8 research outputs found
Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018) : Change management in allergic rhinitis and asthma multimorbidity using mobile technology
- Author
- Aberer W.
- Agache I.
- Agache Ioana
- Akdis C. A.
- Akdis M.
- Alberti M. R.
- Almeida R.
- Amat F.
- Amat Flore
- Angles R.
- Annesi-Maesano I.
- Annesi-Maesano Isabella
- Ansotegui I. J.
- Ansotegui Ignacio J.
- Anto J. M.
- Anto Josep M.
- Arnavielle S.
- Arshad H.
- Asarnoj A.
- Asayag E.
- Avolio F.
- Bacci E.
- Bachert C.
- Bachert Claus
- Baiardini I.
- Barbagallo M.
- Barbara C.
- Baroni I.
- Barreto B. A.
- Basagana X.
- Bateman E. D.
- Bateman Eric D.
- Bedbrook A.
- Bedbrook Anna
- Bedolla-Barajas M.
- Beghe B.
- Bel E. H.
- Bennoor K. S.
- Bennoor Kazi
- Benson M.
- Bergmann K. C.
- Bertorello L.
- Bewick M.
- Bewick Mickael
- Bialek S.
- Biaoszewski A. Z.
- Bieber T.
- Bindslev-Jensen C.
- Bindslev-Jensen Carsten
- Bjermer L.
- Blain H.
- Blasi F.
- Blua A.
- Bogado D. Mora
- Bogus-Buczynska I.
- Boner A. L.
- Bonini M.
- Bonini S.
- Bosnic-Anticevich C. S.
- Bosnic-Anticevich Sinthia
- Bosse I.
- Bosse Isabelle
- Bouchard J.
- Boulet L. P.
- Bourret R.
- Bousquet J.
- Bousquet Jean
- Bousquet P. J.
- Braido F.
- Briedis V.
- Brightling C. E.
- Brozek J.
- Brozek Jan
- Brussino Luisa
- Bucca C.
- Buhl R.
- Buonaiuto R.
- Burte E.
- Bush A.
- Caballero-Fonseca F.
- Cabanas M. T. Burguete
- Caillot D.
- Caimmi D.
- Calderon M. A.
- Camargos P. A. M.
- Campos J. J. Matta
- Camuzat T.
- Canfora G.
- Canonica G. W.
- Canonica Giorgio W.
- Cardona V.
- Cardona Victoria
- Carlsen K. C. Lodrup
- Carlsen K. H.
- Carlsen Karin Lodrup
- Carr W.
- Carreiro-Martins P.
- Carriazo A. M.
- Cartier C.
- Casale T.
- Casale Thomas
- Castellano G.
- Cecchi L.
- Cecchi Lorenzo
- Chavannes N. H.
- Chavannes Niels H.
- Chen Y.
- Chiron R.
- Chivato T.
- Chkhartishvili E.
- Christoff G.
- Chuchalin A. G.
- Chung K. F.
- Ciaravolo M. M.
- Ciceran A.
- Cingi C.
- Ciprandi G.
- Cisneros M. Ortega
- Coehlo A. C. Carvalho
- Colas L.
- Colgan E.
- Coll J.
- Conforti D.
- Cortes-Grimaldo R. M.
- Corti F.
- Costa E.
- Costa Elisio
- Costa-Dominguez C.
- Courbis A. L.
- Cox L.
- Crescenzo M.
- Cruz A. A.
- Cruz Alvaro A.
- Custovic A.
- Czarlewski W.
- Czarlewski Wienczyslawa
- da Silva J.
- Dahlen S. E.
- Dario C.
- Darsow U.
- Dauvilliers Y.
- De Blay F.
- De Carlo G.
- De Carlo Giuseppe
- De Feo G.
- De Feo Giulia
- De Martino B.
- de Mello J. Ferreira, Jr.
- de Sousa J. Correia
- de Sousa Jaime Correia
- De Vries G.
- Dedeu T.
- Deleanu D.
- Demoly P.
- Demoly Pascal
- Denburg J. A.
- Devillier P.
- Devillier Philippe
- Di Carluccio N.
- Diaz S. Gonzalez
- Didier A.
- Dokic D.
- Dominguez-Silva M. G.
- Douagui H.
- Dray G.
- Du Toit G.
- Dubakiene R.
- Durham S. R.
- Dykewicz M. S.
- Dykewicz Mark S.
- Eklund P.
- El-Gamal Y.
- El-Gamal Yehia
- Eller E.
- Eller Esben E.
- Emerson M. de Fatima
- Emuzyte R.
- Ercolano S. Di Capua
- Farrell J.
- Farsi A.
- Ferrero J.
- Fink-Wagner A.
- Fiocchi A.
- Fokkens W. J.
- Fokkens Wytske J.
- Fonseca J. A.
- Fonseca Joao A.
- Fontaine J. F.
- Fontaine Jean-Francois
- Forti S.
- Fuentes-Perez J. M.
- Galvez-Romero J. L.
- Gamkrelidze A.
- Garcia-Aymerich J.
- Garcia-Cobas C. Y.
- Garcia-Cruz M. H.
- Gemicioglu B.
- Genova S.
- Gereda J. E.
- Gomez R. M.
- Gomez-Vera J.
- Gonzalez M. Rodriguez
- Gotua M.
- Grisle I.
- Guidacci M.
- Guldemond N. A.
- Gutter Z.
- Guzman M. A.
- Guzman Maria-Antonieta
- Haahtela T.
- Haahtela Tari
- Hajjam J.
- Hellings P. W.
- Hellings Peter W.
- Hernandez L.
- Hourihane J. O'B.
- Huerta-Villalobos Y. R.
- Humbert M.
- Iaccarino G.
- Illario M.
- Illario Maddalena
- Ivancevich J. C.
- Ivancevich Juan-Carlos
- Jares E. J.
- Jassem E.
- Johnston S. L.
- Joos G.
- Jung K. S.
- Just Jocelyne
- Jutel M.
- Kaidashev I.
- Kaidashev Igor
- Kalayci O.
- Kalayci Omer
- Kalyoncu A. F.
- Kardas P.
- Karjalainen J.
- Keenoy E. De Manuel
- Keil T.
- Keil Thomas
- Keith P. K.
- Khaitov M.
- Khaitov Musa
- Khaltaev N.
- Kleine-Tebbe J.
- Klimek L.
- Klimek Ludger
- Kowalski M. L.
- Kowalski Marek L.
- Krzych-Fata E.
- Kuitunen M.
- Kull I.
- Kuna P.
- Kuna Piotr
- Kupczyk M.
- Kvedariene V.
- Kvedariene Violeta
- Lacwik P.
- Larenas-Linnemann D.
- Larenas-Linnemann Desiree
- Laune D.
- Laune Daniel
- Lauri D.
- Lavrut J.
- Le L. T. T.
- Le Lan T. T.
- Lessa M.
- Levato G.
- Li J.
- Lieberman P.
- Lipiec A.
- Lipworth B.
- Louis R.
- Lourenco O.
- Lourenco Olga
- Luna-Pech J. A.
- M Mobile Airways Sentinel Network
- Maciej K.
- Magnan A.
- Mahboub B.
- Mahboub Bassam
- Maier D.
- Mair A.
- Mair Alpana
- Majer I.
- Malva J.
- Mandajieva E.
- Manning P.
- Marciniak M. Bochenska
- Marshall G. D.
- Masjedi M. R.
- Maspero J. F.
- Mathieu-Dupas E.
- Matos A. L.
- Maurer M.
- Mavale-Manuel S.
- Mayora O.
- Medina-Avalos M. A.
- Melen E.
- Melo-Gomes E.
- Meltzer E. O.
- Menditto E.
- Menditto Enrica
- Mercier J.
- Miculinic N.
- Mihaltan F.
- Milenkovic B.
- Milenkovic Branislava
- Moda G.
- Mogica-Martinez M. D.
- Mohammad Y.
- Momas I.
- Montefort S.
- Monti R.
- Morais-Almeida M.
- Morais-Almeida Mario
- Morato-Castro F. F.
- Mosges R.
- Mosges Ralph
- Mota-Pinto A.
- Mullol J.
- Mullol Joaquim
- Munter L.
- Muraro A.
- Murray R.
- Murray Ruth
- Naclerio R.
- Naclerio Robert
- Nadif R.
- Nalin M.
- Namazova-Baranova L.
- Namazova-Baranova Leyla
- Napoli L.
- Neffen H.
- Nekam K.
- Neou A.
- Niedeberger V.
- Nieto A.
- Nogueira-Silva L.
- Nogues M.
- Novellino E.
