51 research outputs found
Compensated right ventricular function of the onset of pulmonary hypertension in a rat model depends on chamber remodeling and contractile augmentation.
- Author
- Abe K
- Alencar A
- Arts T
- Bellofiore A
- Benoist D
- Benoist D
- Blaudszun G
- Cheng DC
- Correia-Pinto J
- de Man FS
- Ewalenko P
- Gomez-Arroyo JG
- Guccione JM
- Handoko ML
- Handoko ML
- Hardy MEL
- Hessel MHM
- Hoeper MM
- Langer SFJ
- Lee LC
- Pacher P
- Provencher S
- Rain S
- Schermuly RT
- Shintani H
- ter Keurs HE
- Trip P
- Umar S
- Vaillancourt M
- Vanderpool RR
- Vinnakota KC
- Wang Z
- Werchan PM
- White RJ
- Yin X
- Zhang X
- Publication venue
- eScholarship, University of California
- Publication date
- 01/10/2018
- Field of study
Right-ventricular function is a good indicator of pulmonary arterial hypertension (PAH) prognosis; however, how the right ventricle (RV) adapts to the pressure overload is not well understood. Here, we aimed at characterizing the time course of RV early remodeling and discriminate the contribution of ventricular geometric remodeling and intrinsic changes in myocardial mechanical properties in a monocrotaline (MCT) animal model. In a longitudinal study of PAH, ventricular morphology and function were assessed weekly during the first four weeks after MCT exposure. Using invasive measurements of RV pressure and volume, heart performance was evaluated at end of systole and diastole to quantify contractility (end-systolic elastance) and chamber stiffness (end-diastolic elastance). To distinguish between morphological and intrinsic mechanisms, a computational model of the RV was developed and used to determine the level of prediction when accounting for wall masses and unloaded volume measurements changes. By four weeks, mean pulmonary arterial pressure and elastance rose significantly. RV pressures rose significantly after the second week accompanied by significant RV hypertrophy, but RV stroke volume and cardiac output were maintained. The model analysis suggested that, after two weeks, this compensation was only possible due to a significant increase in the intrinsic inotropy of RV myocardium. We conclude that this MCT-PAH rat is a model of RV compensation during the first month after treatment, where geometric remodeling on EDPVR and increased myocardial contractility on ESPVR are the major mechanisms by which stroke volume is preserved in the setting of elevated pulmonary arterial pressure. The mediators of this compensation might themselves promote longer-term adverse remodeling and decompensation in this animal model
Predictive value of vrk 1 and 2 for rectal adenocarcinoma response to neoadjuvant chemoradiation therapy: a retrospective observational cohort study
- Author
- A Sevilla
- A Valbuena
- A Zaanan
- AH Banham
- AM Gamper
- Arancha Cebrian
- Aurea Borrero-Palacios
- B Glimelius
- Begoña Lopez-Botet
- C Lu
- CC Compton
- CR Santos
- Cristina Carames
- David Arroyo-Manzano
- H Hur
- I Rodriguez-Hernandez
- IF Fernandez
- IF Fernandez
- IJ Park
- J Nezu
- Javier Martinez-Useros
- Jesús Garcia-Foncillas
- JF Bosset
- JG Kuremsky
- Juan Pablo Marin-Arango
- JW Huh
- K Horisberger
- K Kim
- Laura del Puerto-Nevado
- M Mohiuddin
- M Salzano
- M Salzano
- M Sanz-Garcia
- Maria Jesus Fernandez-Aceñero
- Maria Rodriguez-Remirez
- Marlid Cruz-Ramos
- P Peduzzi
- R Farkas
- RJ Nichols
- RJ Nichols
- S Aust
- S Blanco
- S Blanco
- S Detre
- S Lopez-Borges
- SH Lim
- T Watanabe
- Teresa Gomez del Pulgar
- TH Kang
- TH Kang
- YT Yeh
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
- Abeysekara AU
- Abramo LR
- Abramowski A
- Abreu P
- Acernese F
- Acero F
- Ackermann M
- Ackley K
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- Adams C
- Adams J
- Adams SM
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- Addesso P
- Adhikari RX
- Adya VB
- Affeldt C
- Afrough M
- Agarwal B
- Agathos M
- Agatsuma K
- Aggarwal N
- Aglietta M
- Agliozzo C
- Agudo I
- Aguiar OD
- Aguilar JA
- Aharonian F
- Ahlers M
- Ahrens M
- Aiello L
- Ain A
- Ajith P
- Akras S
- Al Samarai I
- Albert A
- Albert A
- Albuquerque IFM
- Albury JM
- Alcaniz JS
- Alexander KD
- Alfaro R
- Alighieri S Di Serego
- Allam S
- Allekotte I
- Allen B
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- Altmann D
- Alvarez C
- Alvarez JD
- Alvarez M Dovale
- Alvarez-Muiz J
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- Arnaud N
