Transnational Impulses as Simulation in Colin Johnson's (Mudrooroo's) Fiction.

Works of Australian Literature have frequently been situated within national literary frameworks. But there is much recent scholarship that contests such ideas and explores transnational engagement in literary production. An author that has been seen as embodying the spectral nature of the Australian literary paradigm is Colin Johnson, pseudonym Mudrooroo. While, the complexities around Mudrooroo's identity as black Australian author are infamous: these biographical complexities are not the focus of this paper. Instead, Mudrooroo's Master of the Ghost Dreaming Series is explored as an evocation of place that encompasses a series of ever widening spheres: the local, the regional, the national, the transnational, the trans-human and the cosmic

Understanding camp dogs : the relationship between Aboriginal culture and western welfare

This article examines how rising concern for animal welfare in Australia is manifested in increased media coverage of these topics, including growing coverage of animal sentience, rights, and welfare. In Australia, canine existence is often determined by their positioning within cultural frames. Dogs have been integral to Aboriginal social, family, and environmental relationships for generations; however, colonisation brought fundamental changes to these established relationships, with ramifications that have prompted welfare concerns about camp dog populations. The goal of this article is to review existing research discourses and epistemological positioning of the supposed camp dog problem. We are not assessing individual programmes or reporting on fieldwork conducted with communities. Instead, this initial paper reviews some of the current literature to identify ways forward in facilitating Aboriginal self-determining of camp dog interactions in communities. © The Author(s) 2023

Cover Page, Table of Contents, Editorial and Contributor Biographies

Animal Studies Journal 2022 11(1): Cover Page, Table of Contents, Editorial and Contributor Biographies

David Malouf’s Remembering Babylon as a Reconsideration of Pastoral Idealisation

David Malouf's oeuvre is characterised by a specific treatment of the natural world. Malouf’s sensitivity towards nature is very present in 'Remembering Babylon', inspired by the true story of Gemmy Morrill, ‘lost’ in the ‘wilds’, the novel framed by epigraphs drawn from Romantic poetry. This paper seeks to re-examine this treatment through an ecocritical lens. That is, I seek to explore the novel in terms of its redress of denigrating, exploitative, or idealistic views of human relationships with the non-human natural realm. 'Remembering Babylon' pits characters’ interactions with the natural world in diverse ways and the culminating impression is far from idealistic or apolitical. Ultimately, the novel’s complex rendering of human relationships with place and the non-human animal offers a specific challenge to romanticised visions of place. This argument is counter to some criticism of the novel as idealisation of the natural world at the expense of historically salient political considerations. 'Remembering Babylon' explores the significant political issue of human attitudes to the natural realm in complex ways. In order to reconsider the criticism of idealism, the novel is examined in terms of the genre most closely associated with idealisation of the environment: the pastoral. 'Remembering Babylon' appears to have a complex relationship with what can loosely be termed ‘the pastoral’. The novel revises idealising visions of nature and gently parodies the notion that nature is separate from or a tool of human, cultural concerns, particularly through its figurative and literal foregrounding of the nonhuman animal. The epigraph provides a deliberate and significant signal of Malouf’s challenge to pastoral understandings of nature because the poets cited within it, William Blake and John Clare, arguably offer in their wider body of work what might be termed a post-pastoral ethos that evokes, challenges and thus adapts pastoral idealism of nature. The paper suggests that 'Remembering Babylon' expresses such a post-pastoral ethos, if in a very different context and form from Blake and Clare

Ecological and Cultural Understanding as a Basis for Management of a Globally Significant Island Landscape

Islands provide the opportunity to explore management regimes and research issues related to the isolation, uniqueness, and integrity of ecological systems. K’gari (Fraser Island) is an Australian World Heritage property listed based on its outstanding natural value, specifically, the unique wilderness characteristics and the diversity of ecosystem types. Our goal was to draw on an understanding of the natural and cultural environment of K’gari as a foundation on which to build a management model that includes First Nations Peoples in future management and research. Our research involved an analysis of papers in the peer-reviewed scientific literature, original reports, letters, and other manuscripts now housed in the K’gari Fraser Island Research Archive. The objectives of the research were: (1) to review key historical events that form the cultural, social, and environmental narrative; (2) review the major natural features of the island and threats; (3) identify the gaps in research; (4) analyse the management and conservation challenges associated with tourism, biosecurity threats, vegetation management practices, and climate change and discuss whether the requirements for sustaining island ecological integrity can be met in the future; and (5) identify commonalities and general management principles that may apply globally to other island systems and other World Heritage sites listed on the basis of their unique natural and cultural features. We found that the characteristics that contribute to island uniqueness are also constraints for research funding and publication; however, they are important themes that warrant more investment. Our review suggests that K’gari is a contested space between tourist visitation and associated environmental impacts, with an island that has rich First Nations history, extraordinary ecological diversity, and breathtaking aesthetic beauty. This juxtaposition is reflected in disparate views of custodianship and use, and the management strategies are needed to achieve multiple objectives in an environmentally sustainable way whilst creating cultural equity in modern times. We offer a foundation on which to build a co-management model that includes First Nations Peoples in governance, management, research, and monitoring

Barriers to the sustainability of an intervention designed to improve patient engagement within NHS mental health rehabilitation units: a qualitative study nested within a randomised controlled trial.

BACKGROUND: We undertook a cluster randomised controlled trial to assess the effectiveness of a staff training intervention to improve patient engagement in activities in inpatient mental health rehabilitation units. Concurrently, we undertook a qualitative study to investigate the experiences of staff within the intervention units and the contextual issues that may have influenced the effectiveness of the intervention. METHOD: We conducted focus groups with staff working in the inpatient units that received the intervention, sampled using a maximum variation strategy. RESULTS: The intervention was accepted by staff. However, the skills gained, and changes to the unit's processes and structures that were agreed with the intervention team were not sustained after they left. The main reasons for this were a) external factors (economic recession, resource limitations); b) organisation level factors (lack of senior staff support; competing priorities); c) limitations of the intervention itself (length of intensive training period; reinforcement of skills). CONCLUSION: This study illustrates some of the inter-related factors which operate at different levels within and outside of NHS organisations that may impact on the success of complex interventions. These factors need to be considered when designing interventions to ensure adequate buy-in from senior staff. TRIAL REGISTRATION: Current Controlled Trials ISRCTN25898179 (Registered 23 April 2010)

Genetic mechanisms of critical illness in COVID-19.

Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 ×  10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease