Network analytical view of international trade in music

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Urban Studies and Planning, 2010.Cataloged from PDF version of thesis.Includes bibliographical references (p. 187-209).What are the effects of imports on export development? Would low influence from imports provide more opportunity to local producers to develop radically new products that could later be exported as a uniquely local specialization? Or would a lack of influence from imports only lead to local products being incompatible with foreign tastes or standards, thus hindering export development? I argue that consuming imports has a homogenizing effect on tastes, and domestic music that thrives in such an altered selective environment is more likely to be exportable as well. In a longitudinal network analysis of trade in music recordings, I find that success in developing new export markets was strongly dependent on importing history. The strongest effect from consuming imports for a given country's industry was in the likelihood of exporting to other countries that have experienced the same influences. I find that other industries describe a spectrum in terms of how strongly trade patterns are shaped by common influence effects in a cross-sectional network analysis of trade patterns beyond music. Other industries that were strongly shaped by common influence effects included goods that are largely valued in terms of personal tastes or cultural context. Industries at the opposite end of the spectrum, with very low common influence effects, included goods that are highly uniform or have an essentially objective utilitarian function. A middle group included goods for which personal taste is relevant, but also have widely shared criteria for quality. These findings are novel and important in that they require us to add the demand side, via the history of consumption of imports, to our understanding of global competitiveness in export development. The method of quantitative network analysis allows for a careful analysis of the endogenous dynamics of the global pattern of trade.by Jesse Conan Chu-Shore.Ph.D

Clobazam as an adjunctive therapy in treating seizures associated with Lennox–Gastaut syndrome

Lennox–Gastaut syndrome (LGS) is a devastating childhood epilepsy syndrome characterized by the occurrence of multiple types of seizures and cognitive decline. Most children suffer from frequent seizures that are refractory to current medical management. Recent clinical trials have suggested that addition of clobazam may improve the clinical outcome for some LGS patients. Although clobazam has been available for over five decades, it has only recently been approved by the US Food and Drug Administration for this indication. As a 1,5-benzodiazepine, clobazam is structurally related to the widely used 1,4-benzodiazepines, which include diazepam. Clobazam has been shown to modulate GABAergic neurotransmission by positive allosteric modulation of GABAA receptors, and to increase expression of transporters for both GABA and glutamate. The active metabolite n-desmethylclobazam (norclobazam) also modulates GABAA receptors, and the relative importance of these two compounds in the clinical effectiveness of clobazam remains an open question. Clinical trials involving clobazam as an addon therapy in a variety of pediatric epilepsy populations have found a significant improvement in seizure control. In patients with LGS, clobazam may have greatest efficacy for drop seizures. Longstanding clinical experience suggests that clobazam is a safe and well tolerated antiepileptic drug with infrequent and mild adverse effects. These results suggest that adjunctive treatment with clobazam may be a reasonable option for LGS patients, particularly those who are treatment-resistant

Superluminal Noncommutative Photons

With the help of the Seiberg-Witten map, one can obtain an effective action of a deformed QED from a noncommutative QED. Starting from the deformed QED, we investigate the propagation of photons in the background of electromagnetic field, up to the leading order of the noncommutativity parameter. In our setting (both the electric and magnetic fields are parallel to the coordinate axis $x^1$ and the nonvanishing component of the noncommutativity parameter is $\theta^{23}$), we find that the electric field has no effect on the propagation of photons, but the velocity of photons can be larger than the speed of light ($c=1$) when the propagating direction of photons is perpendicular to the direction of background magnetic field, while the light-cone condition does not change when the propagating direction is parallel to the background magnetic field. The causality associated with the superluminal photons is discussed briefly.Comment: Revtex, 11 pages, v3: corrected an estimation on page 7 of deviation from the speed of ligh

Secular changes in severity of intellectual disability in tuberous sclerosis complex: A reflection of improved identification and treatment of epileptic spasms?

Tuberous sclerosis complex (TSC) is a multisystem genetic disorder caused by mutations in TSC1 or TSC2. Epilepsy occurs in 80 to 90% of affected individuals during their lifetime, and up to one third of children with TSC will develop epileptic (infantile) spasms, for which vigabatrin has been shown to be particularly effective. Epilepsy severity and epileptic spasms are consistent markers of risk for the development of intellectual impairment in TSC. While previous studies demonstrate a bimodal distribution of intellectual ability in TSC, recent findings suggest a unimodal distribution, which may reflect a change in IQ distribution over time. We compared three large historical UK cohorts of TSC (n=331) that show varied distributions of intellectual ability, first ruling out differences in study methodology. Later‐born individuals had a higher frequency of reported spasms and higher likelihood of vigabatrin administration, but were less likely to have profound intellectual impairment, compared to the earlier‐born individuals. Our findings suggest that epileptic spasms went undetected in the older patients and therefore were not treated, leading to a higher occurrence of profound impairment, whereas the later born cohort had better access to treatment. These findings support the importance of early identification and treatment of seizures in TSC

Quasiparticle excitations in relativistic quantum field theory

We analyze the particle-like excitations arising in relativistic field theories in states different than the vacuum. The basic properties characterizing the quasiparticle propagation are studied using two different complementary methods. First we introduce a frequency-based approach, wherein the quasiparticle properties are deduced from the spectral analysis of the two-point propagators. Second, we put forward a real-time approach, wherein the quantum state corresponding to the quasiparticle excitation is explicitly constructed, and the time-evolution is followed. Both methods lead to the same result: the energy and decay rate of the quasiparticles are determined by the real and imaginary parts of the retarded self-energy respectively. Both approaches are compared, on the one hand, with the standard field-theoretic analysis of particles in the vacuum and, on the other hand, with the mean-field-based techniques in general backgrounds.Comment: 53 pages, 4 figures. Version accepted for publication in Ann. Phy

Moments of Nucleon Light Cone Quark Distributions Calculated in Full Lattice QCD

Moments of the quark density, helicity, and transversity distributions are calculated in unquenched lattice QCD. Calculations of proton matrix elements of operators corresponding to these moments through the operator product expansion have been performed on $16^3 \times 32$ lattices for Wilson fermions at $\beta = 5.6$ using configurations from the SESAM collaboration and at $\beta = 5.5$ using configurations from SCRI. One-loop perturbative renormalization corrections are included. At quark masses accessible in present calculations, there is no statistically significant difference between quenched and full QCD results, indicating that the contributions of quark-antiquark excitations from the Dirac Sea are small. Close agreement between calculations with cooled configurations containing essentially only instantons and the full gluon configurations indicates that quark zero modes associated with instantons play a dominant role. Naive linear extrapolation of the full QCD calculation to the physical pion mass yields results inconsistent with experiment. Extrapolation to the chiral limit including the physics of the pion cloud can resolve this discrepancy and the requirements for a definitive chiral extrapolation are described.Comment: 53 Pages Revtex, 26 Figures, 9 Tables. Added additional reference and updated referenced data in Table I

Coupling ultracold atoms to mechanical oscillators

In this article we discuss and compare different ways to engineer an interface between ultracold atoms and micro- and nanomechanical oscillators. We start by analyzing a direct mechanical coupling of a single atom or ion to a mechanical oscillator and show that the very different masses of the two systems place a limit on the achievable coupling constant in this scheme. We then discuss several promising strategies for enhancing the coupling: collective enhancement by using a large number of atoms in an optical lattice in free space, coupling schemes based on high-finesse optical cavities, and coupling to atomic internal states. Throughout the manuscript we discuss both theoretical proposals and first experimental implementations.Comment: 19 pages, 9 figure

Theta dependence of SU(N) gauge theories in the presence of a topological term

We review results concerning the theta dependence of 4D SU(N) gauge theories and QCD, where theta is the coefficient of the CP-violating topological term in the Lagrangian. In particular, we discuss theta dependence in the large-N limit. Most results have been obtained within the lattice formulation of the theory via numerical simulations, which allow to investigate the theta dependence of the ground-state energy and the spectrum around theta=0 by determining the moments of the topological charge distribution, and their correlations with other observables. We discuss the various methods which have been employed to determine the topological susceptibility, and higher-order terms of the theta expansion. We review results at zero and finite temperature. We show that the results support the scenario obtained by general large-N scaling arguments, and in particular the Witten-Veneziano mechanism to explain the U(1)_A problem. We also compare with results obtained by other approaches, especially in the large-N limit, where the issue has been also addressed using, for example, the AdS/CFT correspondence. We discuss issues related to theta dependence in full QCD: the neutron electric dipole moment, the dependence of the topological susceptibility on the quark masses, the U(1)_A symmetry breaking at finite temperature. We also consider the 2D CP(N) model, which is an interesting theoretical laboratory to study issues related to topology. We review analytical results in the large-N limit, and numerical results within its lattice formulation. Finally, we discuss the main features of the two-point correlation function of the topological charge density.Comment: A typo in Eq. (3.9) has been corrected. An additional subsection (5.2) has been inserted to demonstrate the nonrenormalizability of the relevant theta parameter in the presence of massive fermions, which implies that the continuum (a -> 0) limit must be taken keeping theta fixe

A pre-docking source for the power-law behavior of spontaneous quantal release: application to the analysis of LTP

In neurons, power-law behavior with different scaling exponents has been reported at many different levels, including fluctuations in membrane potentials, synaptic transmission up to neuronal network dynamics. Unfortunately in most cases the source of this nonlinear feature remains controversial. Here we have analyzed the dynamics of spontaneous quantal release at hippocampal synapses and characterized their power-law behavior. While in control conditions a fractal exponent greater than zero was rarely observed, its value was greatly increased by α-latrotoxin (α-LTX), a potent stimulator of spontaneous release, known to act at the very last step of vesicle fusion. Based on computer modeling, we confirmed that at an increase in fusion probability would unmask a pre-docking phenomenon with 1/f structure, where α estimated from the release series appears to sense the increase in release probability independently from the number of active sites. In the simplest scenario the pre-docking 1/f process could coincide with the Brownian diffusion of synaptic vesicles. Interestingly, when the effect of long-term potentiation (LTP) was tested, a ∼200% long-lasting increase in quantal frequency was accompanied by a significant increase in the scaling exponent. The similarity between the action of LTP and of α-LTX suggests an increased contribution of high release probability sites following the induction of LTP. In conclusion, our results indicate that the source of the synaptic powerlaw behavior arises before synaptic vesicles dock to the active zone and that the fractal exponent α is capable of sensing a change in release probability independently from the number of active sites or synapses. © 2015 Lamanna, Signorini, Cerutti and Malgaroli