36 research outputs found
Tumor immune infiltration estimated from gene expression profiles predicts colorectal cancer relapse
- Author
- Alonso Aguado Maria Henar
- Amos Christopher I.
- Bonner Joseph D.
- Cheng Chao
- Dwan Dennis
- Felder Seth I.
- Frost H. Robert
- Gruber Stephen B.
- Hoehn Hannah J.
- Kamal Yasmin
- Kim Youngchul
- Lazaris Charalampos
- Melas Marilena
- Moreno Aguado VĂctor
- Rennert Gad
- Rennert Hedy S.
- Sanz Pamplona Rebeca
- Schell Michael J.
- Schmit Stephanie L.
- Shibata David
- Siegel Erin M.
- Publication venue
- 'Informa UK Limited'
- Publication date
- 08/04/2021
- Field of study
A substantial fraction of patients with stage I-III colorectal adenocarcinoma (CRC) experience disease relapse after surgery with curative intent. However, biomarkers for predicting the likelihood of CRC relapse have not been fully explored. Therefore, we assessed the association between tumor infiltration by a broad array of innate and adaptive immune cell types and CRC relapse risk. We implemented a discovery-validation design including a discovery dataset from Moffitt Cancer Center (MCC; Tampa, FL) and three independent validation datasets: (1) GSE41258 (2) the Molecular Epidemiology of Colorectal Cancer (MECC) study, and (3) GSE39582. Infiltration by 22 immune cell types was inferred from tumor gene expression data, and the association between immune infiltration by each cell type and relapse-free survival was assessed using Cox proportional hazards regression. Within each of the four independent cohorts, CD4+ memory activated T cell (HR: 0.93, 95% CI: 0.90-0.96; FDR = 0.0001) infiltration was associated with longer time to disease relapse, independent of stage, microsatellite instability, and adjuvant therapy. Based on our meta-analysis across the four datasets, 10 innate and adaptive immune cell types associated with disease relapse of which 2 were internally validated using multiplex immunofluorescence. Moreover, immune cell type infiltration was a better predictors of disease relapse than Consensus Molecular Subtype (CMS) and other expression-based biomarkers (Immune-AICMCC:238.1-238.9; CMS-AICMCC: 241.0). These data suggest that transcriptome-derived immune profiles are prognostic indicators of CRC relapse and quantification of both innate and adaptive immune cell types may serve as candidate biomarkers for predicting prognosis and guiding frequency and modality of disease surveillance
Genetic architecture of subcortical brain structures in 38,851 individuals
- Author
- Abramovic Lucija
- Adams Hieab H. H.
- Agartz Ingrid
- Alhusaini Saud
- Ames David
- Amin Najaf
- Amouyel Philippe
- Andersson Micael
- Andreassen Ole A.
- Arfanakis Konstantinos
- Arias-Vasquez Alejandro
- Aribisala Benjamin S.
- Armstrong Nicola J.
- Assareh Amelia A.
- Athanasiu Lavinia
- Axelsson Tomas
- Bastin Mark E.
- Becker Diane M.
- Becker James T.
- Beiser Alexa S.
- Bennett David A.
- Bernard Manon
- Bis Joshua C.
- Bohlken Marc M.
- Boks Marco P.
- Boomsma Dorret
- Bralten Janita
- Brodaty Henry
- Brouwer Rachel M.
- Brunner Han G.
- Buckner Randy L.
- Buitelaar Jan K.
- Bulayeva Kazima B.
- Burkhardt Ralph
- Cahn Wiepke
- Calhoun Vince D.
- Carmichael Owen
- Cavalleri Gianpiero L.
- Chakravarty M. Mallar
- Chauhan Ganesh
- Chen Christopher
- Chen Qiang
- Cheng Ching-Yu
- Cheung Joshua W.
- Ching Christopher R. K.
- Cichon Sven
- Crespo-Facorro Benedicto
- Crivello Fabrice
- Cuellar-Partida Gabriel
- Dale Anders M.
- Davies Gareth E.
- de Geus Eco J. C.
- De Jager Philip L.
- de Zubicaray Greig
- Deary Ian J.
- Debette Stephanie
- DeCarli Charles
- Delanty Norman
- den Braber Anouk
- Depondt Chantal
- Desrivieres Sylvane
- DeStefano Anita L.
- Djurovic Srdjan
- Ehrlich Stefan
- Eicher John D.
- Erk Susanne
- Espeseth Thomas
- Fedko Iryna O.
- Fernandez Guilln
- Filippi Irina
- Fisher Simon E.
- Fleischman Debra A.
- Fletcher Evan
- Fornage Myriam
- Foroud Tatiana M.
- Francks Clyde
- Franke Barbara
- Giddaluru Sudheer
- Goldman Aaron L.
- Gollub Randy L.
- Grabe Hans J.
- Green Robert C.
- Greve Douglas N.
- Grimm Oliver
- Groenewold Nynke A.
- Gruber Oliver
- Guadalupe Tulio
- Gudnason Vilmundur
- Haberg Asta K.
- Hagenaars Saskia P.
- Hansell Narelle K.
- Harris Tamara B.
- Hartman Catharina A.
- Haukvik Unn K.
- Hegenscheid Katrin
- Heinz Andreas
- Hernandez Maria C. Valdes
- Heslenfeld Dirk J.
- Hibar Derrek P.
- Hilal Saima
- Himali Jayandra J.
- Ho Beng-Choon
- Hoehn David
- Hoekstra Pieter J.
- Hofer Edith
- Hoffmann Wolfgang
- Hofman Albert
- Holmes Avram J.
- Holsboer Florian
- Homuth Georg
- Hoogman Martine
- Hosten Norbert
- Hottenga Jouke-Jan
- Hu Yanhui
- Huentelman Matthew
- Ikram M. Arfan
- Ikram M. Kamran
- Ipser Jonathan C.
- Jack Clifford R. Jr.
- Jahanshad Neda
- Janowitz Deborah
- Jia Tianye
- Jian Xueqiu
- Johnson Andrew D.
- Jones Hannah J.
- Jonsson Erik G.
- Kahn Rene S.
- Kanai Ryota
- Kasperaviciute Dalia
- Kim Sungeun
- Klein Marieke
- Kloszewska Iwona
- Knol Maria J.
