Método clínico centrado na pessoa os desafios entre o modelo biomédico e a longitudinalidade na promoção social de saúde

O modelo biomédico é diminuto para compreender e atender o processo do adoecimento de uma forma ampla. Para isso, a medicina centrada na pessoa cumpre uma quebra de paradigmas na produção social de saúde. Sendo assim, o objetivo deste trabalho é analisar o Método Clínico Centrado na Pessoa (MCCP) como estratégia de promoção de saúde para o cumprimento da longitudinalidade. Trata-se de uma mini revisão de literatura, que utilizou os bancos de dados Google Acadêmico e Scientific Electronic Library Online (SciELO). Foram utilizadas combinações entre as seguintes palavras-chave, consideradas descritores no Descritores em Ciências de Saúde (DeCs): Medicina Clínica, Tomada de Decisão Compartilhada, Assistência Centrada no Paciente e selecionados 5 artigos publicados nos últimos dez anos e em língua portuguesa. Os resultados demonstraram que mais da metade dos pacientes não são incluídos pelo profissional no planejamento do tratamento e cuidado. Há queixas que os médicos não explicam de forma clara e acessível as indicações terapêuticas ao paciente em um número significativo das consultas, bem como não verificam a sua compreensão. O paciente assume o papel de submissão, o que compromete o seguimento da orientação terapêutica e adesão ao tratamento proposto. Conclui-se que o MCCP traz resultados mais satisfatórios para as consultas médicas quando comparado ao modelo biomédico, uma vez que engloba o biopsicossocial e a experiência do indivíduo com a doença.&nbsp

Expression profile of genes associated with mastitis in dairy cattle

In order to characterize the expression of genes associated with immune response mechanisms to mastitis, we quantified the relative expression of the IL-2, IL-4, IL-6, IL-8, IL-10, IFN-γ and TNF- α genes in milk cells of healthy cows and cows with clinical mastitis. Total RNA was extracted from milk cells of six Black and White Holstein (BW) cows and six Gyr cows, including three animals with and three without mastitis per breed. Gene expression was analyzed by real-time PCR. IL-10 gene expression was higher in the group of BW and Gyr cows with mastitis compared to animals free of infection from both breeds (p < 0.05). It was also higher in BW Holstein animals with clinical mastitis (p < 0.001), but it was not significant when Gyr cows with and without mastitis were compared (0.05 < p < 0.10). Among healthy cows, BW Holstein animals tended to present a higher expression of all genes studied, with a significant difference for the IL-2 and IFN- γ genes (p < 0.001). For animals with mastitis no significant difference in gene expression was observed between the two breeds. These findings suggest that animals with mastitis develop a preferentially cell-mediated immune response. Further studies including larger samples are necessary to better characterize the gene expression profile in cows with mastitis

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

Study of the B-c(+) -> J/psi D-s(+) and Bc(+) -> J/psi D-s*(+) decays with the ATLAS detector

The decays B-c(+) -> J/psi D-s(+) and B-c(+) -> J/psi D-s*(+) are studied with the ATLAS detector at the LHC using a dataset corresponding to integrated luminosities of 4.9 and 20.6 fb(-1) of pp collisions collected at centre-of-mass energies root s = 7 TeV and 8 TeV, respectively. Signal candidates are identified through J/psi -> mu(+)mu(-) and D-s(()*()+) -> phi pi(+)(gamma/pi(0)) decays. With a two-dimensional likelihood fit involving the B-c(+) reconstructed invariant mass and an angle between the mu(+) and D-s(+) candidate momenta in the muon pair rest frame, the yields of B-c(+) -> J/psi D-s(+) and B-c(+) -> J/psi D-s*(+), and the transverse polarisation fraction in B-c(+) -> J/psi D-s*(+) decay are measured. The transverse polarisation fraction is determined to be Gamma +/-+/-(B-c(+) -> J/psi D-s*(+))/Gamma(B-c(+) -> J/psi D-s*(+)) = 0.38 +/- 0.23 +/- 0.07, and the derived ratio of the branching fractions of the two modes is B-Bc+ -> J/psi D-s*+/B-Bc+ -> J/psi D-s(+) = 2.8(-0.8)(+1.2) +/- 0.3, where the first error is statistical and the second is systematic. Finally, a sample of B-c(+) -> J/psi pi(+) decays is used to derive the ratios of branching fractions B-Bc+ -> J/psi D-s*+/B-Bc+ -> J/psi pi(+) = 3.8 +/- 1.1 +/- 0.4 +/- 0.2 and B-Bc+ -> J/psi D-s*+/B-Bc+ -> J/psi pi(+) = 10.4 +/- 3.1 +/- 1.5 +/- 0.6, where the third error corresponds to the uncertainty of the branching fraction of D-s(+) -> phi(K+ K-)pi(+) decay. The available theoretical predictions are generally consistent with the measurement

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear understanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5,6,7 vast areas of the tropics remain understudied.8,9,10,11 In the American tropics, Amazonia stands out as the world's most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepresented in biodiversity databases.13,14,15 To worsen this situation, human-induced modifications16,17 may eliminate pieces of the Amazon's biodiversity puzzle before we can use them to understand how ecological communities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple organism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region's vulnerability to environmental change. 15%–18% of the most neglected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lost

A search for an excited muon decaying to a muon and two jets in pp collisions at √s = 8 TeV with the ATLAS detector

A new search signature for excited leptons is explored. Excited muons are sought in the channel $pp \to \mu\mu^* \to \mu \mu\textrm{ jet jet}$, assuming both the production and decay occur via a contact interaction. The analysis is based on 20.3 fb$^{-1}$ of $pp$ collision data at a centre-of-mass energy of $\sqrt{s}$ = 8 TeV taken with the ATLAS detector at the Large Hadron Collider. No evidence of excited muons is found, and limits are set at the 95% confidence level on the cross section times branching ratio as a function of the excited-muon mass $m_{\mu^*}$. For $m_{\mu^*}$ between 1.3 TeV and 3.0 TeV, the upper limit on $\sigma B(\mu^* \to \mu q \bar{q}$) is between 0.6 and 1 fb. Limits on $\sigma B$ are converted to lower bounds on the compositeness scale $\Lambda$. In the limiting case $\Lambda = m_{\mu^*}$, excited muons with a mass below 2.9 TeV are excluded. With the same model assumptions, these limits at larger $\mu^*$ masses improve upon previous limits from traditional searches based on the gauge-mediated decay $\mu^* \to \mu \gamma$.Comment: 33 pages in total, author list starting page 16, 4 figures, 5 tables, final version published by New Journal of Physics including corrections in Erratum https://dx.doi.org/10.1088/1367-2630/ab46ed. All figures including auxiliary are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/EXOT-2015-0

Search for anomalous electroweak production of WW/WZ in association with a high-mass dijet system in pp collisions at √s=8 TeV with the ATLAS detector

A search is presented for anomalous quartic gauge boson couplings in vector-boson scattering. The data for the analysis correspond to $20.2$ fb$^{-1}$ of $\sqrt{s}=8$ TeV $pp$ collisions, and were collected in 2012 by the ATLAS experiment at the Large Hadron Collider. The search looks for the production of $WW$ or $WZ$ boson pairs accompanied by a high-mass dijet system, with one $W$ decaying leptonically, and a $W$ or $Z$ decaying hadronically. The hadronically decaying $W/Z$ is reconstructed as either two small-radius jets or one large-radius jet using jet substructure techniques. Constraints on the anomalous quartic gauge boson coupling parameters $\alpha_4$ and $\alpha_5$ are set by fitting the transverse mass of the diboson system, and the resulting 95% confidence intervals are $-0.024<\alpha_4<0.030$ and $-0.028<\alpha_5<0.033$.Comment: 38 pages in total, author list starting page 22, 5 figures, 2 tables, published in Phys. Rev. D. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2015-09