Cos y Cnido. Esencia Hipocrática en la práctica profesional enfermera

El desarrollo de la filosofia y las ciencias humanas en la Greda del siglo V a. de C. supuso en términos de salud un avance cualitativo fundamental, desde un modelo mitológico primigenio, hasta la condición de disciplina clentífica que se mantiene hasta nuestros días. Este artículo analiza la aportación de las dos principales escuelas de salud de la Grecia Clásica, COS y CNIDO, sobre el concepto modemo del cuidado y las bases actuales de la disciplina enfermera. Los autores concluyen, que al contrario de la Escuela de CNIDO, el pensamiento hipocrático de la Escuela de COS ha contribuido sustancialmente no solo a la construcción de la medicina modema, sino también a la Ciencia De los Cuidados Enfermeros

New types of radio communication: the investiture of Pedro Sánchez 'broadcast' on Instagram

La evolución de la radio en los últimos años ha derivado en una creciente presencia y utilización de las redes sociales como canal de comunicación con sus audiencias y la aparición de nuevas narrativas. Esta investigación explora el tratamiento que las cuatro principales cadenas radiofónicas españolas -SER, COPE, Onda Cero y Radio Nacional de España- realizaron en Instagram durante la investidura de Pedro Sánchez como presidente del Gobierno de España. Del análisis de contenido cuantitativo y cualitativo realizado se deriva que la implantación de la radio en Instagram es, todavía, incipiente en algunos casos, pero que, sin embargo, cadenas como SER y COPE ya aplican nuevas narrativas en la red social. La radio emplea Instagram para informar y también como espacio para los géneros opinativos, y lo hace con un impacto notable en las comunidades de seguidores.Radio’s evolution in recent years is characterised by the growing presence and use of social networks as communication channels with their audiences and the emergence of new narratives. This research explores the coverage carried out by the four main Spanish radio stations - Cadena SER, COPE, Onda Cero and Radio Nacional de España - through their Instagram accounts during the inauguration of Pedro Sánchez as President of the Government of Spain. The results obtained from an analysis of quantitative and qualitative content reveal that, in some cases, the introduction of radio on Instagram is still in its infancy. However, stations such as SER and COPE have already implemented new narratives in this social network. The radio uses Instagram to inform and also as a platform for opinion genres having a significant impact on the communities of followers.Este trabajo ha sido realizado en el marco del Grupo de Investigación en Comunicación e Información Digital (GICID) de la Universidad de Zaragoza, reconocido como grupo de referencia por el Gobierno de Aragón con el código S29_20R (Núm. 62 del Boletín Oficial de Aragón, de fecha 26/03/2020), dentro del área de Ciencias Sociales y financiado por el Fondo Social Europeo de Desarrollo Regional, FEDER “Construyendo Europa desde Aragón”

Investigación científica y práctica basada en la evidencia. Desarrollo de competencias en Grado y Postgrado de Ciencias de la Salud

Es una necesidad que los profesionales de la salud egresen con competencias básicas en materia de investigación científica y que en la formación postgrado alcancen un mayor nivel de desarrollo en dichas competencias, para asegurar unos cuidados de la salud basados en la mejor evidencia disponible y disminuir la variabilidad de la práctica clínica, aumentando con ello la seguridad del paciente. El objetivo general de este proyecto es: Diseñar y concretar herramientas para la mejora docente, analizando las propuestas surgidas en la práctica. Como objetivos específicos se plantean: Desarrollar instrumentos adecuados para la evaluación de la adquisición de competencias. Facilitar un instrumento de seguimiento de cada experiencia de innovación docente, que permita realizar una autoevaluación del grado de cumplimiento de objetivos y de la satisfacción de los agentes implicados. Potenciar las tutorías de orientación como actividad docente. Para alcanzar esos objetivos se diseña un proyecto de innovación consistente en la simulación en el aula de las fases de la investigación científica: búsqueda de información, diseño de proyectos, recogida de datos, análisis de datos, redacción del informe de investigación y revisión por pares del mismo. En primer año de desarrollo se diseñan los instrumentos para la redacción del informe y la revisión por pares y se implanta en las asignaturas de los posgrados oficiales de Máster en sexología y Máster en Ciencias de la Enfermería. El desarrollo de la experiencia de innovación docente ha permitido al alumno adquirir la competencia, “haciendo”. Esto es, diseñando, entre los alumnos de cada asignatura, desde el principio un proyecto de investigación y siguiendo todo el proceso metodológico para llevarlo a cabo y publicar los resultados

Red haloBODIPYs as theragnostic agents: The role of the substitution at meso position

Three different molecular designs based on BODIPY dye have been proposed as photosensitizers (PSs) for photodynamic therapy (PDT) by the inclusion of halogen atoms (Iodine) at 2,6-positions and with extended conjugation at 3, 5-positions and varying the substitution at meso position. The synthesis is described and their main photophysical features including singlet oxygen production and triplet states were characterized by absorption and fluorescence spectroscopy (steady-state and time-correlated) and nanosecond transient absorption spectroscopy. The results were compared with the commercial Chlorin e6. The three new red-halogen-BODIPYs showed a great balance between singlet oxygen generation (Phi(Delta)>= 0.40) and fluorescence (Phi(fl)>= 0.22) for potential application on PDT, and particularly in theragnosis. In vitro experiments in HeLa cells were done to study their performance and to elucidate the best potential candidate for PDT.This research was funded by the Basque Government, grant numbers IT912-16, IT-1302-19 and IT1639-22. This work is supported by Min-isterio de Ciencia, Innovacion y Universidades-Agencia Estatal de Investigacion (MCI/AEI) , grant numbers MAT2017-83856-C3-2-P and 3-P, PID2020-114347RB-C32, PID2020-114755 GB-C32 and the Uni-versity of the Basque Country (UPV/EHU) , grant number COLAB19/01. R.P.M. thanks UPV/EHU for postdoctoral felowship (DOCREC 20/55) . Open Access funding is provided by University of Basque Country

Red haloBODIPYs as theragnostic agents: The role of the substitution at meso position

Three different molecular designs based on BODIPY dye have been proposed as photosensitizers (PSs) for photodynamic therapy (PDT) by the inclusion of halogen atoms (Iodine) at 2,6-positions and with extended conjugation at 3, 5-positions and varying the substitution at meso position. The synthesis is described and their main photophysical features including singlet oxygen production and triplet states were characterized by absorption and fluorescence spectroscopy (steady-state and time-correlated) and nanosecond transient absorption spectroscopy. The results were compared with the commercial Chlorin e6. The three new red-halogen-BODIPYs showed a great balance between singlet oxygen generation (ΦΔ≥0.40) and fluorescence (Φfl≥0.22) for potential application on PDT, and particularly in theragnosis. In vitro experiments in HeLa cells were done to study their performance and to elucidate the best potential candidate for PDT

Single versus tandem autologous stem-cell transplantation in patients with newly diagnosed multiple myeloma and high-risk cytogenetics. A retrospective, open-label study of the PETHEMA/Spanish Myeloma Group (GEM)

Tandem ASCT has been suggested as a valid approach to improve the prognosis of patients with MM and HR cytogenetic. In this observational, retrospective study, 213 patients with newly diagnosed MM and HR cytogenetic in 35 hospitals from the Spanish Myeloma Group underwent single or tandem ASCT between January 2015 and December 2019 after induction with VTD/VRD. HR cytogenetic was defined as having ≥1 of the following: del17p, t(4;14), t(14;16) or gain 1q21. More patients in the tandem group had R-ISS 3 and >1 cytogenetic abnormality at diagnosis. With a median follow-up of 31 months (range, 10–82), PFS after single ASCT was 41 months versus 48 months with tandem ASCT (p = 0.33). PFS in patients with del17p undergoing single ASCT was 41 months, while 52% of patients undergoing tandem ASCT were alive and disease free at 48 months. In conclusion, tandem ASCT partly overcomes the bad prognosis of HR cytogenetic

Exploring BODIPY Derivatives as Singlet Oxygen Photosensitizers for PDT

This minireview is devoted to honoring the memory of Dr. Thomas Dougherty, a pioneer of modern photodynamic therapy (PDT). It compiles the most important inputs made by our research group since 2012 in the development of new photosensitizers based on BODIPY chromophore which, thanks to the rich BODIPY chemistry, allows a finely tuned design of the photophysical properties of this family of dyes to serve as efficient photosensitizers for the generation of singlet oxygen. These two factors, photophysical tuning and workable chemistry, have turned BODIPY chromophore as one of the most promising dyes for the development of improved photosensitizers for PDT. In this line, this minireview is mainly related to the establishment of chemical methods and structural designs for enabling efficient singlet oxygen generation in BODIPYs. The approaches include the incorporation of heavy atoms, such as halogens (iodine or bromine) in different number and positions on the BODIPY scaffold, and also transition metal atoms, by their complexation with Ir(III) center, for instance. On the other hand, low‐toxicity approaches, without involving heavy metals, have been developed by preparing several orthogonal BODIPY dimers with different substitution patterns. The advantages and drawbacks of all these diverse molecular designs based on BODIPY structural framework are described

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements