FRANKLINIELLA OCCIDENTALIS, F. SCHULTZEI AND F. FUSCA (THYSANOPTERA.THRIPIDAE) IN PUERTO RICO

FRANKLINIELLA OCCIDENTALIS, F. SCHULTZEI AND F. FUSCA (THYSANOPTERA: THRIPIDAE) IN PUERTO RIC

APLICACIÓN DEL SOFTWARE LYCA PARA TIEMPOS DE COMPATIBILIZACIÓN DE LAS PARTIDAS EJECUTADAS EN LA CONSTRUCCIÓN DEL HOSPITAL HERMILIO VALDIZAN – HUÁNUCO, 2020

La presente investigación parte de la premisa de que existen problemas de compatibilización en la gestión de las valorizaciones entre la entidad ejecutora con la entidad supervisora en obras civiles de gran impacto, puesto que las compatibilizaciones para ambas partes demandan recursos de tiempo y personal calificado para realizarla, ya que tiene que desviar el trabajo especializado hacia labores de valorización; lo cual impacta de manera negativamente la ruta crítica. La presente investigación se desarrolló para ayudar a disminuir los tiempos de compatibilización en los metrados y mapeos de las partidas ejecutadas de estructuras y arquitectura. Luego de identificado el problema, se procedió a crear, desarrollar y diseñar el software LYCA, el cual tiene una interfaz amigable y base de datos del proyecto donde se podrá visualizar y procesar metrados, mapeos, planos y reportes. El software LYCA fue instalado a las computadoras de los trabajadores de la obra y se compatibilizaron los datos, de manera eficiente. Las mediciones de los tiempos de compatibilización se realizaron en base a dos áreas importantes: Estructuras y Arquitectura, en relación a las Estructuras se compatibilizaron: Columnas y placas, vigas, y losas; y en el área de Arquitectura se compatibilizaron las partidas de contrapisos, baldosas y falso cielo raso. Las mediciones se hicieron de la forma tradicional y luego utilizando LYCA; es decir se tomaron las mediciones con el software y sin el software. Se elaboró una ficha de medición en la hoja de cálculo Excel para tabular las mediciones hechas en campo, los resultados obtenidos con el software fueron significativamente mejores que el método manual, ya que se xiii comprobó la mejora en los tiempos de compatibilización de metrados y mapeos de las partidas de estructuras y arquitectura. En conclusión, se recomienda el uso de software LYCA para mejorar los tiempos de compatibilización, puesto que por la presente investigación se demuestra que la reducción de tiempo es significativa. Palabras clave: software, estructuras, arquitectura.Tesi

An Imidazoline 2 Receptor Ligand Relaxes Mouse Aorta via Off-Target Mechanisms Resistant to Aging

Imidazoline receptors (IR) are classified into three receptor subtypes (I1R, I2R, and I3R) and previous studies showed that regulation of I2R signaling has neuroprotective potential. In order to know if I2R has a role in modulating vascular tone in health and disease, we evaluated the putative vasoactive effects of two recently synthesized I2R ligands, diethyl (1RS,3aSR,6aSR)-5- (3-chloro-4-fluorophenyl)-4,6-dioxo-1-phenyl-1,3a,4,5,6,6a-hexahydropyrrolo[3,4-c]pyrrole -1- phosphonate (B06) and diethyl [(1-(3-chloro-4-fluorobenzyl)-5,5-dimethyl-4-phenyl-4,5-dihydro- 1H-imidazol-4-yl]phosphonate] (MCR5). Thoracic aortas from Oncins France 1 (3- to 4-monthsold) and C57BL/6 (3- to 4- and 16- to 17-months-old mice) were mounted in tissue baths to measure isometric tension. In young mice of both strains, MCR5 induced greater relaxations than either B06 or the high-affinity I2R selective ligand 2-(2-benzofuranyl)-2-imidazoline (2-BFI), which evokedmarginal responses.MCR5 relaxations were independent of I2R, as IR ligands did not significantly affect them, involved activation of smoothmuscle KATP channels and inhibition of L-type voltage-gated Ca2+ channels, and were only slightly modulated by endothelium-derived nitric oxide (negatively) and prostacyclin (positively). Notably, despite the presence of endothelial dysfunction in old mice, MCR5 relaxations were preserved. In conclusion, the present study provides evidence against a functional contribution of I2R in the modulation of vascular tone in the mouse aorta. Moreover, the I2R ligand MCR5 is an endothelium-independent vasodilator that acts largely via I2R-independent pathways and is resistant to aging. We propose MCR5 as a candidate drug for the management of vascular disease in the elderly