- Novellino Ettore
- Nyembue T. D.
- O'Hehir R. E.
- O'Hehir Robyn E.
- Odzhakova C.
- Ohta K.
- Ohta Ken
- Okamoto Y.
- Okamoto Yoshitaka
- Okubo K.
- Okubo Kimi
- Onorato G. L.
- Onorato Gabrielle L.
- Ouedraogo S.
- Pali-Scholl I.
- Palkonen S.
- Palkonen Susanna
- Panaitescu C.
- Panzner P.
- Panzner Petr
- Papadopoulos N. G.
- Papadopoulos Nikos G.
- Papi A.
- Park H. S.
- Park Hae-Sim
- Passalacqua G.
- Paulino E.
- Paulino Ema
- Pawankar R.
- Pawankar Ruby
- Pedersen S.
- Pepin J. L.
- Pereira A. M.
- Persico M.
- Pfaar O.
- Pfaar Oliver
- Phillips J.
- Picard R.
- Pigearias B.
- Pin I.
- Pitsios C.
- Plavec D.
- Plavec Davor
- Pohl W.
- Popov T. A.
- Popov Ted A.
- Portejoie F.
- Potter P.
- Potter Paul
- Pozzi A. C.
- Price D.
- Prokopakis E. P.
- Prokopakis Emmanuel P.
- Przemecka M.
- Pugin B.
- Puy R.
- Rabe K. F.
- Raciborski F.
- Rajabian-Soderlund R.
- Rajabian-Soderlund Rojin
- Reitsma S.
- Ribeirinho I.
- Rimmer J.
- Rivero-Yeverino D.
- Rizzo J. A.
- Rizzo M. C.
- Robalo-Cordeiro C.
- Rodenas F.
- Rodo X.
- Rodriguez M. Roman
- Rodriguez-Manas L.
- Rodriguez-Zagal E.
- Rolla G.
- Rolland C.
- Roller-Wirnsberger R. E.
- Romano A.
- Romano M.
- Rosado-Pinto J.
- Rosario N.
- Ross R. E. Pulido
- Rottem M.
- Rottem Menachem
- Rubini N. de Paula Motta
- Ryan D.
- Ryan Dermot
- Sagara H.
- Salimaki J.
- Salimaki Johanna
- Samolinski B.
- Samolinski Boleslaw
- Sanchez-Borges M.
- Sanchez-Borges Mario
- Santo P. Moura
- Sarabia A. M. Cepeda
- Sarabia Alfonso M. Cepeda
- Sastre-Dominguez J.
- Scadding G. K.
- Schmid-Grendelmeier P.
- Schunemann H. J.
- Schunemann Holger J.
- Scichilone N.
- Serpa F. S.
- Shamai S.
- Sheikh A.
- Sheikh Aziz
- Sierra M.
- Simons F. E. R.
- Siroux V.
- Sisul J. C.
- Sisul Juan-Carlos
- Skrindo I.
- Sole D.
- Somekh D.
- Sondermann M.
- Sooronbaev T.
- Sooronbaev Talant
- Sorensen M.
- Sorlini M.
- Sova M.
- Spranger O.
- Stellato C.
- Stellato Cristiana
- Stelmach R.
- Strozek J.
- Stukas R.
- Sunyer J.
- Szylling A.
- Tebyrica J. N.
- Thibaudon M.
- To T.
- To Teresa
- Todo-Bom A.
- Todo-Bom Ana-Maria
- Tomazic P. V.
- Tomazic Peter-Valentin
- Toppila-Salmi S.
- Toppila-Salmi Sanna
- Trama U.
- Triggiani M.
- Ulrik C. Suppli
- Urrutia-Pereira M.
- Valenta R.
- Valero A.
- Valero Antonio
- Valiulis A.
- Valiulis Arunas
- Valle S. Rodrigues
- Valovirta E.
- Valovirta Erkka
- van Eerd M.
- van Ganse E.
- van Hague M.
- van Wijk R. Gerth
- Vandenplas O.
- Vasankari T.
- Vatrella A.
- Ventura M. T.
- Ventura Maria-Teresa
- Verissimo M. T.
- Vezzani G.
- Viart F.
- Vicheva D.
- Viegi M.
- Vontetsianos T.
- Wagenmann M.
- Wagenmann Martin
- Walker S.
- Wallace D.
- Wallace Dana
- Wang D. Y.
- Wang De Yun
- Waserman S.
- Waserman Susan
- Werfel T.
- Westman M.
- Wickman M.
- Wickman Magnus
- Williams D. M.
- Williams S.
- Wilson N.
- Wright J.
- Wroczynski P.
- Yakovliev P.
- Yawn B. P.
- Yiallouros P. K.
- Yorgancioglu A.
- Yorgancioglu Arzu
- Yusuf O. M.
- Zar H. J.
- Zernotti M. E.
- Zhang L.
- Zhang Luo
- Zhong N.
- Zhong Nanshan
- Zidarn M.
- Zidarn Mihaela
- Zuberbier T.
- Zuberbier Torsten
- Zubrinich C.
- Zurkuhlen A.
- Publication venue
- Publication date
- 01/01/2018
- Field of study
Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline by using the best approach to integrated care pathways using mobile technology in patients with allergic rhinitis (AR) and asthma multimorbidity. The proposed next phase of ARIA is change management, with the aim of providing an active and healthy life to patients with rhinitis and to those with asthma multimorbidity across the lifecycle irrespective of their sex or socioeconomic status to reduce health and social inequities incurred by the disease. ARIA has followed the 8-step model of Kotter to assess and implement the effect of rhinitis on asthma multimorbidity and to propose multimorbid guidelines. A second change management strategy is proposed by ARIA Phase 4 to increase self-medication and shared decision making in rhinitis and asthma multimorbidity. An innovation of ARIA has been the development and validation of information technology evidence-based tools (Mobile Airways Sentinel Network [MASK]) that can inform patient decisions on the basis of a self-care plan proposed by the health care professional.Peer reviewe
CNL and aCML should be considered as single entity based on molecular profiles and outcomes
- Author
- Alobaidi Magda
- Alvares Caroline L
- Alvarez-Larran Alberto
- Amat Martinez Paula
- Ayala Rosa
- Carreño-Tarragona Gonzalo
- Cross Nicholas Cp
- Cuenca Isabel
- Cutting Robert
- Davidson Kerri
- Ferrer-Marin Francisca
- Francis Sebastian
- Gil-Manso Rodrigo
- Goddard Kathryn
- González-Martínez Teresa
- Gutiérrez Xabier
- Harrison Claire N
- Hernandez-Boluda Juan Carlos
- Koutsavlis Ioannis
- Martínez-López Joaquin
- Martínez-Ávila José Carlos
- Mayani Karan
- McGregor Andrew
- McIlwaine Louisa
- Mead Adam J
- Mora Casterá Elvira
- Morales María Luz
- Moreno Laura
- Narayanan Srinivasan
- Osorio Santiago
- Perez-Encinas Manuel
- Psaila Bethan
- Radia Deepti H
- Raya Jose Maria
- Rozman Maria
- Rufian Laura
- Segura Adrian
- Singh Vikram
- Smith Jeffrey
- Stuckey Ruth
- Sweeney Caroline P
- Toth Peter
- Wang Lihui
- Publication venue
- 'American Society of Hematology'
- Publication date
- 14/11/2022
- Field of study
Chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) are rare myeloid disorders that are challenging with regard to diagnosis and clinical management. To study the similarities and differences of these disorders we undertook a multi-center international study of one of the largest case series (CNL, n=24; aCML, n=37 cases, respectively), focusing on the clinical and mutational profiles (n=53 with molecular data) of these diseases. We found no differences in clinical presentation or outcomes between both entities. As previously described, both CNL and aCML share a complex mutational profile with mutations in genes involved in epigenetic regulation, splicing and signaling pathways. Apart from CSF3R, only EZH2 and TET2 were differentially mutated between them. The molecular profiles support the notion of CNL and aCML being a continuum of the same disease that may fit best within the myelodysplastic/myeloproliferative neoplasms (MDS/MPN). We identified four high-risk mutated genes, specifically CEBPA (β=2.26, HR=9.54, p=0.003), EZH2 (β=1.12, HR=3.062, p=0.009), NRAS (β=1.29, HR=3.63, p=0.048) and U2AF1 (β=1.75, HR=5.74, p=0.013) by multivariate analysis. Our findings underscore the relevance of molecular-risk classification in CNL/aCML as well as the importance of CSF3R mutations in these diseases.</p