- Koen Nastassja
- Koh Jia Yu
- Kraemer Bernd
- Kwok John B. J.
- Launer Lenore J.
- Lawrie Stephen M.
- Le Hellard Stephanie
- Lee Phil H.
- Lee Tom
- Lemaitre Herve
- Li Shuo
- Liewald David C. M.
- Lin Honghuang
- Loeffler Markus
- Longstreth William T. Jr.
- Loohuis Loes M. Olde
- Lopez Oscar L.
- Lovestone Simon
- Luciano Michelle
- Macare Christine
- Maillard Pauline
- Marquand Andre F.
- Martin Nicholas G.
- Martinot Jean-Luc
- Masouleh Shahrzad Kharabian
- Matarin Mar
- Mather Karen A.
- Mattay Venkata S.
- Mattheisen Manuel
- Mazoyer Bernard
- McIntosh Andrew M.
- McMahon Katie L.
- Mecocci Patrizia
- Medland Sarah E.
- Melle Ingrid
- Meyer-Lindenberg Andreas
- Milaneschi Yuri
- Mirza-Schreiber Nazanin
- Mohnke Sebastian
- Montgomery Grant W.
- Mosley Thomas H.
- Muehleisen Thomas W.
- Mueller-Myhsok Bertram
- Nauck Matthias
- Nhat Trung Doan
- Nho Kwangsik
- Niessen Wiro J.
- Noethen Markus M.
- Nyberg Lars
- Nyquist Paul A.
- Oosterlaan Jaap
- Ophoff Roel A.
- Pandolfo Massimo
- Papmeyer Martina
- Paus Tomas
- Pausova Zdenka
- Penninx Brenda W. J. H.
- Pike G. Bruce
- Pol Hilleke E. Hulshoff
- Potkin Steven G.
- Psaty Bruce M.
- Puetz Benno
- Rentera Miguel E.
- Reppermund Simone
- Richards Jennifer S.
- Rietschel Marcella
- Risacher Shannon L.
- Roffman Joshua L.
- Roiz-Santianez Roberto
- Romanczuk-Seiferth Nina
- Rommelse Nanda
- Roshchupkin Gennady
- Rotter Jerome
- Saba Yasaman
- Sachdev Perminder S.
- Saemann Philipp G.
- Saremi Arvin
- Sargurupremraj Muralidharan
- Satizabal Claudia L.
- Saykin Andrew J.
- Schmaal Lianne
- Schmidt Helena
- Schmidt Reinhold
- Schofield Peter R.
- Scholz Markus
- Schork Andrew J.
- Schroeter Matthias L.
- Schumann Gunter
- Seshadri Sudha
- Shen Li
- Shin Jean
- Shulman Joshua M.
- Shumskaya Elena
- Simmons Andrew
- Singh Baljeet
- Sisodiya Sanjay M.
- Smith Albert
- Smith George Davey
- Smoller Jordan W.
- Soininen Hilkka
- Steen Vidar M.
- Stein Dan J.
- Stein Jason L.
- Stevens Allison
- Strike Lachlan T.
- Sussmann Jessika E.
- Teumer Alexander
- Thalamuthu Anbupalam
- Thompson Paul M.
- Toga Arthur W.
- Tordesillas-Gutierrez Diana
- Toro Roberto
- Tsolaki Magda
- Turner Jessica A.
- Tzourio Christophe
- Uitterlinden Andre G.
- van Bokhoven Hans
- van der Lee Sven J.
- van der Meer Dennis
- van der Wee Nic J. A.
- van Donkelaar Marjolein M. J.
- van Duijn Cornelia M.
- van Eijk Kristel R.
- van Erp Theo G. M.
- van Haren Neeltje E. M.
- van Rooij Daan
- van Tol Marie-Jose
- van't Ent Dennis
- Vellas Bruno
- Veltman Dick J.
- Vernooij Meike W.
- Villringer Arno
- Vinke Louis N.
- Voelzke Henry
- Walter Henrik
- Walton Esther
- Wardlaw Joanna M.
- Wassink Thomas H.
- Weinberger Daniel R.
- Weiner Michael W.
- Wen Wei
- Westlye Lars T.
- Westman Eric
- Whelan Christopher D.
- White Charles C.
- White Tonya
- Witte A. Veronica
- Wittfeld Katharina
- Wolf Christiane
- Wolfers Thomas
- Wong Tien Yin
- Wright Margaret J.
- Yanek Lisa R.
- Yang Jingyun
- Yang Qiong
- Zwiers Marcel P.
- Publication venue
- Ludwig-Maximilians-UniversitĂ€t MĂŒnchen
- Publication date
- 01/01/2019
- Field of study
Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease
Genetic architecture of subcortical brain structures in 38,851 individuals
- Author
- Abramovic Lucija
- Adams Hieab H. H.
- Agartz Ingrid
- Alhusaini Saud
- Ames David
- Amin Najaf
- Amouyel Philippe
- Andersson Micael
- Andreassen Ole A.
- Arfanakis Konstantinos
- Arias-Vasquez Alejandro
- Aribisala Benjamin S.
- Armstrong Nicola J.
- Assareh Amelia A.
- Athanasiu Lavinia
- Axelsson Tomas
- Bastin Mark E.
- Becker Diane M.
- Becker James T.
- Beiser Alexa S.
- Bennett David A.
- Bernard Manon
- Bis Joshua C.
- Bohlken Marc M.
- Boks Marco P.
- Boomsma Dorret I.
- Bralten Janita
- Brodaty Henry
- Brouwer Rachel M.
- Brunner Han G.
- Buckner Randy L.
- Buitelaar Jan K.
- Bulayeva Kazima B.
- Burkhardt Ralph
- Cahn Wiepke
- Calhoun Vince D.
- Carmichael Owen
- Cavalleri Gianpiero L.
- Chakravarty M. Mallar
- Chauhan Ganesh
- Chen Christopher
- Chen Qiang
- Cheng Ching-Yu
- Cheung Joshua W.
- Ching Christopher R. K.
- Cichon Sven
- Crespo-Facorro Benedicto
- Crivello Fabrice
- Cuellar-Partida Gabriel
- Dale Anders M.
- Davey Smith George
- Davies Gareth E.
- de Geus Eco J. C.
- De Jager Philip L.
- De Zubicaray Greig I.
- Deary Ian J.
- Debette Stéphanie
- Decarli Charles
- Delanty Norman
- Den Braber Anouk
- Depondt Chantal
- DesriviĂšres Sylvane
- Destefano Anita L.
- Djurovic Srdjan
- Doan Nhat Trung
- Ehrlich Stefan
- Eicher John D.
- Erk Susanne
- Espeseth Thomas
- Fedko Iryna O.
- Fernåndez Guillén
- Filippi Irina
- Fisher Simon E.
- Fleischman Debra A.
- Fletcher Evan
- Fornage Myriam
- Foroud Tatiana M.
- Francks Clyde
- Franke Barbara
- Giddaluru Sudheer
- Goldman Aaron L.
- Gollub Randy L.
- Grabe Hans J.
- Green Robert C
- Greve Douglas N.
- Grimm Oliver
- Groenewold Nynke A.
- Gruber Oliver
- Guadalupe Tulio
- Gudnason Vilmundur
- Hagenaars Saskia P.
- Hansell Narelle K.
- Harris Tamara B.
- Hartman Catharina A.
- Haukvik Unn K.
- Hegenscheid Katrin
- Heinz Andreas
- Heslenfeld Dirk J.
- Hibar Derrek P.
- Hilal Saima
- Himali Jayandra J.
- Ho Beng-Choon
- Hoehn David
- Hoekstra Pieter J.
- Hofer Edith
- Hoffmann Wolfgang
- Hofman Albert
- Holmes Avram J.
- Holsboer Florian
- Homuth Georg
- Hoogman Martine
- Hosten Norbert
- Hottenga Jouke-Jan
- Hu Yanhui
- Huentelman Matthew
- Hulshoff Pol Hilleke E.
- HĂ„berg Asta K.
- Ikram M. Arfan
- Ikram M. Kamran
- Ipser Jonathan C.
- Jack Clifford R.
- Jahanshad Neda
- Janowitz Deborah
- Jia Tianye
- Jian Xueqiu
- Johnson Andrew D.
- Jones Hannah J.
- Jönsson Erik G.
- Kahn René S.
- Kanai Ryota
- Kasperaviciute Dalia
- Kharabian Masouleh Shahrzad
- Kim Sungeun
- Klein Marieke
- Kloszewska Iwona
- Knol Maria J.
- Koen Nastassja
- Koh Jia Yu
- Kraemer Bernd
- Kwok John B. J.
- Launer Lenore J.
- Lawrie Stephen M.
- Le Hellard Stephanie
- Lee Phil H.
- Lee Tom V.
- Lemaßtre Hervé
- Li Shuo
- Liewald David C. M.
- Lin Honghuang
- Loeffler Markus
- Longstreth William T.
- Lopez Oscar L.
- Lovestone Simon
- Luciano Michelle
- Macare Christine
- Maillard Pauline
- Marquand Andre F.
- Martin Nicholas G.
- Martinot Jean-Luc
- Matarin Mar
- Mather Karen A.
- Mattay Venkata S.
- Mattheisen Manuel
- Mazoyer Bernard
- McIntosh Andrew M.
- McMahon Katie L.
- Mecocci Patrizia
- Medland Sarah E.
- Melle Ingrid
- Meyer-Lindenberg Andreas
- Milaneschi Yuri
- Mirza-Schreiber Nazanin
- Mohnke Sebastian
- Montgomery Grant W.
- Mosley Thomas H.
- MĂŒhleisen Thomas W.
- MĂŒller-Myhsok Bertram
- Nauck Matthias
- Nho Kwangsik
- Niessen Wiro J.
- Nyberg Lars
- Nyquist Paul A.
- Nöthen Markus M.
- Olde Loohuis Loes M.
- Oosterlaan Jaap
- Ophoff Roel A.
- Pandolfo Massimo
- Papmeyer Martina
- Paus Tomas
- Pausova Zdenka
- Penninx Brenda W. J. H.
- Pike G. Bruce
- Potkin Steven G.
- Psaty Bruce M.
- PĂŒtz Benno
- RenterĂa Miguel E.
- Reppermund Simone
- Richards Jennifer S.
- Rietschel Marcella
- Risacher Shannon L.
- Roffman Joshua L.
- Roiz-Santiañez Roberto
- Romanczuk-Seiferth Nina
- Rommelse Nanda
- Roshchupkin Gennady V.
- Rotter Jerome I.
- Saba Yasaman
- Sachdev Perminder S.
- Saremi Arvin
- Sargurupremraj Muralidharan
- Satizabal Claudia L.
- Saykin Andrew J.
- Schmaal Lianne
- Schmidt Helena
- Schmidt Reinhold
- Schofield Peter R.
- Scholz Markus
- Schork Andrew J.
- Schroeter Matthias L.
- Schumann Gunter
- Seshadri Sudha
- Shen Li
- Shin Jean
- Shulman Joshua M.
- Shumskaya Elena
- Simmons Andrew
- Singh Baljeet
- Sisodiya Sanjay M.
- Smith Albert V.
- Smoller Jordan W.
- Soininen Hilkka
- Steen Vidar M.
- Stein Dan J.
- Stein Jason L.
- Stevens Allison
- Strike Lachlan T.
- Sussmann Jessika E.
- SĂ€mann Philipp G.
- Teumer Alexander
- Thalamuthu Anbupalam
- Thompson Paul M.
- Toga Arthur W.
- Tordesillas-Gutierrez Diana
- Toro Roberto
- Tsolaki Magda
- Turner Jessica A.
- Tzourio Christophe
- Uitterlinden André G.
- Valdés Hernåndez Maria C.
- Van Bokhoven Hans
- Van Der Lee Sven J.
- van der Meer Dennis
- Van Der Wee Nic J. A.
- Van Donkelaar Marjolein M. J.
- Van Duijn Cornelia M.
- Van Eijk Kristel R.
- Van Erp Theo G. M.
- Van Haren Neeltje E. M.
- Van Rooij Daan
- Van Tol Marie-Jose
- van ât Ent Dennis
- Vellas Bruno
- Veltman Dick J.
- Vernooij Meike W.
- Villringer Arno
- Vinke Louis N.
- Völzke Henry
- Walter Henrik
- Walton Esther
- Wardlaw Joanna M.
- Wassink Thomas H.
- Weinberger Daniel R.
- Weiner Michael W.
- Wen Wei
- Westlye Lars T.
- Westman Eric
- Whelan Christopher D.
- White Charles C.
- White Tonya
- Witte A. Veronica
- Wittfeld Katharina
- Wolf Christiane
- Wolfers Thomas
- Wong Tien Yin
- Wright Margaret J.
- Yanek Lisa R.
- Yang Jingyun
- Yang Qiong
- Zwiers Marcel P.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease
HE-LHC: The High-Energy Large Hadron Collider â Future Circular Collider Conceptual Design Report Volume 4
- Author
- Abada A.
- Abbrescia M.
- AbdusSalam S. S.
- Abdyukhanov I.
- Abelleira Fernandez J.
- Abramov A.
- Aburaia M.
- Acar A. O.
- Adzic P. R.
- Agrawal P.
- Aguilar-Saavedra J. A.
- Aguilera-Verdugo J. J.
- Ahnen J. von
- Aiba M.
- Aichinger I.
- Aielli G.
- Akay A.
- Akhundov A.
- Aksakal H.
- Albacete J. L.
- Albergo S.
- Alekou A.
- Aleksa M.
- Aleksan R.
- Alemany Fernandez R. M.
- Alexahin Y.
- Alioli S.
- Alipour Tehrani N.
- Allanach B. C.
- Allport P. P.
- Altınlı M.
- Altmannshofer W.
- AlĂa R. G.
- Ambrosio G.
- Amorim D.
- Amstutz O.
- Anderlini L.
- Andreazza A.
- Andreini M.
- Andriatis A.
- Andris C.
- Andronic A.
- Angelucci M.
- Antinori F.
- Antipov S. A.
- Antonelli M.
- Antonello M.
- Antonioli P.
- Antusch S.
- Anulli F.
- ApolinĂĄrio L.
- Apollinari G.
- Apollonio A.
- Appelö D.
- Appleby R. B.
- Apyan A.
- Apyan A.
- Arbey A.
- Arbuzov A.
- Arduini G.
- Arı V.
- Arias S.
- Armesto N.
- Arnaldi R.
- Arsenyev S. A.
- Arzeo M.
- Asai S.
- Aslanides E.
- Astapovych D.
- Atanasov M.
- Atieh S.
- Attié D.
- Auchmann B.
- Audurier A.
- Aull S.
- Aumon S.
- Aune S.
- Avino F.
- Avrillaud G.
- Aydın G.
- Azatov A.
- Azuelos G.
- Azzi P.
- Azzolini O.
- Azzurri P.
- AĂmann R. W.
- Bacchetta N.
- Bacchiocchi E.
- Bachacou H.
- Baek Y. W.
- Baglin V.
- Bai Y.
- Baird S.
- Baker M. J.
- Baldwin M. J.
- Ball A. H.
- Ballarino A.
- Banerjee S.
- Barber D. P.
- Barducci D.
- Barjhoux P.
- Barna D.
- Barnaföldi G. G.
- Barnes M. J.
- Barr A.
- Barranco GarcĂa J.
- Barreiro GuimarĂŁes da Costa J.
- Bartmann W.
- Baryshevsky V.
- Barzi E.
- Bass S. A.
- Bastianin A.
- Baudouy B.
- Bauer F.
- Bauer M.
- Baumgartner T.
- Bautista-GuzmĂĄn I.
- Bayındır C.
- Beaudette F.
- Bedeschi F.
- Bellafont I.
- Bellagamba L.
- Bellegarde N.
- Belli E.
- Bellingeri E.
- Bellini F.
- Bellomo G.
- Belomestnykh S.
- Bencivenni G.
- Benedikt M.
- Bernardi G.
- Bernardi J.
- Bernet C.
- Bernhardt J. M.
- Bernini C.
- Berriaud C.
- Bertarelli A.
- Bertolucci S.
- Besana M. I.
- Besançon M.
- Beznosov O.
- Bhat C.
- Bhat P.
- Biagini M. E.
- Biarrotte J.-L.
- Bibet Chevalier A.
- Bielert E. R.
- Biglietti M.
- Bilei G. M.
- Bilki B.
- Biscari C.
- Bishara F.
- Blanco-GarcĂa O. R.
- Blas J. de
- Blekman F.
- Blondel A.
- BlĂĄnquez F. R.
- BlĂŒmlein J.
- Boccali T.
- Boels R.
- Bogacz S. A.
- Bogomyagkov A.
- Boine-Frankenheim O.
- Boland M. J.
- Bologna S.
- Bolukbasi O.
- Bomben M.
- Bondarenko S.
- Bonvini M.
- Boos E.
- Bordini B.
- Bordry F.
- Borghello G.
- Borgonovi L.
- Borowka S.
- Bortoletto D.
- Boscherini D.
- Boscolo M.
- Boselli S.
- Bosley R. R.
- Bossu F.
- Botta C.
- Bottura L.
- Boughezal R.
- Boutin D.
- Bovone G.
- Bozbey A.
- Bozzi C.
- Bozzini D.
- BoĆŸoviÄ JelisaviÄ I.
- Braccini V.
- Braibant-Giacomelli S.
- Bramante J.
- Braun-Munzinger P.
- Briffa J. A.
- Britzger D.
- Brodsky S. J.
- Brooke J. J.
- Bruce R.
- Bruna E.
- Brunner K.
- Brunner O.
- Bruzzone P.
- BrĂŒckman De Renstrom P.
- BrĂŒning O.
- Buffat X.
- Bulyak E.
- Burkart F.
- Burkhardt H.
- Burnet J.-P.
- Butin F.
- Buttazzo D.
- Butterworth A.
- BĂ©guin M.
- Caccia M.
- Cai Y.
- Caiffi B.
- Cairo V.
- Cakir O.
- Calaga R.
- Calatroni S.
- Calderini G.
- Calderola G.
- Caliskan A.
- Calvet D.
- Calviani M.
- Camalich J. M.
- Camarri P.
- Campanelli M.
- Camporesi T.
- Canbay A. C.
- Canepa A.
- Cantergiani E.
- Cantore-Cavalli D.
- Capeans M.
- Cardarelli R.
- Cardella U.
- Cardini A.
- Carloni Calame C. M.
- Carra F.
- Carra S.
- Carvalho A.
- Casalbuoni S.
- Casas J.
- Cascella M.
- Castelnovo P.
- Castorina G.
- Catalano G.
- Cavasinni V.
- Cazzato E.
- Cennini E.
- Cerri A.
- Cerutti F.
- Cervantes J.
- Chaikovska I.
- Chakrabortty J.
- Chala M.
- Chamizo-Llatas M.
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- Zupan J.
- Zurita J.
- Ăzcan V.
- Ăzdemir K.
- Publication venue
- Springer Verlag
- Publication date
- 09/02/2021
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre-of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries
FCC-ee: The Lepton Collider â Future Circular Collider Conceptual Design Report Volume 2
- Author
- Abada A.
- Abbrescia M.
- AbdusSalam S. S.
- Abdyukhanov I.
- Abelleira Fernandez J.
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- Vysotsky V.
- Völkl V.
- Wagner U.
- Wallny R.
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- Wang L. -T.
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- Ward B. F. L.
- Watson N. K.
- Watson T. P.
- Weiland C.
- Weinzierl S.
- Welsch C. P.
- Wenninger J.
- Widorski M.
- Wiedemann U. A.
- Wienands H. -U.
- Wilkinson G.
- Williams P. H.
- Winter A.
- Wohlfahrt A.
- WojtoĆ T.
- Wollmann D.
- Womersley J.
- Woog D.
- Ws Z.
- Wu X.
- Wulzer A.
- Yanehsari M. K.
- Yang G.
- Yang H. J.
- Yao W. -M.
- Yazgan E.
- Yermolchik V.
- Yilmaz A.
- Yilmaz A.
- Yoo H. -D.
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- Yu F.
- Yu T. -T.
- Zaborowska A.
- Zadeh S. G.
- Zahnd M.
- Zanetti M.
- Zanotto L.
- Zawiejski L.
- Zeiler P.
- Zerlauth M.
- Zernov S. M.
- Zevi Dell Porta G.
- Zhang C.
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- Zhang Y.
- Zhang Z.
- Zhao Z.
- Zhong Y. -M.
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- Zupan J.
- Zurita J.
- Ăzcan V.
- Ăzdemir K.
- Publication venue
- Springer Verlag
- Publication date
- 14/11/2019
- Field of study
The genetic architecture of the human cerebral cortex
- Author
- Adams Hieab H. H.
- Agartz Ingrid
- Alhusaini Saud
- Almeida Marcio A. A.
- Alnaes Dag
- Alvim Marina K. M.
- Ames David
- Amlien Inge K.
- Anderson Tim J.
- Andersson Micael
- Andreassen Ole A.
- Ard Tyler
- Arias-Vasquez Alejandro
- Armstrong Nicola J.
- Artiges Eric
- Ashley-Koch Allison
- Assareh Amelia A.
- Atkins Joshua R.
- Ayesa-Arriola Rosa
- Bastin Mark E.
- Baune Bernhard T.
- Beckham Jean C.
- Belger Aysenil
- Bernard Manon
- Bis Joshua C.
- Blangero John
- Boomsma Dorret I.
- Bralten Janita
- Brandt Christine L.
- Brodaty Henry
- Brouwer Rachel M.
- Brown Gregory G.
- Brunner Han G.
- Buckner Randy L.
- Buimer Elizabeth E. L.
- Buitelaar Jan K.
- Bulow Robin
- Burger Christian
- Bustillo Juan R.
- Cahn Wiepke
- Cairns Murray J.
- Calhoun Vince
- Cannon Dara M.
- Carr Vaughan J.
- Caseras Xavier
- Caspers Svenja
- Cavalleri Gianpiero L.
- Cendes Fernando
- Chakravarty Mallar
- Chen Qiang
- Cheung Joshua W.
- Ching Christopher R. K.
- Cichon Sven
- Colodro-Conde Lucia
- Corvin Aiden
- Couvy-Duchesne Baptiste
- Crespo-Facorro Benedicto
- Curran Joanne E.
- Dale Anders M.
- Dalrymple-Alford John C.
- Dalvie Shareefa
- Dannlowski Udo
- Davies Gareth E.
- de Araujo Tania K.
- de Geus Eco J. C.
- de Zubicaray Greig I.
- de Zwarte Sonja M. C.
- Deary Ian J.
- Debette Stephanie
- Decarli Charles
- Degenhardt Franziska
- Delanty Norman
- den Braber Anouk
- Dennis Michelle F.
- Depondt Chantal
- Desrivieres Sylvane
- Dietsche Bruno
- Djurovic Srdjan
- Doherty Colin P.
- Dohm Katharina
- Donohoe Gary
- Ehrlich Stefan
- Engelbrecht Hannah-Ruth
- Erk Susanne
- Espeseth Thomas
- Espiritu Ryan
- Fan Chun Chieh
- Fedko Iryna O.
- Fernandez Guillen
- Fisher Simon E.
- Flor Herta
- Foley Sonya F.
- Ford Judith M.
- Fornage Myriam
- Forstner Andreas J.
- Francks Clyde
- Franke Barbara
- Fukunaga Masaki
- Garijo Daniel
- Garrett Melanie E.
- Ge Tian
- Giddaluru Sudheer
- Gil Yolanda
- Glahn David C.
- Goldman Aaron L.
- Gollub Randy L.
- Gowland Penny A.
- Grabe Hans J.
- Grasby Katrina L.
- Green Melissa J.
- Green Robert C.
- Groenewold Nynke A.
- Grotegerd Dominik
- Gruber Oliver
- Gudnason Vilmundur
- Gurholt Tiril P.
- Gutman Boris A.
- Haberg Asta K.
- Hansell Narelle K.
- Hariri Ahmad R.
- Harris Mathew A.
- Harrison Marc B.
- Hartman Catharina A.
- Hashimoto Ryota
- Haswell Courtney C.
- Hauser Michael
- Hausler Alexander N.
- Heindel Walter
- Heinz Andreas
- Henskens Frans A.
- Herms Stefan
- Heslenfeld Dirk J.
- Hibar Derrek P.
- Hillegers Manon H. J.
- Ho Beng-Choon
- Ho New Fei
- Hoehn David
- Hoekstra Pieter J.
- Hofer Edith
- Hoffmann Per
- Hoffmann Wolfgang U.
- Holleran Laurena
- Holmes Avram J.
- Holsboer Florian
- Homuth Georg
- Hong L. Elliot
- Hoogman Martine
- Hopkins William D.
- Hosten Norbert
- Hottenga Jouke-Jan
- Ikeda Masashi
- Ikram M. Arfan
- Jack Clifford R.
- Jahanshad Neda
- Jang MiHyun
- Janowitz Deborah
- Jansen Andreas
- Jansen Iris E.
- Jernigan Terry L.
- Jia Tianye
- Jockwitz Christiane
- Jonsson Erik G.
- Kahn Rene S.
- Kanai Ryota
- Karama Sherif
- Kasperaviciute Dalia
- Kaufmann Tobias
- Kelly Sinead
- Kennedy Martin A.
- Kikuchi Masataka
- Kimbrel Nathan A.
- Kircher Tilo T. J.
- Klein Marieke
- Knapp Michael
- Knodt Annchen R.
- Kochunov Peter
- Kolskar Knut
- Koops Sanne
- Kramer Bernd
- Krug Axel
- Kwok John B. J.
- Lam Max
- Lancaster Thomas M.
- Launer Lenore
- Le Hellard Stephanie
- Lee Phil H.
- Lett Tristram A.
- Lewis Lindsay B.
- Lim Kelvin O.
- Lind Penelope A.
- Longstreth W. T.
- Loohuis Loes M. Olde
- Lopes-Cendes Iscia
- Lopez Oscar L.
- Loughland Carmel M.
- Luciano Michelle
- Luykx Jurjen J.
- Macciardi Fabio
- Marquand Andre F.
- Martin Nicholas G.
- Martinot Jean-Luc
- Martinot Marie-Laure Paillere
- Mathalon Daniel H.
- Mather Karen A.
- Mathias Samuel R.
- Mattay Venkata S.
- Matthews Sarah
- Mazoyer Bernard
- McDonald Colm
- McEwen Sarah C.
- McMahon Katie L.
- McMahon Mary Agnes B.
- Medland Sarah E.
- Melle Ingrid
- Melzer Tracy R.
- Meyer-Lindenberg Andreas
- Michie Patricia T.
- Milaneschi Yuri
- Mirza-Schreiber Nazanin
- Moreira Jose C. V.
- Morey Rajendra A.
- Morris Derek W.
- Mosley Thomas H.
- Mota Nina R.
- Mowry Bryan
- Mueller Bryon A.
- Mueller-Myhsok Bertram
- Muhleisen Thomas W.
- Najt Pablo
- Nakahara Soichiro
- Nauck Matthias
- Nhat Trung Doan
- Nho Kwangsik
- Noethen Markus M.
- Nordvik Jan E.
- Nyberg Lars
- O'Leary Daniel S.
- Oosterlaan Jaap
- Opel Nils
- Ophoff Roel A.
- Orfanos Dimitri Papadopoulos
- Painter Jodie N.
- Pantelis Christos
- Paus Tomas
- Pausova Zdenka
- Pearson John F.
- Penninx Brenda W. J. H.
- Pike G. Bruce
- Pitcher Toni L.
- Pizzagalli Fabrizio
- Pol Hilleke E. Hulshoff
- Polderman Tinca J. C.
- Posthuma Danielle
- Preda Adrian
- Putz Benno
- Quide Yann
- Quinlan Erin B.
- Ragothaman Anjanibhargavi
- Rashid Faisal M.
- Rasser Paul E.
- Ratnakar Varun
- Reay William R.
- Redlich Ronny
- Reinbold Celine S.
- Reppermund Simone
- Repple Jonathan
- Richard Genevieve
- Riedel Brandalyn C.
- Rietschel Marcella
- Risacher Shannon L.
- Rocha Cristiane S.
- Roffman Joshua L.
- Roshchupkin Gennady V.
- Rowland Laura M.
- Sachdev Perminder S.
- Salminen Lauren
- Samann Philipp G.
- Saremi Arvin
- Satizabal Claudia L.
- Saykin Andrew J.
- Schall Ulrich
- Schlag Fenja
- Schmaal Lianne
- Schmidt Reinhold
- Schofield Peter R.
- Schumann Gunter
- Scott Rodney J.
- Secolin Rodrigo
- Seshadri Sudha
- Shapland Chin Yang
- Shatokhina Natalia
- Shen Li
- Shin Jean
- Shumskaya Elena
- Sim Kang
- Sisodiya Sanjay M.
- Smoller Jordan W.
- Sommer Iris E.
- Sonderby Ida E.
- Sprooten Emma
- St Pourcain Beate
- Steen Vidar M.
- Stein Dan J.
- Stein Jason L.
- Strike Lachlan T.
- Tansey Katherine E.
- Teumer Alexander
- Thalamuthu Anbupalam
- Thomopoulos Sophia I.
- Thompson Paul M.
- Toga Arthur W.
- Tooney Paul A.
- Tordesillas-Gutierrez Diana
- Torres Fabio R.
- Trollor Julian N.
- Turner Jessica A.
- Uhlmann Anne
- Vallerga Costanza L.
- van der Meer Dennis
- Van der Wee Nic J. A.
- van Donkelaar Marjolein M. J.
- van Eijk Liza
- van Erp Theo G. M.
- van Haren Neeltje E. M.
- van Rooij Daan
- Van Son Jaqueline Mayoral
- van Tol Marie-Jose
- van't Ent Dennis
- Veldink Jan H.
- Veltman Dick J.
- Verhoef Ellen
- Volzke Henry
- Voyvodic James T.
- Walter Henrik
- Walton Esther
- Wang Mingyuan
- Wang Yunpeng
- Wardlaw Joanna M.
- Weber Bernd
- Weinberger Daniel R.
- Wen Wei
- Westlye Lars T.
- Whelan Christopher D.
- Whelan Robert
- White Tonya
- Witt Stephanie H.
- Wittfeld Katharina
- Wolf Christiane
- Wolfers Thomas
- Wright Margaret J.
- Wu Jing Qin
- Yamamori Hidenaga
- Yang Qiong
- Yasuda Clarissa L.
- Zaremba Dario
- Zhang Zuo
- Zhou Juan
- Zhu Alyssa H.
- Zsembik Leo C. P.
- Zwiers Marcel P.
- Publication venue
- Ludwig-Maximilians-UniversitĂ€t MĂŒnchen
- Publication date
- 01/01/2020
- Field of study
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder
FCC-ee: The Lepton Collider: Future Circular Collider Conceptual Design Report Volume 2
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agaliotis EL
- Agrawal P
- Aguilar-Saavedra JA
- Aguilera-Verdugo JJ
- Aiba M
- Aichinger I
- Aielli G
- Akay A
- Akhundov A
- Aksakal H
- Alaniz EC
- Albacete JL
- Albergo S
- Alekou A
- Aleksa M
- Aleksan R
- Alexahin Y
- Alia RG
- Alioli S
- Allanach BC
- Allport PP
- Altinli M
- Altmannshofer W
- Ambrosio G
- Amorim D
- Amstutz O
- Anderlini L
- Andreazza A
- Andreini M
- Andriatis A
- Andris C
- Andronic A
- Angelucci M
- Antinori F
- Antipov SA
- Antonelli M
- Antonello M
- Antonioli P
- Antusch S
- Anulli F
- Apolinario L
- Apollinari G
- Apollonio A
- Appelo D
- Appleby RB
- Apyan A
- Apyan A
- Arbey A
- Arbuzov A
- Arduini G
- Ari V
- Arias S
- Armesto N
- Arnaldi R
- Arsenyev SA
- Arzeo M
- Asai S
- Aslanides E
- Assmann RW
- Astapovych D
- Atanasov M
- Atieh S
- Attie D
- Auchmann B
- Audurier A
- Aull S
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- Viehhauser G
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- Woog D
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- Wulzer A
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- Yanehsari MK
- Yang G
- Yang HJ
- Yao W-M
- Yazgan E
- Yermolchik V
- Yildiz HD
- Yilmaz A
- Yilmaz A
- Yoo H-D
- Yost SA
- You T
- Young C
- Yu F
- Yu T-T
- Zaborowska A
- Zadeh SG
- Zadeh SG
- Zahnd M
- Zanetti M
- Zanotto L
- Zawiejski L
- Zeiler P
- Zerlauth M
- Zernov SM
- Zhang C
- Zhang H
- Zhang Y
- Zhang Z
- Zhao Z
- Zhong Y-M
- Zhou D
- Zhou J
- Zhuang P
- Zick G
- Zimmermann F
- Zinn-Justin J
- Zivkovic L
- Zlobin AV
- Zobov M
- Zupan J
- Zurita J
- Publication venue
- SPRINGER HEIDELBERG
- Publication date
- 01/06/2019
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics, the Future Circular Collider (FCC) study was launched, as an international collaboration hosted by CERN. This study covers a highest-luminosity high-energy lepton collider (FCC-ee) and an energy-frontier hadron collider (FCC-hh), which could, successively, be installed in the same 100 km tunnel. The scientific capabilities of the integrated FCC programme would serve the worldwide community throughout the 21st century. The FCC study also investigates an LHC energy upgrade, using FCC-hh technology. This document constitutes the second volume of the FCC Conceptual Design Report, devoted to the electron-positron collider FCC-ee. After summarizing the physics discovery opportunities, it presents the accelerator design, performance reach, a staged operation scenario, the underlying technologies, civil engineering, technical infrastructure, and an implementation plan. FCC-ee can be built with todayâs technology. Most of the FCC-ee infrastructure could be reused for FCC-hh. Combining concepts from past and present lepton colliders and adding a few novel elements, the FCC-ee design promises outstandingly high luminosity. This will make the FCC-ee a unique precision instrument to study the heaviest known particles (Z, W and H bosons and the top quark), offering great direct and indirect sensitivity to new physics
HE-LHC: The High-Energy Large Hadron Collider: Future Circular Collider Conceptual Design Report Volume 4
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abelleira Fernandez J
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agrawal P
- Aguilar-Saavedra JA
- Aguilera-Verdugo JJ
- Aiba M
- Aichinger I
- Aielli G
- Akay A
- Akhundov A
- Aksakal H
- Albacete JL
- Albergo S
- Alekou A
- Aleksa M
- Aleksan R
- Alemany Fernandez RM
- Alexahin Y
- Alia RG
- Alioli S
- Alipour Tehrani N
- Allanach BC
- Allport PP
- Altinli M
- Altmannshofer W
- Ambrosio G
- Amorim D
- Amstutz O
- Anderlini L
- Andreazza A
- Andreini M
- Andriatis A
- Andris C
- Andronic A
- Angelucci M
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- Antipov SA
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- Antusch S
- Anulli F
- Apolinario L
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- Apollonio A
- Appeloe D
- Appleby RB
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- Aslanides E
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- Attie D
- Auchmann B
- Audurier A
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- Baek YW
- Baglin V
- Bai Y
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- Bellini F
- Bellomo G
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- Fiorendi S
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- Thomas S
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- Zlobin AV
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- Zurita J
- Publication venue
- SPRINGER HEIDELBERG
- Publication date
- 01/07/2019
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre-of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries
FCC Physics Opportunities: Future Circular Collider Conceptual Design Report Volume 1
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agrawal P
- Aguilar-Saavedra JA
- Aguilera-Verdugo JJ
- Ahnen JV
- Aiba M
- Aichinger I
- Aielli G
- Akay A
- Akhundov A
- Aksakal H
- Alaniz EC
- Albacete JL
- Albergo S
- Alekou A
- Aleksa M
- Aleksan R
- Alexahin Y
- Alia RG
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- Allport PP
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- Altmannshofer W
- Amann RW
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- Andronic A
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- Yanehsari MK
- Yang G
- Yang HJ
- Yao W-M
- Yazgan E
- Yermolchik V
- Yildiz HD
- Yilmaz A
- Yilmaz A
- Yoo H-D
- Yost SA
- You T
- Young C
- Yu F
- Yu T-T
- Zaborowska A
- Zadeh SG
- Zadeh SG
- Zahnd M
- Zanetti M
- Zanotto L
- Zawiejski L
- Zeiler P
- Zerlauth M
- Zernov SM
- Zevi Dell Porta G
- Zhang C
- Zhang H
- Zhang Y
- Zhang Z
- Zhao Z
- Zhong Y-M
- Zhou D
- Zhou J
- Zhuang P
- Zick G
- Zimmermann F
- Zinn-Justin J
- Zivkovic L
- Zlobin AV
- Zobov M
- Zupan J
- Zurita J
- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 01/06/2019
- Field of study
We review the physics opportunities of the Future Circular Collider, covering its e+e-, pp, ep and heavy ion programmes. We describe the measurement capabilities of each FCC component, addressing the study of electroweak, Higgs and strong interactions, the top quark and flavour, as well as phenomena beyond the Standard Model. We highlight the synergy and complementarity of the different colliders, which will contribute to a uniquely coherent and ambitious research programme, providing an unmatchable combination of precision and sensitivity to new physics
FCC-hh: The Hadron Collider: Future Circular Collider Conceptual Design Report Volume 3
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abelleira Fernandez J
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agrawal P
- Aguilar-Saavedra JA
- Aguilera-Verdugo JJ
- Aiba M
- Aichinger I
- Aielli G
- Akay A
- Akhundov A
- Aksakal H
- Albacete JL
- Albergo S
- Alekou A
- Aleksa M
- Aleksan R
- Alemany Fernandez RM
- Alexahin Y
- Alia RG
- Alioli S
- Alipour Tehrani N
- Allanach BC
- Allport PP
- Altinli M
- Altmannshofer W
- Ambrosio G
- Amorim D
- Amstutz O
- Anderlini L
- Andreazza A
- Andreini M
- Andriatis A
- Andris C
- Andronic A
- Angelucci M
- Antinori F
- Antipov SA
- Antonelli M
- Antonello M
- Antonioli P
- Antusch S
- Anulli F
- Apolinario L
- Apollinari G
- Apollonio A
- Appeloe D
- Appleby RB
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- Arbuzov A
- Arduini G
- Ari V
- Arias S
- Armesto N
- Arnaldi R
- Arsenyev SA
- Arzeo M
- Asai S
- Aslanides E
- Assmann RW
- Astapovych D
- Atanasov M
- Atieh S
- Attie D
- Auchmann B
- Audurier A
- Aull S
- Aumon S
- Aune S
- Avino F
- Avrillaud G
- Aydin G
- Azatov A
- Azuelos G
- Azzi P
- Azzolini O
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- Bacchetta N
- Bacchiocchi E
- Bachacou H
- Baek YW
- Baglin V
- Bai Y
- Baird S
- Baker MJ
- Baldwin MJ
- Ball AH
- Ballarino A
- Banerjee S
- Barber DP
- Barducci D
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- Barnafoeldi GG
- Barnes MJ
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- Barranco Garcia J
- Barreiro Guimaraes da Costa J
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- Bastianin A
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- Baumgartner T
- Bautista-Guzman I
- Bayindir C
- Beaudette F
- Bedeschi F
- Beguin M
- Bellafont I
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- Belomestnykh S
- Bencivenni G
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- Bernhardt JM
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- Bertolucci S
- Besana MI
- Besancon M
- Beznosov O
- Bhat C
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- Bibet Chevalier A
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- Bilei GM
- Bilki B
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- Bishara F
- Blanco-Garcia OR
- Blanquez FR
- Blekman F
- Blondel A
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- Boland MJ
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- Boos E
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- Bosley RR
- Bossu F
- Botta C
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- Boughezal R
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- Bovone G
- Bozbey A
- Bozovic Jelisavic I
- Bozzi C
- Bozzini D
- Braccini V
- Braibant-Giacomelli S
- Bramante J
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- Britzger D
- Brodsky SJ
- Brooke JJ
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- Bruzzone P
- Buffat X
- Bulyak E
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- Cook CTA
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- Crivellin A
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- Cruz Alaniz E
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- De Renstrom P Brueckman
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- De Roeck A
- de Vivie de Regie JB
- Deandrea A
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- Dell'Acqua A
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- Denegri D
- Deniau L
- Denisov D
- Denizli H
- Denner A
- Derue F
- Deschamps O
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- Dev PSB
- Dewanjee RK
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- Di Micco B
- Di Nezza P
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- Dillon BM
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- Dominjon A
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- Drago A
- Draper P
- Drasal Z
- Drewes M
- du Pree T
- Duarte L
- Dubovyk I
- Duda P
- Dudarev A
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- Duenser M
- Duran Yildiz H
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- Dziewit B
- Eisenhardt S
- Eisterer M
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- El Khechen D
- Ellis J
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- Englert C
- Eriksson H
- Eskola KJ
- Esposito LS
- Etisken O
- Etzion E
- Fabbricatore P
- Falkowski A
- Falou A
- Faltova J
- Fan J
- Fano L
- Farilla A
- Farinelli R
- Farinon S
- Faroughy DA
- Fartoukh SD
- Faus-Golfe A
- Fawcett WJ
- Felici G
- Felsberger L
- Ferdeghini C
- Fernandez Navarro AM
- Fernandez-Tellez A
- Ferradas Troitino J
- Ferrara G
- Ferrari R
- Ferreira da Silva P
- Ferreira L
- Ferrera G
- Ferro F
- Fiascaris M
- Fiorendi S
- Fiorio C
- Fischer E
- Fischer O
- Flieger W
- Florio M
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- Forte S
- Fouaidy M
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- Fox J
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- Franceschini R
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- Furuseth SV
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- Honorato CG
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- Jamin DO
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- Jimenez JM
- Jones MA
- Jones OR
- Jowett JM
- Jung S
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- Kalinowski J
- Kamenik JF
- Kannike K
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- Karpov I
- Kartal S
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- Katharina Behr J
- Kaya U
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 18/12/2018
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries