-Il
- Chou John Paul
- Choudhary Brajesh C.
- Choudhury Rajani Kant
- Choudhury Somnath
- Christiansen Tim
- Chuang Shan-Huei
- Chung Jin Hyuk
- Chung Yeon Sei
- Chwalek Thorsten
- Ciesielski Robert
- Cihangir Selcuk
- Cimmino Anna
- Cirino Guy
- Cittolin Sergio
- Ciulli Vitaliano
- Civinini Carlo
- Claes Daniel R.
- Clare Robert
- Clarida Warren
- Clement Emyr
- Clerbaux Barbara
- Cline David
- CMS Collaboration
- Coarasa Perez Jose Antonio
- Cockerill David J. A.
- Codispoti Giuseppe
- Colafranceschi Stefano
- Colaleo Anna
- Cole Joanne
- Colino Nicanor
- Collard Caroline
- Colling David
- Conetti Sergio
- Contardo Didier
- Conte Eric
- Contreras-Campana Christian
- Contreras-Campana Emmanuel
- Conway John
- Conway Rylan
- Cooper Seth
- Cooper William
- Cornelis Tom
- Correa Martins Junior Marcos
- Cossutti Fabio
- Costa Marco
- Costa Salvatore
- Costantini Silvia
- Coughlan John A.
- Cousins Robert
- Covarelli Roberto
- Cox Bradley
- Cox Peter Timothy
- Creanza Donato
- Cremaldi Lucien Marcus
- Cripps Nicholas
- Cuevas Javier
- Cuffiani Marco
- Cumalat John Perry
- Cuplov Vesna
- Curé Benoît
- Cushman Priscilla
- Cussans David
- Custódio Analu
- Cutajar Michael
- Cutts David
- Cwiok Mikolaj
- Czellar Sandor
- D'Agnolo Raffaele Tito
- D'Alessandro Raffaello
- D'Alfonso Mariarosaria
- D'Enterria David
- D'Hondt Jorgen
- Da Cunha Marinho Franciole
- Daci Nadir
- Dahmes Bryan
- Dahms Torsten
- Dallavalle Gaetano-Marco
- Damgov Jordan
- Dammann Dirk
- Danielson Thomas
- Das Souvik
- Daskalakis Georgios
- Dasu Sridhara
- Daubie Evelyne
- Dauncey Paul
- David Tinoco Mendes Andre
- Davids Martina
- Davies Gavin
- De Almeida Dias Flavia
- de Barbaro Pawel
- De Benedetti Abraham
- De Boer Wim
- De Cosa Annapaola
- De Favereau De Jeneret Jerome
- De Filippis Nicola
- De Gruttola Michele
- De Guio Federico
- De Jesus Damiao Dilson
- De La Cruz Begona
- De La Cruz-Burelo Eduard
- De Lentdecker Gilles
- De Mattia Marco
- De Moraes Gregores Eduardo
- De Oliveira Martins Carley
- De Palma Mauro
- De Roeck Albert
- de Trocóniz Jorge F.
- De Visscher Simon
- De Wolf Eddi A.
- Deisher Amanda
- Deiters Konrad
- Dejardin Marc
- Del Re Daniele
- Delaere Christophe
- Delgado Peris Antonio
- Deliomeroglu Mehmet
- Dell'Orso Roberto
- Della Negra Michel
- Della Ricca Giuseppe
- Demaria Natale
- Demina Regina
- Demortier Luc
- Denegri Daniel
- Deniz Muhammed
- Depasse Pierre
- Dermenev Alexander
- Dero Vincent
- Dhingra Nitish
- Di Giovanni Gian Piero
- Di Guida Salvatore
- Di Marco Emanuele
- Di Matteo Leonardo
- Diamond Brendan
- Diemoz Marcella
- Dierlamm Alexander
- Dietz Charles
- Dietz-Laursonn Erik
- Diez Pardos Carmen
- Dimitrov Anton
- Dinardo Mauro Emanuele
- Dirkes Guido
- Dissertori Günther
- Dittmar Michael
- Djordjevic Milos
- Dobrzynski Ludwik
- Dobson Marc
- Dobur Didar
- Doesburg Robert
- Dogangun Oktay
- Dolen James
- Dominguez Aaron
- Dominik Wojciech
- Domínguez Vázquez Daniel
- Dorigo Tommaso
- Dorney Brian
- Doroba Krzysztof
- Dos Reis Martins Thiago
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- Dozen Candan
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- Dubinin Mikhail
- Dudero Phillip Russell
- Dudko Lev
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- Duris Joseph
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- Eartly David P.