Effect of Nuclear Factor κB Inhibition on Serotype 9 Adeno-Associated Viral (AAV9) Minidystrophin Gene Transfer to the mdx Mouse
- Author
- A Kumar
- A Martinez-Amat
- AE Emery
- AEH Emery
- AK Zaiss
- B Bostick
- B Wang
- C Zincarelli
- D Pan
- D Townsend
- Daniel P Reay
- DM Rothwarf
- DP Reay
- E Hoffman
- EE Zubrzycka-Gaarn
- Eugene Raggi
- G Bulfield
- Gabriela A Niizawa
- HH Stedman
- J Tilstra
- J Watchko
- Ja’Nean C Reay
- JF Watchko
- JH Shin
- JL Sapp
- JM Ervasti
- JM Peterson
- JN Kornegay
- Jon F Watchko
- K Inagaki
- L Qin
- MC Monici
- Molly Daood
- Paula R Clemens
- PM Janssen
- RV Machado
- S Acharyya
- S Eghtesad
- S Messina
- S Messina
- Y Tang
- Y Xu
- Y Yue
- Publication venue
- ScholarOne
- Publication date
- Field of study
Gene therapy studies for Duchenne muscular dystrophy (DMD) have focused on viral vector-mediated gene transfer to provide therapeutic protein expression or treatment with drugs to limit dystrophic changes in muscle. The pathological activation of the nuclear factor (NF)-κB signaling pathway has emerged as an important cause of dystrophic muscle changes in muscular dystrophy. Furthermore, activation of NF-κB may inhibit gene transfer by promoting inflammation in response to the transgene or vector. Therefore, we hypothesized that inhibition of pathological NF-κB activation in muscle would complement the therapeutic benefits of dystrophin gene transfer in the mdx mouse model of DMD. Systemic gene transfer using serotype 9 adeno-associated viral (AAV9) vectors is promising for treatment of preclinical models of DMD because of vector tropism to cardiac and skeletal muscle. In quadriceps of C57BL/10ScSn-Dmdmdx/J (mdx) mice, the addition of octalysine (8K)–NF-κB essential modulator (NEMO)-binding domain (8K-NBD) peptide treatment to AAV9 minidystrophin gene delivery resulted in increased levels of recombinant dystrophin expression suggesting that 8K-NBD treatment promoted an environment in muscle tissue conducive to higher levels of expression. Indices of necrosis and regeneration were diminished with AAV9 gene delivery alone and to a greater degree with the addition of 8K-NBD treatment. In diaphragm muscle, high-level transgene expression was achieved with AAV9 minidystoophin gene delivery alone; therefore, improvements in histological and physiological indices were comparable in the two treatment groups. The data support benefit from 8K-NBD treatment to complement gene transfer therapy for DMD in muscle tissue that receives incomplete levels of transduction by gene transfer, which may be highly significant for clinical applications of muscle gene delivery
MASK 2017: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma multimorbidity using real-world-evidence
- Author
- Aberer W.
- Agache I.
- Akdis C. A.
- Akdis M.
- Alberti M. R.
- Almeida R.
- Amat F.
- Angles R.
- Annesi-maesano I.
- Ansotegui I. J.
- Anto J. M.
- Arnavielhe S.
- Arnavielle S.
- Arshad H.
- Asarnoj A.
- Asayag E.
- Avolio F.
- Bacci E.
- Bachert C.
- Baiardini I.
- Barbagallo M.
- Barbara C.
- Baroni I.
- Barreto B. A.
- Basagana X.
- Bateman E. D.
- Bedbrook A.
- Bedolla-Barajas M.
- Beghe' B.
- Bel E. H.
- Bennoor K. S.
- Benson M.
- Bergmann K. C.
- Bertorello L.
- Bewick M.
- Bialek S.
- Bialoszewski A. Z.
- Bieber T.
- Bindslev-jensen C.
- Bjermer L.
- Blain H.
- Blasi F.
- Blua A.
- Bochenska Marciniak M.
- Bogus-Buczynska I.
- Boner A. L.
- Bonini M.
- Bonini S.
- Bosnic-Anticevich C. S.
- Bosnic-anticevich S.
- Bosse I.
- Bouchard J.
- Boulet L. P.
- Bourret R.
- Bousquet J.
- Bousquet P. J.
- Braido F.
- Briedis V.
- Brightling C. E.
- Brozek J.
- Bucca C.
- Buhl R.
- Buonaiuto R.
- Burguete Cabanas M. T.
- Burte E.
- Bush A.
- Caballero-Fonseca F.
- Caillot D.
- Caimmi D.
- Calderon M. A.
- Camargos P. A. M.
- Camuzat T.
- Canfora G.
- Canonica G. W.
- Cardona V.
- Carlsen K. H.
- Carr W.
- Carreiro-Martins P.
- Carriazo A. M.
- Cartier C.
- Carvalho Coehlo A. C.
- Casale T.
- Castellano G.
- Cecchi L.
- Cepeda A. M.
- Chavannes N. H.
- Chen Y.
- Chiron R.
- Chivato T.
- Chkhartishvili E.
- Chuchalin A. G.
- Chung K. F.
- Ciaravolo M. M.
- Ciceran A.
- Cingi C.
- Ciprandi G.
- Colas L.
- Colgan E.
- Coll J.
- Conforti D.
- Correia de Sousa J.
- Cortes-Grimaldo R. M.
- Corti F.
- Costa E.
- Costa-Dominguez M. C.
- Courbis A. L.
- Cox L.
- Crescenzo M.
- Cruz A. A.
- Custovic A.
- Czarlewski W.
- da Silva J.
- Dahlen S. E.
- Dario C.
- Darsow U.
- Dauvilliers Y.
- De Blay F.
- De Carlo G.
- de Fatima Emerson M.
- De Feo G.
- De Manuel Keenoy E.
- De Martino B.
- de Paula Motta Rubini N.
- De Vries G.
- Dedeu T.
- Deleanu D.
- Demoly P.
- Denburg J. A.
- Devillier P.
- Di Capua Ercolano S.
- Di Carluccio N.
- Didier A.
- Dokic D.
- Dominguez-Silva M. G.
- Douagui H.
- Dray G.
- Du Toit G.
- Dubakiene R.
- Durham S. R.
- Dykewickz M.
- Dykewicz M. S.
- Eklund P.
- El-Gamal Y.
- Eller E.
- Emuzyte R.
- Farrell J.
- Farsi A.
- Ferreira de Mello J.
- Ferrero J.
- Fink-Wagner A.
- Fiocchi A.
- Fokkens W. J.
- Fonseca J.
- Fonseca J. A.
- Fontaine J. F.
- Forti S.
- Fuentes Perez M.
- Fuentes-Perez J. M.
- Galvez-Romero J. L.
- Gamkrelidze A.
- Garcia-Aymerich J.
- Garcia-Cobas C. Y.
- Garcia-Cruz M. H.
- Gemicioglu B.
- Genova S.
- George C.
- Gereda J. E.
- Gerth van Wijk R.
- Gomez R. M.
- Gomez-Vera J.
- Gonzalez Diaz S.
- Gotua M.
- Grisle I.
- Guidacci M.
- Guldemond N. A.
- Gutter Z.
- Guzman M. A.
- Haahtela T.
- Hajjam J.
- Hellings P.
- Hellings P. W.
- Hernandez L.
- Hourihane J. O. '. B.
- Huerta Villabolos Y. R.
- Huerta-Villalobos Y. R.
- Humbert M.
- Iaccarino G.
- Illario M.
- Ivancevich J. C.
- Jares E. J.
- Jassem E.
- Johnston S. L.
- Joos G.
- Jung K. S.
- Just J.
- Jutel M.
- Kaidashev I.
- Kalayci O.
- Kalyoncu A. F.
- Kardas P.
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- Publication venue
- BioMed Central
- Publication date
- 01/01/2018
- Field of study
Health, such as apps running on consumer smart devices is becoming increasingly popular and has the potential to profoundly affect healthcare and health outcomes. However, it may be disruptive and results achieved are not always reaching the goals. Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline using the best evidence-based approach to care pathways suited to real-life using mobile technology in allergic rhinitis (AR) and asthma multimorbidity. Patients largely use over-the-counter medications dispensed in pharmacies. Shared decision making centered around the patient and based on self-management should be the norm. Mobile Airways Sentinel networK (MASK), the Phase 3 ARIA initiative, is based on the freely available MASK app (the Allergy Diary, Android and iOS platforms). MASK is available in 16 languages and deployed in 23 countries. The present paper provides an overview of the methods used in MASK and the key results obtained to date. These include a novel phenotypic characterization of the patients, confirmation of the impact of allergic rhinitis on work productivity and treatment patterns in real life. Most patients appear to self-medicate, are often non-adherent and do not follow guidelines. Moreover, the Allergy Diary is able to distinguish between AR medications. The potential usefulness of MASK will be further explored by POLLAR (Impact of Air Pollution on Asthma and Rhinitis), a new Horizon 2020 project using the Allergy Diary
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
- Author
- Abad Jorge
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Accordino Giulia
- Achille Cristian
- Acosta-Ampudia Yeny
- Agra Juan José Cáceres
- Aguilera-Albesa Sergio
- Aguiló-Cucurull Aina
- Aiuti Alessandro
- Aiuti Alessandro
- Aiuti Alessandro
- Akcan Özge Metin
- Al-Muhsen Saleh
- Al-Mulla Fahd
- Alavoine Loubna
- Albert Matthew
- Albisures Jonathan Antonio Roblero
- Alcover Andres
- Aldave Juan
- Algera Anne Geke
- Aliberti Anna
- Alkan Gulsum
- Alkhater Suzan
- Alkhater Suzan
- Allardet-Servent Jerome
- Allavena Clotilde
- Allende Luis
- Alonso-Arias Rebeca
- Alshahrani Mohammed
- Alsina Laia
- Alvarez Josep Trenado
- Alyanakian Marie-Alexandra
- Amador-Borrero Blanca
- Amat Karine
- Amoura Zahir
- Anaya Juan-Manuel
- Anderson Mark
- Anderson Mark
- Andreakos Evangelos
- Andreakos Evangelos
- Andrejak Claire
- Andrés Ana De
- Anglicheau Dany
- Angoulvant François
- Annereau Jean-Philippe
- Antolí Arnau
- Appelman Brent
- Arias Andrés
- Arias Andrés Augusto
- Arkin Lisa
- Arquero Miguel Fernandez
- Arranz María Jesús
- Arrestier Romain
- Arrestier Romain
- Asano Takaki
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- Aubart Mélodie
- Auguet Teresa
- Avramenko Iryna
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- Aytekin Selma Erol
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- Mouquet Hugo
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- Okamoto Keisuke
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- Ozcelik Tayfun
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- Tancevski Ivan
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- Tiberghien Pierre
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- Tubiana Sarah
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- Uddin Mohammed
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- Utsumi Takanori
- Uzunhan Yurdagul
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- Valencia-Ramos Juan
- Valsecchi Maria Grazia
- van Agtmael Michiel
- van Baarle Frank
- van Braeckel Eva
- van de Beek Diederik
- van de Beek Diederik
- van de Beek Diederik
- van den Rym Ana Maria
- van der Poll Tom
- van der Valk Marc
- van der Werf Sylvie
- van der Werf Sylvie
- van Mourik Niels
- van Praet Jens
- van Vugt Michèle
- Vanderlinden Dimitri
- Vandernoot Isabelle
- Vanel Noémie
- Vasse Marc
- Veelo Denise
- Veislinger Aurélie
- Velez-Santamaria Valentina
- Veliz Silvia Patricia Zuniga
- Venet Fabienne
- Vergara José Alejandro Daza
- Vidaur Loreto
- Vidaur Loreto
- Vidigal Mateus
- Vidigal Mateus
- Viel Sébastien
- Vignali Valérie
- Vilaire-Meunier Marie
- Villain Cédric
- Villar-García Judit
- Vincent Audrey
- Vinh Donald
- Vinh Donald
- Visseaux Benoit
- Visseaux Benoit
- Vlaar Alexander
- Vogt Guillaume
- Voiriot Guillaume
- Volleman Carolien
- Volokha Alla
- von Bernuth Horst
- von Stemann Jakob Hjorth
- Vught Lonneke
- Vuotto Fanny
- Vélez Verónica Posada
- Waucquier Nawal
- Wauters Els
- Wauters Joost
- Wauters Joost
- Wauters Joost
- Wiedemann Aurélie
- Wiersinga W. Joost
- Wouters Dorien
- Wu Alan
- Wu Tak-Chiu
- Yahşi Aysun
- Yang Rui
- Yasar Kadriye Kart
- Yazdanpanah Yazdan
- Yazdanpanah Yazdan
- Yepes Jairo David Torres
- Yesilbas Osman
- Yildiz Mehmet
- Young Barnaby
- Yükselmiş Ufuk
- Zatz Mayana
- Zatz Mayana
- Zatz Mayana
- Zawadzki Pawel
- Zhang Peng
- Zhang Qian
- Zhang Shen-Ying
- Zhang Yu
- Zimmer Christophe
- Zins Marie
- Zins Marie
- Zuccaro Valentina
- Zwinderman A.
- Íñigo-Campos Antonio
- Öz Şadiye Kübra Tüter
- Özkan Esra Akyüz
- Özçelik Tayfun
- Publication venue
- 'Proceedings of the National Academy of Sciences'
- Publication date
- 24/05/2022
- Field of study
International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
- Author
- Abad Jorge
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Accordino Giulia
- Achille Cristian
- Acosta-Ampudia Yeny
- Agra Juan José Cáceres
- Aguilera-Albesa Sergio
- Aguiló-Cucurull Aina
- Aiuti Alessandro
- Aiuti Alessandro
- Aiuti Alessandro
- Akcan Özge Metin
- Al-Muhsen Saleh
- Al-Mulla Fahd
- Alavoine Loubna
- Albert Matthew
- Albisures Jonathan Antonio Roblero
- Alcover Andres
- Aldave Juan
- Algera Anne Geke
- Aliberti Anna
- Alkan Gulsum
- Alkhater Suzan
- Alkhater Suzan
- Allardet-Servent Jerome
- Allavena Clotilde
- Allende Luis
- Alonso-Arias Rebeca
- Alshahrani Mohammed
- Alsina Laia
- Alvarez Josep Trenado
- Alyanakian Marie-Alexandra
- Amador-Borrero Blanca
- Amat Karine
- Amoura Zahir
- Anaya Juan-Manuel
- Anderson Mark
- Anderson Mark
- Andreakos Evangelos
- Andreakos Evangelos
- Andrejak Claire
- Andrés Ana De
- Anglicheau Dany
- Angoulvant François
- Annereau Jean-Philippe
- Antolí Arnau
- Appelman Brent
- Arias Andrés
- Arias Andrés Augusto
- Arkin Lisa
- Arquero Miguel Fernandez
- Arranz María Jesús
- Arrestier Romain
- Arrestier Romain
- Asano Takaki
- Aschard Hugues
- Aubart Mélodie
- Auguet Teresa
- Avramenko Iryna
- Aytekin Gökhan
- Aytekin Selma Erol
- Azot Axelle
- Azoulay Cecile
- Bachelet Delphine
- Bahram Seiamak
- Bajolle Fanny
- Baldanti Fausto
- Baldolli Aurélie
- Ballester Maite
- Baris-Feldman Hagit
- Barreiros Lucila
- Barrou Benoit
- Bartoli Marie
- Barzaghi Federica
- Basmaci Romain
- Basso Sabrina
- Bastard Paul
- Batten Isabella
- Bauters Fré
- Bax Diane
- Bayhan Gulsum Iclal
- Behillil Sylvie
- Behillill Sylvie
- Bellani Giacomo
- Belot Alexandre
- Belot Alexandre
- Belot Alexandre
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Beretta Ilaria
- Bergin Colm
- Bertholon Frédérique
- Bettini Laura Rachele
- Beudel Martijn
- Bezrodnik Liliana
- Bhavsar Krishna
- Biggs Catherine
- Biggs Catherine
- Bilbao Agurtzane
- Bilguvar Kaya
- Biondi Andrea
- Bitker Laurent
- Bizien Lucy
- Blanchard-Rohner Geraldine
- Blanco Ignacio
- Blandinières Adeline
- Bleibtreu Alexandre
- Bloomfield Marketa
- Blázquez-Gamero Daniel
- Bogaard Harm Jan
- Bogunovic Dusan
- Boisson Bertrand
- Bolivar-Prados Mireia
- Bolze Alexandre
- Bomers Marije
- Bondarenko Anastasiia
- Bondarenko Anastasiia
- Bondarenko Anastasiia
- Bonfanti Paolo
- Bonneaudeau Brigitte
- Bonta Peter
- Borghesi Alessandro
- Borie Raphael
- Borrero Blanca Amador
- Bos Lieuwe
- Bosteels Cédric
- Botdhlo-Nevers Elisabeth
- Botelho-Nevers Elisabeth
- Botta Michela
- Bouadma Lila
- Bouadma Lila
- Boucherit Soraya
- Boudhabhay Idris
- Bouiller Kévin
- Boulanger Cécile
- Bourgeois Fleur Le
- Bourgeon Marilou
- Bourke Nollaig
- Bourke Nollaig
- Bourke Nollaig
- Bouscambert-Duchamp Maude
- Bousfiha Ahmed
- Bousfiha Ahmed
- Bousfiha Ahmed
- Bousquet Aurore
- Bousso Philippe
- Boutolleau David
- Bouvattier Claire
- Boyarchuk Oksana
- Boyarchuk Oksana
- Bozdemir Şefika Elmas
- Bravais Juliette
- Briones M. Luisa
- Briseño-Roa Luis
- Brodin Petter
- Brodin Petter
- Brouwer Matthijs
- Bruhns Pierre
- Bruneau Léa
- Brunner Marie-Eve
- Bruno Raffaele
- Bryceson Yenan
- Bueno Maria Rita P.
