143 research outputs found
Signal Transmission Across Tile Assemblies: 3D Static Tiles Simulate Active Self-Assembly by 2D Signal-Passing Tiles
The 2-Handed Assembly Model (2HAM) is a tile-based self-assembly model in
which, typically beginning from single tiles, arbitrarily large aggregations of
static tiles combine in pairs to form structures. The Signal-passing Tile
Assembly Model (STAM) is an extension of the 2HAM in which the tiles are
dynamically changing components which are able to alter their binding domains
as they bind together. For our first result, we demonstrate useful techniques
and transformations for converting an arbitrarily complex STAM tile set
into an STAM tile set where every tile has a constant, low amount of
complexity, in terms of the number and types of ``signals'' they can send, with
a trade off in scale factor.
Using these simplifications, we prove that for each temperature
there exists a 3D tile set in the 2HAM which is intrinsically universal for the
class of all 2D STAM systems at temperature (where the STAM does
not make use of the STAM's power of glue deactivation and assembly breaking, as
the tile components of the 2HAM are static and unable to change or break
bonds). This means that there is a single tile set in the 3D 2HAM which
can, for an arbitrarily complex STAM system , be configured with a
single input configuration which causes to exactly simulate at a scale
factor dependent upon . Furthermore, this simulation uses only two planes of
the third dimension. This implies that there exists a 3D tile set at
temperature in the 2HAM which is intrinsically universal for the class of
all 2D STAM systems at temperature . Moreover, we show that for each
temperature there exists an STAM tile set which is intrinsically
universal for the class of all 2D STAM systems at temperature ,
including the case where .Comment: A condensed version of this paper will appear in a special issue of
Natural Computing for papers from DNA 19. This full version contains proofs
not seen in the published versio
Synaptic targeting and localization of Discs-large is a stepwise process controlled by different domains of the protein
AbstractBackground: Membrane-associated guanylate kinases (MAGUKs) assemble ion channels, cell-adhesion molecules and components of second messenger cascades into synapses, and are therefore potentially important for co-ordinating synaptic strength and structure. Here, we have examined the targeting of the Drosophila MAGUK Discs-large (DLG) to larval neuromuscular junctions.Results: During development, DLG was first found associated with the muscle subcortical compartment and plasma membrane, and later was recruited to the postsynaptic membrane. Using a transgenic approach, we studied how mutations in various domains of the DLGprotein affect DLG targeting. Deletion of the HOOKregionâthe region between the Src homology 3 (SH3) domain and the guanylate-kinase-like (GUK) domainâprevented association of DLG with the subcortical network and rendered the protein largely diffuse. Loss of the first two PDZ domains led to the formation of large clusters throughout the plasma membrane, with scant targeting to the neuromuscular junction. Proper trafficking of DLG missing the GUK domain depended on the presence of endogenous DLG.Conclusions: Postsynaptic targeting of DLG requires a HOOK-dependent association with extrasynaptic compartments, and interactions mediated by the first two PDZ domains. The GUK domain routes DLG between compartments, possibly by interacting with recently identified cytoskeletal-binding partners
Synaptic targeting and localization of Discs-large is a stepwise process controlled by different domains of the protein
AbstractBackground: Membrane-associated guanylate kinases (MAGUKs) assemble ion channels, cell-adhesion molecules and components of second messenger cascades into synapses, and are therefore potentially important for co-ordinating synaptic strength and structure. Here, we have examined the targeting of the Drosophila MAGUK Discs-large (DLG) to larval neuromuscular junctions.Results: During development, DLG was first found associated with the muscle subcortical compartment and plasma membrane, and later was recruited to the postsynaptic membrane. Using a transgenic approach, we studied how mutations in various domains of the DLGprotein affect DLG targeting. Deletion of the HOOKregionâthe region between the Src homology 3 (SH3) domain and the guanylate-kinase-like (GUK) domainâprevented association of DLG with the subcortical network and rendered the protein largely diffuse. Loss of the first two PDZ domains led to the formation of large clusters throughout the plasma membrane, with scant targeting to the neuromuscular junction. Proper trafficking of DLG missing the GUK domain depended on the presence of endogenous DLG.Conclusions: Postsynaptic targeting of DLG requires a HOOK-dependent association with extrasynaptic compartments, and interactions mediated by the first two PDZ domains. The GUK domain routes DLG between compartments, possibly by interacting with recently identified cytoskeletal-binding partners
RC infilled building performance against the evidence of the 2016 EEFIT Central Italy post-earthquake reconnaissance mission:empirical fragilities and comparison with the FAST method
Damage data on low-to-mid-rise Reinforced Concrete (RC) buildings, collected during the UK Earthquake Engineering Field Investigation Team post-earthquake reconnaissance mission on the August 24 Central Italy earthquake, are employed to derive empirical fragility relationships. Given the small dataset, the new data distributions are used for the Bayesian update of fragility functions derived for the LâAquila earthquake (same seismic region and similar construction typologies). Other properties such as number of storeys, age of construction and shape in plan of the buildings are also analyzed. This information is employed to assess the ability of the FAST method to predict damage states in non-regular infilled RC buildings for the municipalities of Amatrice, Accumoli, Arquata del Tronto and Norcia, all severely affected by the 2016 Central Italy sequence. FAST is a spectral-based method to derive capacity curves and peak ground acceleration damage state thresholds for buildings. It is a dedicated methodology for regular RC frame buildings with masonry infills, first calibrated on damage data from the 2009 LâAquila earthquake and applied to the 2011 Lorca (Spain), the 2012 Emilia (Italy) events for damage back-analyses. The new data from the August 2016 Central Italy earthquake provide a test-bed for FAST further employments in case of less homogenous building samples. The application of FAST presented here accounts for different shake-maps produced by both the United States Geological Survey and the Italian National Institute of Geophysics and Volcanology which are significantly different and representative of different refinements of the demand scenario. For the area of Amatrice, where the two shake-maps provide similar estimates and the buildings considered match reasonably well the typology for which FAST is calibrated, the comparison between damage level observed and as provided by FAST is very satisfactory. For other structural typologies like RC industrial structures and dwellings with non-hollow-clay-bricks as infills, FAST needs further calibration
Diffusive Charge Transport in Graphene on SiO2
We review our recent work on the physical mechanisms limiting the mobility of
graphene on SiO2. We have used intentional addition of charged scattering
impurities and systematic variation of the dielectric environment to
differentiate the effects of charged impurities and short-range scatterers. The
results show that charged impurities indeed lead to a conductivity linear in
density in graphene, with a scattering magnitude that agrees quantitatively
with theoretical estimates [1]; increased dielectric screening reduces
scattering from charged impurities, but increases scattering from short-range
scatterers [2]. We evaluate the effects of the corrugations (ripples) of
graphene on SiO2 on transport by measuring the height-height correlation
function. The results show that the corrugations cannot mimic long-range
(charged impurity) scattering effects, and have too small an
amplitude-to-wavelength ratio to significantly affect the observed mobility via
short-range scattering [3, 4]. Temperature-dependent measurements show that
longitudinal acoustic phonons in graphene produce a resistivity linear in
temperature and independent of carrier density [5]; at higher temperatures,
polar optical phonons of the SiO2 substrate give rise to an activated, carrier
density-dependent resistivity [5]. Together the results paint a complete
picture of charge carrier transport in graphene on SiO2 in the diffusive
regime.Comment: 28 pages, 7 figures, submitted to Graphene Week proceeding
Magnetic Reconnection in Extreme Astrophysical Environments
Magnetic reconnection is a basic plasma process of dramatic rearrangement of
magnetic topology, often leading to a violent release of magnetic energy. It is
important in magnetic fusion and in space and solar physics --- areas that have
so far provided the context for most of reconnection research. Importantly,
these environments consist just of electrons and ions and the dissipated energy
always stays with the plasma. In contrast, in this paper I introduce a new
direction of research, motivated by several important problems in high-energy
astrophysics --- reconnection in high energy density (HED) radiative plasmas,
where radiation pressure and radiative cooling become dominant factors in the
pressure and energy balance. I identify the key processes distinguishing HED
reconnection: special-relativistic effects; radiative effects (radiative
cooling, radiation pressure, and Compton resistivity); and, at the most extreme
end, QED effects, including pair creation. I then discuss the main
astrophysical applications --- situations with magnetar-strength fields
(exceeding the quantum critical field of about 4 x 10^13 G): giant SGR flares
and magnetically-powered central engines and jets of GRBs. Here, magnetic
energy density is so high that its dissipation heats the plasma to MeV
temperatures. Electron-positron pairs are then copiously produced, making the
reconnection layer highly collisional and dressing it in a thick pair coat that
traps radiation. The pressure is dominated by radiation and pairs. Yet,
radiation diffusion across the layer may be faster than the global Alfv\'en
transit time; then, radiative cooling governs the thermodynamics and
reconnection becomes a radiative transfer problem, greatly affected by the
ultra-strong magnetic field. This overall picture is very different from our
traditional picture of reconnection and thus represents a new frontier in
reconnection research.Comment: Accepted to Space Science Reviews (special issue on magnetic
reconnection). Article is based on an invited review talk at the
Yosemite-2010 Workshop on Magnetic Reconnection (Yosemite NP, CA, USA;
February 8-12, 2010). 30 pages, no figure
The composition of the protosolar disk and the formation conditions for comets
Conditions in the protosolar nebula have left their mark in the composition
of cometary volatiles, thought to be some of the most pristine material in the
solar system. Cometary compositions represent the end point of processing that
began in the parent molecular cloud core and continued through the collapse of
that core to form the protosun and the solar nebula, and finally during the
evolution of the solar nebula itself as the cometary bodies were accreting.
Disentangling the effects of the various epochs on the final composition of a
comet is complicated. But comets are not the only source of information about
the solar nebula. Protostellar disks around young stars similar to the protosun
provide a way of investigating the evolution of disks similar to the solar
nebula while they are in the process of evolving to form their own solar
systems. In this way we can learn about the physical and chemical conditions
under which comets formed, and about the types of dynamical processing that
shaped the solar system we see today.
This paper summarizes some recent contributions to our understanding of both
cometary volatiles and the composition, structure and evolution of protostellar
disks.Comment: To appear in Space Science Reviews. The final publication is
available at Springer via http://dx.doi.org/10.1007/s11214-015-0167-
Astronomical Distance Determination in the Space Age: Secondary Distance Indicators
The formal division of the distance indicators into primary and secondary leads to difficulties in description of methods which can actually be used in two ways: with, and without the support of the other methods for scaling. Thus instead of concentrating on the scaling requirement we concentrate on all methods of distance determination to extragalactic sources which are designated, at least formally, to use for individual sources. Among those, the Supernovae Ia is clearly the leader due to its enormous success in determination of the expansion rate of the Universe. However, new methods are rapidly developing, and there is also a progress in more traditional methods. We give a general overview of the methods but we mostly concentrate on the most recent developments in each field, and future expectations. © 2018, The Author(s)
Measurement of the cross section for isolated-photon plus jet production in pp collisions at âs=13 TeV using the ATLAS detector
The dynamics of isolated-photon production in association with a jet in protonâproton collisions at a centre-of-mass energy of 13 TeV are studied with the ATLAS detector at the LHC using a dataset with an integrated luminosity of 3.2 fbâ1. Photons are required to have transverse energies above 125 GeV. Jets are identified using the anti- algorithm with radius parameter and required to have transverse momenta above 100 GeV. Measurements of isolated-photon plus jet cross sections are presented as functions of the leading-photon transverse energy, the leading-jet transverse momentum, the azimuthal angular separation between the photon and the jet, the photonâjet invariant mass and the scattering angle in the photonâjet centre-of-mass system. Tree-level plus parton-shower predictions from Sherpa and Pythia as well as next-to-leading-order QCD predictions from Jetphox and Sherpa are compared to the measurements
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