Measurements of the charge asymmetry in top-quark pair production in the dilepton final state at s √ =8 TeV with the ATLAS detector

Measurements of the top-antitop quark pair production charge asymmetry in the dilepton channel, characterized by two high-pT leptons (electrons or muons), are presented using data corresponding to an integrated luminosity of 20.3  fb−1 from pp collisions at a center-of-mass energy s√=8  TeV collected with the ATLAS detector at the Large Hadron Collider at CERN. Inclusive and differential measurements as a function of the invariant mass, transverse momentum, and longitudinal boost of the tt¯ system are performed both in the full phase space and in a fiducial phase space closely matching the detector acceptance. Two observables are studied: AℓℓC based on the selected leptons and Att¯C based on the reconstructed tt¯ final state. The inclusive asymmetries are measured in the full phase space to be AℓℓC=0.008±0.006 and Att¯C=0.021±0.016, which are in agreement with the Standard Model predictions of AℓℓC=0.0064±0.0003 and Att¯C=0.0111±0.0004

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049

La planificaci\uf3n tributaria en la gerencia de recaudaci\uf3n de la Alcald\ueda del Municipio Iribarren del Estado Lara

El objeto de estudio del presente trabajo, es la planificaci\uf3n Tributaria en la Gerencia de Recaudaci\uf3n de la Alcald\ueda del Municipio Iribarren del Estado Lara. La metodolog\ueda utilizada se ubica dentro de la modalidad investigaci\uf3n de campo, de acuerdo con los objetivos de car\ue1cter descriptivo porque el inter\ue9s estuvo enfocado en las propiedades del objeto. La muestra qued\uf3 constituida por 12 funcionarios adscritos al departamento de Rentas del Municipio Iribarren en la ciudad de Barquisimeto, Divisi\uf3n de Rentas del Distrito Iribarren. La informaci\uf3n se recolect\uf3 a trav\ue9s de la observaci\uf3n directa del personal y posteriormente se aplic\uf3 un cuestionario tipo encuesta conformado por diez \uedtems con una escala dicot\uf3mica, con el objetivo de diagnosticar el cumplimiento de los objetivos de Recaudaci\uf3n y Fiscalizaci\uf3n que se utilizan. Para la validez se utiliz\uf3 el juicio de expertos en el \ue1rea tributaria. Se concluy\uf3 que la Direcci\uf3n de Hacienda necesita metodolog\ueda para mejorar la formulaci\uf3n de objetivos y la fijaci\uf3n de metas que puedan contribuir a optimizar el proceso de recaudaci\uf3n y fiscalizaci\uf3n, por lo que se sugirieron objetivos, estrategias y t\ue9cnicas de fiscalizaci\uf3n para determinar la Planificaci\uf3n Tributaria en la Gerencia de Recaudaci\uf3n de la Alcald\ueda del Municipio Iribarren del Estado Lara

Diversidad de ma\uedz en la sierra sur de Oaxaca, M\ue9xico: conocimiento y manejo tradicional

The state of Oaxaca represents an important pool of maize in Mexico. Previous studies have indicated the presence of many local varieties and agronomic races, mainly at the Northern Sierra and Central Valleys. The Southern Sierra has not been studied, in spite of the presence of indigenous Zapotec communities, which cultivate maize, among other crops, and have preserved local varieties. The present study is focused on the following questions: Which is the maize diversity, in terms of traditional varieties and agronomic races, in the Zapotec region of Los Loxicha? Does Maize diversity follow a pattern of distribution along an altitudinal interval? Which practices promote, and maintain this diversity? To answer these questions, we conducted a study within five municipalities at the Southern part of Oaxaca. During 2007, structured interviews were applied to 930 farmers in order to obtain a descriptive process of seed management. Morphological characterization of agronomic races was based on ear specimens obtained from a sample of 375 "milpas", with 20 plants per "milpa". High levels of local maize diversity were recorder, with 36 traditional varieties belonging to 10 races. Races exhibited differences in terms of phenotypic variation, and altitudinal distribution, and some could indicate local adaptation. People practice some ancestral management of ear and seed selection, thus maintaining differentiation among varieties and agronomic races. Nevertheless, sowing many local varieties in the same field, promotes gene flow and introgression among them, maintaining, and promoting phenotypic and genetic diversity.El estado de Oaxaca representa un importante acervo de maíz en México. Estudios previos han indicado la presencia de muchas variedades locales y razas agronómicas en la Sierra Norte y Valles Centrales. La Sierra Sur ha sido poco estudiada a pesar de la presencia de comunidades indígenas zapotecas, las cuales cultivan maíz, entre otras especies, y han preservado las variedades locales. El presente estudio responde a las siguientes preguntas: ¿cuál es la diversidad de maíz en términos de variedades tradicionales y razas agronómicas en la región zapoteca de Los Loxicha?, ¿la diversidad de maíz sigue un patrón de distribución a lo largo de un gradiente altitudinal?, ¿cuáles prácticas promueven y mantienen esta diversidad? Para contestar estas preguntas se realizó un estudio en cinco municipios de la Sierra Sur de Oaxaca. Durante 2007 se aplicaron entrevistas estructuradas a 930 agricultores para describir el proceso de manejo de semilla. La caracterización morfológica de las razas agronómicas se basó en muestras de mazorcas obtenidas en 375 milpas, con 20 plantas por milpa. Se encontraron altos niveles de diversidad local de maíz, con 36 variedades tradicionales correspondientes a 10 razas agronómicas. Las razas exhibieron diferencias en términos de variación fenotípica, distribución altitudinal y algunas muestran adaptación local. Los agricultores practican algunas formas de manejo ancestral para la selección de mazorcas y semillas, manteniendo, así, ciertos niveles de diferenciación entre las variedades y las razas agronómicas. Sin embargo, al sembrar diferentes variedades dentro de la misma parcela, se promueve el flujo génico y la introgresión entre ellas, manteniendo y promoviendo la diversidad fenotípica y genética

International and multicenter real-world study of sorafenib-treated patients with hepatocellular carcinoma under dialysis

Information on safety and efficacy of systemic treatment in patients with hepatocellular carcinoma under dialysis are limited due to patient exclusion from clinical trials. Thus, we aimed to evaluate the rate, prevalence, tolerability, and outcome of sorafenib in this population

La \uabmetaf\uedsica de la experiencia interior\ubb clave teor\ue9tica de la estructura relacional de la persona.

Riflessione sull'esperienza interiore come esperienza metafisica della relazionalit\ue0 accessibile all'essere uman