- Array LWA Long Wavelength
- Array MWA Murchison Widefield
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- Arteaga-Velzquez JC
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- Zimmermann B
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- Zuccarello F
- Zucker ME
- Zuniga J
- Zweizig J
- Zywucka N
- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Evaluation of appendicitis risk prediction models in adults with suspected appendicitis
- Author
- Abbas Sh
- Abbas Sh
- Abbassi Oa
- Abbott T
- Abdelgadir Am
- Abdelrahman A
- Abdelrahman M
- Abdelrahman M
- Abdelwahed A
- Abellan M
- Abellán Am
- Abellán Am
- Abulafi M
- Acharya A
- Acosta A
- Adam Me
- Adams Re
- Adegbola So
- Adegbola So
- Adimonye A
- Adnan M
- Afshar S
- Agresta F
- Agua Ia
- Aguayo Jl
- Agudo Ar
- Ahad A
- Ahel J
- Ahern Dp
- Ahmad A
- Ahmed B
- Ahmed G
- Ahmed Os
- Ahmed Os
- Ahmed S
- Ainsworth P
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- Ais G
- Aisoni F
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- Akhtar K
- Akinsola O
- Akram F
- Al-Faham Z
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- Al-Khyatt W
- Al-Musawi S
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- Al-Sheikh M
- Alagna V
- Alani M
- Alberca-Paramo A
- Aldrey I
- Alexander R
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- Alhammali T
- Ali M
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- Choong Jh
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- Kirkby-Bott J
- Kirkham En
- Knight B
- Knight Ka
- Knight Sr
- Knight Sr
- Kochupapy R
- Kong Cy
- Kosti A
- Kosti A
- Kouli O
- Kouroumpas E
- Krishnamoorthy A
- Krivan S
- Kumar K
- Kumar S
- Kung V
- Kung V
- Kuo R
- Kälviäinen Hk
- La Valle G
- Ladwa N
- Lafaurie G
- Lai Cw
- Lal N
- Lal N
- Landaluce-Olavarria A
- Landaluce-Olavarria A
- Lara Mc
- Lara-Fernandez Y
- Lau E
- Laughlin Dm
- Laurenson M
- Laviano E
- Law Jj
- Lawday S
- Lawday S
- Layman S
- Layton Gr
- Lazzari G
- Lazzaro A
- Lecky-Thompson L
- Lee Ka
- Lee Ka
- Lee Kj
- Lee M
- Leighton Pa
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- Lek C
- Lennox-Warburton Hc
- Leon C
- Leung El
- Leusink A
- Li Ch
- Liaw G
- Licari L
- Lim Jm
- Lima F
- Lima M
- Limb C
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- Listorti C
- Littlehales Dj
- Lizzi V
- Ljungqvist G
- Llacer E
- Llewelyn O
- Lloyd G
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- Logan Pc
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- Longheu A
- Longshaw A
- Lopez M
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- Lopez-Duran Bl
- Lopez-Ruiz Ja
- Lorettu A
- Louro Hc
- Louw C
- Lucchi A
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- Lund Jn
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- Luzzi Ap
- Ly C
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- López Af
- Ma J
- Macinnes E
- Macinnes E
- Macleod C
- Maderuelo Vm
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- Magalhães Js
- Magnoli M
- Magro T
- Mahapatra R
- Mahendran B
- Mahmood F
- Mahmood F
- Mahmoud A
- Mahon D
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- Mahoney R
- Mai D
- Maina A
- Makhija R
- Malabarba S
- Malam Y
- Malik A
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- Malik K
- Malik Sn
- Malik Y
- Mambrilla-Herrero S
- Manas Oc
- Manda Vm
- Manektella Km
- Manias T
- Mann C
- Manoharan P
- Manson R
- Mansoor S
- Mansour Mm
- Mansour S
- Maqboul F
- Maragouthakis D
- Marangoni G
- Marano A
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- Marano L
- Mardhiah S
- Maretto I
- Marinello F
- Maripi H
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- Martin Lm
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- Martinez Et
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- Mehigan B
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- Oliva I
- Olivares-Oliver C
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- Padilla-Valverde D
- Paget C
- Pais M
- Pala M
- Palani-Velu Lk
- Palani-Velu Lk
- Pan Y
- Panagiotopoulos Sp
- Panda N
- Panda N
- Panda N
- Pandey V
- Pandya D
- Pandya R
- Paniagua M
- Pankin Gp
- Papandrea M
- Parajó Ae
- Paramasevon Kr
- Pareja-Ciuró F
- Parisi A
- Park Jh
- Park Jh
- Parkola Mj
- Parra Jm
- Parwaiz I
- Pascua-Sole M
- Pascual-Miguelañez I
- Pasquali S
- Pata F
- Pata F
- Pata F
- Pata F
- Pata F
- Pata F.
