284 research outputs found
Assessment of the acute toxicity of eutrophic sediments after the addition of calcium nitrate (Ibirité reservoir, Minas Gerais-SE Brazil): initial laboratory experiments
- Author
- AA. Mozeto
- ALLEN HE.
- ANDERSEN HB.
- BABIN J.
- BARBOSA FAR
- BURTON JUNIOR GA.
- CAMARGO JA.
- Camargo JA.
- CMR. Botta
- DAS. Beraldo
- DI TORO DM.
- DORNFELD CB.
- FEIBICKE M.
- FONSECA AL.
- FONSECA AL.
- FONSECA AL.
- FOY RH.
- H. Janke
- HAMILTON MA.
- HOCKETT JR.
- LASIER PJ.
- MADIGAN MT.
- MARSDEN MW.
- MCAULIFFE TF.
- MOZETO AA.
- MOZETO AA.
- Mozeto AA.
- MRL. Nascimento
- MURPHY T.
- Nascimento MRL.
- Oliveira-Neto AL.
- PETZOLDT T.
- RAND GM.
- RIPL W.
- SANTOS MAPF.
- SCHAUSER I.
- SCOTT G.
- Silvério PF.
- Sotero-Santos RB.
- SOUCEK DJ.
- STUMM W.
- TAKENAKA RA.
- TM. Yamada
- TRIVINHO-STRIXINO S.
- TUNDISI JG.
- VACCARI DA.
- VAN RIJN JAAP
- YAMADA TM.
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Compressed representation of a partially defined integer function over multiple arguments
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdelalim AA
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta MV
- Adair A
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Agram J-L
- Aguilar-Benitez M
- Ahmad M
- Ahmad WH
- Ahuja S
- Akchurin N
- Akgun B
- Akgun U
- Akin IV
- Alagoz E
- Albajar C
- Albayrak EA
- Albergo S
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- Alcaraz Maestre J
- Alda Junior WL
- Alderweireldt S
- Alexander J
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- Amsler C
- Anagnostou G
- Anastassov A
- Anderson J
- Andrea J
- Andreev V
- Andreev V
- Andreev Y
- Andrews W
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- Antunovic Z
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- Askew A
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- Bahtiyar H
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- Yun JC
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- Zabi A
- Zablocki J
- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti A
- Zanetti M
- Zarubin A
- Zeinali M
- Zeise M
- Zenz SC
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang L
- Zheng Y
- Zhokin A
- Zhu RY
- Zhukov V
- Zhukova V
- Zielinski M
- Zito G
- Zotto P
- Zou W
- Zsigmond AJ
- Zucchetta A
- Zumerle G
- Zuranski A
- Publication venue
- Publication date
- 01/01/2013
- Field of study
In OLAP (OnLine Analitical Processing) data are analysed in an n-dimensional cube. The cube may be represented as a partially defined function over n arguments. Considering that often the function is not defined everywhere, we ask: is there a known way of representing the function or the points in which it is defined, in a more compact manner than the trivial one
Implications of the polymorphism of HLA-G on its function, regulation, evolution and disease association
- Author
- A Abbas
- A Aguilera
- A Arnaiz-Villena
- A Arnaiz-Villena
- A Cabello
- A Fabris
- A Ishitani
- A Ishitani
- A Ishitani
- A Kroner
- A Lin
- A Meer van der
- A Pirri
- A Rivero
- Antonio Arnaiz-Villena
- AP Fernandes
- B Basturk
- B Durand
- B Park
- B Park
- B Seliger
- B Seliger
- BF Barrier
- C Creput
- C Li
- C Matte
- C Matte
- C Matte
- C Matte
- C Ober
- C Ober
- C Ober
- C Ober
- C Ober
- C Parga-Lozano
- C Saguez
- C Solier
- CM Schmidt
- CS Clements
- CS Moreno
- CT Mendes-Junior
- CY Tan
- CY Tan
- D Auboeuf
- D Brown
- D Nicolae
- D Piancatelli
- DE Geraghty
- DI Watkins
- DI Watkins
- Diego Rey
- DK Langat
- E Fainardi
- EA Cordero
- EC Castelli
- EC Castelli
- EC Castelli
- EC Ibrahim
- ED Carosella
- ED Carosella
- ED Carosella
- Eduardo A. Donadi
