Using Shape Memory Alloys: A Dynamic Data Driven Approach

AbstractShape Memory Alloys (SMAs) are capable of changing their crystallographic structure due to changes of either stress or temperature. SMAs are used in a number of aerospace devices and are required in some devices in exotic environments. We are developing dynamic data driven application system (DDDAS) tools to monitor and change SMAs in real time for delivering payloads by aerospace vehicles. We must be able to turn on and off the sensors and heating units, change the stress on the SMA, monitor on-line data streams, change scales based on incoming data, and control what type of data is generated. The application must have the capability to be run and steered remotely as an unmanned feedback control loop

Anti-haemostatic compounds from the vampire snail Cumia reticulata: Molecular cloning and in-silico structure-function analysis

Blood-feeding animals are known for their ability to produce bioactive compounds to impair haemostasis and suppress pain perception in the host. These compounds are extremely appealing for pharmacological development since they are generally very effective and specific for their molecular target. A preliminary RNA-Seq based characterization of the secretion from salivary and mid-oesophageal tissues of the vampire snail Cumia reticulata, revealed a complex mixture of feeding-related transcripts with potential anaesthetic and anticoagulant action. Based on the cloned full-length mRNAs, it was possible to verify the sequence of five genes encoding haematophagy-related products. The in silico modelled three-dimensional structure of each translational product was analysed to gain information on their potential biochemical activity. We have hereby validated and further investigated the assembled transcripts presumably involved in the antihaemostatic action, to improve our comprehensive understanding of this subset of the feeding secretion. The studied proteins included both inhibitors of primary haemostasis such as the vWFA domain-containing proteins, and compounds targeting different steps of the coagulation cascade, as e.g. the Turripeptide-like/protease inhibitor, the TFPI-like multiple Kunitz-type protease inhibitors, the Meprin-like metalloproteases and the Astacin/ShKT-like domain-containing proteins. All these molecules showed promising potential for pharmacological development