- Bugiani Marianna
- Buis David
- Bukhari Huda
- Bulle Esther
- Burdet Charles
- Burdet Charles
- Burrel Sonia
- Bustamante Carlos
- Bustamante Jacinta
- Butte Manish
- Béziat Vivien
- Cannet Dorothée
- Capra Ruggero
- Carapito Raphael
- Carrabba Maria
- Carrillo Jorge
- Casanova Jean-Laurent
- Casanova Jean-Laurent
- Casari Giorgio
- Casari Giorgio
- Casari Giorgio
- Casasnovas Carlos
- Caseris Marion
- Cassaniti Irene
- Castagnoli Riccardo
- Castelle Martin
- Castelli Francesco
- Castro Mateus
- Catherinot Emilie
- Cazzaniga Marina
- Celik Jale Bengi
- Cerf-Bensussan Nadine
- Cervantes-Gonzalez Minerva
- Ceschi Alessandro
- Chahine Abir
- Chair Anissa
- Chakravorty Samya
- Chalumeau Martin
- Charbit Bruno
- Charpentier Charlotte
- Chauvineau-Grenier Angélique
- Chen Jie
- Cheng Matthew
- Chirouze Catherine
- Chirouze Catherine
- Chouchane Osoul
- Chrabieh Maya
- Christodoulou John
- Ciceri Fabio
- Citerio Giuseppe
- Clavé Pere
- Clercq Jozefien De
- Cloherty Alex
- Clotet Bonaventura
- Cobat Aurélie
- Codina Anna
- Coelho Alexandra
- Coeuret-Pellicer Mireille
- Cognasse Fabrice
- Cognasse Fabrice
- Cohen Yves
- Colobran Roger
- Colobran Roger
- Comarmond Cloé
- Combes Alain
- Comoli Patrizia
- Condino-Neto Antonio
- Condino-Neto Antonio
- Conlon Niall
- Connolly Emma
- Constantinescu Stefan
- Conti Francesca
- Contro Ernesto
- Cooper Megan
- Cordel Hugues
- Correales Luisa Paola Duarte
- Corsico Angelo
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Couffin-Cadiergues Sandrine
- Coulongeat Matthieu
- Coşkuner Taner
- Cruz Inés Marín
- Cuadros Esmeralda Nuñez
- Cumano Ana
- Cvetkovski Aleksandar
- Cyrus Cyril
- Daganou Maria
- Dalgard Clifton
- Dalgard Clifton
- Dalmau David
- Dalmau David
- Danielson Jeffrey
- Danion François
- Darazam Ilad Alavi
- Darley David Ross
- Das Vincent
- Dauby Nicolas
- Dauger Stéphane
- de Brabander Justin
- de Bree Godelieve
- de Bruin Sanne
- de Chambrun Marc Pineton
- de Diego Rebeca Perez
- de Jong Menno
- de la Chapelle Aliénor
- de Lamballerie Xavier
- de Montmollin Etienne
- de Munter Paul
- de Pontual Loic
- de Prost Nicolas
- de Rotte Maurits
- de Vera Martín Castillo
- de Vries Heder
- Debard Alexa
- Debette Stéphanie
- Debette Stéphanie
- Debray Marie-Pierre
- Dechanet Aline
- Dehban Amin
- Delmonte Ottavia
- Delplancq Geoffroy
- Demar Magalie
- Demirkol Yasemin Kendir
- Demoule Alexandre
- Deplanque Dominique
- Deplanque Dominique
- Deriano Ludovic
- Desai Murkesh
- Descamps Diane
- Descamps Diane
- Desguerre Isabelle
- Desille-Dugast Mireille
- Desmarets Maxime
- Desvallée Mathilde
- Di Sabatino Antonio
- Di Santo James
- Diallo Alpha
- Diego Rebeca Pérez De
- Diehl Jean-Luc
- Diehl Jean-Luc
- Dijkstra Mirjam
- Dillies Marie-Agnès
- Ding Li
- Dinh Khoa Manh
- Diouf Alphonsine
- Djossou Félix
- Dobbelaere Stephanie
- Dobbs Kerry
- Dominguez-Garrido Elena
- Domínguez-Garrido Elena
- Dongelmans Dave
- Dorgham Karim
- Dorival Céline
- Drolet Beth
- Dromer Françoise
- Dubos François
- Dubost Clément
- Duffy Darragh
- Duffy Darragh
- Dufouil Carole
- Dujardin Romein
- Dunne Jean
- Dupont Annabelle
- Duval Xavier
- Duval Xavier
- Duvlis Sotirija
- Dyer Adam
- D’angio Mariella
- D’enfert Christophe
- D’ortenzio Eric
- Eberl Gérard
- Ecobichon Jean-Luc
- Ekwall Olov
- El Baghdadi Jamila
- El Bakkouri Jalila
- Elbers Paul
- Elnagdy Marwa
- Eloy Philippine
- Emiroglu Melike
- Endo Akifumi
- Enninga Jost
- Enouf Vincent
- Enouf Vincent
- Epaulard Olivier
- Erdeniz Emine Hafize
- Erikstrup Christian
- Erikstrup Christian
- Esperou Hélène
- Espinosa-Padilla Sara
- Esposito-Farase Marina
- Espérou Hélène
- Etienne Manuel
- Eto Shohei
- Euvrard Romain
- Fabio Giovanna
- Faivre Laurence
- Falck Antonin
- Fallon Aoife
- Fartoukh Muriel
- Faure Morgane
- Fekkar Arnaud
- Feldman Hagit Baris
- Feldman Hagit Baris
- Fellay Jacques
- Fellay Jacques
- Fellay Jacques
- Ferrer Ricard
- Ferreres Jose
- Fievet Nathalie
- Flaig Amandine
- Fleuren Lucas
- Flores Carlos
- Flores Carlos
- Florkin Benoit
- Fontes Magnus
- Foti Giuseppe
- Fouchard Julie
- Franco José Luis
- Franco José Luis
- Francois Bruno
- Frezouls Wahiba
- Froidure Antoine
- Fumadó Victoria
- Fung Kitty
- Fusco Francesca
- Gagneux-Brunon Amandine
- Gagro Alenka
- Gallian Pierre
- Garcia-Prat Marina
- García Paula Andrea Gaviria
- Garot Denis
- Garçon Pierre
- Gatineau Audrey Giraud
- Gaudet Alexandre
- Gault Nathalie
- Gaussem Pascale
- Gaymard Alexandre
- Gayretli Zeynep
- Geerlings Suzanne
- Geijtenbeek Theo
- Gentile Stéphanie
- Gervais Adrian
- Ghirardello Stefano
- Ghosn Jade
- Gigante Tristan
- Gil-Herrera Juana
- Gilardin Laurent
- Gilardin Laurent
- Gilg Morgane
- Girbes Armand
- Girona-Alarcón Mònica
- Gissot Valérie
- Godínez Karen Alejandra Cifuentes
- Goehringer François
- Goffard Jean-Christophe
- Goldberg Marcel
- Gomperts-Boneca Ivo
- Gonzales Nacho
- Gonzalez-Granado Luis
- González-Montelongo Rafaela
- Goorhuis Bram
- Gorochov Guy
- Got Stéphane Le
- Gregersen Peter
- Gregersen Peter
- Gribouval Olivier
- Grimbacher Bodo
- Grobusch Martin
- Guaqueta Jeser Santiago Grass
- Guedj Jérémie
- Guerder Antoine
- Gumucio Victor Daniel
- Gunst Jan
- Gut Marta
- Gálvez-Romero José Luis
- Gérardin Patrick
- Gómez Oscar
- Gülhan Belgin
- Hadjadj Jérôme
- Haerynck Filomeen
- Haerynck Filomeen
- Haerynck Filomeen
- Hafkamp Florianne
- Hagens Laura
- Hagin David
- Hagin David
- Haljasmägi Liis
- Halwani Rabih
- Halwani Rabih
- Halwani Rabih
- Hamann Jorg
- Hammarström Lennart
- Hammarström Lennart
- Hammarström Lennart
- Hamzeh-Cognasse Hind
- Hancerli Selda
- Hanitsch Leif Gunnar
- Hansen Morten Bagge
- Hariyan Tetyana
- Harris Vanessa
- Hasan Milena
- Hatipoglu Nevin
- Heath James
- Heath James
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- Hendou Samia
- Henny Joseph
- Henrickson Sarah
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- Ho Po-Ki
- Hoctin Alexandre
- Hoffmann Hans-Heinrich
- Hoffmann Isabelle
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- Holland Steven
- Hollmann Markus
- Horcajada Juan
- Horn Janneke
- Hoste Eric
- Hoste Levi
- Houas Ikram
- Houhou Nadhira
- Hovius Joppe
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- Nukui Yoko
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- Okamoto Keisuke
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- Oualha Mehdi
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- Ozcelik Tayfun
- Ozguler Anna
- Ozkaya-Parlakay Aslinur
- O’farrelly Cliona
- O’farrelly Cliona
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- Pagani Michele
- Pan-Hammarström Qiang
- Pan-Hammarström Qiang
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- Paul Stéphane
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- Pedraza-Sánchez Sigifredo
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- Peigne Vincent
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- Perlin David
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- Planas Anna
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- Poissy Julien
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- Quintana-Murci Lluis
- Quintana-Murci Lluis
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- Shahrooei Mohammad
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- Sottini Alessandra
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- Spaan András
- Stella Giulia Maria
- Stepanian Alain
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- Stijnis Cornelis
- Stilma Willemke
- Stoclin Annabelle
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- Su Helen
- Su Helen
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- Sánchez-Ramón Silvia
- Särekannu Karita
- Sözeri Betül
- Sørensen Erik
- Taccone Fabio
- Talouarn Estelle
- Tanaka Junko
- Tancevski Ivan
- Tancevski Ivan
- Tandjaoui-Lambiotte Yacine
- Tandjaoui-Lambiotte Yacine
- Tangy Frédéric
- Tangye Stuart
- Tangye Stuart
- Tardivon Coralie
- Tardy Bernard
- Taupin Jean-Luc
- Tavernier Simon
- Tayoun Ahmad Abou
- Tellier Marie-Capucine
- Terrier Benjamin
- Terrier Olivier
- Teunissen Charlotte
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- Thibault Chloé
- Thiery Guillaume
- Thoral Patrick
- Thorball Christian
- Thorn Karolina
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- Thy Michael
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- Tiberghien Pierre
- Timsit Jean-François
- Tipu Imran
- Tolstrup Martin
- Tolstrup Martin
- Tomasoni Gabriele
- Toubert Antoine
- Toubiana Julie
- Touvier Mathilde
- Townsend Liam
- Triantafyllia Vasiliki
- Trouillet-Assant Sophie
- Trouillet-Assant Sophie
- Troya Jesús
- Troya Jesús
- Tsang Owen
- Tserel Liina
- Tso Eugene
- Tsonas Anissa
- Tsumura Miyuki
- Tual Christelle
- Tubiana Sarah
- Tubiana Sarah
- Tucci Alessandra
- Tuinman Pieter
- Turvey Stuart
- Tzourio Christophe
- Téoulé François
- Uddin K.
- Uddin Mohammed
- Ungeheuer Marie-Noëlle
- Ursini Matilde Valeria
- Utsumi Takanori
- Uzunhan Yurdagul
- Vabres Pierre
- Valencia-Ramos Juan
- Valsecchi Maria Grazia
- van Agtmael Michiel
- van Baarle Frank
- van Braeckel Eva
- van de Beek Diederik
- van de Beek Diederik
- van de Beek Diederik
- van den Rym Ana Maria
- van der Poll Tom
- van der Valk Marc
- van der Werf Sylvie
- van der Werf Sylvie
- van Mourik Niels
- van Praet Jens
- van Vugt Michèle
- Vanderlinden Dimitri
- Vandernoot Isabelle
- Vanel Noémie
- Vasse Marc
- Veelo Denise
- Veislinger Aurélie
- Velez-Santamaria Valentina
- Veliz Silvia Patricia Zuniga
- Venet Fabienne
- Vergara José Alejandro Daza
- Vidaur Loreto
- Vidaur Loreto
- Vidigal Mateus
- Vidigal Mateus
- Viel Sébastien
- Vignali Valérie
- Vilaire-Meunier Marie
- Villain Cédric
- Villar-García Judit
- Vincent Audrey
- Vinh Donald
- Vinh Donald
- Visseaux Benoit
- Visseaux Benoit
- Vlaar Alexander
- Vogt Guillaume
- Voiriot Guillaume
- Volleman Carolien
- Volokha Alla
- von Bernuth Horst
- von Stemann Jakob Hjorth
- Vught Lonneke
- Vuotto Fanny
- Vélez Verónica Posada
- Waucquier Nawal
- Wauters Els
- Wauters Joost
- Wauters Joost
- Wauters Joost
- Wiedemann Aurélie
- Wiersinga W. Joost
- Wouters Dorien
- Wu Alan
- Wu Tak-Chiu
- Yahşi Aysun
- Yang Rui
- Yasar Kadriye Kart
- Yazdanpanah Yazdan
- Yazdanpanah Yazdan
- Yepes Jairo David Torres
- Yesilbas Osman
- Yildiz Mehmet
- Young Barnaby
- Yükselmiş Ufuk
- Zatz Mayana
- Zatz Mayana
- Zatz Mayana
- Zawadzki Pawel
- Zhang Peng
- Zhang Qian
- Zhang Shen-Ying
- Zhang Yu
- Zimmer Christophe
- Zins Marie
- Zins Marie
- Zuccaro Valentina
- Zwinderman A.
- Íñigo-Campos Antonio
- Öz Şadiye Kübra Tüter
- Özkan Esra Akyüz
- Özçelik Tayfun
- Publication venue
- 'Proceedings of the National Academy of Sciences'
- Publication date
- 24/05/2022
- Field of study
International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population
Empagliflozin in Patients with Chronic Kidney Disease
- Author
- Aamir Navivala
- Abdulwahab Arbi
- Abegail Hernandez Pena
- Abraham Hanburry
- Adedolapo Adeleke
- Adeera Levin
- Adil Hazara
- Adline Ghazi
- Agnes Masengu
- Ahmad Tuffaha
- Ahmed Awad
- Ahmed Ghanem
- Ai Fukasawa
- Aik Kheng Lee
- Aiko Terakawa
- Aiko Tomita
- Aiko Yamada
- Ailsa Geddes
- Airi Sato
- Akane Katanosaka
- Akane Yamamoto
- Akihiro Fujimoto
- Akihiro Katayama
- Akihito Tanaka
- Akiko Fujita
- Akiko Hashimoto
- Akiko Ishiguro
- Akiko Omata
- Akimasa Asai
- Akinwande Akinfolarin
- Akio Kanazawa
- Akiyo Nishiyama
- Akiyo Tanabe
- Alastair Rankin
- Alastair Woodman
- Albert Hing
- Albert Power
- Alberto Rosati
- Aldo P Maggioni
- Aldo Peixoto
- Aleksandra Murawska
- Alessandro D'Amelio
- Alex Aguilera
- Alex Baxter
- Alex Howson
- Alexa Wonnacott
- Alexander Hadley
- Alexander Hodakowski
- Alexander Paliege
- Alexis Africano
- Alexis Stevenson
- Alfio Giuffrida
- Alfred K Cheung
- Alia Hasan
- Alia Zubaidah Bahtar
- Alice Aitken
- Alice Guerini
- Aliseiya Garza
- Alison Cowley
- Alison Jenkins
- Alison Timadjer
- Allen Young
- Allison Leslie
- Amalia Caamano
- Amanda Aliu
- Amanda Axler
- Amanda Davis
- Amanda Scott
- Amanda Tyler
- Amar Ali
- Amber Avery
- Amber Hurst
- Amelia Te
- Ami Inamori
- Amin Oomatia
- Amir Kazory
- Amret Hawfield
- Amritanshu Pandey
- Amy Hudson
- Amy Hunter
- Amy Mottl
- Ana Moncada
- Anand Srivastava
- Anastassiya Reisler
- Anca Gherman
- Andre Valleteau
- Andrea Lorimer
- Andrea Schwab
- Andrea Webster
- Andrea Wilson
- Andreas Schneider
- Andrew Breach
- Andrew Connor
- Andrew Frankel
- Andrew Gordon
- Andrew Lewington
- Andrew Shepherd
- Andrew Steele
- Andy Burke
- Andy Measor
- Angela Bergner
- Angela Chamberlain
- Angela Field
- Angela Moon
- Angeline Mbuyisa
- Angharad Williams