- Erick C. Castelli
- F Gros
- F Megret
- F Navarro
- F Puppo
- FA Le Gal
- FD Burton
- FO Aikhionbare
- FO Aikhionbare
- G La Nasa
- G Mouillot
- G Singer
- GA Harrison
- GF Gao
- GL Silva
- GL Silva
- GM Park
- GP Dunn
- GP Dunn
- I Algarra
- IJ Wastowski
- J Caumartin
- J Dietrich
- J Lajoie
- J Lajoie
- J Lajoie
- J Lajoie
- J Lajoie
- J Lajoie
- J LeMaoult
- J LeMaoult
- J Luque
- J Luque
- J Qiu
- J Robinson
- J Wu
- JC Crispim
- JC Crispim
- JE Boyson
- JM Lozano
- JX She
- K Masternak
- K Ven van der
- KC Hsu
- KK Yelavarthi
- L Donaghy
- L Segat
- M Adithi
- M Alvarez
- M Alvarez
- M Alvarez-Tejado
- M Alvarez-Tejado
- M Bezuhly
- M Diehl
- M Howard
- M Lafon
- M Martinetti
- M Onno
- M O’Brien
- M Peltola
- M Shiroishi
- M Shiroishi
- M Shiroishi
- M Urosevic
- MB Suarez
- MC Eike
- MI Torres
- Michel Roger
- MJ Castro
- MJ Castro
- MJ Castro
- N Lee
- N Lila
- N Lila
- N Rudstein-Svetlicky
- O Brugiere
- O Sipak-Szmigiel
- O Sipak-Szmigiel
- O Sipak-Szmigiel
- P Contini
- P Moreau
- P Moreau
- P Moreau
- P Moreau
- P Paul
- P Paul
- P Rousseau
- P Rousseau
- P Rousseau
- P Sommer
- P Tripathi
- Philippe Moreau
- PJ Elsen van den
- R Apps
- R Hackmon
- R Mantovani
- R Rizzo
- R Rizzo
- R Sheshgiri
- RC Lee
- RT Simoes
- S Flajollet
- S Griffiths-Jones
- S Ishigami
- S Kuersten
- S Lefebvre
- S Lefebvre
- S Rosado
- S Ugurel
- SE Baranzini
- SE Hiby
- SJ Gobin
- SJ Gobin
- SJ Gobin
- SJ Gobin
- SJ Gobin
- SM Yie
- SM Yie
- SM Yie
- T Fujii
- T Gonen-Gross
- TD Veit
- TD Veit
- TD Veit
- TH Hansen
- TV Hviid
- TV Hviid
- TV Hviid
- TV Hviid
- TV Hviid
- UM Nagarajan
- V Cirulli
- V Rebmann
- V Rebmann
- V Rebmann
- V Steimle
- VL Doherty
- VM Fernandez-Soria
- W Chu
- WH Yan
- WH Yan
- WH Yan
- X Leleu
- Y Fukushima
- Y Shi
- Z Tan
- Z Tan
- Publication venue
- SP Birkhäuser Verlag Basel
- Publication date
- 01/01/2010
- Field of study
The HLA-G gene displays several peculiarities that are distinct from those of classical HLA class I genes. The unique structure of the HLA-G molecule permits a restricted peptide presentation and allows the modulation of the cells of the immune system. Although polymorphic sites may potentially influence all biological functions of HLA-G, those present at the promoter and 3′ untranslated regions have been particularly studied in experimental and pathological conditions. The relatively low polymorphism observed in the MHC-G coding region both in humans and apes may represent a strong selective pressure for invariance, whereas, in regulatory regions several lines of evidence support the role of balancing selection. Since HLA-G has immunomodulatory properties, the understanding of gene regulation and the role of polymorphic sites on gene function may permit an individualized approach for the future use of HLA-G for therapeutic purposes
Improved functionalization of oleic acid-coated iron oxide nanoparticles for biomedical applications
- Author
- Abid M
- Accini JL
- Acuña S
- Adawi F
- Adenuga B
- Adina PM
- Ageev F
- Aguilar-Orozco R
- Ahmad Z
- Aimaretti G
- Aizenberg D
- Akahori H
- Akhmedzhanov N
- Akinboboye O
- Akright L
- Al Mahmeed W
- Alanko J
- Alappat P
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- Alfonso T
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- Andjelic Jelic M
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- Belousov Y
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- Wilding J
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- Yakushin S
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- Yañez M
- Yeap B
- Yigit Z
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- Yuen K.
- Yupanqui H
- Zadionchenko V
- Zalevskaya A
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- Zarankiene R
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- Zhuravleva L
- Zidi B
- Zorkun C
- Zubiate C
- Publication venue
- Springer Nature
- Publication date
- 01/01/2012
- Field of study
Superparamagnetic iron oxide nanoparticles
can providemultiple benefits for biomedical applications
in aqueous environments such asmagnetic separation or
magnetic resonance imaging. To increase the colloidal
stability and allow subsequent reactions, the introduction
of hydrophilic functional groups onto the particles’
surface is essential. During this process, the original
coating is exchanged by preferably covalently bonded
ligands such as trialkoxysilanes. The duration of the
silane exchange reaction, which commonly takes more
than 24 h, is an important drawback for this approach. In
this paper, we present a novel method, which introduces
ultrasonication as an energy source to dramatically
accelerate this process, resulting in high-quality waterdispersible nanoparticles around 10 nmin size. To prove
the generic character, different functional groups were
introduced on the surface including polyethylene glycol
chains, carboxylic acid, amine, and thiol groups. Their
colloidal stability in various aqueous buffer solutions as
well as human plasma and serum was investigated to
allow implementation in biomedical and sensing
applications.status: publishe
Study of double parton scattering using W+2-jet events in proton-proton collisions at √s=7 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
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- Abdulsalam A
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- Acosta MV
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- Adiguzel A
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- Agram J-L
- Aguilar-Benitez M
- Ahmad M
- Ahmad WH
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- Akgun B
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- Albayrak EA
- Albergo S
- Albrow M
- Alcaraz Maestre J
- Alda Junior WL
- Alderweireldt S
- Alexander J
- Aliev T
- Alimena J
- Alvarez JDR
- Alverson G
- Alves GA
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- Amsler C
- Anagnostou G
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- Anderson J
- Andrea J
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- Andreev V
- Andreev Y
- Andrews W
- Androsov K
- Antonelli L
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- Apanasevich L
- Apollinari G
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- Apresyan A
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- Arenton MW
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- Auzinger G
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- Avetisyan A
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- Azhgirey I
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- Publication venue
- Publication date
- 01/01/2013
- Field of study
Peer reviewe
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- Author
- A Abbate
- A Abhyankar
- A Adams
- A Agafina
- A Akyea-Djamson
- A Alan
- A Alfieri
- A Alfrey
- A Alvarisqueta
- A Amos
- A Anadiotis
- A Anneveldt
- A Antolick
- A Arthur
- A Aslam
- Abaci F
- Abdullakutty J
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- Aggarwal Rk
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- Akatova E
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- Amerena J
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- Zielinski M
- Zieve F
- Zineldine A.
- Zirlik A
- Zucchetti C
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.
Observation of the diphoton decay of the Higgs boson and measurement of its properties
- Author
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- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta JG
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- Publication venue
- Publication date
- 01/01/2014
- Field of study
Peer reviewe
Search for new physics in the multijet and missing transverse momentum final state in proton-proton collisions at √s=8 Tev
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdelalim AA
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta JG
- Acosta MV
- Adair A
- Adam W
- Adams MR
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- Zheng Y
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- Zhukov V
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- Publication venue
- Publication date
- 01/01/2014
- Field of study
Peer reviewe
Precise determination of the mass of the Higgs boson and tests of compatibility of its couplings with the standard model predictions using proton collisions at 7 and 8 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta JG
- Adair A
- Adam W
- Adams JR
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Afanasiev S
- Agapitos A
- Agram JL
- Ahmad A
- Ahmad M
- Ahuja S
- Akchurin N
- Akgun B
- Akin IV
- Albajar C
- Albayrak EA
- Albergo S
- Albrow M
- Alcaraz Maestre J
- Aldaya Martin M
- Alderweireldt S
- Aleksandrov A
- Alexander J
- Alimena J
- Alverson G
- Alves GA
- Amapane N
- Amsler C
- Anagnostou G
- Anderson I
- Anderson J
- Andrea J
- Andreev V
- Andreev Y
- Androsov K
- Antonelli L
- Antunovic Z
- Apanasevich L
- Apollinari G
- Appelt E
- Apresyan A
- Apyan A
- Arcidiacono R
- Arenton MW
- Argiro S
- Arneodo M
- Arora S
- Asavapibhop B
- Asawatangtrakuldee C
- Asin I
- Askew A
- Aslanoglou X
- Assran Y
- Ata M
- Attikis A
- Aubin A
- Auffray E
- Autermann C
- Auzinger G
- Avdeeva E
- Avery P
- Avetisyan A
- Avila C
- Azarkin M
- Azhgirey I
- Aziz T
- Azzi P
- Azzolini V
- Azzurri P
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- Publication venue
- Publication date
- 01/01/2014
- Field of study
Peer reviewe
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
- Adam S
- Adams D
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- Adamson M
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- Adelaja Y
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- Adenekan A
- Adenike O
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- Afshari A
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- Aimoniotou-Georgiou E
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- Al-Soudaine Y
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- Zoulamoglou M
- Zsisku L
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
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