Parallel Online Time Warping for Real-Time Audio-to-Score Alignment in Multi-core Systems

[EN] The Audio-to-Score framework consists of two separate stages: pre- processing and alignment. The alignment is commonly solved through offline Dynamic Time Warping (DTW), which is a method to find the path over the distortion matrix with the minimum cost to determine the relation between the performance and the musical score times. In this work we propose a par- allel online DTW solution based on a client-server architecture. The current version of the application has been implemented for multi-core architectures (x86, x64 and ARM), thus covering either powerful systems or mobile devices. An extensive experimentation has been conducted in order to validate the software. The experiments also show that our framework allows to achieve a good score alignment within the real-time window by using parallel computing techniques.This work has been partially supported by Spanish Ministry of Science and Innovation and FEDER under Projects TEC2012-38142-C04-01, TEC2012-38142-C04-03, TEC2012-38142-C04-04, TEC2015-67387-C4-1-R, TEC2015-67387-C4-3-R, TEC2015-67387-C4-4-R, the European Union FEDER (CAPAP-H5 network TIN2014-53522-REDT), and the Generalitat Valenciana under Grant PROMETEOII/2014/003.Alonso-Jordá, P.; Cortina, R.; Rodríguez-Serrano, F.; Vera-Candeas, P.; Alonso-González, M.; Ranilla, J. (2017). Parallel Online Time Warping for Real-Time Audio-to-Score Alignment in Multi-core Systems. The Journal of Supercomputing. 73(1):126-138. https://doi.org/10.1007/s11227-016-1647-5S126138731Joder C, Essid S, Richard G (2011) A conditional random field framework for robust and scalable audio-to-score matching. 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In: 16th International Society for music information retrieval conference, pp 742–748Rodríguez-Serrano FJ, Menéndez-Canal J, Vidal A, Cañadas-Quesada FJ, Cortina R (2015) A DTW based score following method for score-informed sound source separation. In: Proceedings of the 12th sound and music computing conference 2015 (SMC-15), Ireland, pp 491–496Carabias-Ortí JJ, Rodríguez-Serrano FJ, Vera-Candeas P, Cañadas-Quesada FJ, Ruíz-Reyes N (2013) Constrained non-negative sparse coding using learnt instrument templates for realtime music transcription. Eng Appl Artif Intell 26(7):1671–1680Raphael C (2006) Aligning music audio with symbolic scores using a hybrid graphical model. Mach Learn 65:389–409Schreck-Ensemble (2001–2004) ComParser 1.42. http://home.hku.nl/~pieter.suurmond/SOFT/CMP/doc/cmp.html . Accessed Sept 2015Itakura F (1975) Minimum prediction residual principle applied to speech recognition. 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Real-time Soundprism

[EN] This paper presents a parallel real-time sound source separation system for decomposing an audio signal captured with a single microphone in so many audio signals as the number of instruments that are really playing. This approach is usually known as Soundprism. The application scenario of the system is for a concert hall in which users, instead of listening to the mixed audio, want to receive the audio of just an instrument, focusing on a particular performance. The challenge is even greater since we are interested in a real-time system on handheld devices, i.e., devices characterized by both low power consumption and mobility. The results presented show that it is possible to obtain real-time results in the tested scenarios using an ARM processor aided by a GPU, when this one is present.This work has been supported by the "Ministerio de Economia y Competitividad" of Spain and FEDER under projects TEC2015-67387-C4-{1,2,3}-R.Muñoz-Montoro, AJ.; Ranilla, J.; Vera-Candeas, P.; Combarro, EF.; Alonso-Jordá, P. (2019). Real-time Soundprism. The Journal of Supercomputing. 75(3):1594-1609. https://doi.org/10.1007/s11227-018-2703-0S15941609753Alonso P, Cortina R, Rodríguez-Serrano FJ, Vera-Candeas P, Alonso-González M, Ranilla J (2017) Parallel online time warping for real-time audio-to-score alignment in multi-core systems. J Supercomput 73:126. https://doi.org/10.1007/s11227-016-1647-5Carabias-Orti JJ, Cobos M, Vera-Candeas P, Rodríguez-Serrano FJ (2013) Nonnegative signal factorization with learnt instrument models for sound source separation in close-microphone recordings. EURASIP J Adv Signal Process 2013:184. https://doi.org/10.1186/1687-6180-2013-184Carabias-Orti JJ, Rodriguez-Serrano FJ, Vera-Candeas P, Canadas-Quesada FJ, Ruiz-Reyes N (2015) An audio to score alignment framework using spectral factorization and dynamic time warping. In: 16th International Society for Music Information Retrieval Conference, pp 742–748Díaz-Gracia N, Cocaña-Fernández A, Alonso-González M, Martínez-Zaldívar FJ, Cortina R, García-Mollá VM, Alonso P, Ranilla J (2014) NNMFPACK: a versatile approach to an NNMF parallel library. In: Proceedings of the 2014 International Conference on Computational and Mathematical Methods in Science and Engineering, pp 456–465Díaz-Gracia N, Cocaña-Fernández A, Alonso-González M, Martínez-Zaldívar FJ, Cortina R, García-Mollá VM, Vidal AM (2015) Improving NNMFPACK with heterogeneous and efficient kernels for $$\beta$$ β -divergence metrics. 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What they fill in today, may not be useful tomorrow: Lessons learned from studying Medical Records at the Women hospital in Tabriz, Iran

<p>Abstract</p> <p>Background</p> <p>The medical record is used to document patient's medical history, illnesses and treatment procedures. The information inside is useful when all needed information is documented properly. Medical care providers in Iran have complained of low quality of Medical Records. This study was designed to evaluate the quality of the Medical Records at the university hospital in Tabriz, Iran.</p> <p>Methods</p> <p>In order to get a background of the quality of documentation, 300 Medical Records were randomly selected among all hospitalized patient during September 23, 2003 and September 22, 2004. Documentation of all records was evaluated using checklists. Then, in order to combine objective data with subjective, 10 physicians and 10 nurses who were involved in documentation of Medical Records were randomly selected and interviewed using two semi structured guidelines.</p> <p>Results</p> <p>Almost all 300 Medical Records had problems in terms of quality of documentation. There was no record in which all information was documented correctly and compatible with the official format in Medical Records provided by Ministry of Health and Medical Education. Interviewees believed that poor handwriting, missing of sheets and imperfect documentation are major problems of the Paper-based Medical Records, and the main reason was believed to be high workload of both physicians and nurses.</p> <p>Conclusion</p> <p>The Medical Records are expected to be complete and accurate. Our study has unveiled that the Medical Records are not documented properly in the university hospital where the Medical Records are also used for educational purposes. Such incomplete Medical Records are not reliable resources for medical care too. Some influencing factors external to the structure of the Medical Records (i.e. human factors and work conditions) are involved.</p

Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector

Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente

Regulator of G-Protein Signaling 14 (RGS14) Is a Selective H-Ras Effector

Background: Regulator of G-protein signaling (RGS) proteins have been well-described as accelerators of Ga-mediated GTP hydrolysis (‘‘GTPase-accelerating proteins’’ or GAPs). However, RGS proteins with complex domain architectures are now known to regulate much more than Ga GTPase activity. RGS14 contains tandem Ras-binding domains that have been reported to bind to Rap- but not Ras GTPases in vitro, leading to the suggestion that RGS14 is a Rap-specific effector. However, more recent data from mammals and Drosophila imply that, in vivo, RGS14 may instead be an effector of Ras.Methodology/Principal Findings: Full-length and truncated forms of purified RGS14 protein were found to bind indiscriminately in vitro to both Rap- and Ras-family GTPases, consistent with prior literature reports. In stark contrast, however, we found that in a cellular context RGS14 selectively binds to activated H-Ras and not to Rap isoforms. Co- transfection / co-immunoprecipitation experiments demonstrated the ability of full-length RGS14 to assemble a multiprotein complex with components of the ERK MAPK pathway in a manner dependent on activated H-Ras. Small interfering RNA-mediated knockdown of RGS14 inhibited both nerve growth factor- and basic fibrobast growth factor- mediated neuronal differentiation of PC12 cells, a process which is known to be dependent on Ras-ERK signaling.Conclusions/Significance: In cells, RGS14 facilitates the formation of a selective Ras?GTP-Raf-MEK-ERK multiprotein complex to promote sustained ERK activation and regulate H-Ras-dependent neuritogenesis. This cellular function for RGS14 is similar but distinct from that recently described for its closely-related paralogue, RGS12, which shares the tandem Ras- binding domain architecture with RGS14

Characteristics of hepatitis C virus resistance in an international cohort after a decade of direct-acting antivirals

Background & Aims: Direct-acting antiviral (DAA) regimens provide a cure in >95% of patients with chronic HCV infection. However, in some patients in whom therapy fails, resistance-associated substitutions (RASs) can develop, limiting retreatment options and risking onward resistant virus transmission. In this study, we evaluated RAS prevalence and distribution, including novel NS5A RASs and clinical factors associated with RAS selection, among patients who experienced DAA treatment failure. Methods: SHARED is an international consortium of clinicians and scientists studying HCV drug resistance. HCV sequence linked metadata from 3,355 patients were collected from 22 countries. NS3, NS5A, and NS5B RASs in virologic failures, including novel NS5A substitutions, were examined. Associations of clinical and demographic characteristics with RAS selection were investigated. Results: The frequency of RASs increased from its natural prevalence following DAA exposure: 37% to 60% in NS3, 29% to 80% in NS5A, 15% to 22% in NS5B for sofosbuvir, and 24% to 37% in NS5B for dasabuvir. Among 730 virologic failures, most were treated with first-generation DAAs, 94% had drug resistance in ≥1 DAA class: 31% single-class resistance, 42% dual-class resistance (predominantly against protease and NS5A inhibitors), and 21% triple-class resistance. Distinct patterns containing ≥2 highly resistant RASs were common. New potential NS5A RASs and adaptive changes were identified in genotypes 1a, 3, and 4. Following DAA failure, RAS selection was more frequent in older people with cirrhosis and those infected with genotypes 1b and 4. Conclusions: Drug resistance in HCV is frequent after DAA treatment failure. Previously unrecognized substitutions continue to emerge and remain uncharacterized. Lay summary: Although direct-acting antiviral medications effectively cure hepatitis C in most patients, sometimes treatment selects for resistant viruses, causing antiviral drugs to be either ineffective or only partially effective. Multidrug resistance is common in patients for whom DAA treatment fails. Older patients and patients with advanced liver diseases are more likely to select drug-resistant viruses. Collective efforts from international communities and governments are needed to develop an optimal approach to managing drug resistance and preventing the transmission of resistant viruses

Human cell types important for Hepatitis C Virus replication in vivo and in vitro. Old assertions and current evidence

Hepatitis C Virus (HCV) is a single stranded RNA virus which produces negative strand RNA as a replicative intermediate. We analyzed 75 RT-PCR studies that tested for negative strand HCV RNA in liver and other human tissues. 85% of the studies that investigated extrahepatic replication of HCV found one or more samples positive for replicative RNA. Studies using in situ hybridization, immunofluorescence, immunohistochemistry, and quasispecies analysis also demonstrated the presence of replicating HCV in various extrahepatic human tissues, and provide evidence that HCV replicates in macrophages, B cells, T cells, and other extrahepatic tissues. We also analyzed both short term and long term in vitro systems used to culture HCV. These systems vary in their purposes and methods, but long term culturing of HCV in B cells, T cells, and other cell types has been used to analyze replication. It is therefore now possible to study HIV-HCV co-infections and HCV replication in vitro

Search for High-Mass Resonances Decaying to τν in pp Collisions at √s=13 TeV with the ATLAS Detector

A search for high-mass resonances decaying to τν using proton-proton collisions at √s=13 TeV produced by the Large Hadron Collider is presented. Only τ-lepton decays with hadrons in the final state are considered. The data were recorded with the ATLAS detector and correspond to an integrated luminosity of 36.1 fb−1. No statistically significant excess above the standard model expectation is observed; model-independent upper limits are set on the visible τν production cross section. Heavy W′ bosons with masses less than 3.7 TeV in the sequential standard model and masses less than 2.2–3.8 TeV depending on the coupling in the nonuniversal G(221) model are excluded at the 95% credibility level

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to 300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m 2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years