Control of gene expression by steroid hormones

International audienc

Protéomique et Vieillissement

National audienc

Proteases genes : Structure, expression and regulation. Cellular proteases : Properties and biological functions

National audienc

Control of gene expression by steroid hormones

International audienc

Foxo3 controls dangerous proteolytic liaisons

Previews Refers to: FoxO3 Controls Autophagy in Skeletal Muscle In Vivo Cell Metabolism, Volume 6, Issue 6, 5 December 2007, Pages 458-471 Refers to: FoxO3 Coordinately Activates Protein Degradation by the Autophagic/Lysosomal and Proteasomal Pathways in Atrophying Muscle Cells Cell Metabolism, Volume 6, Issue 6, 5 December 2007, Pages 472-483International audienceFoxO3 regulates the transcription of critical components of the ubiquitin-proteasome system in muscle wasting. Two reports (Mammucari et al., 2007; Zhao et al., 2007) now implicate FoxO3 in the transcription of autophagy-related genes and provide the first direct evidence for a coordinated role of autophagy in muscle atrophy

Ubiquitin-proteasome-dependent muscle proteolysis

International audienc

Lysosomal proteolysis in skeletal muscle

ReviewInternational audienceLysosomal proteases are abundantly expressed in fetal muscles, but poorly represented in the adult skeletal muscles. The lysosomal proteolytic system is nonetheless stimulated in adult muscles in a variety of pathological conditions. Furthermore, recent investigations describe autophagosomes in muscle fibers in vitro and in vivo, and report myopathies with excessive autophagy. This review presents our current knowledge about the lysosomal proteolytic system and summarizes the evidences pertaining to the role of lysosomes and autophagosomes in muscle physiology and pathology

Regulation of skeletal muscle proteolysis by amino acids

International audienc