The Features of Acute Brucellosis in Azerbaijan Republic

It is well known, that the injury of organs and systems and also immunological rates considerably determine clinical course and the result of brucellosis. In the article are presented the results of examination of 120 patients with acute brucellosis. The control group included 30 practically healthy persons. Groups were representative by the age and sex. The diagnosis of brucellosis was set on the base of complaints, anamnesis, epidemiological and clinical data and the results of serological examination of the blood. All patients also underwent the fixation of interleukin -6, іinterleukin-4 and TLR-2 in the blood serum. The detailed epidemiological, clinical and immunological characteristic of patients with brucellosis was presented. Among examined persons prevailed men, persons of young able-bodied persons and rural dwellers. It was revealed, that the dominating way of transmission was the contact one. The highest level of infection was fixed among the workers of farm enterprises and veterinarians. The season features were also revealed, the highest level of morbidity was in summer-autumn period. The main clinical features were: fever, arthralgia, risen disposition to perspire, hepatosplenomegaly. It was revealed, that the level of pro-inflammatory interleukins considerably prevailed over the level of anti-inflammatory ones. Despite the high sensitivity of PCR diagnostics, the positive results in our research were received only in one third of patients

Il-4 Polymorphism in Patients with Acute Brucellosis in the Republic of Azerbaijan

Currently, there are isolated data on the relationship between IL-4 polymorphism (C-589T) and susceptibility to brucellosis. Therefore, the purpose of the study was to determine the frequency of polymorphism of IL-4 (C-589T) in patients with acute brucellosis.Materials and methods: the article presents the results of surveys of 120 patients with acute brucellosis. The control group consisted of 30 practically healthy persons. The diagnosis of brucellosis was based on complaints, anamnesis, epidemiological and clinical data, and the results of a specific study. The definition of the polymorphism of IL-4 (C-589T) was performed for all patients in the main and control group. A detailed description of patients with brucellosis is presented. Among the observed prevailed men and young people of working age.Results: A mild degree was established in 74 (61.66 %) patients, while severe - only in 11 (9.17 %) patients. It was determined that the genotype CT (65.83 %) was significantly more common among patients with brucellosis than in the control group, where the frequency of this genotype was only 16.66 %. While the CC genotype was 3.2 times more common among healthy individuals than among patients in the main group (76.67 % versus 24.17 %), it was found that the CC genotype of the IL-4 gene was 13 times more common in patients for acute brucellosis with mild progress than with severe.Conclusions: The genotype IL-4 (C-589T) SS is significantly associated with the mild course of brucellosis

