175 research outputs found
Caenorhabditis elegans Operons Contain a Higher Proportion of Genes with Multiple Transcripts and Use 3′ Splice Sites Differentially
- Author
- Publication venue
- Public Library of Science
- Publication date
- 27/08/2010
- Field of study
RNA splicing generates multiple transcript isoforms from a single gene and enhances the complexity of eukaryotic gene expression. In some eukaryotes, operon exists as an ancient regulatory mechanism of gene expression that requires strict positional and regulatory relationships among its genes. It remains unknown whether operonic genes generate transcript isoforms in a similar manner as non-operonic genes do, the expression of which is less likely limited by their positions and relationships with surrounding genes. We analyzed the number of transcript isoforms of Caenorhabditis elegans operonic genes and found that C. elegans operons contain a much higher proportion of genes with multiple transcript isoforms than non-operonic genes do. For genes that express multiple transcript isoforms, there is no apparent difference between the number of isoforms in operonic and non-operonic genes. C. elegans operonic genes also have a different preference of the 20 most common 3′ splice sites compared to non-operonic genes. Our analyses suggest that C. elegans operons enhance expression complexity by increasing the proportion of genes that express multiple transcript isoforms and maintain splicing efficiency by differential use of common 3′ splice sites
ExpressionPlot: a web-based framework for analysis of RNA-Seq and microarray gene expression data
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/12/2010
- Field of study
RNA-Seq and microarray platforms have emerged as important tools for detecting changes in gene expression and RNA processing in biological samples. We present ExpressionPlot, a software package consisting of a default back end, which prepares raw sequencing or Affymetrix microarray data, and a web-based front end, which offers a biologically centered interface to browse, visualize, and compare different data sets. Download and installation instructions, a user's manual, discussion group, and a prototype are available at http://expressionplot.com/ webcite.ALS Therapy Allianc
The gene for trypsin inhibitor CMe is regulated in trans by the lys 3a locus in the endosperm of barley (Hordeum vulgare L.)
- Author
- A Brandt
- A Lazaro
- A Lazaro
- A Lazaro
- AM Maxam
- AP Feinberg
- B Søgaard
- C Domoney
- D Barber
- DE Woods
- ET Mertz
- F Garcia-Olmedo
- F Sanger
- G Salcedo
- H Doll
- H Doll
- H Doll
- H Doll
- H Doll
- HE Hopp
- J Hejgaard
- J Hejgaard
- J Hejgaard
- J Ingversen
- J Paz-Ares
- J Paz-Ayes
- KE Karlsson
- KE Karlsson
- KR Yamamoto
- L Munck
- M Kreis
- M Kreis
- M Kreis
- MB Sørensen
- MG Murray
- OE Nelson
- PR Shewry
- R Balasaraswathi
- R Singh
- R Thompson
- S Boisen
- S Odani
- T Maniatis
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1989
- Field of study
A cDNA encoding trypsin inhibitor CMe from barley endosperm has been cloned and characterized. The longest open reading frame of the cloned cDNA codes for a typical signal peptide of 24 residues followed by a sequence which is identical to the known amino acid sequence of the inhibitor, except for an Ile/Leu substitution at position 59. Southern blot analysis of wheat-barley addition lines has shown that chromosome 3H of barley carries the gene for CMe. This protein is present at less than 2%–3% of the wild-type amount in the mature endosperm of the mutant Risø 1508 with respect to Bomi barley, from which it has been derived, and the corresponding steady state levels of the CMe mRNA are about I%. One or two copies of the CMe gene (synonym Itc1) per haploid genome have been estimated both in the wild type and in the mutant, and DNA restriction patterns are identical in both stocks, so neither a change in copy number nor a major rearrangement of the structural gene account for the markedly decreased expression. The mutation at the lys 3a locus in Risø 1508 has been previously mapped in chromosome 7 (synonym 5H). A single dose of the wild-type allele at this locus (Lys 3a) restores the expression of gene CMe (allele CMe-1) in chromosome 3H to normal levels
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Achkar B
- Adachi S
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adersberger M
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Ahmed WS
- Ai X
- Aielli G
- Akatsuka S
- Akesson TPA
- Akilli E
- Akimov A
- Al Khoury K
- Alberghi GL
- Albert J
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
- Alfonsi F
- Alhroob M
- Ali B
- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alvarez Estevez M
- Alviggi MG
- Amaral Coutinho Y
- Ambler A
- Ambroz L
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amoroso S
- Amrouche CS
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- Anders CF
- Anders JK
- Andreazza A
- Andrei V
- Anelli CR
- Angelidakis S
- Angerami A
- Anisenkov A
- Annovi A
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- Anthony MT
- Antipov E
- Antonelli M
- Antrim DJA
- Anulli F
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- Araya ST
- Arcangeletti C
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- Asimakopoulou EM
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- Caltabiano A
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- Calvet D
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- Tsukerman II
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- Vukotic I
- Wagner P
- Wagner W
- Wagner-Kuhr J
- Wahdan S
- Wahlberg H
- Walbrecht VM
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- Walker SD
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- Warburton A
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- White MJ
- Whiteson D
- Whitmore BW
- Wiedenmann W
- Wiel C
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- Wolff R
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- Wolter MW
- Wolters H
- Wong VWS
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- Wraight K
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- Xella S
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- Yao W-M
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- Yexley MR
- Yigitbasi E
- Yildiz HD
- Yorita K
- Yoshihara K
- Young C
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- Yue X
- Zaazoua M
- Zabinski B
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- Zaitsev AM
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- Zakharchuk N
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- Zaripovas DR
- Zeissner S
- Zeitnitz C
- Zemaityte G
- Zeng JC
- Zenin O
- Zenis T
- Zerwas D
- Zgubic M
- Zhang B
- Zhang DF
- Zhang G
- Zhang H
- Zhang J
- Zhang L
- Zhang M
- Zhang R
- Zhang S
- Zhang X
- Zhang Y
- Zhang Z
- Zhao P
- Zhao Z
- Zhemchugov A
- Zheng Z
- Zhong D
- Zhou B
- Zhou C
- Zhou M
- Zhou MS
- Zhou N
- Zhou Y
- Zhu C
- Zhu CG
- Zhu H
- Zhu HL
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine N
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zu Theenhausen HM
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente
Discovery and Annotation of Functional Chromatin Signatures in the Human Genome
- Author
- A Barski
- A Siepel
- AJ Saldanha
- AP Boyle
- B Li
- BE Bernstein
- Bing Ren
- CR Vakoc
- DM Lonard
- EM Blackwood
- Eran Segal
- ES Lander
- ET Wang
- F Hsu
- G Dennis Jr
- G Hon
- GA Maston
- Gary Hon
- GC Hon
- GE Crawford
- H Tilgner
- J Jurka
- J Schug
- K Luger
- KD Pruitt
- KW Lynch
- L Guelen
- LO Barrera
- M Ashburner
- M Gaszner
- M Guttman
- MG Guenther
- N Spies
- ND Heintzman
- ND Heintzman
- OJ Rando
- P Carninci
- P Kolasinska-Zwierz
- PV Kharchenko
- R Andersson
- S Oberdoerffer
- SI Grewal
- T Kouzarides
- T Maniatis
- T Xiao
- TS Mikkelsen
- Wei Wang
- WJ Kent
- Y Fu
- Y Zhang
- Z Wang
- Z Wang
- Publication venue
- Public Library of Science
- Publication date
- 01/11/2009
- Field of study
Transcriptional regulation in human cells is a complex process involving a
multitude of regulatory elements encoded by the genome. Recent studies have
shown that distinct chromatin signatures mark a variety of functional genomic
elements and that subtle variations of these signatures mark elements with
different functions. To identify novel chromatin signatures in the human genome,
we apply a de novo pattern-finding algorithm to genome-wide
maps of histone modifications. We recover previously known chromatin signatures
associated with promoters and enhancers. We also observe several chromatin
signatures with strong enrichment of H3K36me3 marking exons. Closer examination
reveals that H3K36me3 is found on well-positioned nucleosomes at exon
5′ ends, and that this modification is a global mark of exon
expression that also correlates with alternative splicing. Additionally, we
observe strong enrichment of H2BK5me1 and H4K20me1 at highly expressed exons
near the 5′ end, in contrast to the opposite distribution of
H3K36me3-marked exons. Finally, we also recover frequently occurring chromatin
signatures displaying enrichment of repressive histone modifications. These
signatures mark distinct repeat sequences and are associated with distinct modes
of gene repression. Together, these results highlight the rich information
embedded in the human epigenome and underscore its value in studying gene
regulation
Conserved Alternative Splicing and Expression Patterns of Arthropod N-Cadherin
- Author
- A Goren
- A Nern
- AJ Lopez
- Akira Chiba
- B Tasic
- BJ Blencowe
- BR Graveley
- CH Lee
- Chi-Hon Lee
- Chun-Yuan Ting
- CT Hsu
- CW Smith
- CW Sugnet
- CY Ting
- D Schmucker
- DL Black
- DL Black
- DM Standiford
- Eric Rulifson
- ET Wang
- FC Chen
- G Grenningloh
- G Yeo
- H Nagaso
- H Zhu
- HM Bomze
- Hugh M. Robertson
- HW Mewes
- ID Broadbent
- J Wang
- JM Johnson
- K Iida
- K Tamura
- L Cartegni
- LF Lareau
- MD Adams
- R Sorek
- S Goeke
- S Hamada
- S Prakash
- S Yonekura
- S Zhang
- Shinichi Yonekura
- Shu-Ning Hsu
- T Hummel
- T Maniatis
- Tadashi Uemura
- W Gilbert
- WH Li
- XL Zhan
- Y Iwai
- Y Iwai
- Y Xing
- Youichi Iwai
- Publication venue
- Public Library of Science
- Publication date
- 01/04/2009
- Field of study
Metazoan development requires complex mechanisms to generate cells with diverse function. Alternative splicing of pre-mRNA not only expands proteomic diversity but also provides a means to regulate tissue-specific molecular expression. The N-Cadherin gene in Drosophila contains three pairs of mutually-exclusive alternatively-spliced exons (MEs). However, no significant differences among the resulting protein isoforms have been successfully demonstrated in vivo. Furthermore, while the N-Cadherin gene products exhibit a complex spatiotemporal expression pattern within embryos, its underlying mechanisms and significance remain unknown. Here, we present results that suggest a critical role for alternative splicing in producing a crucial and reproducible complexity in the expression pattern of arthropod N-Cadherin. We demonstrate that the arthropod N-Cadherin gene has maintained the three sets of MEs for over 400 million years using in silico and in vivo approaches. Expression of isoforms derived from these MEs receives precise spatiotemporal control critical during development. Both Drosophila and Tribolium use ME-13a and ME-13b in “neural” and “mesodermal” splice variants, respectively. As proteins, either ME-13a- or ME-13b-containing isoform can cell-autonomously rescue the embryonic lethality caused by genetic loss of N-Cadherin. Ectopic muscle expression of either isoform beyond the time it normally ceases leads to paralysis and lethality. Together, our results offer an example of well-conserved alternative splicing increasing cellular diversity in metazoans
Development of real-time NASBA assays with molecular beacon detection to quantify mRNA coding for HHV-8 lytic and latent genes
- Author
- A Heim
- B Van Gemen
- BM Darke
- C Bais
- C Blasig
- DA Davis
- DH Kedes
- DM Koelle
- E Cesarman
- E Cesarman
- EA Mesri
- EHY Cheng
- ES Maxwell
- ET Lennette
- F Neipel
- FR Stamey
- FWN Wit
- G Ascherl
- G Leone
- J Compton
- J Goudsmit
- J Nicholas
- J Soulier
- JM Orenstein
- JM Prins
- Jr Friborg J
- JR Kirshner
- JR LaDuca
- JW Romano
- KA Staskus
- L Arvanitakis
- LG Chatlynne
- LL Decker
- M Luppi
- M Sturzl
- M Sturzl
- MA Cotter
- MA Davis
- MB Rettig
- MC Sirianni
- MC Sirianni
- MC Sirianni
- ME Ballestas
- MJ Blok
- MP De Baar
- MS Smith
- N Renwick
- PS Moore
- R Burger
- R Higuchi
- R Sarid
- RG Jenner
- S Tyagi
- SA Morre
- SJ Gao
- T Kievits
- T Maniatis
- TB Campbell
- TJ Spira
- V Fiorelli
- Y Chang
- YQ Huang
- Publication venue
- BioMed Central
- Publication date
- 01/01/2002
- Field of study
BACKGROUND: Human herpesvirus-8 (HHV-8) is linked to the pathogenesis of Kaposi's sarcoma (KS), and the HHV-8 DNA load in peripheral blood mononuclear cells (PBMC) is associated with the clinical stage of KS. To examine the expression of HHV-8 in PBMC, four HHV-8 mRNA specific NASBA assays were developed METHODS: We have developed four quantitative nucleic acid sequence-based amplification assays (NASBA-QT) specifically to detect mRNA coding for ORF 73 (latency-associated nuclear antigen, LANA), vGCR (a membrane receptor), vBcl-2 (a viral inhibitor of apoptosis) and vIL-6 (a viral growth factor). The NASBA technique amplifies nucleic acids without thermocycling and mRNA can be amplified in a dsDNA background. A molecular beacon is used during amplification to enable real-time detection of the product. The assays were tested on PBMC samples of two AIDS-KS patients from the Amsterdam Cohort. RESULTS: For all four assays, the limit of detection (LOD) of 50 molecules and the limit of quantification (LOQ) of 100 molecules were determined using in vitro transcribed RNA. The linear dynamic range was 50 to 10(7) molecules of HHV-8 mRNA. We found HHV-8 mRNA expression in 9 out of the 10 tested samples. CONCLUSION: These real-time NASBA assays with beacon detection provide tools for further study of HHV-8 expression in patient material
Measurement of VH, H → b b ¯ production as a function of the vector-boson transverse momentum in 13 TeV pp collisions with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abbott DC
- Abdinov O
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Adachi S
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adersberger M
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Aielli G
- Akatsuka S
- Akesson TPA
- Akilli E
- Akimov AV
- Al Khoury K
- Alberghi GL
- Alberich LC
- Albert J
- Alconada Verzini MJ
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexandre D
- Alexopoulos T
- Alfonsi A
- Alhroob M
- Ali B
- Alimonti G
- Alison J
- Alkire SP
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alstaty MI
- Alvarez Estevez M
- Alvarez Piqueras D
- Alviggi MG
- Amaral Coutinho Y
- Ambler A
- Ambroz L
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amoroso S
- Amrouche CS
- An F
- Anastopoulos C
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Andreazza A
- Andrei V
- Anelli CR
- Angelidakis S
- Angelozzi I
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antonelli M
- Antrim DJA
- Anulli F
- Aoki M
- Aparisi Pozo JA
- Arabidze G
- Araque JP
- Araujo Ferraz V
- Araujo Pereira R
- Araya ST
- Arce ATH
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Arling J-H
- Armadans RC
- Armbruster AJ
- Armitage LJ
- Armstrong A
- Arnaez O
- Arnold H
- Artamonov A
- Artoni G
- Artz S
- Asai S
- Asbah N
- Asimakopoulou EM
- Asquith L
- Assamagan K
- Astalos R
- Astigarraga MEP
- Atkin RJ
- Atkinson M
- Atlay NB
- Atmani H
- Augsten K
- Avolio G
- Avramidou R
- Ayoub MK
- Azoulay AM
- Azuelos G
- Baas AE
- Baca MJ
- Bachacou H
- Bachas K
- Backes M
- Backman F
- Bagnaia P
- Bahmani M
- Bahrasemani H
- Bailey AJ
- Bailey VR
- Baines JT
- Bajic M
- Bakalis C
- Baker OK
- Bakker PJ
- Balaji S
- Baldin EM
- Balek P
- Balli F
- Balunas WK
- Balz J
- Banas E
- Bandyopadhyay A
- Banerjee S
- Bannoura AAE
- Barajas CAC
- Barak L
- Barbe WM
- Barberio EL
- Barberis D
- Barbero M
- Barillari T
- Barisits M-S
- Barkeloo J
- Barklow T
- Barnea R
- Barnes SL
- Barnett BM
- Barnett RM
- Barnovska-Blenessy Z
- Baroncelli A
- Barone G
- Barr AJ
- Barranco Navarro L
- Barreiro F
- Bartoldus R
- Bartolini G
- Barton AE
- Bartos P
- Basalaev A
- Bassalat A
- Bates RL
- Batista SJ
- Batlamous S
- Batley JR
- Batool B
- Battaglia M
- Bauce M
- Bauer F
- Bauer KT
- Bawa HS
- Beacham JB
- Beau T
- Beauchemin PH
- Bechtle P
- Beck HC
- Beck HP
- Becker K
- Becker M
- Becot C
- Beddall A
- Beddall AJ
- Bednyakov VA
- Bedognetti M
- Bee CP
- Beermann TA
- Begalli M
- Begel M
- Behera A
- Behr JK
- Beisiegel F
- Bell AS
- Bella G
- Bella LA
- Bellagamba L
- Bellerive A
- Bellos P
- Beloborodov K
- Belotskiy K
- Belyaev NL
- Benary O
- Benchekroun D
- Benekos N
- Benhammou Y
- Benjamin DP
- Benoit M
- Bensinger JR
- Bentvelsen S
- Beresford L
- Beretta M
- Berge D
- Berger N
- Bergmann B
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- Zhao P
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- Zhemchugov A
- Zheng Z
- Zhong D
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- Zhu CG
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- Zhuang X
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- Zhulanov V
- Zieminska D
- Zimine NI
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zu Theenhausen HM
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Cross-sections of associated production of a Higgs boson decaying into bottom-quark pairs and an electroweak gauge boson, W or Z, decaying into leptons are measured as a function of the gauge boson transverse momentum. The measurements are performed in kinematic fiducial volumes defined in the `simplified template cross-section' framework. The results are obtained using 79.8 fb-1 of proton-proton collisions recorded by the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy of 13 TeV. All measurements are found to be in agreement with the Standard Model predictions, and limits are set on the parameters of an effective Lagrangian sensitive to modifications of the Higgs boson couplings to the electroweak gauge bosons
Search for heavy neutral Higgs bosons produced in association with b-quarks and decaying into b-quarks at root s=13 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abdinov O
- Abeling K
- Abhayasinghe DK
- Abidi SH
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- Zhemchugov A
- Zheng Z
- Zhong D
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- Zhu CG
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- Zhuang X
- Zhukov K
- Zhulanov V
- Zieminska D
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- Zimmermann S
- Zinonos Z
- Ziolkowski M
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- Zorbas TG
- Zou R
- Zu Theenhausen HM
- Zwalinski L
- Publication venue
- AMER PHYSICAL SOC
- Publication date
- 13/08/2020
- Field of study
A search for heavy neutral Higgs bosons produced in association with one or two
b
-quarks and decaying to
b
-quark pairs is presented using
27.8
fb
−
1
of
√
s
=
13
TeV
proton-proton collision data recorded by the ATLAS detector at the Large Hadron Collider during 2015 and 2016. No evidence of a signal is found. Upper limits on the heavy neutral Higgs boson production cross section times its branching ratio to
b
¯
b
are set, ranging from 4.0 to 0.6 pb at 95% confidence level over a Higgs boson mass range of 450 to 1400 GeV. Results are interpreted within the two-Higgs-doublet model and the minimal supersymmetric Standard Model
Measurement of single top-quark production in association with a W boson in the single-lepton channel at \sqrt{s} = 8\,\text {TeV} with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
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- Casado MP
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- Castelijn R
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- Catinaccio A
- Catmore JR
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- Zacharis G
- Zaffaroni E
- Zahreddine J
- Zaitsev AM
- Zakareishvili T
- Zakharchuk N
- Zambito S
- Zanzi D
- Zaripovas DR
- Zeissner S
- Zeitnitz C
- Zemaityte G
- Zeng JC
- Zenin O
- Zenis T
- Zerwas D
- Zhang B
- Zhang DF
- Zhang G
- Zhang H
- Zhang J
- Zhang L
- Zhang L
- Zhang M
- Zhang R
- Zhang X
- Zhang Y
- Zhang Z
- Zhang Z
- Zhao P
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zheng Z
- Zhong D
- Zhou B
- Zhou C
- Zhou M
- Zhou MS
- Zhou N
- Zhou Y
- Zhu C
- Zhu CG
- Zhu H
- Zhu HL
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine N
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zu Theenhausen HM
- Zwalinski L
- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 01/01/2021
- Field of study
The production cross-section of a top quark in association with a W boson is measured using proton–proton collisions at \sqrt{s} = 8\,\text {TeV}. The dataset corresponds to an integrated luminosity of 20.2\,\text {fb}^{-1}, and was collected in 2012 by the ATLAS detector at the Large Hadron Collider at CERN. The analysis is performed in the single-lepton channel. Events are selected by requiring one isolated lepton (electron or muon) and at least three jets. A neural network is trained to separate the tW signal from the dominant t{\bar{t}} background. The cross-section is extracted from a binned profile maximum-likelihood fit to a two-dimensional discriminant built from the neural-network output and the invariant mass of the hadronically decaying W boson. The measured cross-section is \sigma _{tW} = 26 \pm 7\,\text {pb}, in good agreement with the Standard Model expectation
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