Проектирование дифракционных оптических элементов с заданным распределением интенсивности

У роботі пропонується ітераційний метод розв’язання оберненої задачі на основі скалярної теорії дифракції до застосування в проектуванні фазових оптичних елементів. Детально описаний ітераційний алгоритм у полярних системах координат застосовується для розрахунку дифракційних оптичних елементів, що формують заданий розподіл інтенсивності в площині спостереження. Звернено увагу на виконання закону збереження енергії та на використання і -ї кількості вихідних площин для осьового розподілу інтенсивності. Наведені приклади розрахунку ДОЕ, що формують рівномірну освітленість у кільці, точці та в осьовому відрізку. Результати розрахованих розподілів інтенсивності дають високу енергетичну ефективність та малу середньоквадратичну похибку, що говорить про високу наближеність розподілів інтенсивності до зданих. Розглянутий ітераційний алгоритм може бути використаний для проектування мультиспектральних спекл - картин. У подальшому планується використання характеристик створюваних ДОЕ для розрахунку більш складніших фокусаторів та виготовлення їх фотошаблонів.In this paper we propose iterative technique for inverse problem, based on the scalar diffraction theory, used in the design of phase optical elements. Iterative algorithm which is described in detail in the polar coordinate system is used to calculate the diffractive optical elements that form a given intensity distribution in the observation plane. More attention has been given to the law of conservation of energy and using of i, number of output surfaces for the axial intensity distribution. We present the examples of diffraction optical element calculating, forming a uniform illumination on the ring, on the point, and on the axial segment. Results calculated intensity distributions provide high energy efficiency and low mean square error, indicating that the high intensity distributions proximity to buildings. Considered an iterative algorithm can be used for designing multispectral speckle - paintings. Plans are generated using features of DOE to calculate more complex focusators and manufacture of photomasks.В данной работе предлагается итерационный метод решения обратной задачи на основе скалярной теории дифракции для применения в проектировании фазовых оптических элементов. Детально описанный итерационный алгоритм в полярных системах координат применяется для расчета дифракционных оптических элементов, которые формируют заданное распределение интенсивности в плоскости наблюдения. Обращено внимание на выполнение закона сохранения энергии и на использование і -го количества выходных плоскостей для осевого распределения интенсивности. Приведены примеры расчета ДОЭ, которые формируют равномерную освещенность в кольце, точке и в осевом отрезке. Результаты рассчитанных распределений интенсивности дают высокую энергетическую эффективность и малую среднеквадратическую погрешность, что свидетельствует о высокой приближенности распределений интенсивности к заданным. Рассмотренный итерационный алгоритм может быть использован для проектирования мультиспектральных спекл – картин. В дальнейшем планируется использование характеристик созданных ДОЭ для расчета более сложных фокусаторов и изготовления их фотошаблонов

Interferometric Bell-state preparation using femtosecond-pulse-pumped Spontaneous Parametric Down-Conversion

We present theoretical and experimental study of preparing maximally entangled two-photon polarization states, or Bell states, using femtosecond pulse pumped spontaneous parametric down-conversion (SPDC). First, we show how the inherent distinguishability in femtosecond pulse pumped type-II SPDC can be removed by using an interferometric technique without spectral and amplitude post-selection. We then analyze the recently introduced Bell state preparation scheme using type-I SPDC. Theoretically, both methods offer the same results, however, type-I SPDC provides experimentally superior methods of preparing Bell states in femtosecond pulse pumped SPDC. Such a pulsed source of highly entangled photon pairs is useful in quantum communications, quantum cryptography, quantum teleportation, etc.Comment: 11 pages, two-column format, to appear in PR

Impact of hypoglycemia on daily life of type 2 diabetes patients in Ukraine

This study evaluates the impact of hypoglycemia on the lives of Ukrainian patients with type 2 diabetes mellitus. The secondary objective was to explore patient-physician relationships and the attitudes of patients towards various informational resources on diabetes management. Three focus groups with 26 patients were conducted. Qualitative information was evaluated using content analysis. The results show that patients with type 2 diabetes mellitus in Ukraine are adapting to potential attacks of hypoglycemia; however, they still experience periodic manifestations of hypoglycemia that significantly affect their psychological well-being. This result is similar to observations made in other countries. Ukrainian patients >40 years old mainly receive information on disease management from endocrinologists, and rarely use internet resources on diabetes management. Information provision was especially important at the early stage of the disease, when patients lack information on hypoglycemia manifestations and could therefore fail to identify and manage it properly

The effect of agitation speed, enzyme loading and substrate concentration on enzymatic hydrolysis of cellulose from brewer’s spent grain

Brewer’s spent grain components (cellulose, hemicellulose and lignin) were fractionated in a two-step chemical pretreatment process using dilute sulfuric acid and sodium hydroxide solutions. The cellulose pulp produced was hydrolyzed with a cellulolytic complex, Celluclast 1.5 L, at 45 ºC to convert the cellulose into glucose. Several conditions were examined: agitation speed (100, 150 and 200 rpm), enzyme loading (5, 25 and 45 FPU/g substrate), and substrate concentration (2, 5 and 8% w/v), according to a 2 3 full factorial design aiming to maximize the glucose yield. The obtained results were interpreted by analysis of variance and response surface methodology. The optimal conditions for enzymatic hydrolysis of brewer’s spent grain were identified as 100 rpm, 45 FPU/g and 2% w/v substrate. Under these conditions, a glucose yield of 93.1% and a cellulose conversion (into glucose and cellobiose) of 99.4% was achieved. The easiness of glucose release from BSG makes this substrate a raw material with great potential to be used in bioconversion processes.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo), Brazil. Novozymes ( FAPESP )Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq

Effect of SGLT2 inhibitors on stroke and atrial fibrillation in diabetic kidney disease: Results from the CREDENCE trial and meta-analysis

BACKGROUND AND PURPOSE: Chronic kidney disease with reduced estimated glomerular filtration rate or elevated albuminuria increases risk for ischemic and hemorrhagic stroke. This study assessed the effects of sodium glucose cotransporter 2 inhibitors (SGLT2i) on stroke and atrial fibrillation/flutter (AF/AFL) from CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation) and a meta-Analysis of large cardiovascular outcome trials (CVOTs) of SGLT2i in type 2 diabetes mellitus. METHODS: CREDENCE randomized 4401 participants with type 2 diabetes mellitus and chronic kidney disease to canagliflozin or placebo. Post hoc, we estimated effects on fatal or nonfatal stroke, stroke subtypes, and intermediate markers of stroke risk including AF/AFL. Stroke and AF/AFL data from 3 other completed large CVOTs and CREDENCE were pooled using random-effects meta-Analysis. RESULTS: In CREDENCE, 142 participants experienced a stroke during follow-up (10.9/1000 patient-years with canagliflozin, 14.2/1000 patient-years with placebo; hazard ratio [HR], 0.77 [95% CI, 0.55-1.08]). Effects by stroke subtypes were: ischemic (HR, 0.88 [95% CI, 0.61-1.28]; n=111), hemorrhagic (HR, 0.50 [95% CI, 0.19-1.32]; n=18), and undetermined (HR, 0.54 [95% CI, 0.20-1.46]; n=17). There was no clear effect on AF/AFL (HR, 0.76 [95% CI, 0.53-1.10]; n=115). The overall effects in the 4 CVOTs combined were: Total stroke (HRpooled, 0.96 [95% CI, 0.82-1.12]), ischemic stroke (HRpooled, 1.01 [95% CI, 0.89-1.14]), hemorrhagic stroke (HRpooled, 0.50 [95% CI, 0.30-0.83]), undetermined stroke (HRpooled, 0.86 [95% CI, 0.49-1.51]), and AF/AFL (HRpooled, 0.81 [95% CI, 0.71-0.93]). There was evidence that SGLT2i effects on total stroke varied by baseline estimated glomerular filtration rate (P=0.01), with protection in the lowest estimated glomerular filtration rate (45 mL/min/1.73 m2]) subgroup (HRpooled, 0.50 [95% CI, 0.31-0.79]). CONCLUSIONS: Although we found no clear effect of SGLT2i on total stroke in CREDENCE or across trials combined, there was some evidence of benefit in preventing hemorrhagic stroke and AF/AFL, as well as total stroke for those with lowest estimated glomerular filtration rate. Future research should focus on confirming these data and exploring potential mechanisms

Fungal enzyme sets for plant polysaccharide degradation

Enzymatic degradation of plant polysaccharides has many industrial applications, such as within the paper, food, and feed industry and for sustainable production of fuels and chemicals. Cellulose, hemicelluloses, and pectins are the main components of plant cell wall polysaccharides. These polysaccharides are often tightly packed, contain many different sugar residues, and are branched with a diversity of structures. To enable efficient degradation of these polysaccharides, fungi produce an extensive set of carbohydrate-active enzymes. The variety of the enzyme set differs between fungi and often corresponds to the requirements of its habitat. Carbohydrate-active enzymes can be organized in different families based on the amino acid sequence of the structurally related catalytic modules. Fungal enzymes involved in plant polysaccharide degradation are assigned to at least 35 glycoside hydrolase families, three carbohydrate esterase families and six polysaccharide lyase families. This mini-review will discuss the enzymes needed for complete degradation of plant polysaccharides and will give an overview of the latest developments concerning fungal carbohydrate-active enzymes and their corresponding families

Multi-messenger observations of a binary neutron star merger

On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to 300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m 2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

Multiwavelength observations of GRB 140629A: A long burst with an achromatic jet break in the optical and X-ray afterglow

Aims. We investigate the long gamma-ray burst (GRB) 140629A through multiwavelength observations to derive the properties of the dominant jet and its host galaxy. Methods. The afterglow and host galaxy observations were taken in the optical (Swift/UVOT and various facilities worldwide), infrared (Spitzer), and X-rays (Swift/XRT) between 40 s and 3 yr after the burst trigger. Results. Polarisation observations by the MASTER telescope indicate that this burst is weakly polarised. The optical spectrum contains absorption features, from which we confirm the redshift of the GRB as originating at z = 2.276 ± 0.001. We performed spectral fitting of the X-rays to optical afterglow data and find there is no strong spectral evolution. We determine the hydrogen column density NH to be 7.2 × 1021 cm−2 along the line of sight. The afterglow in this burst can be explained by a blast wave jet with a long-lasting central engine expanding into a uniform medium in the slow cooling regime. At the end of energy injection, a normal decay phase is observed in both the optical and X-ray bands. An achromatic jet break is also found in the afterglow light curves ∼0.4 d after trigger. We fit the multiwavelength data simultaneously with a model based on a numerical simulation and find that the observations can be explained by a narrow uniform jet in a dense environment with an opening angle of 6.7◦ viewed 3.8◦ off-axis, which released a total energy of 1.4 × 1054 erg. Using the redshift and opening angle, we find GRB 140629A follows both the Ghirlanda and Amati relations. From the peak time of the light curve, identified as the onset of the forward shock (181s after trigger), the initial Lorentz factor (Γ0) is constrained in the range 82-118. Fitting the host galaxy photometry, we find the host to be a low mass, star-forming galaxy with a star formation rate of log (SFR) = 1.1+−00.94 M yr−1. We obtain a value of the neutral hydrogen density by fitting the optical spectrum, log NHI = 21.0 ± 0.3, classifying this host as a damped Lyman-alpha. High ionisation lines (N v, Si iv) are also detected in the spectrum. © ESO 2019.China Scholarship Council, CSCNational Science Foundation, NSFNational Basic Research Program of China (973 Program): DST/IMRCD/BRICS/Pilotcall/ProFCheap/2017, 2018YFA0404204, NSFC-1183300317-52-80133Agenzia Spaziale Italiana, ASI: 2015-046-R.0Ministry of Education and Science of the Russian Federation, Minobrnauka: 2019-05-595-0001-2496, 2019-05-592-0001-729317-52-80139 BRICS-aAgenzia Spaziale Italiana, ASI201406660015Leverhulme TrustEuropean Regional Development Fund, FEDER: AYA-2015-71718-RNational Research Foundation, NRF: 2018R1A2A1A05022685Horizon 2020 Framework Programme, H2020: 654215★ Research supported by the China Scholarship Council. † Deceased.7 IRAF is distributed by the National Optical Astronomy Observatory, which is operated by the Association of Universities for Research in Astronomy, Inc. under cooperative agreement with the National Science Foundation. http://ast.noao.edu/data/softwareAcknowledgements. Acknowledge the support by the program of China Scholarships Council (CSC) under the Grant no. 201406660015. We also acknowledge support from the Spanish MINEICO ministry and European FEDER funds AYA-2015-71718-R. SRO gratefully acknowledges the support of the Leverhulme Trust Early Career Fellowship. RS-R acknowledges support from ASI (Italian Space Agency) through the Contract no. 2015-046-R.0 and from European Union Horizon 2020 Programme under the AHEAD project (grant agreement no. 654215). MASTER equipment is supported by Lomonosov MSU Development Program and by Moscow Union OPTIKA. VL,EG, NT, VK are supported by BRICS RFBR grant 17-52-80133. MASTER-Tunka equipment is supported of Russian Federation Ministry of Science and High Education (grants 2019-05-592-0001-7293 and 2019-05-595-0001-2496). B.-B.Z. acknowledges support from the National Key Research and Development Program of China (2018YFA0404204), and NSFC-11833003. S.B.P. acknowledges BRICS grant DST/IMRCD/BRICS/Pilotcall/ProFCheap/2017(G) for this work. I.D. acknowledges L. Piro his invitation and financial support to visit and work at IAPS (Rome). We also acknowledge the use of the public data from the Swift data archive. We thank the excellent support form the GTC staff which is located at Observatorio del Roque de los Muchachos at Canary Islands (Spain). Thanks to the data support by NASA with Spitzer Space Telescope. SP and RB acknowledge support from RBRF grant 17-52-80139 BRICS-a. IHP acknowledges support from NRF 2018R1A2A1A05022685. Finally, we want to thank the anonymous referee for his/her comments, which have substantially improved the manuscript