- Anil George
- Anita Hepditch
- Anita Kamarzarian
- Anja Knoppe
- Anju Oommen
- Anke Torp
- Ankit Mehta
- Ann Bennett
- Ann Cooper
- Ann Vasseur
- Anna Brewer
- Anna Liew
- Anna Postal
- Anna Romo
- Anna Sampson
- Annalisa Aloisi
- Anne Froment
- Anne Grace
- Anne Schreiber
- Anne-Marie Beneat
- Annegret Fleischer
- Annette Kraemer-Guth
- Annie Saillant
- Annika Küpper
- Anoushka Bhatt
- Anthony Lambert
- Anthony Torres
- Anthoula Apostolidi
- Antonia Schuster
- Antonio Cardone
- Aoife O'Sullivan
- Aparna Padiyar
- Arash Rashidi
- Archie Maskill
- Arelis Madera
- Arif Khwaja
- Arihiro Kiyosue
- Asako Takesada
- Ashlee Morris
- Ashleigh Wheeler
- Ashley Lawson
- Ashwathy Varughese
- Ashwini Gore
- Asma Sabarai
- Astrid Maselli
- Atsuko Nakatsuka
- Atsuyuki Tokuyama
- Auguste Kutschat
- Autumn Wood
- Aya Kawase
- Aya Tanaka
- Aya Yamanaka
- Ayako Imai
- Ayana Tatsuzawa
- Aydin Er
- Ayesha Ali
- Ayesha Irtiza-Ali
- Aziee Sudin
- Bader Al-Zeer
- Baigent Colin
- Bak Leong Goh
- Balwinder Gill
- Ban Chai Peng
- Baochun Guo
- Barbara Bartolomei Mecatti
- Barbara Tucky
- Barbara Winter-Goodwin
- Barbara Zander
- Barry Johns
- Beate Schumacher
- Bellovich Keith
- Ben Bagwell
- Ben Caplin
- Bernd Hohenstein
- Bernd Kruger
- Bernd Schroppel
- Bernd Stratmann
- Bernhard Banas
- Bernhard Kraemer
- Bernhard Winkelmann
- Bethelihem Gebeyehu
- Bhavya Kothapalli
- Bhrigu Sood
- Bhupinder Grewal
- Bianca Weber
- Bianka Rettenmaier
- Binbin Jin
- Bob Goodenough
- Bradley Eilerman
- Brandy Caudill
- Brenner Susanne
- Brian Camilleri
- Brigitte Fuchs
- Britta Brettschneider
- Britta Zemann
- Brittany Cleveland
- Brittany Golson
- Brittany Whitmore
- Brueckmann Martina
- Camille Galloway
- Cara Healy
- Carina Krieger
- Carl-Philipp Roesch
- Carlo Castillo
- Carlo Garofalo
- Carlos Hernandez-Cassis
- Carlos Martinez
- Carly McDonald
- Carol Buckman
- Carol Knott
- Caroline Blake
- Carolyn Hutchinson
- Cashmere Hardy
- Cassandra Johnson
- Cassandra Kimber
- Cat Guest
- Cath Byrne
- Cathy Jackson
- Cecilia Barnini
- Cesira Cafiero
- Chakradhar Velagapudi
- Charalampos Kriatselis
- Charles Daniels
- Charles Herzog
- Charlotte Kamundi
- Chee Koon Low
- Chek Loong Loh
- Chelsia Bao Tyng Chan
- Chen Cheng
- Chen Hua Ching
- Cheng Beng Goh
- Cherney David
- Chetna Tailor
- Cheung Alfred K
- Chiara Saccà
- Chiara Salviani
- Chidambaram Nethaji
- Chie Hashimoto
- Chie Saito
- Chigusa Higuchi
- Chigusa Yamashita
- Chiho Murakami
- Chika Kuribayashi
- Chimaki Unekawa
- Chintankumar Barot
- Chloe Bird
- Chong Men Leong
- Chris Bowler
- Chrissie Ambrose
- Christian Albert
- Christian Hartner
- Christian Hugo
- Christina Büttner
- Christina Reith
- Christine Bond
- Christine Braun
- Christine Brown
- Christine McClary-Wright
- Christine Meshykhi
- Christine Pötz
- Christoph Stellbrink
- Christoph Wanner
- Christopher Goldsmith
- Christopher Hill
- Christopher Marshall
- Christopher Provenzano
- Christopher Sze Bing Sim
- Christopher Wong
- Chuanwen Xu
- Chukwuma Chukwu
- Chun Leong Low
- Chye Chung Gan
- Cindy Castro
- Cindy Vanhoy
- Claire Burston
- Claire Sharpe
- Claire Shenton
- Clare Hui Hong Tan
- Clare Macdonald
- Claudia Donhauser
- Claudia Foellinger
- Claudia Hanf
- Claudia Schmidt
- Claudia Schneider-Danwitz
- Clorinda Falcone
- Cole Valletta
- Conception Pugay
- Concetta Gangemi
- Conor Moran
- Cristina Badin
- Cristina Calvi
- Curtis Knight
- Cynthia Mohandas
- Daisuke Sato
- Daisy Arteaga
- Damini Jeyarajah
- Daniel Kraus
- Daniel Pinto
- Daniel Steffl
- Daniela Farrugia
- Danijela Bovan
- Danny Sugimoto
- Daria Motta
- Darya Hosein
- David Bains
- David Cherney
- David Loader
- David MacLean
- David Preiss
- David Sutton
- David Tietjen
- Davina Hewitt
- Debasish Banerjee
- Debbie Domingo
- Debbie Griffin
- Deborah Glowski
- Deborah Lund
- Deirdre Fottrell-Gould
- Denise Donaldson
- Denise Fleming-Brown
- Denise Laurienti
- Dennis Karounos
- Deo Rajat
- Derrick Bennett
- Devasmita Dev
- Dheeptha Radhakrishnan
- Diane Campbell
- Diane Watkins
- Diethelm Tschope
- Diliana Draganova
- Divya Birudaraju
- Dolores Rijos
- Domenico Santoro
- Dominic Fellowes
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- Takehiko Wada
- Takehiro Sugiyama
- Takeshi Kurose
- Takeshi Miyatsuka
- Takeshi Ogihara
- Takuji Ishimoto
- Takuma Kojo
- Takuya Haraguchi
- Takuya Yokoyama
- Tamaki Sasaki
- Tamara Isakova
- Tammi Glider
- Tammy Ross
- Tanaji Dasgupta
- Taneera Ghate
- Taniya Nimbkar
- Tanvi Talsania
- Tara Johnson
- Tasuku Nagasawa
- Tatsuhito Himeno
- Tatyana Chavagnon
- Tejas Patel
- Teresa Kozlowski
- Teresa McKinley
- Terri Chant
- Tetsuya Hosooka
- Tetsuya Shigehara
- Thahir Abdul-Samad
- The EMPA-KIDNEY Collaborative Group: Colin Baigent
- Theresa McCarthy
- Thiemo Pfab
- Thisun Saram
- Thomas Arnold
- Thomas Jones
- Thomas Phillips
- Thomas Pickett
- Thomas Sitter
- Thomas Walters
- Thomas Weinreich
- Tim Doulton
- Tim Williams
- Timothy Ellam
- Tina Harding
- Tina Ramsey
- Ting Meng
- Tingting Kan
- Tobias Bergler
- Toluleyi Sobande
- Tomoe Sato
- Tomohide Hayami
- Tomohito Gohda
- Tomohito Izumi
- Tomoka Nakamura
- Tomoki Kosugi
- Tomoko Hisatake
- Tomoko Morisaki
- Tomoko Takahashi
- Tomoko Takai
- Tomonori Hasegawa
- Tomoya Mita
- Torsten Schramm
- Toru Ikeda
- Toshiki Kano
- Toshimasa Yamauchi
- Toshiya Yamamoto
- Toshiyuki Komiya
- Toyoyoshi Uchida
- Tracey Cummins
- Tracy Fuller
- Tracy Spinola
- Trevor Greene
- Tricia Young
- Tristan Daniels
- Tsukasa Iwakura
- Tuttle Katherine R
- Tze Jian Ng
- Ulla Ludwig
- Ulrike Giebeln-Hudnell
- Ulrike Schmidt
- Urs Benck
- Ursula Hohenstatt
- Usah Lilavivat
- Vahid Mahabadi
- Vanessa Rivers
- Verlaine Stewart-Ray
- Veronica Poma
- Veronica Yousif
- Vesta Lai
- Vicki Adell
- Vicki Brindle
- Vicki Dodds
- Vicki Donley
- Vickie Jones
- Victoria Carnall
- Victoria Gonce
- Vimal Derebail
- Vinay Varad
- Vittorio Ortalda
- Vivian Yiu
- Vladimir Cejka
- Volker Schettler
- Volker Vielhauer
- Wael Eid
- Wagdy Basily
- Wakako Isari
- Wallendszus Karl
- Waltraud Kmietschak
- Wan Ahmad Faizal Alaidin Razali
- Wan Hazlina Wan Mohamad
- Wanner Christoph
- Waqar Ayub
- Waseem Karsan
- Wasim Deeb
- Wasim Hanif
- Wataru Ogawa
- Wei Wang
- Wei Wei
- Weijing Bian
- Weiping Hou
- Weixin Kong
- Wen Jiun Liu
- Wen Liu
- Wendy Arriaga
- Wiebke Kaluza-Schilling
- Will Stevens
