INTEGRATED CIRCUITS FOR HIGH ENERGY PHYSICS EXPERIMETNS

Integrated Circuits are used in most people\u2019s lives in the modern societies. An important branch of research and technology is focused on Integrated Circuit (IC) design, fabrication, and their efficient applications; moreover most of these activities are about commercial productions with applications in ambient environment. However the ICs play very important role in very advance research fields, as Astronomy or High Energy Physics experiments, with absolutely extreme environments which require very interdisciplinary research orientations and innovative solutions. For example, the Fast TracKer (FTK) electronic system, which is an important part of triggering system in ATLAS experiment at European Organization for Nuclear Research (CERN), in every second of experiment selects 200 interesting events among 40 millions of total events due to collision of accelerated protons. The FTK function is based on ICs which work as Content Addressable Memory (CAM). A CAM compares the income data with stored data and gives the addresses of matching data as an output. The amount of calculation in FTK system is out of capacity of commercial ICs even in very advanced technologies, therefore the development of innovative ICs is required. The high power consumption due to huge amount of calculation was an important limitation which is overcome by an innovative architecture of CAM in this dissertation. The environment of ICs application in astrophysics and High Energy Physics experiments is different from commercial ICs environment because of high amount of radiation. This fact started to get seriously attention after the first \u201cTelstar I\u201d satellite failure because of electronic damages due to radiation effects in space, and opened a new field of research mostly about radiation hard electronics. The multidisciplinary research in radiation hard electronic field is about radiation effects on semiconductors and ICs, deep understanding about the radiation in the extreme environments, finding alternative solutions to increase the radiation tolerance of electronic components, and development of new simulation method and test techniques. Chapter 2 of this dissertation is about the radiation effects on Silicon and ICs. Moreover, In this chapter, the terminologies of radiation effects on ICs are explained. In chapter 3, the space and high energy physics experiments environments, which are two main branches of radiation hard electronics research, are studied. The radiation tolerance in on-chip circuits is achieving by two kinds of methodology: Radiation Hardening By Process (RHBP) and Radiation Hardening By Design (RHBD). RHBP is achieved by changing the conventional fabrication process of commercial ICs. RHBP is very expensive so it is out of budget for academic research, and in most cases it is exclusive for military application, with very restricted rules which make the access of non-military organizations impossible. RHBD with conventional process is the approach of radiation hard IC design in this dissertation. RHBD at hardware level can be achieved in different ways: \u2022 System level RHBD: radiation hardening at system level is achieved by algorithms which are able to extract correct data using redundant information. \u2022Architecture level RHBD: some hardware architectures are able to prevent of lost data or mitigate the radiation effects on stored data without interfacing of software. Error Correction Code (ECC) circuits and Dual Interlocked storage CEll (DICE) architecture are two examples of RHBD at architecture level. \u2022 Circuit level RHBD: at circuit level, some structures are avoided or significantly reduced. For example, feedback loops with high gain are very sensitive to radiation effects. \u2022 Layout level RHBD: there are also different solutions in layout design level to increase the radiation tolerance of circuits. Specific shapes of transistor design, optimization of the physical distance between redundant data and efficient polarization of substrate are some techniques commonly used to increase significantly the radiation tolerance of ICs. An innovative radiation hard Static Random Access Memory (SRAM), designed in three versions, is presented in chapter 4. The radiation hardening is achieved by RHBD approach simultaneously at architecture, circuit and layout levels. Complementary Metal-Oxide-Semiconductor (CMOS) 65 nm is the technology of design and the prototype chip is fabricated at Taiwan Semiconductor Manufacturing Company (TSMC). Chapter 5 is about the development of simulation models that can help to predict the radiation effect in the behavior of SRAM block. The setup system developed to characterize the radiation hard SRAM prototype chip is presented in Chapter 5. The setup system gives the possibility of testing the prototype exposed under radiation in a vacuum chamberand regular laboratory environment. Chapter 6 is about the contribution of this dissertation on FTK project and the conclusion of all research activities is shown in the final part of this dissertation. The research activities of this dissertation in supported by Italian National Institute for Nuclear Physics (INFN) as part of CHIPIX65 project and RD53 collaboration at CERN