ДИНАМІКА БІОХІМІЧНИХ ПОКАЗНИКІВ, IL-4 ТА IL-6 ПРИ ГОСТРОМУ БРУЦЕЛЬОЗІ ПІД ВПЛИВОМ ЛІКУВАННЯ

Brucellosis remains a global problem for many countries around the world. The aim of our study was to determine the dynamics of serum levels of IL-4 and IL-6 in the patients with acute brucellosis before and after treatment. Materials and methods. We examined 178 patients with clinic signs of acute brucellosis who applied for medical assistance. Specific methods of the study were conducted by ELISA with the detection of IgM and IgG. From 178 surveyed patients, only 120 persons were included in the main group according to the criteria. The control group consisted of 30 practically healthy persons. Among the surveyed, men were in the majority – 75.0 %. The average age of the patients with brucellosis was (35.9±2.8) years. Results and discussion. Among the patients with acute brucellosis, the most commonly observed were such clinical symptoms: fever – 86.7 %, general weakness – 87.5 %, sweating in 70.0 % of patients, and arthralgia in 64.2 % of patients. At the same time, the least of all patients indicated the presence of myalgia – in 35.0 % of patients and weight loss – in 25.8 % of patients. In the objective survey, it was found that 77.5 % of patients had certain problems of the cardiovascular system, whereas only one patient (0.8 %) had disorders of the sexual system in the form of orchitis. A reliable difference was found between the overall blood count and the biochemical parameters among the main group before and after treatment and healthy individuals. It was found that the level of IL-4 in the serum of patients with acute brucellosis before treatment was (11.3±0.7) and the level of IL-6 was (15.3±1.4) pg/ml versus (15.3±1,4) and (8.5±0.9) pg/ml after therapy, respectively. Conclusions. The level of hemoglobin in patients with acute brucellosis was 1.2 times lower compared with the control group. The levels of ALT and AST before treatment were 1.7 and 1.9 times higher, respectively, compared to post-treatment and 1.9 and 2.5 times higher compared to control group. IL-4 and IL-6 levels were 1.6 and 1.8 times higher in patients with acute brucellosis before and after treatment, and 1.8 and 2.0 times higher than healthy subjects.Бруцельоз залишається глобальною проблемою для багатьох країн. Метою дослідження було визначення динаміки показників IL-4 та Il-6 у хворих на гострий бруцельоз під впливом лікування. Пацієнти і методи. Обстежено 178 хворих з клінікою гострого бруцельозу, які зверталися за медичною допомогою. Специфічні методи дослідження проводили методом ІФА з виявленням IgM та IgG. Згідно з критеріями включення в дослідження, зі 178 обстежених хворих повністю відповідало всім критеріям лише 120 осіб, які і склали основну групу. До конт­рольної групи увійшло 30 практично здорових осіб. Серед обстежених переважали особи чоловічої статі – 75,0 %. Середній вік пацієнтів з бруцельозом становив (35,9±2,8) року. Результати досліджень та їх обговорення. У хворих на гострий бруцельоз найчастіше виявляли наступні клінічні симптоми: гарячку – у 86,7 % осіб, загальну слабкість – у 87,5 %, пітливість – у 70,0 %, а також артралгії у 64,2 % пацієнтів. Тоді як найрідше хворі вказували на наявність міалгій – у 35,0 % та втрату маси тіла – у 25,8 % хворих. При об’єктивному обстежені було виявлено, що 77,5 % осіб мали ті чи інші проблеми з боку серцево-судинної системи, тоді як ураження статевої системи у вигляді орхіту мало місце лише в 1 хворого (0,8 %). Була встановлена достовірна різниця між показниками загального аналізу крові та біохімічних показників серед основної групи до та після лікування і здоровими особами. Так, виявлено, що рівень IL-4 в сироватці крові хворих на гострий бруцельоз до лікування становив (11,3±0,7), а рівень IL-6 – (15,3±1,4) пг/мл проти (15,3±1,4) та (8,5±0,9) пг/мл після терапії відповідно. Висновки. Рівні АЛТ та АСТ до лікування були в 1,7 та 1,9 разу вищими порівняно з показниками після терапії та в 1,9 і в 2,5 разу – порівняно з показниками контрольної групи. Рівні IL-4 та IL-6 були в 1,6 та в 1,8 разу вищими у хворих на гострий бруцельоз до лікування, та в 1,8 та в 2,0 рази вищими порівняно зі здоровими особами

Multi-Wavelength Monitoring of the Changing-Look AGN NGC 2617 during State Changes

Optical and near-infrared photometry, optical spectroscopy, and soft X-ray and UV monitoring of the changing-look active galactic nucleus NGC 2617 show that it continues to have the appearance of a type-1 Seyfert galaxy. An optical light curve for 2010-2017 indicates that the change of type probably occurred between 2010 October and 2012 February and was not related to the brightening in 2013. In 2016 and 2017 NGC 2617 brightened again to a level of activity close to that in 2013 April. However, in 2017 from the end of the March to end of July 2017 it was in very low level and starting to change back to a Seyfert 1.8. We find variations in all passbands and in both the intensities and profiles of the broad Balmer lines. A new displaced emission peak has appeared in Hβ. X-ray variations are well correlated with UV-optical variability and possibly lead by ̃2-3 d. The K band lags the J band by about 21.5 ± 2.5 d and lags the combined B + J bands by ̃25 d. J lags B by about 3 d. This could be because J-band variability arises predominantly from the outer part of the accretion disc, while K-band variability is dominated by thermal re-emission by dust. We propose that spectral-type changes are a result of increasing central luminosity causing sublimation of the innermost dust in the hollow bi-conical outflow. We briefly discuss various other possible reasons that might explain the dramatic changes in NGC 2617.Fil: Oknyansky, V. L.. Sternberg Astronomical Institute; RusiaFil: Gaskell, C. M.. Department of Astronomy and Astrophysics. University of California. Santa Cruz; Estados UnidosFil: Mikailov, K. M.. Shamakhy Astrophysical Observatory, National Academy of Sciences. Pirkuli; AzerbaiyánFil: Lipunov, V. M.. Sternberg Astronomical Institute. M.V.Lomonosov Moscow State University ; RusiaFil: Shatsky, N. I.. Sternberg Astronomical Institute. M.V.Lomonosov Moscow State University; RusiaFil: Tsygankov, S. S.. Tuorla Observatory, Department of Physics and Astronomy. University of Turku.; FinlandiaFil: Gorbovskoy, E. S.. Sternberg Astronomical Institute. M.V.Lomonosov Moscow State University; RusiaFil: Tatarnikov, A. M.. Sternberg Astronomical Institute. M.V.Lomonosov Moscow State University; RusiaFil: Metlov, V. G.. Sternberg Astronomical Institute. M.V.Lomonosov Moscow State University; RusiaFil: Malanchev, K. L.. Sternberg Astronomical Institute. M.V.Lomonosov Moscow State University; RusiaFil: Brotherton, M.B.. University of Wyoming; Estados UnidosFil: Kasper, D.. University of Wyoming; Estados UnidosFil: Du, P.. Institute of High Energy Physics. Chinese Academy of Sciences; ChinaFil: Chen, X.. School of Space Science and Physics. Shandong University; ChinaFil: Burlak, M. A.. Sternberg Astronomical Institute. M.V.Lomonosov Moscow State University; RusiaFil: Buckley, D. A. H.. The South African Astronomical Observatory; SudáfricaFil: Rebolo, R.. Instituto de Astrofisica de Canarias; EspañaFil: Serra-Ricart, M.. Instituto de Astrofisica de Canarias; EspañaFil: Podestá, R.. Universidad Nacional de San Juan; ArgentinaFil: Levato, O. H.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Instituto de Ciencias Astronómicas, de la Tierra y del Espacio. Universidad Nacional de San Juan. Instituto de Ciencias Astronómicas, de la Tierra y del Espacio; Argentin

Identifying damage in a bridge by analysing rotation response to a moving load

This is the author accepted manuscript. The final version is available from Routledge via the DOI in this recordThis article proposes a bridge damage detection method using direct rotation measurements. Initially, numerical analyses are carried out on a one-dimensional (1D) simply supported beam model loaded with a single moving point load to investigate the sensitivity of rotation as a main parameter for damage identification. As a result of this study, the difference in rotation measurements due to a single moving point load obtained for healthy and damaged states is proposed as a damage indicator. A relatively simple laboratory experiment is conducted on a 3-m long simply supported beam structure to validate the results obtained from the numerical analysis. The case of multi-axle vehicles is investigated through numerical analyses of a 1D bridge model and a theoretical basis for damage detection is presented. Finally, a sophisticated 3D dynamic finite element model of a 20-m long simply supported bridge structure is developed by an independent team of researchers and used to test the robustness of the proposed damage detection methodology in a series of blind tests. Rotations from an extensive range of damage scenarios were provided to the main team who applied their methods without prior knowledge of the extent or location of the damage. Results from the blind test simulations demonstrate that the proposed methodology provides a reasonable indication of the bridge condition for all test scenarios.European Union Horizon 202

Single hadron response measurement and calorimeter jet energy scale uncertainty with the ATLAS detector at the LHC

The uncertainty on the calorimeter energy response to jets of particles is derived for the ATLAS experiment at the Large Hadron Collider (LHC). First, the calorimeter response to single isolated charged hadrons is measured and compared to the Monte Carlo simulation using proton-proton collisions at centre-of-mass energies of sqrt(s) = 900 GeV and 7 TeV collected during 2009 and 2010. Then, using the decay of K_s and Lambda particles, the calorimeter response to specific types of particles (positively and negatively charged pions, protons, and anti-protons) is measured and compared to the Monte Carlo predictions. Finally, the jet energy scale uncertainty is determined by propagating the response uncertainty for single charged and neutral particles to jets. The response uncertainty is 2-5% for central isolated hadrons and 1-3% for the final calorimeter jet energy scale.Comment: 24 pages plus author list (36 pages total), 23 figures, 1 table, submitted to European Physical Journal

Measurement of the cross-section and charge asymmetry of WW bosons produced in proton-proton collisions at s=8\sqrt{s}=8 TeV with the ATLAS detector

This paper presents measurements of the $W^+ \rightarrow \mu^+\nu$ and $W^- \rightarrow \mu^-\nu$ cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables, submitted to EPJC. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13

Search for chargino-neutralino production with mass splittings near the electroweak scale in three-lepton final states in √s=13 TeV pp collisions with the ATLAS detector

A search for supersymmetry through the pair production of electroweakinos with mass splittings near the electroweak scale and decaying via on-shell W and Z bosons is presented for a three-lepton final state. The analyzed proton-proton collision data taken at a center-of-mass energy of √s=13  TeV were collected between 2015 and 2018 by the ATLAS experiment at the Large Hadron Collider, corresponding to an integrated luminosity of 139  fb−1. A search, emulating the recursive jigsaw reconstruction technique with easily reproducible laboratory-frame variables, is performed. The two excesses observed in the 2015–2016 data recursive jigsaw analysis in the low-mass three-lepton phase space are reproduced. Results with the full data set are in agreement with the Standard Model expectations. They are interpreted to set exclusion limits at the 95% confidence level on simplified models of chargino-neutralino pair production for masses up to 345 GeV