Polymorphism in the corticotropin-releasing factor receptor 1 (CRF1-R) gene plays a role in shaping the high anxious phenotype of Marchigian Sardinian alcohol-preferring (msP) rats

Introduction: Marchigian Sardinian alcohol-preferring (msP) rats exhibit innate preference for alcohol along with anxious phenotype. In these animals, two single-nucleotide polymorphisms in position -1,836 and -2,097 from the first start codon of the CRF1-R transcript have been found. Materials and Methods: Here, we examined whether these point mutations account for the heightened anxiety-like behavior and stress responsiveness of msP rats. We rederived the msP rats to obtain two distinct lines carrying the wild-type (GG) and point mutations (AA), respectively. Results: CRF1-R gene expression analysis revealed significant dysregulation of the system in the extended amygdala of AA rats. At the behavioral level, using the elevated plus maze, we found that both AA and GG lines had higher basal anxiety compared to Wistar rats. In the defensive burying test, AA rats showed decreased burying behavior compared to the GG and the unselected Wistar lines. Freezing/immobility did not differ among AA and GG but was higher than that of Wistars. The selective CRF1-R antagonist antalarmin (0, 10, and 20 mg/kg) reduced burying behavior in Wistar animals. However, antalarmin (10 mg/kg) tended to increase rather than reducing this behavior when tested in the msP lines, an effect that appeared more marked in the GG as compared to the AA line. Conclusion: The present data suggest that rats with msP genetic background are more anxious and show different sensitivity to stress and CRF1-R blockade than Wistars. The point mutations occurring in the CRF1-R gene do not seem to influence basal anxiety while they appear to affect active responses to stress

Physical exercise neuroprotects ovariectomized 3xTg-AD mice through BDNF mechanisms

Postmenopausal women may be more vulnerable to cognitive loss and Alzheimer's disease (AD) than premenopausal women because of their deficiency in estrogens, in addition to their usually older age. Aerobic physical exercise has been proposed as a therapeutic approach for maintaining health and well-being in postmenopausal women, and for improving brain health and plasticity in populations at high risk for AD. To study the neuroprotective mechanisms of physical exercise in a postmenopausal animal model, we submitted previously ovariectomized, six-month old non-transgenic and 3xTg-AD mice to three months of voluntary exercise in a running wheel. At nine months of age, we observed lower grip strength and some exacerbation of the behavioral and psychological symptoms of dementia (BPSD)-like involving active exploratory activities. A similar major cognitive impairment was observed of ovariectomized 3xTg-AD mice in comparison with sham-operated 3xTg-AD mice. A reduction of bodily fitness and lack of retention of memory were observed in the ovariectomized non-transgenic mice. Physical exercise protected against all deleterious behaviors and normalized learning and memory. It also protected against body frailty, as expected. Analyses of hippocampal key markers of antioxidant and neuroplasticity signaling pathways, showed that ovariectomy impairs the activation of CREB through physical exercise. Furthermore, molecular and behavioral correlates suggested a central role of BDNF in the neuroprotection mediated by physical exercise therapy against apathy and memory loss induced by ovariectomy and the AD-genotype. © 2014 Elsevier Ltd.This study was supported by grants: SAF2009-13093-C02-02, SAF2010-19498, SAF2012-39852-C02-02 and CSD2010-00045 from the Spanish MINECO; 2009/SGR/214 from the Generalitat and 062931 from the Fundació La Marató de TV3, of Catalonia; and 35NEURO GentxGent. Yoelvis García-Mesa acknowledges support received from the Fundació La Marató de TV3Peer Reviewe

Adquisición de competencias para elaborar Trabajos Fin de Grado a través de estrategias metodológicas activas