Evaluation of anti-inflammatory and analgesic activity of the extract and fractions of Astragalus hamosus in animal models

The objective of this study was to evaluate the anti-inflammatory and analgesic activities of the hydro-alcoholic extract of the pods of Astragalus hamosus (HAAH), a plant used in Iranian traditional medicine, and antinociceptive effects of different fractions in animal models. The anti-inflammatory effect was evaluated by the rat paw edema induced by formalin. Also the analgesic effect was examined by the acetic-acid-induced writhing response and hot plate test. The analgesic effects of chloroform, hexane, ethyl acetate and aqueous fractions were evaluated by the hot-plate method. The hydroalcoholic extract of Astragalus hamosus could reduce the edema in a dose-dependent manner (P<0.05). In the acute phase, the result of 1000 mg/Kg and in the chronic phase, the result of 100 and 300 mg/Kg of the extract were more significant and comparable with the effect of sodium salicylate. Also application of different doses of HAAH had significant anti-nociceptive effects on both animal models. The findings showed that HAAH at doses of 700 and 1000 mg/Kg produced analgesic effects comparable to sodium salicylate. The hexane and ethyl acetate (but not the other fractions) showed significant analgesic activity in hot plate test, when compared to morphine. The results of this study demonstrated the anti-inflammatory and analgesic effects of HAAH extract and hexane and ethyl acetate fractions of the extract in animal models and justify traditional use of this plant in the treatment of pain and inflammatory conditions. More studies to clarify the active components are necessary. © 2015 by School of Pharmacy Shaheed Beheshti University of Medical Sciences and Health Services

An innovative radiation hardened CAM architecture

An innovative Content Addressable Memory (CAM) cell with radiation hardened (RH) architecture is presented. The RH-CAM is designed using a commercial 28 nm CMOS technology. The circuit has been simulated in worst-case conditions, and the effects due to single particles have been analyzed by injecting a current pulse into a circuit node. The proposed architecture is suitable for real-time pattern recognition tasks in harsh environments, such as front-end electronics in the ATLAS experiment at the Large Hadron Collider (LHC) and in space applications

Anticonvulsant Activity of Hydroalcoholic Extract of Citrullus colocynthis Fruit: Involvement of Benzodiazepine and Opioid Receptors

This study investigated the anticonvulsant activity of Citrullus colocynthis fruit extract used traditionally in the treatment of convulsion. Albino mice were pretreated with extract in different doses (10, 25, 50, and 100 mg/kg), prior to injection of pentylenetetrazole. Animals received pretreatments with naloxone and flumazenil to further clarify the mechanisms of anticonvulsant action. The total flavonoid content of Citrullus colocynthis extract was also determined. Citrullus colocynthis hydroalcoholic extract with doses 25 and 50 mg/kg prolonged the onset of seizures and decreased the duration compared with control group. Pretreatment by flumazenil could inhibit the effect of Citrullus colocynthis on latency of seizure to some extent and administration of naloxone significantly inhibited changes in latency and duration of seizure produced by Citrullus colocynthis. This study showed that Citrullus colocynthis has significant anticonvulsant effect in pentylenetetrazole-induced seizures in mice, and these effects may be related to its effect on γ-aminobutyric acid-ergic and opioid systems. These results confirmed the traditional use of Citrullus colocynthis in Iranian traditional medicine. © 2015, © The Author(s) 2015

CMOS IC radiation hardening by design

Design techniques for radiation hardening of integrated circuits in commercial CMOS technologies are presented. Circuits designed with the proposed approaches are more tolerant to both total dose and to single event effects. The main drawback of the techniques for radiation hardening by design is the increase of silicon area, compared with a conventional design

The effects of doxorubicin, ethanol extract and flavonoid-rich fraction of euphorbia splendida mobayen on the PARP level, and APC gene expression in HT-29 human colon cancer cell line

Background: Natural products derived from various sources are being used to develop chemotherapeutic drugs. Euphorbiaceae is widely used to treat different types of cancers. Colorectal cancer (CRC) is the second and third cause of cancer in women and men, respectively. CRC is strongly associated with the deregulation of the Adenomatous polyposis coli (APC) gene and Poly ADP-ribose polymerase (PPAR) protein. Objectives: The current study aimed to examine the effect of doxorubicin, ethanol extract, and the flavonoid-rich fraction of Euphorbia Splendida Mobayen on colon cancer HT-29 cell line death, APC gene expression, and PPAR concentration. Methods: Following treatment of cells by Euphorbia ethanol extract, Euphorbia flavonoid-rich fraction, and doxorubicin, cell viability assay was used to investigate the viability status of the HT-29 cell line. Total RNA was isolated from the cell line and converted into cDNA. The expression level of the APC gene was determined by quantitative real-time PCR. Poly (ADP-ribose) polymerase (PPAR) protein was detected by the ELIZA method. Results: We found that Euphorbia ethanol extract, Euphorbia flavonoid-rich fraction, and doxorubicin can stimulate dose-dependent cell death in the HT-29 cell line, increase ACP gene expression (P = 0.001, P = 0.041, P = 0.019), and decrease PARP level (P = 0.001, P = 0.001, P = 0.001, respectively). Conclusions: The findings indicated that doxorubicin, ethanol extract, and the flavonoid-rich fraction of Euphorbia Splendida Mobayen had cytotoxic effects on human colon cancer HT-29 cell line by possibly stimulating apoptosis. Copyright © 2020, Author(s)

65 nm Technology for HEP: Status and Perspective

The development of new experiments such as CLIC and the the foreseen Phase 2 pixel upgrades of ATLAS and CMS have very challenging requirements for the design of hybrid pixel readout chips, both in terms of performances and reliability. To face these challenges, the use of a more downscaled CMOS technology compared to previous projects is necessary. The CERN RD53 collaboration is undertaking a R&D programme to evaluate the use of a commercial 65 nm technology and to develop tools and frameworks which will help to design future pixel detectors. This paper gives a short overview of the RD53 collaboration activities and describes some examples of recent developments

A Pixel Read-Out Front-End in 28 nm CMOS with Time and Space Resolution

Future high luminosity colliders will require front-end electronics with unprecedented performance, both in space and time resolution (tens of micrometers and tens of picoseconds) and in radiation hardness (tens of megagray). Moreover, the high number of events will generate an enormous quantity of data (some terabits per second), and the limited bandwidth requires to perform data selection as close as possible to the front-end stage, to reduce the amount of data transmitted and stored for off-line analysis.The TimeSpOT (TIME and SPace real-time Operating Tracker) project, funded by INFN, is developing a complete demonstrator of a tracking device including all the features needed for future high luminosity experiments.In this presentation, we describe the first prototype of the readout electronics in 28 nm CMOS technology. The modules of the front-end circuitry have been designed and integrated in a test chip, which will allow us to characterize each block separately, and to connect them in a processing chain to evaluate the overall performance

Measurement of the cross-section and charge asymmetry of WW bosons produced in proton-proton collisions at s=8\sqrt{s}=8 TeV with the ATLAS detector

This paper presents measurements of the $W^+ \rightarrow \mu^+\nu$ and $W^- \rightarrow \mu^-\nu$ cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables, submitted to EPJC. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13

Search for squarks and gluinos in events with isolated leptons, jets and missing transverse momentum at s√=8 TeV with the ATLAS detector

The results of a search for supersymmetry in final states containing at least one isolated lepton (electron or muon), jets and large missing transverse momentum with the ATLAS detector at the Large Hadron Collider are reported. The search is based on proton-proton collision data at a centre-of-mass energy s√=8 TeV collected in 2012, corresponding to an integrated luminosity of 20 fb−1. No significant excess above the Standard Model expectation is observed. Limits are set on supersymmetric particle masses for various supersymmetric models. Depending on the model, the search excludes gluino masses up to 1.32 TeV and squark masses up to 840 GeV. Limits are also set on the parameters of a minimal universal extra dimension model, excluding a compactification radius of 1/R c = 950 GeV for a cut-off scale times radius (ΛR c) of approximately 30