- Pata G
- Pata G
- Pata G
- Patel As
- Patel By
- Patel By
- Patel C
- Patel H
- Patel Mm
- Patel N
- Patel Pk
- Patel Rt
- Patil Sd
- Patti S
- Pau R
- Payne Cj
- Payne Re
- Payá-Llorente C
- Payá-Llorente C
- Peacock M
- Pearce J
- Pearce J
- Pearce L
- Pearce L
- Pearson R
- Pedder A
- Peirce Cb
- Peiris Gb
- Peixoto R
- Peleki A
- Peleki A
- Pellegrino L
- Pellicanò Ga
- Pellicer-Franco E
- Pellino G
- Pento V
- Pento V
- Peponis C
- Peprah D
- Pereira A
- Pereira Am
- Pereira J
- Pereira-Mosquera E
- Perera Mi
- Perez-Calvo J
- Perin A
- Pertile D
- Pertile D
- Peña-Barturen C
- Phelan L
- Photiou D
- Pierre R
- Pietrabissa A
- Pigem A
- Pila U
- Pilkington Jp
- Pineño-Flores C
- Pinillos-Somalo A
- Pinkney Td
- Pinkney Td
- Pinkney Td
- Pinna E
- Pino-Perez O
- Pirari Pf
- Pisanu A
- Piu F
- Planellas P
- Plua-Muniz Kt
- Poacher A
- Podda F
- Podda M
- Podda M
- Podda M
- Poillucci G
- Pollard H
- Ponchietti L
- Popova D
- Poudevigne M
- Prats Ma
- Prideaux A
- Prieto-Nieto Mi
- Primo Jc
- Pronin S
- Provenza G
- Puerta E
- Pulighe F
- Pullabatla-Venkata Up
- Punj S
- Pérez-Sanchez Le
- Quddus A
- Quill S
- Quinn Em
- Quinn Hc
- Rabie M
- Rabie Ma
- Rabie Mr
- Radwan Rw
- Radwan Rw
- Rahim A
- Rahman M
- Rahmani Ls
- Rajagopal S
- Rajaram R
- Rajaretnam N
- Rajjoub Y
- Rallage H
- Ramcharan S
- Ramirez L
- Ramirez-Redondo Aa
- Ramos Xh
- Ramos-Bernado Mi
- Ramírez-Faraco M
- Ranathunga S
- Rangarajan K
- Rao M
- Rao V
- Raofi A
- Rashid M
- Rate A
- Ravindran R
- Raymond M
- Raza Ss
- Recreo Ac
- Reddy A
- Reddy A
- Redmond Ae
- Redondo E
- Redondo E
- Redondo-Calvo Fj
- Reese G
- Regina G
- Rehman S
- Rehman S
- Rekhraj S
- Ren Kz
- Renshaw S
- Renshaw S
- Renzi Cr
- Resende Fm
- Rezacova M
- Rezvani S
- Riaz W
- Riba-Combatti L
- Ribaudo M
- Ribeiro B
- Rich Je
- Richardson Td
- Ridaura N
- Riera E
- Rigby S
- Rigney B
- Rinkoff S
- Ripoli Mc
- Robb Hd
- Robertson C
- Robinson A
- Robinson A
- Robinson D
- Robinson D
- Rocha R
- Rodger V
- Rodicio-Miravalles Jl
- Rodriguez L
- Rodriguez-Lopez M
- Rodriguez-Lopez M
- Rodriguez-Lopez M
- Rodríguez Ec
- Rojo Ja
- Roldán-Ortiz S
- Rolph R
- Romano J
- Romano R
- Romario Uf
- Romoli L
- Roncero Ls
- Ronda Rn
- Roomi S
- Rosa Mj
- Rosat A
- Roscio F
- Roscio F
- Roscio F
- Rossi C
- Rossi D
- Rossi Gm
- Roth N
- Rothnie K
- Roxburgh C
- Roy C
- Ruano A
- Rubbini M
- Rudland I
- Ruffolo C
- Rufo E
- Ruggiu Gv
- Ruiz-Marín M
- Ruiz-Marín M
- Rupani S
- Rupasinghe Sn
- Rupasinghe Sn
- Rutherford Dg
- Ruzvidzo F
- Ruzzenente A
- Saad M
- Saad M
- Saavedra-Chacón M
- Saba A
- Sabia D
- Sacco R
- Sacks R
- Sadek S
- Saghir N
- Sagnotta A
- Sagnotta A
- Saha A
- Sahay Sj
- Sahnan K
- Sahnan K
- Sainz B
- Sainz B
- Sajid Ms
- Salama Y
- Salamone G
- Salamone G
- Salamone G
- Salamone G
- Salandini Mc
- Salem A
- Salim S
- Salva Ab
- Salvador H
- Samartin C
- Sammarco G
- Sammarco G
- Samuel M
- Sana S
- Sanchez Er
- Sanchez Er
- Sanchez L
- Sanchez-Garcia S
- Sanchez-Guillen L
- Sanchez-Guillen L
- Sanchez-Martinez A
- Sancho-Muriel J
- Sandu L
- Sanna S
- Santamaria C
- Santamaría Pc
- Santarrufina-Martínez S
- Santos Sc
- Santurro L
- Sanz-Navarro S
- Sarmah P
- Sarmah P
- Sarmah P
- Sarveswaran J
- Sasia D
- Sasia D
- Saunders S
- Savill A
- Savino G
- Savino G
- Savioli F
- Scabini S
- Scabini S
- Scabini S
- Scandroglio Is
- Scanlon K
- Scatizzi M
- Scialandrone G
- Scricciolo M
- Sebastian Jf
- Sebastián-Tomás Jc
- Seddon Tc
- Segalini E
- Segura-Sampedro Jj
- Sena G
- Sena-Ruiz F
- Seneviratne N
- Sepe C
- Serventi F
- Serventi F
- Seth M
- Setshwaelo T
- Sezen E
- Sgardelis P
- Sgrò A
- Sgrò A
- Sgrò A
- Shah J
- Shah K
- Shah Sm
- Shah Sm
- Shaikh Ia
- Shakoor Z
- Shanmuganathan V
- Shanmugarajah K
- Sharma A
- Sharma A
- Sharma P
- Sharp Ol
- Sharp Ol
- Shaw Av
- Shepherd Ja
- Sherif Ma
- Shet S
- Shetty Vd
- Shingler G
- Shiwani Mh
- Shrestha D
- Shurlock J
- Sian T
- Siaw O
- Siddique K
- Siddiqui Mn
- Siddiqui Za
- Sierra-Grañón Je
- Siggens Kl
- Sihra N
- Silva A
- Silva I
- Silvestri V
- Simioni A
- Simmonds L
- Simmonds L
- Simo V
- Simoes J
- Simpson Dj
- Singh A
- Singh J
- Singh P
- Singh S
- Singhal T
- Singhal T
- Sivaloganathan P
- Skalamera I
- Skerritt C
- Slezak I
- Smallcombe N
- Smart Cj
- Smart Cj
- Smart Nj
- Smart Nj
- Smoker H
- Soares A. S.
- Soares As
- Soares As
- Soares As
- Soares As
- Soares As
- Soh B
- Solaini L
- Solar-García L
- Soliani P
- Solinas L
- Sooriyamoorthy T
- Soria-Aledo V
- Soria-Aledo V
- Soriano Jt
- Sorrentino L
- Sousa Hs
- Souter J
- Sparta C
- Spaziani A
- Speake D
- Speake D
- Springate El
- Sreedharan L
- Sreedharan L
- Staderini F
- Stecca T
- Stella M
- Stephens Gf
- Stephens Gf
- Stevenson R
- Stewart Dj
- Stoica I
- Storey R
- Stoyanov Ti
- Strachan E
- Strange Ja
- Stubbs Bm
- Stupalkowska W
- Stupalkowska W
- Suarez-Cabrera A
- Suero Ca
- Sultana A
- Summerfield L
- Sunter H
- Surg Pt
- Suriyakumar S
- Suárez-Sánchez A
- Swords C
- Symons N
- Szentpali K
- Szucs A
- Szucs A
- Sánchez-Cifuentes A
- Sánchez-Fuentes Mn
- Sánchez-Rubio M
- Tabain V
- Taglietti L
- Tague Le
- Tahir W
- Tailor K
- Tallon-Aguilar L
- Tallon-Aguilar L
- Tamayo-López Mj
- Tamborska A
- Tamini N
- Tamini N
- Tamini N
- Tan Cy
- Tan Cy
- Tan E
- Tan Hl
- Tan S
- Tang Am
- Tapiolas I
- Tarazi M
- Tatulli F
- Tay Yh
- Tayeh S
- Taylor M
- Taylor Ns
- Taylor Ns
- Taze D
- Tee A
- Tejero-Pintor Fj
- Tenconi Sm
- Tezas S
- Thaha Ma
- Thakral N
- Thakur D
- Thava B
- Thavanesan N
- Thavanesan N
- Thaventhiran Aj
- Theodoropoulou K
- Thomas At
- Thomas L
- Thompson C
- Thompson Db
- Thompson Db
- Thompson R
- Thompson R
- Thoukididou Sn
- Tiedt La
- Tiedt La
- Ting N
- Tinoco-González J
- Tinsley Bj
- Tognarelli Jm
- Tojal A
- Tokidis E
- Tomasoni M
- Tonini V
- Toomey D
- Toomey Db
- Torkington J
- Torkington J
- Torrado Aa
- Torrance A
- Torrance A
- Townsend Dc
- Townsend Dc
- Tozer Pj
- Trail M
- Trail M
- Trastulli S
- Trew F
- Trostchansky I
- Trujillo-Diaz Jj
- Tsang B
- Tudyka V
- Tudyka V
- Turnbull A
- Turner Ej
- Tutino R
- Twum-Barima Cs
- Twum-Barima Cs
- Tyler R
- Tyler R
- Ugarte-Sierra B
- Vacca A
- Vaccari S
- Vakis S
- Valente Pm
- Valiani Sv
- Vallejo-Bernad C
- Vallve-Bernal M
- Van Boxel Gi
- Vance-Daniel J
- Vannucchi A
- Varcada M
- Vargas-Pierola Hj
- Vaughan Em
- Vaughan Em
- Vazquez-Fernandez Ap
- Vega L
- Velchuru Vr
- Velho R
- Venkata Up
- Venkatasubramaniam Ak
- Venn Ml
- Venn Ml
- Venugopal R
- Verea S
- Veres T
- Veres T
- Verroiotou M
- Vescio G
- Vettoretto N
- Vigorita V
- Vijay V
- Vila-Zarate C
- Villarejo-Campos P
- Vinnicombe Z
- Viscosi F
- Vitish-Sharma P
- Viviani E
- Viñas Nl
- Vohra R
- Vohra R
- Vulcano I
- Waite K
- Walji Hd
- Walsh E
- Walsh Tn
- Walters Kj
- Walters U
- Wardle Bg
- Wardle Bg
- Wardle Sd
- Warren O
- Warren Oj
- Warusavitarne J
- Watfah J
- Watson N
- Wauchope J
- Weatherburn Lw
- Weaver J
- Weegenaar Cr
- Weegenaar Cr
- Welsh S
- Wensley F
- West H
- West H
- Wheatstone S
- Wheeler C
- Whewell He
- White F
- Whitehorn Se
- Whitehorn Se
- Whitehouse P
- Whiteman E
- Whittaker L
- Wiggill S
- Wijesundera K
- Wilcox G
- Wilkin R
- Wilkin R
- Wilkin R
- Wilkin R
- Wilkin R. J. W.
- Williams Gl
- Williams M
- Williams R
- Williams S
- Wilson Ej
- Wilson M
- Winter Dc
- Winter Dc
- Wolff J
- Wong A
- Wong C
- Wong J
- Wong J
- Wong Ml
- Wong Sy
- Woo R
- Wood Cs
- Woodrow C
- Woodward A
- Woodward B
- Woodward B
- Worku D
- Worku D
- Wright E
- Wright Hl
- Wu F
- Xidas A
- Yalamarthi S
- Yang P
- Yanni F
- Yardimci E
- Yasin T
- Yen Sk
- Yeung K
- Yeung K
- Yoganathan S
- Yoong S
- Youssef H
- Yow L
- Yow L
- Zaborowski A
- Zadi Az
- Zalla T
- Zarka Za
- Zarka Za
- Zarog Ma
- Zelazek M
- Zerpa C
- Zhang Ay
- Zhou S
- Zorrilla L
- Zuin M
- Zurleni Tz
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2019
- Field of study
Background
Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis.
Methods
A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis).
Results
Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P < 0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cut‐off score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cut‐off score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent).
Conclusion
Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making by identifying adults in the UK at low risk of appendicitis were identified
Mechanisms of Right Heart Failure—A Work in Progress and a Plea for Failure Prevention
- Publication venue
- 'Medknow'
- Publication date
- Field of study
Animal Models of Chronic Right Ventricular Stress and Failure
- Author
- A Andersen
- AS Geha
- D Benoist
- DH Will
- FS Man de
- G Olivetti
- G Olivetti
- G Ruiter
- HJ Bogaard
- HJ Bogaard
- HJ Bogaard
- I Enache
- J Gomez-Arroyo
- JA Cruz
- JF Spann Jr
- JF Williams Jr
- JG Gomez-Arroyo
- JG Gomez-Arroyo
- JI Drake
- JI Drake
- JJ Ryan
- JT Reeves
- JT Reeves
- K Okada
- L Long
- L Piao
- L Taraseviciene-Stewart
- L Taraseviciene-Stewart
- LA Walker
- M Gautier
- M Hardziyenka
- M Jasinska-Stroschein
- M Oka
- MA Borgdorff
- MJ Faber
- MJ Faber
- ML Handoko
- MR Nicolls
- MS Lemler
- NF Voelkel
- PA Murray
- R Colombo
- R Paulin
- RD Brown
- S Usui
- S-F Yet
- SN Sanyal
- T Nishimura
- T Urashima
- TA Fong
- V Euler
- Y Huo
- Y Mitani
- YH Fang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Pyruvate dehydrogenase activation precedes the down-regulation of fatty acid oxidation in monocrotaline-induced myocardial toxicity in mice
- Author
- BL Copple
- CK Winter
- D Shimura
- Daisuke Shimura
- F Akhavein
- Gaku Nakai
- GD Lopaschuk
- H Ashrafian
- HJ Atherton
- HN Sabbah
- Ichige Kajimura
- J George
- J Gomez-Arroyo
- J Mori
- JG Gomez-Arroyo
- JR Ussher
- Ken Uesugi
- L Piao
- MP Chandler
- N Fillmore
- Nobuhito Goda
- Q Jiao
- Qibin Jiao
- R Ventura-Clapier
- S Kumar
- S Rich
- Susumu Minamisawa
- T Daicho
- T Doenst
- T Ezzat
- T Soga
- T Soga
- Tomoyoshi Soga
- TW Petry
- V Lionetti
- WC Stanley
- YH Fang
- Yoichiro Kusakari
- ZV Varga
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Toward Better Reproducibility in Experimental Research on New Agents for Pulmonary Hypertension. An Analysis of Data from Four Hundred Animal Studies
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Serial T1 mapping of right ventricle in pulmonary hypertension: comparison with histology in an animal study
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Early Intervention of Tongxinluo (通心络) on Right Ventricular Function Assessed by Echocardiography in Rats with Pulmonary Arterial Hypertension Induced by Monocrotaline
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
- …