- Eckerlin Guenter
- Ecklund Karl Matthew
- Eckstein Doris
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- Edelmaier Christopher
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- Everaerts Pieter
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- Falkiewicz Anna
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- Farrell Chris
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- Favaro Carlotta
- Favart Denis
- Fay Jean
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- Fehling David
- Feindt Michael
- Felcini Marta
- Feld Lutz
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- Ferencek Dinko
- Ferguson Thomas
- Ferguson William
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- Fernandez Menendez Javier
- Fernandez Marcos
- Fernández Ramos Juan Pablo
- Ferrando Antonio
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- Ferro Cristina
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- Finger jr. Michael
- Finger Miroslav
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- Foudas Costas
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- Funk Wolfgang
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- Gardner Michael
- Gartner Joseph
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- Gascon Susan
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- Gavrilov Vladimir
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- Gaz Alessandro
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- Gerber Cecilia Elena
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- Gerwig Hubert
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- Ghete Vasile Mihai
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- Gibbons Lawrence Kent
- Giffels Manuel
- Gigi Dominique
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- Gomez Moreno Bernardo
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- Gomez-Reino Garrido Robert
- Goncharov Maxim
- Gonella Franco
- Gonzalez Caballero Isidro
- Gonzalez Lopez Oscar
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- Gonzi Sandro
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- Gotra Yury
- Gottschalk Erik
- Goulianos Konstantin
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- Harris Robert M.
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- Heath Greg P.
- Heath Helen F.
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- Herndon Matthew
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- Hill Christopher
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- Hinzmann Andreas
- Hirosky Robert
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- Hits Dmitry
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- Hoch Michael
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- Hoffmann Hans Falk
- Hoffmann Karl-Heinz
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- Hohlmann Marcus
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- Hollingsworth Matthew
- Holzner André
- Honc Simon
- Hong Byung-Sik
- Hooberman Benjamin
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- Neumeister Norbert
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- Newsom Charles Ray
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- Sanders David A.
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- Shepherd-Themistocleous Claire H.
- Shi Xin
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- Shiu Jing-Ge
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- Siroli Gianni
- Sirunyan Albert M.
- Skhirtladze Nikoloz
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- Smith John
- Smith Kenneth
- Smith Vincent J.
- Smith Wesley H.
- Snigirev Alexander
- Snoek Hella
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- Spalding William J.
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- Stiliaris Efstathios
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- Stolin Viatcheslav
- Stone Robert
- Stoye Markus
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- Wu Weimin
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- Wyslouch Bolek
- Wöhri Hermine Katharina
- Würthwein Frank
- Xiao Hong
- Xie Si
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- Yang Fan
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- Yazgan Efe
- Yelton John
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- Yildirim Eda
- Yilmaz Yetkin
- Yohay Rachel
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- Yun Jae Chul
- Zabel James
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- Zablocki Jakub
- Zaganidis Nicolas
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Marco
- Zang Jingjing
- Zang Shi-Lei
- Zarubin Anatoli
- Zatserklyaniy Andriy
- Zeinali Maryam
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- Zeuner Wolfram Dietrich
- Zeyrek Mehmet
- Zhang Jinzhong
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- Zito Giuseppe
- Zotto Pierluigi
- Zou Wei
- Zuranski Andrzej
- Zöller Marc Henning
- Publication venue
- Publication date
- 01/01/2012
- Field of study
Granulocyte-Colony Stimulating Factor Increases Cerebral Blood Flow via a NO Surge Mediated by Akt/eNOS Pathway to Reduce Ischemic Injury
- Publication venue
- Hindawi Limited
- Publication date
- 01/01/2015
- Field of study
Granulocyte-colony stimulating factor (G-CSF) protects brain from ischemic/reperfusion (I/R) injury, and inhibition of nitric oxide (NO) synthases partially reduces G-CSF protection. We thus further investigated the effects of G-CSF on ischemia-induced NO production and its consequence on regional cerebral blood flow (rCBF) and neurological deficit. Endothelin-1 (ET-1) microinfused above middle cerebral artery caused a rapid reduction of rCBF (ischemia) which lasted for 30 minutes and was followed by a gradual recovery of blood flow (reperfusion) within the striatal region. Regional NO concentration increased rapidly (NO surge) during ischemia and recovered soon to the baseline. G-CSF increased rCBF resulting in shorter ischemic duration and an earlier onset of reperfusion. The enhancement of the ischemia-induced NO by G-CSF accompanied by elevation of phospho-Akt and phospho-eNOS was noted, suggesting an activation of Akt/eNOS. I/R-induced infarct volume and neurological deficits were also reduced by G-CSF treatment. Inhibition of NO synthesis by L-NG-Nitroarginine Methyl Ester (L-NAME) significantly reduced the effects of G-CSF on rCBF, NO surge, infarct volume, and neurological deficits. We conclude that G-CSF increases rCBF through a NO surge mediated by Akt/eNOS, which partially contributes to the beneficial effect of G-CSF on brain I/R injury
Effects of endothelin in portal hypertensive rats
- Publication venue
- 'Portland Press Ltd.'
- Publication date
- Field of study
- …