This study has been carried out with two groups of students from different degree courses at the University of Cordoba. Specifically, a group of 48 fourth-year university students enrolled in the subject Educational Intervention Strategies in the Pre-primary Education Degree and another group of 52 third-year students enrolled in the subject Medieval History of Spain in the History Degree. The aim was to check whether the students acquire the necessary competencies to carry out a future Final Degree Project and, more specifically, an innovation or research project, at the same time as they acquire specific competencies of the two subjects, which were taught through lectures combined with active methodological strategies such as guided discoverylearning and cooperative groups. The results show an increase in the development of these competencies in both groupsEste estudio se ha llevado a cabo con dos grupos de discentes de diferentes titulaciones de grado de la Universidad de Córdoba. Concretamente, un grupo de 48 universitarios matriculados en la asignatura de Estrategias de Intervención Educativa de 4º curso del Grado de Educación Infantil, y otro grupo de 52 alumnos matriculados en la asignatura de Historia Medieval de España de 3º curso del Grado de Historia. El objetivo ha sido comprobar si adquieren determinadas competencias relacionadas con la realización de un futuro Trabajo de Fin de Grado y, específicamente, de un proyecto de innovación o de investigación, a la vez que adquieren competencias específicas de dichas asignaturas. Estas fueron impartidas a través de clases expositivas combinadas con las estrategias metodológicas activas del aprendizaje por descubrimiento guiado y los grupos cooperativos. Los resultados de esta investigación muestran, en ambos grupos, un aumento en el desarrollo de dichas competencias

Integral strategy to supportive care in breast cancer survivors through occupational therapy and a m-health system: design of a randomized clinical trial

Background: Technological support using e-health mobile applications (m-health) is a promising strategy to improve the adherence to healthy lifestyles in breast cancer survivors (excess in energy intake or low physical activity are determinants of the risk of recurrence, second cancers and cancer mortality). Moreover, cancer rehabilitation programs supervised by health professionals are needed due to the inherent characteristics of these breast cancer patients. Our main objective is to compare the clinical efficacy of a m-health lifestyle intervention system alone versus an integral strategy to improve Quality of Life in breast cancer survivors. Methods: This therapeutic superiority study will use a two-arm, assessor blinded parallel RCT design. Women will be eligible if: they are diagnosed of stage I, II or III-A breast cancer; are between 25 and 75 years old; have a Body Mass Index > 25 kg/m2; they have basic ability to use mobile apps; they had completed adjuvant therapy except for hormone therapy; and they have some functional shoulder limitations. Participants will be randomized to one of the following groups: integral group will use a mobile application (BENECA APP) and will receive a face-to-face rehabilitation (8-weeks); m-health group will use the BENECA app for 2-months and will received usual care information. Study endpoints will be assessed after 8 weeks and 6 months. The primary outcome will be Quality of Life measured by The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core and breast module. The secondary outcomes: body composition; upper-body functionality (handgrip, Disability of the Arm, Shoulder and Hand questionnaire, goniometry); cognitive function (Wechsler Adult Intelligence Scale, Trail Making Test); anxiety and depression (Hospital Anxiety and Depression Scale); physical fitness (Short version of the Minnesota Leisure Time Physical Activity Questionnaire, Self-Efficacy Scale for Physical Activity); accelerometry and lymphedema. Discussion: This study has been designed to seek to address the new needs for support and treatment of breast cancer survivors, reflecting the emerging need to merge new low cost treatment options with much-needed involvement of health professionals in this type of patients. Trial registration: ClinicalTrials.gov Identifier: NCT02817724 (date of registration: 22/06/2016).The study was funded by the Spanish Ministry of Economy and Competitiveness (Plan Estatal de I + D + I 2013-2016), Fondo de Investigación Sanitaria del Instituto de Salud Carlos III (PI14/01627), Fondos Estructurales de la Unión Europea (FEDER) and by the Spanish Ministry of Education (FPU14/01069). This is part of a Ph.D. Thesis conducted in the Clinical Medicine and Public Health Doctoral Studies of the University of Granada, Spain

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements