First Search for Axion-Like Particles in a Storage Ring Using a Polarized Deuteron Beam

Based on the notion that the local dark-matter field of axions or axion-like particles (ALPs) in our Galaxy induces oscillating couplings to the spins of nucleons and nuclei (via the electric dipole moment of the latter and/or the paramagnetic axion-wind effect), we performed the first experiment to search for ALPs using a storage ring. For that purpose, we used an in-plane polarized deuteron beam stored at the Cooler Synchrotron COSY, scanning momenta near 970 MeV/c. This entailed a scan of the spin precession frequency. At resonance between the spin precession frequency of deuterons and the ALP-induced EDM oscillation frequency there will be an accumulation of the polarization component out of the ring plane. Since the axion frequency is unknown, the momentum of the beam and consequently the spin precession frequency were ramped to search for a vertical polarization change that would occur when the resonance is crossed. At COSY, four beam bunches with different polarization directions were used to make sure that no resonance was missed because of the unknown relative phase between the polarization precession and the axion/ALP field. A frequency window of 1.5-kHz width around the spin precession frequency of 121 kHz was scanned. We describe the experimental procedure and a test of the methodology with the help of a radiofrequency Wien filter located on the COSY ring. No ALP resonance was observed. As a consequence an upper limit of the oscillating EDM component of the deuteron as well as its axion coupling constants are provided.Comment: 25 pages, 24 figures, 7 tables, 67 reference

Meta-analysis of genome-wide association studies for extraversion:Findings from the Genetics of Personality Consortium

Extraversion is a relatively stable and heritable personality trait associated with numerous psychosocial, lifestyle and health outcomes. Despite its substantial heritability, no genetic variants have been detected in previous genome-wide association (GWA) studies, which may be due to relatively small sample sizes of those studies. Here, we report on a large meta-analysis of GWA studies for extraversion in 63,030 subjects in 29 cohorts. Extraversion item data from multiple personality inventories were harmonized across inventories and cohorts. No genome-wide significant associations were found at the single nucleotide polymorphism (SNP) level but there was one significant hit at the gene level for a long non-coding RNA site (LOC101928162). Genome-wide complex trait analysis in two large cohorts showed that the additive variance explained by common SNPs was not significantly different from zero, but polygenic risk scores, weighted using linkage information, significantly predicted extraversion scores in an independent cohort. These results show that extraversion is a highly polygenic personality trait, with an architecture possibly different from other complex human traits, including other personality traits. Future studies are required to further determine which genetic variants, by what modes of gene action, constitute the heritable nature of extraversion

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyper-activity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome. Genetic correlation analyses revealed a meaningful structure within the eight disorders, identifying three groups of inter-related disorders. Meta-analysis across these eight disorders detected 109 loci associated with at least two psychiatric disorders, including 23 loci with pleiotropic effects on four or more disorders and 11 loci with antagonistic effects on multiple disorders. The pleiotropic loci are located within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes. These findings have important implications for psychiatric nosology, drug development, and risk prediction.Peer reviewe

A Supernumerary Soft Robotic Hand-Arm System for Improving Worker Ergonomics

Long exposure to overload and vibration transmission on the upper limb are among the high risk injury factors in industrial environments. They contribute to the development of musculoskeletal disorders, which can lead to economic and social setbacks. To address this issue, robotic systems have been developed that act either as an autonomous system or in collaboration with the workers. In this direction, and with the aim to develop a system that contributes to a simultaneous reduction of the overloading and vibration transmission, we present a novel wearable soft robotic handarm system. Preliminary experimental results in a vibrational tool use are reported to shown the potential of the system in improving worker ergonomics

EndoAbS dataset: Endoscopic abdominal stereo image dataset for benchmarking 3D stereo reconstruction algorithms

Background: 3D reconstruction algorithms are of fundamental importance for augmented reality applications in computer-assisted surgery. However, few datasets of endoscopic stereo images with associated 3D surface references are currently openly available, preventing the proper validation of such algorithms. This work presents a new and rich dataset of endoscopic stereo images (EndoAbS dataset). Methods: The dataset includes (i) endoscopic stereo images of phantom abdominal organs, (ii) a 3D organ surface reference (RF) generated with a laser scanner and (iii) camera calibration parameters. A detailed description of the generation of the phantom and the camera–laser calibration method is also provided. Results: An estimation of the overall error in creation of the dataset is reported (camera–laser calibration error 0.43&nbsp;mm) and the performance of a 3D reconstruction algorithm is evaluated using EndoAbS, resulting in an accuracy error in accordance with state-of-the-art results (&lt;2&nbsp;mm). Conclusions: The EndoAbS dataset contributes to an increase the number and variety of openly available datasets of surgical stereo images, including a highly accurate RF and different surgical conditions

A Novel Soft Robotic Supernumerary Hand for Severely Affected Stroke Patients

Upper limb functions are severely affected in 23% of the chronic stroke patients, compromising their life quality. To re-enable hand use, providing a degree of functionality and motivating against learned non-use, we propose a robotic supernumerary limb, the SoftHand X (SHX), consisting of a robotic hand, a gravity support system, and different sensors to detect the patient's intent for controlling the robotic hand. In this paper, this novel compensational approach is introduced and experimentally evaluated in stroke patients, assessing its efficacy, usability and safety. Ten patients were asked to perform tasks of a modified Action Research Arm Test with the SHX, by using three input methods. The mARAT scores rated the potentiality of the system. Usability was evaluated with the System Usability Scale, while spasticity before and after use was measured by the modified Ashworth Scale (mAS). Nine patients, not able to perform any tasks without external support, completed the whole experimental procedure using the proposed system with a median score greater than 12/30. Among the three input methods tested, the usability of one was rated as "good" while the other two were rated as "ok". Seven patients exhibited a reduction of the mAS. All nine patients stated that they would use the system frequently. Results obtained suggest that the SHX has the potential to partially compensate severely impaired hand function in stroke patients

Photoproduction of the f2(1270)f_2(1270) meson using the CLAS detector

The quark structure of the $f_2(1270)$ meson has, for many years, been assumed to be a pure quark-antiquark ($q\bar{q}$) resonance with quantum numbers $J^{PC} = 2^{++}$. Recently, it was proposed that the $f_2(1270)$ is a molecular state made from the attractive interaction of two $\rho$-mesons. Such a state would be expected to decay strongly to final states with charged pions, due to the dominant decay $\rho \to \pi^+ \pi^-$, whereas decay to two neutral pions would likely be suppressed. Here, we measure for the first time the reaction $\gamma p \to \pi^0 \pi^0 p$, using the CLAS detector at Jefferson Lab for incident beam energies between 3.6-5.4~GeV. Differential cross sections, $d\sigma / dt$, for $f_2(1270)$ photoproduction are extracted with good precision, due to low backgrounds, and are compared with theoretical calculations.The quark structure of the f2(1270) meson has, for many years, been assumed to be a pure quark-antiquark (qq¯) resonance with quantum numbers JPC=2++. Recently, it was proposed that the f2(1270) is a molecular state made from the attractive interaction of two ρ mesons. Such a state would be expected to decay strongly to final states with charged pions due to the dominant decay ρ→π+π-, whereas decay to two neutral pions would likely be suppressed. Here, we measure for the first time the reaction γp→π0π0p, using the CEBAF Large Acceptance Spectrometer detector at Jefferson Lab for incident beam energies between 3.6 and 5.4 GeV. Differential cross sections, dσ/dt, for f2(1270) photoproduction are extracted with good precision due to low backgrounds and are compared to theoretical calculations

Storage Ring to Search for Electric Dipole Moments of Charged Particles -- Feasibility Study

The proposed method exploits charged particles confined as a storage ring beam (proton, deuteron, possibly helium-3) to search for an intrinsic electric dipole moment (EDM) aligned along the particle spin axis. Statistical sensitivities could approach 10$^{-29}$ e$\cdot$cm. The challenge will be to reduce systematic errors to similar levels. The ring will be adjusted to preserve the spin polarisation, initially parallel to the particle velocity, for times in excess of 15 minutes. Large radial electric fields, acting through the EDM, will rotate the polarisation. The slow rise in the vertical polarisation component, detected through scattering from a target, signals the EDM. The project strategy is outlined. It foresees a step-wise plan, starting with ongoing COSY (Cooler Synchrotron, Forschungszentrum J\'ulich) activities that demonstrate technical feasibility. Achievements to date include reduced polarisation measurement errors, long horizontal-plane polarisation lifetimes, and control of the polarisation direction through feedback from the scattering measurements. The project continues with a proof-of-capability measurement (precursor experiment; first direct deuteron EDM measurement), an intermediate prototype ring (proof-of-principle; demonstrator for key technologies), and finally the high precision electric-field storage ring