Immunoexpression of cleaved caspase-3 shows lower apoptotic area indices in lip carcinomas than in intraoral cancer

Objective This study aimed to evaluate apoptosis by assessing cleaved caspase-3 immunoexpression in hyperplastic, potentially malignant disorder (PMD), and malignant tumors in intraoral and lower lip sites. Material and Methods A retrospective study using paraffin blocks with tissues from patients with inflammatory fibrous hyperplasia (IFH), actinic cheilitis, oral leukoplakia, lower lip and intraoral squamous cell carcinoma (SCC) was performed. The tissues were evaluated by immunohistochemical analysis with anti-cleaved caspase-3 antibody. Apoptotic area index was then correlated with lesion type. Results From 120 lesions assessed, 55 (46%) were cleaved caspase-3-positive. The SCC samples (n=40) had the highest apoptotic area indices (n=35; 87.5%). Significant differences were detected between SCCs and PMDs (p=0.0003), as well as SCCs and IFHs (p=0.001), regarding caspase-3 immunopositivity. Carcinomas of the lower lip had lower apoptotic area indices than intraoral cancer (p=0.0015). Conclusions Cleaved caspase-3 immunoexpression showed differences in oral SCCs and PMDs and demonstrated a distinct role of apoptosis in carcinogenesis of intraoral and lower lip cancer. In future, the expression of cleaved caspase-3 with other target molecules in oral cancer may be helpful in delineating the prognosis and treatment of these tumors

Reuse of treated domestic sewage for biquinho pepper cultivation

This study aimed to evaluate the reuse of treated domestic sewage in biquinho pepper (Capsicum chinense L.) cultivation under different irrigation regimes. The experiment was carried out in a greenhouse, in a randomised block design with a 3 x 4 factorial scheme, with four replications. Forty-eight pepper plants were subjected to three treated domestic sewage concentrations (0, 50, and 100%) and four irrigation depths (75, 100, 125, and 150% of the crop evapotranspiration - ETc). Data for ETc estimation were obtained from an automatic meteorological station, which was installed in the greenhouse. The results showed that irrigation depths corresponding to 125 and 150% of the ETc at a concentration of 100% treated domestic sewage resulted in higher plants. Moreover, longer fruits were obtained when plants were subjected to 100% ETc at 100% treated domestic sewage. The studied irrigation depths influenced pepper fruit total weight and yield. No treated domestic sewage concentrations significantly influenced the variables analysed. Treated domestic sewage reuse can constitute an alternative for quality water saving and for chemical fertilisation of biquinho pepper crop. Highlights: The growing of beak pepper with domestic sewage treated can bring benefits in terms of providing nutrients to the crops; Adequate levels of water replacement with domestic sewage treated may promote good crop development. The use of treated domestic sewage can be an alternative to reduce the use of better quality water and chemical fertilization in the growing of beak pepper. Reduction of environmental impact may be possible with the replacement of chemical fertilizer by domestic sewage treated in the growing of beak pepper.This study aimed to evaluate the reuse of treated domestic sewage in biquinho pepper (Capsicum chinense L.) cultivation under different irrigation regimes. The experiment was carried out in a greenhouse, in a randomised block design with a 3 x 4 factorial scheme, with four replications. Forty-eight pepper plants were subjected to three treated domestic sewage concentrations (0, 50, and 100%) and four irrigation depths (75, 100, 125, and 150% of the crop evapotranspiration - ETc). Data for ETc estimation were obtained from an automatic meteorological station, which was installed in the greenhouse. The results showed that irrigation depths corresponding to 125 and 150% of the ETc at a concentration of 100% treated domestic sewage resulted in higher plants. Moreover, longer fruits were obtained when plants were subjected to 100% ETc at 100% treated domestic sewage. The studied irrigation depths influenced pepper fruit total weight and yield. No treated domestic sewage concentrations significantly influenced the variables analysed. Treated domestic sewage reuse can constitute an alternative for quality water saving and for chemical fertilisation of biquinho pepper crop. Highlights: The growing of beak pepper with domestic sewage treated can bring benefits in terms of providing nutrients to the crops; Adequate levels of water replacement with domestic sewage treated may promote good crop development. The use of treated domestic sewage can be an alternative to reduce the use of better quality water and chemical fertilization in the growing of beak pepper. Reduction of environmental impact may be possible with the replacement of chemical fertilizer by domestic sewage treated in the growing of beak pepper

New possibilities for militancy in the field of healthcare: affirmation of deviations in encounters among SUS workers, managers and users

The authors make comments about militancy in the field of healthcare, especially for defending the Brazilian Unified Health System (SUS) as a universal public policy. After indicating some strategies for such militancy, the text discusses centralism and the identifying nature of these practices. It highlights and questions four forms of centralism: the common good in its representations; procedures as offers of health technologies; users and notions about their needs/demands; and careless protection of life. As an alternative, the authors propose a new form of militancy within SUS, as intensive practice produced at the meeting point within the dimension of the relationship between managers, workers and users.Os autores tecem considerações sobre a militância no campo da saúde, em especial na defesa do Sistema Único de Saúde (SUS), enquanto uma política pública universal. Após apontar algumas estratégias desta militância, o texto discute o centralismo e o caráter identitário dessas práticas. Destacam e problematizam quatro formas de centralismo: do bem comum em suas representações; o procedimento como oferta de tecnologias de saúde; do usuário e as concepções sobre suas necessidades/demandas; e da proteção inadvertida da vida. Propõem, como alternativa, uma nova militância no SUS, como prática intensiva e produzida no encontro, na dimensão relacional, entre gestores, trabalhadores e usuários.Los autores elaboran consideraciones sobre la militanoia en el campo de la salud, especialmente en defensa del Sistema Único de Salud (SUS) como política públioa universal. Tras presentar algunas estrategias de esta miliancia, el texto discute el centralismo y el caracter de identidad de estas prácticas. Destacan el conjunto de problemas de cuatro formas de centralismo: del bien común en sus representaciones; el procedimiento como oferta de tecnologías de salud; del usuario y los conceptos sobre sus necesidades/demandas; el de la protección inadvertida de la vida. Proponen como alternativa una nueva militancia en el SUS como práctica intensiva y producida en el encuentro, en dimensión nacional, entre gestores, trabajadores y usuarios.52352

Magnitude e determinantes da mortalidade neonatal e pós-neonatal em Goiânia, Goiás: um estudo de coorte retrospectivo, 2012

Objective. To estimate magnitude and determinants of neonatal and post-neonatal mortality rates in Goiânia, Brazil, 2012. Methods.  Retrospective cohort study, using linkage of Live Births Information System and Mortality Information System. It has been used logistic regression to evaluate neonatal e post-neonatal death associated factors. Results. Neonatal mortality (0-27 days of life) was 9.4; and post-neonatal (28-364 days of life) was 3.0 deaths per 1,000 live births. Neonatal mortality associated factors were: 0-3 prenatal care visits (OR=13.10 – CI95% 7.48;22.96), 19-34-week pregnancy (OR=6.25 – CI95% 2.26;17.29), weight at birth <1,500g (OR=62.42 – CI95% 22.72;171.48) and cesarean delivery (OR=0.54 – CI95% 0.37;0.79). For post-neonatal period they were: 0-3 prenatal appointments (OR=4.16 – CI95% 1.51;11.43) and weight at birth <1.500g (OR=18.74 – CI95% 4.04;87.00). Conclusion: Low number of prenatal care visits, premature delivery and low weight at birth were the main determinants of neonatal and post-neonatal mortality.Objetivo. Estimar a magnitude e determinantes da mortalidade infantil neonatal e pós-neonatal em Goiânia, Brasil, em 2012. Métodos. Estudo de coorte retrospectiva, utilizando relacionamento entre o Sistema de Informações sobre Nascidos Vivos e o Sistema de Informações sobre Mortalidade. Aplicou-se regressão logística para avaliar os fatores associados ao óbito neonatal e pós-neonatal. Resultados. A mortalidade neonatal (0-27 dias de vida) foi de 9,4; e a pós-neonatal (28-364 dias de vida), de 3,0 óbitos/1000 nascidos vivos. Os fatores associados à mortalidade neonatal foram: 0-3 consultas de pré-natal (OR=13,10 – IC95% 7,48;22,96); gestações de 19-34 semanas (OR=6,25 – IC95% 2,26;17,29); peso ao nascer <1.500g (OR=62,42 – IC95% 22,72;171,48); e parto cesáreo (OR=0,54 – IC95% 0,37;0,79). Associaram-se à mortalidade no período pós-neonatal: 0-3 consultas de pré-natal (OR=4,16 – IC95% 1,51;11,43); e peso ao nascer <1.500g (OR=18,74 – IC95% 4,04;87,00). Conclusão. Baixo número de consultas, prematuridade e baixo peso foram os principais fatores de risco da mortalidade neonatal e pós-neonatal

Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector

A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results

Observation of associated near-side and away-side long-range correlations in √sNN=5.02 TeV proton-lead collisions with the ATLAS detector

Two-particle correlations in relative azimuthal angle (Δϕ) and pseudorapidity (Δη) are measured in √sNN=5.02  TeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1  μb-1 of data as a function of transverse momentum (pT) and the transverse energy (ΣETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Δη|<5) “near-side” (Δϕ∼0) correlation that grows rapidly with increasing ΣETPb. A long-range “away-side” (Δϕ∼π) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ΣETPb, is found to match the near-side correlation in magnitude, shape (in Δη and Δϕ) and ΣETPb dependence. The resultant Δϕ correlation is approximately symmetric about π/2, and is consistent with a dominant cos⁡2Δϕ modulation for all ΣETPb ranges and particle pT

Jet size dependence of single jet suppression in lead-lead collisions at sqrt(s(NN)) = 2.76 TeV with the ATLAS detector at the LHC

Measurements of inclusive jet suppression in heavy ion collisions at the LHC provide direct sensitivity to the physics of jet quenching. In a sample of lead-lead collisions at sqrt(s) = 2.76 TeV corresponding to an integrated luminosity of approximately 7 inverse microbarns, ATLAS has measured jets with a calorimeter over the pseudorapidity interval |eta| < 2.1 and over the transverse momentum range 38 < pT < 210 GeV. Jets were reconstructed using the anti-kt algorithm with values for the distance parameter that determines the nominal jet radius of R = 0.2, 0.3, 0.4 and 0.5. The centrality dependence of the jet yield is characterized by the jet "central-to-peripheral ratio," Rcp. Jet production is found to be suppressed by approximately a factor of two in the 10% most central collisions relative to peripheral collisions. Rcp varies smoothly with centrality as characterized by the number of participating nucleons. The observed suppression is only weakly dependent on jet radius and transverse momentum. These results provide the first direct measurement of inclusive jet suppression in heavy ion collisions and complement previous measurements of dijet transverse energy imbalance at the LHC.Comment: 15 pages plus author list (30 pages total), 8 figures, 2 tables, submitted to Physics Letters B. All figures including auxiliary figures are available at http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/HION-2011-02