1,101 research outputs found
Effect of Ambrotose AOÂź on resting and exercise-induced antioxidant capacity and oxidative stress in healthy adults
<p>Abstract</p> <p>Background</p> <p>The purpose of this investigation was to determine the effects of a dietary supplement (Ambrotose AO<sup>Âź</sup>) on resting and exercise-induced blood antioxidant capacity and oxidative stress in exercise-trained and untrained men and women.</p> <p>Methods</p> <p>25 individuals (7 trained and 5 untrained men; 7 trained and 6 untrained women) received Ambrotose AO<sup>Âź </sup>(4 capsules per day = 2 grams per day) or a placebo for 3 weeks in a random order, double blind cross-over design (with a 3 week washout period). Blood samples were collected at rest, and at 0 and 30 minutes following a graded exercise treadmill test (GXT) performed to exhaustion, both before and after each 3 week supplementation period. Samples were analyzed for Trolox Equivalent Antioxidant Capacity (TEAC), Oxygen Radical Absorbance Capacity (ORAC), malondialdehyde (MDA), hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), and nitrate/nitrite (NOx). Quality of life was assessed using the SF-12 form and exercise time to exhaustion was recorded. Resting blood samples were analyzed for complete blood count (CBC), metabolic panel, and lipid panel before and after each 3 week supplementation period. Dietary intake during the week before each exercise test was recorded.</p> <p>Results</p> <p>No condition effects were noted for SF-12 data, for GXT time to exhaustion, or for any variable within the CBC, metabolic panel, or lipid panel (p > 0.05). Treatment with Ambrotose AO<sup>Âź </sup>resulted in an increase in resting levels of TEAC (p = 0.02) and ORAC (p < 0.0001). No significant change was noted in resting levels of MDA, H<sub>2</sub>O<sub>2</sub>, or NOx (p > 0.05). Exercise resulted in an acute increase in TEAC, MDA, and H<sub>2</sub>O<sub>2 </sub>(p < 0.05), all which were higher at 0 minutes post exercise compared to pre exercise (p < 0.05). No condition effects were noted for exercise related data (p > 0.05), with the exception of ORAC (p = 0.0005) which was greater at 30 minutes post exercise for Ambrotose AO<sup>Âź </sup>compared to placebo.</p> <p>Conclusion</p> <p>Ambrotose AO<sup>Âź </sup>at a daily dosage of 4 capsules per day increases resting blood antioxidant capacity and may enhance post exercise antioxidant capacity. However, no statistically detected difference is observed in resting or exercise-induced oxidative stress biomarkers, in quality of life, or in GXT time to exhaustion.</p
The alhambra survey: evolution of galaxy spectral segregation
We study the clustering of galaxies as a function of spectral type and redshift in the range 0.35 <z <1.1 using data from the Advanced Large Homogeneous Area Medium Band Redshift Astronomical (ALHAMBRA) survey. The data cover 2.381 deg2 in 7 fields, after applying a detailed angular selection mask, with accurate photometric redshifts down to IAB <24. From this catalog we draw five fixed number density redshift-limited bins. We estimate the clustering evolution for two different spectral populations selected using the ALHAMBRA-based photometric templates: quiescent and star-forming galaxies. For each sample we measure the real-space clustering using the projected correlation function. Our calculations are performed over the range [0.03, 10.0] h-1 Mpc, allowing us to find a steeper trend for Mpc, which is especially clear for star-forming galaxies. Our analysis also shows a clear early differentiation in the clustering properties of both populations: star-forming galaxies show weaker clustering with evolution in the correlation length over the analyzed redshift range, while quiescent galaxies show stronger clustering already at high redshifts and no appreciable evolution. We also perform the bias calculation where similar segregation is found, but now it is among the quiescent galaxies where a growing evolution with redshift is clearer (abrigatted). These findings clearly corroborate the well-known color-density relation, confirming that quiescent galaxies are mainly located in dark matter halos that are more massive than those typically populated by star-forming galaxies.Ministerio de EconomĂa y Competitividad y FEDER AYA2010-22111-C03-02 AYA2013-48623-C2-2 AYA2012-39620 AYA2013-40611-P AYA2013-42227-P AYA2013-43188-P AYA2013-48623-C2-1 ESP2013-48274 AYA2014-58861-C3-1Junta de AndalucĂa TIC114 JA2828 P10-FQM-644
The ALHAMBRA survey: evolution of galaxy spectral segregation
We study the clustering of galaxies as a function of spectral type and
redshift in the range using data from the Advanced Large
Homogeneous Area Medium Band Redshift Astronomical (ALHAMBRA) survey. The data
cover 2.381 deg in 7 fields, after applying a detailed angular selection
mask, with accurate photometric redshifts [] down to
. From this catalog we draw five fixed number density,
redshift-limited bins. We estimate the clustering evolution for two different
spectral populations selected using the ALHAMBRA-based photometric templates:
quiescent and star-forming galaxies. For each sample, we measure the real-space
clustering using the projected correlation function. Our calculations are
performed over the range Mpc, allowing us to find a
steeper trend for Mpc, which is especially clear for
star-forming galaxies. Our analysis also shows a clear early differentiation in
the clustering properties of both populations: star-forming galaxies show
weaker clustering with evolution in the correlation length over the analysed
redshift range, while quiescent galaxies show stronger clustering already at
high redshifts, and no appreciable evolution. We also perform the bias
calculation where similar segregation is found, but now it is among the
quiescent galaxies where a growing evolution with redshift is clearer. These
findings clearly corroborate the well known colour-density relation, confirming
that quiescent galaxies are mainly located in dark matter halos that are more
massive than those typically populated by star-forming galaxies.Comment: 14 pages, 9 figures, accepted by Ap
The ALHAMBRA survey : Estimation of the clustering signal encoded in the cosmic variance
The relative cosmic variance () is a fundamental source of
uncertainty in pencil-beam surveys and, as a particular case of count-in-cell
statistics, can be used to estimate the bias between galaxies and their
underlying dark-matter distribution. Our goal is to test the significance of
the clustering information encoded in the measured in the ALHAMBRA
survey. We measure the cosmic variance of several galaxy populations selected
with band luminosity at as the intrinsic dispersion in
the number density distribution derived from the 48 ALHAMBRA subfields. We
compare the observational with the cosmic variance of the dark
matter expected from the theory, . This provides an
estimation of the galaxy bias . The galaxy bias from the cosmic variance is
in excellent agreement with the bias estimated by two-point correlation
function analysis in ALHAMBRA. This holds for different redshift bins, for red
and blue subsamples, and for several band luminosity selections. We find
that increases with the band luminosity and the redshift, as expected
from previous work. Moreover, red galaxies have a larger bias than blue
galaxies, with a relative bias of . Our results
demonstrate that the cosmic variance measured in ALHAMBRA is due to the
clustering of galaxies and can be used to characterise the affecting
pencil-beam surveys. In addition, it can also be used to estimate the galaxy
bias from a method independent of correlation functions.Comment: Astronomy and Astrophysics, in press. 9 pages, 4 figures, 3 table
The ALHAMBRA survey : band luminosity function of quiescent and star-forming galaxies at by PDF analysis
Our goal is to study the evolution of the band luminosity function (LF)
since using ALHAMBRA data. We used the photometric redshift and the
band selection magnitude probability distribution functions (PDFs) of those
ALHAMBRA galaxies with mag to compute the posterior LF. We
statistically studied quiescent and star-forming galaxies using the template
information encoded in the PDFs. The LF covariance matrix in
redshift-magnitude-galaxy type space was computed, including the cosmic
variance. That was estimated from the intrinsic dispersion of the LF
measurements in the 48 ALHAMBRA sub-fields. The uncertainty due to the
photometric redshift prior is also included in our analysis. We modelled the LF
with a redshift-dependent Schechter function affected by the same selection
effects than the data. The measured ALHAMBRA LF at and the
evolving Schechter parameters both for quiescent and star-forming galaxies
agree with previous results in the literature. The estimated redshift evolution
of is and , and of is
and . The measured faint-end slopes are and . We find a significant
population of faint quiescent galaxies, modelled by a second Schechter function
with slope . We find a factor decrease in the
luminosity density of star-forming galaxies, and a factor
increase in the of quiescent ones since , confirming the continuous
build-up of the quiescent population with cosmic time. The contribution of the
faint quiescent population to increases from 3% at to 6% at .
The developed methodology will be applied to future multi-filter surveys such
as J-PAS.Comment: Accepted for publication in Astronomy and Astrophysics. 25 pages, 20
figures, 7 table
Acoustic Intensity Causes Perceived Changes in Arousal Levels in Music: An Experimental Investigation
Listener perceptions of changes in the arousal expressed by classical music have been found to correlate with changes in sound intensity/loudness over time. This study manipulated the intensity profiles of different pieces of music in order to test the causal nature of this relationship. Listeners (Nâ=â38) continuously rated their perceptions of the arousal expressed by each piece. An extract from Dvorak's Slavonic Dance Opus 46 No 1 was used to create a variant in which the direction of change in intensity was inverted, while other features were retained. Even though it was only intensity that was inverted, perceived arousal was also inverted. The original intensity profile was also superimposed on three new pieces of music. The time variation in the perceived arousal of all pieces was similar to their intensity profile. Time series analyses revealed that intensity variation was a major influence on the arousal perception in all pieces, in spite of their stylistic diversity
High-resolution analysis of HLA class I alterations in colorectal cancer
BACKGROUND: Previous studies indicate that alterations in Human Leukocyte Antigen (HLA) class I expression are frequent in colorectal tumors. This would suggest serious limitations for immunotherapy-based strategies involving T-cell recognition. Distinct patterns of HLA surface expression might conceal different immune escape mechanisms employed by the tumors and are worth further study. METHOD: We applied four-color multiparameter flow cytometry (FCM), using a large panel of alloantigen-specific anti-HLA-A and -B monoclonal antibodies, to study membranous expression of individual HLA alleles in freshly isolated colorectal cancer cell suspensions from 21 patients. RESULTS: Alterations in HLA class I phenotype were observed in 8 (38%) of the 21 tumors and comprised loss of a single A or B alleles in 4 cases, and loss of all four A and B alleles in the other 4 cases. Seven of these 8 tumors were located on the right side of the colon, and those showing loss of both HLA-A and -B membranous expression were all of the MSI-H phenotype. CONCLUSION: FCM allows the discrimination of complex phenotypes related to the expression of HLA class I. The different patterns of HLA class I expression might underlie different tumor behavior and influence the success rate of immunotherapy
Cultural Transmission of Traditional Knowledge in two populations of North-western Patagonia
<p>Abstract</p> <p>Background</p> <p>In the present study we have investigated the cultural transmission of two types of traditional plant knowledge in two communities of North-western Patagonia, Argentina. In the Pilcaniyeu community, we studied the transmission of traditional knowledge related to horticultural practices in home-gardens, greenhouses and gardens; while in the community of Cuyin Manzano, we studied wild plant gathering customs.</p> <p>Methods</p> <p>Ethnobotanical fieldwork was conducted by means of semi-structured interviews, in which we investigated which plants are used, at what life history phase was learned, modes of transmission and who the principal transmitters were in childhood and adulthood. In both communities, each of this three aspects related to cultural transmission were categorized and the frequencies of each category were obtained. The total number of species recorded in each community was also calculated. Frequencies were analyzed with the Chi-square test of independence.</p> <p>Results and discussion</p> <p>In both communities, transmission of traditional plant knowledge begins at an early age, as a family custom, in which women play a predominant role. Wild plant use and horticultural knowledge continue to be learned during adulthood. This was particularly registered associated with horticultural learning, which receives greater influence from extension agents who are introducing new practices and technology. This outside influence, which implies novelty, could imply syncretism but also traditional knowledge loss.</p> <p>Conclusion</p> <p>Given the remarkable acculturation processes occurring at present in rural communities of Northwestern Patagonia, it might be of vital importance to document traditional knowledge of ancient practices. Moreover, it could be interesting to share our results with both populations in order to encourage participatory activities within the communities which could enhance traditional knowledge horizontal transmission, particularly among elder adults and youngsters.</p
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at â s = 8 TeV with the ATLAS detector
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fbâ1 of â s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente
Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector
The inclusive and dijet production cross-sections have been measured for jets
containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass
energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The
measurements use data corresponding to an integrated luminosity of 34 pb^-1.
The b-jets are identified using either a lifetime-based method, where secondary
decay vertices of b-hadrons in jets are reconstructed using information from
the tracking detectors, or a muon-based method where the presence of a muon is
used to identify semileptonic decays of b-hadrons inside jets. The inclusive
b-jet cross-section is measured as a function of transverse momentum in the
range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet
cross-section is measured as a function of the dijet invariant mass in the
range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets
and the angular variable chi in two dijet mass regions. The results are
compared with next-to-leading-order QCD predictions. Good agreement is observed
between the measured cross-sections and the predictions obtained using POWHEG +
Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet
cross-section. However, it does not reproduce the measured inclusive
cross-section well, particularly for central b-jets with large transverse
momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final
version published in European Physical Journal
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