- William Durham
- William G Herrington
- William G Herrington
- William Hodge
- William Petchey
- Wolf-Adam Seeger
- Wolfgang Seeger
- Wuhanbilige Hundei
- Xavier Rossello
- Xia Song
- Xiangcheng Xiao
- Xiaojing Jiao
- Xiaojue Li
- Xiaoliang Wang
- Xinzhou Zhang
- Xiumei Hu
- Xuejiao Liu
- Xueying Wang
- Yan Li
- Yanmei Xu
- Yanping Wang
- YanRu Qiao
- Yanwu Yu
- Yanyun Xie
- Yao Weng
- Yao Yao
- Yasemin Kavak
- Yasuhiko Furukawa
- Yasuhiko Ito
- Yasuhiko Kanaguchi
- Yasuhiro Suzuki
- Yasushi Iwaita
- Ye Mun Low
- Yee Yan Lee
- Yew Fong Liew
- Yi Loon Tye
- Yik Hong Wong
- Yik Shen Lim
- Ying Hu
- Ying Jiang
- Ying Kuan
- Ying Lu
- Yinghua Chen
- Yohei Ejima
- Yoko Inukai
- Yolanda Miller
- Yong Chieh Chan
- Yonghong Bu
- Yoshiaki Morishita
- Yoshie Shibata
- Yoshifumi Tamura
- Yoshihiko Yamasaki
- Yoshihisa Wada
- Yoshikazu Tamori
- Yoshiki Suzuki
- Yoshimitsu Yamasaki
- Yoshinari Yasuda
- Yoshinori Osaki
- Yoshiro Kato
- Yoshiyuki Hamamoto
- Yosuke Hirakawa
- Yosuke Nakagawa
- Youcef Mostefai
- Young Lee-Barkey
- Yu An
- Yu Chen
- Yu Chen Ong
- Yu Yamanouchi
- Yuana Mohd Yusoff
- Yuichiro Munakata
- Yuji Oe
- Yuka Sato
- Yuka Ueda
- Yukari Miura
- Yuki Fujita
- Yuki Fukao
- Yuki Omori
- Yukihiro Shimizu
- Yukihiro Yamaji
- Yukiko Nakayama
- Yukiko Toyonaga
- Yukiko Wakita
- Yuko Katsuda
- Yuko Makita
- Yuko Okada
- Yuko Orimo
- Yumi Osawa
- Yushi Hirota
- Yusuke Suzuki
- Yutaka Kamimura
- Yuya Nishida
- Yvette Webley
- Yvonne Ehrl
- Yvonne Jackson
- Zabrina Lozon
- Zaid Azhari
- Zaiha Harun
- Zainab Sheriff
- Zanaida Cooper
- Zay Htet
- Zhang Duan Tham
- Zhi-Hong Liu
- Zhirui Zhao
- Zhu Doreen
- Zhuo Tang
- Zohreh Forghani
- Zuber Patel
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2023
- Field of study
Background The effects of empagliflozin in patients with chronic kidney disease who are at risk for disease progression are not well understood. The EMPA-KIDNEY trial was designed to assess the effects of treatment with empagliflozin in a broad range of such patients. Methods We enrolled patients with chronic kidney disease who had an estimated glomerular filtration rate (eGFR) of at least 20 but less than 45 ml per minute per 1.73 m(2) of body-surface area, or who had an eGFR of at least 45 but less than 90 ml per minute per 1.73 m(2) with a urinary albumin-to-creatinine ratio (with albumin measured in milligrams and creatinine measured in grams) of at least 200. Patients were randomly assigned to receive empagliflozin (10 mg once daily) or matching placebo. The primary outcome was a composite of progression of kidney disease (defined as end-stage kidney disease, a sustained decrease in eGFR to < 10 ml per minute per 1.73 m(2), a sustained decrease in eGFR of & GE;40% from baseline, or death from renal causes) or death from cardiovascular causes. Results A total of 6609 patients underwent randomization. During a median of 2.0 years of follow-up, progression of kidney disease or death from cardiovascular causes occurred in 432 of 3304 patients (13.1%) in the empagliflozin group and in 558 of 3305 patients (16.9%) in the placebo group (hazard ratio, 0.72; 95% confidence interval [CI], 0.64 to 0.82; P < 0.001). Results were consistent among patients with or without diabetes and across subgroups defined according to eGFR ranges. The rate of hospitalization from any cause was lower in the empagliflozin group than in the placebo group (hazard ratio, 0.86; 95% CI, 0.78 to 0.95; P=0.003), but there were no significant between-group differences with respect to the composite outcome of hospitalization for heart failure or death from cardiovascular causes (which occurred in 4.0% in the empagliflozin group and 4.6% in the placebo group) or death from any cause (in 4.5% and 5.1%, respectively). The rates of serious adverse events were similar in the two groups. Conclusions Among a wide range of patients with chronic kidney disease who were at risk for disease progression, empagliflozin therapy led to a lower risk of progression of kidney disease or death from cardiovascular causes than placebo
Descriptive epidemiology of 30,223 histopathologically confirmed meningiomas in France: 2006–2015
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- Peyre M.
- Philippe A.
- Pialat J.
- Pierre G. Saint
- Pimenta N. J. G.
- Pinelli C.
- Piot B.
- Plas B.
- Plas J. Y.
- Pluot M.
- Polivka M.
- Polo G.
- Pommepuy I.
- Popa C.
- Popa C. P.
- Porhiel V.
- Porhiel V.
- Postelnicu A.
- Pouit B.
- Pradere M.
- Privat J. M.
- Projetti F.
- Proust F.
- Pruvot-Occean A. S.
- Puget S.
- Quintana M.
- Quintin I.
- Quintyn-Ranty M. L.
- Rabehenoina C.
- Rabhi M.
- Ragragui O.
- Rambolarimanana T.
- Ramos J.
- Ranchere R.S.
- Ranfaing E.
- Raoul S.
- Raoux D.
- Rasendrarijao D.
- Raynaud P.
- Raynaud P.
- Rech F.
- Redondo A.
- Regis J.
- Reina V.
- Remond J
- Remond J.
- Renaud F.
- Renaud F.
- Renjard L.
- Reynier Y.
- Reyns N.
- Reyre J.
- Richard P.
- Richard S.
- Richet A.
- Richet A.
- Ricouart F.
- Riegel S.
- Riem T.
- Riffaud L.
- Rigal C. Musso
- Rigau V.
- Rigau Valérie
- Rigoard P.
- Ringenbach F.
- Riviere B.
- Robert G.
- Robert R.
- Robier A.
- Robles S. Gil
- Roche Pierre-Hugues
- Rodriguez M.-A.
- Rodriguez V.
- Roger P.
- Ros M.
- Roualdes G.
- Roualdes V.
- Rougier A.
- Roujeau T.
- Rouquette I.
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- Rousselot C.
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- Roux F. X.
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- Saint-Paul M. C.
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- Salon C.
- Sam L.
- Samaison l.
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- Sankaredja J. M.
- Sautreaux J. L.
- Sauvaget F.
- Sauvaget F.
- Savin C.
- Saïkali S.
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- Selves J.
- Seng E. Chan
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- Srour R.
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- Streichenberger N.
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- Taillandier Luc
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- Vallee B.
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- Zaïri F.
- Zemmoura Ilyess
- Zerah M.
- Ziyadeh J.
- Zolo D. Memia
- Zouaoui Sonia
- Publication venue
- Publication date
- 14/05/2024
- Field of study