Learning signals of adverse drug-drug interactions from the unstructured text of electronic health records.

Drug-drug interactions (DDI) account for 30% of all adverse drug reactions, which are the fourth leading cause of death in the US. Current methods for post marketing surveillance primarily use spontaneous reporting systems for learning DDI signals and validate their signals using the structured portions of Electronic Health Records (EHRs). We demonstrate a fast, annotation-based approach, which uses standard odds ratios for identifying signals of DDIs from the textual portion of EHRs directly and which, to our knowledge, is the first effort of its kind. We developed a gold standard of 1,120 DDIs spanning 14 adverse events and 1,164 drugs. Our evaluations on this gold standard using millions of clinical notes from the Stanford Hospital confirm that identifying DDI signals from clinical text is feasible (AUROC=81.5%). We conclude that the text in EHRs contain valuable information for learning DDI signals and has enormous utility in drug surveillance and clinical decision support

Uso de antihelmínticos en ovinos :I. Ensayo de 4 drogas en el control de parásitos gastrointestinales

Se ensayan 4 drogas comerciales en el control de parásitos gastrointestinales en 50 ovejas de 14 meses de edad, altamente infestadas por los géneros Haemonchus, Troichostrongylus, Strongyloides, Bunostonum y Oesophagastomun, y baja infestación de Nematodirus, Cooperia y Ostertagia. En efecto del Thiabenzadole duró 6 semanas contra los géneros Trichostrongylus, Cooperia, Chabertia y Ostertagia, 2 semanas contra Haemonchus, Strongyloides, Oesophagostomum y Bunostomum. El efecto general de la droga una semana después del tratamiento fué de 91.44 por ciento. El promintic fué efectivo por 6 semanas contra los géneros Trichostrongylus, Cooperia, Chabertia y Ostertagia, por 2 semanas contra Haemonchus, Strongyloides, Oesophagastomum y Bunostomum. El efecto general una semana después del tratamiento fué del 70.0 por ciento. El neguvón fué efectivo por 6 semanas contra Trichostrongylus y Oesophagostomum, por 2 semanas contra Bunostomum, por una semana contra Haemonchus y Strongyloides. El efecto general después de una semana de tratamiento fué del 80.3 por ciento. La fenotiazina mineralizada fué efectiva por 6 semanas contra Chabertia, por 3 semanas contra Bematodirus, por 2 semanas contra Cooperia, Oesphagastomum y Bunostomum. No mostró efectividad contra los géneros Haemonchus, Strongyloides y Trichostrongylus, y su efecto general comparativo una semana después del tratamiento fué negativo (menos 10.6 por ciento).Ovinos-Ganado ovino - Ovis arie

Informe clinicopatológico preliminar del ganado vacuno de los Llanos Orientales de Colombia.

Con el propósito de examinar el estado general de salud existente en el ganado del Vichada, en los Llanos Orientales de Colombia, se hizo este reconocimiento limitado. Se incluyen datos de hematología, serología, parasitología y bacteriología. Los valores hematológicos encontrados se consideran dentro de los límites normales. Los porcentajes de leucocitos encontrados son típicos de las especies bovinas, el volumen corpuscular medio, calculados los índices de eritrocidos, se encuentra dentro de los límites normales, los valores de la concentración de hemoglobina corpuscular media indican que cada eritrocito tiene aproximadamente un 3 por ciento más de hemoglobina que el promedio aceptado. Los datos serológicos indican una alta incidencia de anaplasmosis y relativamente altos niveles de brucelosis, se analizaron 511 muestras de 4 hatos. Se encontró que el número de animales afectados por brucelosis se acerca a un nivel del 20 por ciento, el que es considerado epidémico. Se encontró que los ectoparásitos y endoparásitos afectan la mayoría del ganado estudiado. Al gran número de garrapatas encontrado puede atribuírse en parte la alta incidencia de títulos de anaplasmosis. No fué posible demostrar hemoparásitos durante el examen superficial de extensiones de sangre. En relación con los estudios bacteriológicos, los contaminantes encontrados en los pocos exámenes realizados, son esencialmente los mismos que se encuentran en todas partes. Una discusión corta acompaña cada uno de los estudiosGanado de doble propósito-Ganaderia doble proposit

Search for squarks and gluinos in events with isolated leptons, jets and missing transverse momentum at s√=8 TeV with the ATLAS detector

The results of a search for supersymmetry in final states containing at least one isolated lepton (electron or muon), jets and large missing transverse momentum with the ATLAS detector at the Large Hadron Collider are reported. The search is based on proton-proton collision data at a centre-of-mass energy s√=8 TeV collected in 2012, corresponding to an integrated luminosity of 20 fb−1. No significant excess above the Standard Model expectation is observed. Limits are set on supersymmetric particle masses for various supersymmetric models. Depending on the model, the search excludes gluino masses up to 1.32 TeV and squark masses up to 840 GeV. Limits are also set on the parameters of a minimal universal extra dimension model, excluding a compactification radius of 1/R c = 950 GeV for a cut-off scale times radius (ΛR c) of approximately 30

Evidence for the Higgs-boson Yukawa coupling to tau leptons with the ATLAS detector

Results of a search for H → τ τ decays are presented, based on the full set of proton-proton collision data recorded by the ATLAS experiment at the LHC during 2011 and 2012. The data correspond to integrated luminosities of 4.5 fb−1 and 20.3 fb−1 at centre-of-mass energies of √s = 7 TeV and √s = 8 TeV respectively. All combinations of leptonic (τ → `νν¯ with ` = e, µ) and hadronic (τ → hadrons ν) tau decays are considered. An excess of events over the expected background from other Standard Model processes is found with an observed (expected) significance of 4.5 (3.4) standard deviations. This excess provides evidence for the direct coupling of the recently discovered Higgs boson to fermions. The measured signal strength, normalised to the Standard Model expectation, of µ = 1.43 +0.43 −0.37 is consistent with the predicted Yukawa coupling strength in the Standard Model

Measurement of the cross-section and charge asymmetry of WW bosons produced in proton-proton collisions at s=8\sqrt{s}=8 TeV with the ATLAS detector

This paper presents measurements of the $W^+ \rightarrow \mu^+\nu$ and $W^- \rightarrow \mu^-\nu$ cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables, submitted to EPJC. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13

Measurements of fiducial and differential cross sections for Higgs boson production in the diphoton decay channel at s√=8 TeV with ATLAS

Measurements of fiducial and differential cross sections are presented for Higgs boson production in proton-proton collisions at a centre-of-mass energy of s√=8 TeV. The analysis is performed in the H → γγ decay channel using 20.3 fb−1 of data recorded by the ATLAS experiment at the CERN Large Hadron Collider. The signal is extracted using a fit to the diphoton invariant mass spectrum assuming that the width of the resonance is much smaller than the experimental resolution. The signal yields are corrected for the effects of detector inefficiency and resolution. The pp → H → γγ fiducial cross section is measured to be 43.2 ±9.4(stat.) − 2.9 + 3.2 (syst.) ±1.2(lumi)fb for a Higgs boson of mass 125.4GeV decaying to two isolated photons that have transverse momentum greater than 35% and 25% of the diphoton invariant mass and each with absolute pseudorapidity less than 2.37. Four additional fiducial cross sections and two cross-section limits are presented in phase space regions that test the theoretical modelling of different Higgs boson production mechanisms, or are sensitive to physics beyond the Standard Model. Differential cross sections are also presented, as a function of variables related to the diphoton kinematics and the jet activity produced in the Higgs boson events. The observed spectra are statistically limited but broadly in line with the theoretical expectations

Measurement of the top pair production cross section in 8 TeV proton-proton collisions using kinematic information in the lepton plus jets final state with ATLAS

A measurement is presented of the $t\bar{t}$ inclusive production cross-section in $pp$ collisions at a center-of-mass energy of $\sqrt{s}=8$ TeV using data collected by the ATLAS detector at the CERN Large Hadron Collider. The measurement was performed in the lepton+jets final state using a data set corresponding to an integrated luminosity of 20.3 fb$^{-1}$. The cross-section was obtained using a likelihood discriminant fit and $b$-jet identification was used to improve the signal-to-background ratio. The inclusive $t\bar{t}$ production cross-section was measured to be $260\pm 1{\textrm{(stat.)}} ^{+22}_{-23} {\textrm{(syst.)}}\pm 8{\textrm{(lumi.)}}\pm 4{\mathrm{(beam)}}$ pb assuming a top-quark mass of 172.5 GeV, in good agreement with the theoretical prediction of $253^{+13}_{-15}$ pb. The $t\bar{t}\to (e,\mu)+{\mathrm{jets}}$ production cross-section in the fiducial region determined by the detector acceptance is also reported.Comment: Published version, 19 pages plus author list (35 pages total), 3 figures, 2 tables, all figures including auxiliary figures are available at http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/TOPQ-2013-06