638 research outputs found
Central sleep apnoea is related to the severity and short-term prognosis of acute coronary syndrome
Objective
To evaluate the relation of central sleep apnoea (CSA) to the severity and short-term prognosis
of patients who experience acute coronary syndrome (ACS).
Methods
Observational study with cross-sectional and longitudinal analyses. Patients acutely admitted
to participating hospitals because of ACS underwent respiratory polygraphy during the
first 24 to 72 h. CSA was defined as an apnoea-hypopnoea index (AHI) >15 events·h-1
(>50% of central apnoeas). ACS severity (Killip class, ejection fraction, number of diseased
vessels and peak plasma troponin) was evaluated at baseline, and short-term prognosis
(length of hospitalization, complications and mortality) was evaluated at discharge.This work was supported by: ResMed Ltd. (Australia); Fondo de InvestigacioĂn Sanitaria (PI10/02763 and PI10/02745), Fondo Europeo de Desarrollo Regional (FEDER), Una manera de hacer Europa; the Spanish Respiratory Society (SEPAR); the Catalonian Cardiology Society, Esteve-Teijin (Spain); Oxigen Salud (Spain); and ALLER. This project has received funding from the European Union's Seventh Framework Programme for research, technological development and demonstration under grant agreement no [609396]. Cofunded by Ministerio de EconomĂ”Ăa y Competitividad [COFUND2014-51501]
Intensive care unit discharge to the ward with a tracheostomy cannula as a risk factor for mortality: A prospective, multicenter propensity analysis
To analyze the impact of decannulation before intensive care unit
discharge on ward survival in nonexperimental conditions. DESIGN: Prospective,
observational survey. SETTING: Thirty-one intensive care units throughout Spain.
PATIENTS: All patients admitted from March 1, 2008 to May 31, 2008.
INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: At intensive care unit
discharge, we recorded demographic variables, severity score, and intensive care
unit treatments, with special attention to tracheostomy. After intensive care
unit discharge, we recorded intensive care unit readmission and hospital
survival. STATISTICS: Multivariate analyses for ward mortality, with Cox
proportional hazard ratio adjusted for propensity score for intensive care unit
decannulation. We included 4,132 patients, 1,996 of whom needed mechanical
ventilation. Of these, 260 (13%) were tracheostomized and 59 (23%) died in the
intensive care unit. Of the 201 intensive care unit tracheostomized survivors, 60
were decannulated in the intensive care unit and 141 were discharged to the ward
with cannulae in place. Variables associated with intensive care unit
decannulation (non-neurologic disease [85% vs. 64%], vasoactive drugs [90% vs.
76%], parenteral nutrition [55% vs. 33%], acute renal failure [37% vs. 23%], and
good prognosis at intensive care unit discharge [40% vs. 18%]) were included in a
propensity score model for decannulation. Crude ward mortality was similar in
decannulated and nondecannulated patients (22% vs. 23%); however, after
adjustment for the propensity score and Sabadell Score, the presence of a
tracheostomy cannula was not associated with any survival disadvantage with an
odds ratio of 0.6 [0.3-1.2] (p=.1). CONCLUSION: In our multicenter setting,
intensive care unit discharge before decannulation is not a risk factor
THE ESTROFA-MI REGISTRY: COMPARISON OF PACLITAXEL-ELUTING STENT AND EVEROLIMUS-ELUTING STENT IN ST-ELEVATION MYOCARDIAL INFARCTION. RESULTS AT 2 YEARS FOLLOW-UP
Plasma and CSF biomarkers in a memory clinic: Head-to-head comparison of phosphorylated tau immunoassays
INTRODUCTION: Direct comparisons of the main blood phosphorylated tau immunoassays in memory clinic populations are needed to understand possible differences. METHODS: In the BIODEGMAR study, 197 participants presenting with cognitive complaints were classified into an Alzheimer's disease (AD) or a non-AD cerebrospinal fluid (CSF) profile group, according to their amyloid beta 42/ phosphorylated tau (AÎČ42/p-tau) ratio. We performed a head-to-head comparison of nine plasma and nine CSF tau immunoassays and determined their accuracy to discriminate abnormal CSF AÎČ42/p-tau ratio. RESULTS: All studied plasma tau biomarkers were significantly higher in the AD CSF profile group compared to the non-AD CSF profile group and significantly discriminated abnormal CSF AÎČ42/p-tau ratio. For plasma p-tau biomarkers, the higher discrimination accuracy was shown by Janssen p-tau217 (r = 0.76; area under the curve [AUC] = 0.96), ADx p-tau181 (r = 0.73; AUC = 0.94), and Lilly p-tau217 (r = 0.73; AUC = 0.94). DISCUSSION: Several plasma p-tau biomarkers can be used in a specialized memory clinic as a stand-alone biomarker to detect biologically-defined AD. HIGHLIGHTS: Patients with an Alzheimer's disease cerebrospinal fluid (AD CSF) profile have higher plasma phosphorylated tau (p-tau) levels than the non-AD CSF profile group. All plasma p-tau biomarkers significantly discriminate patients with an AD CSF profile from the non-AD CSF profile group. Janssen p-tau217, ADx p-tau181, and Lilly p-tau217 in plasma show the highest accuracy to detect biologically defined AD. Janssen p-tau217, ADx p-tau181, Lilly p-tau217, Lilly p-tau181, and UGot p-tau231 in plasma show performances that are comparable to their CSF counterparts
The Fourteenth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the extended Baryon Oscillation Spectroscopic Survey and from the second phase of the Apache Point Observatory Galactic Evolution Experiment
The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in
operation since July 2014. This paper describes the second data release from
this phase, and the fourteenth from SDSS overall (making this, Data Release
Fourteen or DR14). This release makes public data taken by SDSS-IV in its first
two years of operation (July 2014-2016). Like all previous SDSS releases, DR14
is cumulative, including the most recent reductions and calibrations of all
data taken by SDSS since the first phase began operations in 2000. New in DR14
is the first public release of data from the extended Baryon Oscillation
Spectroscopic Survey (eBOSS); the first data from the second phase of the
Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2),
including stellar parameter estimates from an innovative data driven machine
learning algorithm known as "The Cannon"; and almost twice as many data cubes
from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous
release (N = 2812 in total). This paper describes the location and format of
the publicly available data from SDSS-IV surveys. We provide references to the
important technical papers describing how these data have been taken (both
targeting and observation details) and processed for scientific use. The SDSS
website (www.sdss.org) has been updated for this release, and provides links to
data downloads, as well as tutorials and examples of data use. SDSS-IV is
planning to continue to collect astronomical data until 2020, and will be
followed by SDSS-V.Comment: SDSS-IV collaboration alphabetical author data release paper. DR14
happened on 31st July 2017. 19 pages, 5 figures. Accepted by ApJS on 28th Nov
2017 (this is the "post-print" and "post-proofs" version; minor corrections
only from v1, and most of errors found in proofs corrected
Higher versus lower nut consumption and changes in cognitive performance over two years in a population at risk of cognitive decline: a cohort study
Background: Tree nuts and peanuts (henceforth, nuts) are nutrient-dense foods rich in neuroprotective components; thus, their consumption could benefit cognitive health. However, evidence to date is limited and inconsistent regarding the potential benefits of nuts for cognitive function. Objective: To prospectively evaluate the association between nut consumption and 2-y changes in cognitive performance in older adults at cognitive decline risk. Methods: A total of 6,630 participants aged 55 to 75 y (mean age 65.0±4.9 y, 48.4% women) with overweight/obesity and metabolic syndrome completed a validated semi-quantitative food frequency questionnaire and a comprehensive battery of neuropsychological tests at baseline and a 2-y follow-up. Composite cognitive scores were used to assess global, general, attention, and executive function domains. Nut consumption was categorized as Results: Nut consumption was positively associated with 2-y changes in general cognitive function (P-trend Conclusion: Frequent nut consumption was associated with a smaller decline in general cognitive performance over 2 y in older adults at risk of cognitive decline. Randomized clinical trials to verify our findings are warranted
Measurement of the cross-section of high transverse momentum vector bosons reconstructed as single jets and studies of jet substructure in pp collisions at âs = 7 TeV with the ATLAS detector
This paper presents a measurement of the cross-section for high transverse momentum W and Z bosons produced in pp collisions and decaying to all-hadronic final states. The data used in the analysis were recorded by the ATLAS detector at the CERN Large Hadron Collider at a centre-of-mass energy of âs = 7 TeV;{\rm Te}{\rm V}4.6\;{\rm f}{{{\rm b}}^{-1}}{{p}_{{\rm T}}}\gt 320\;{\rm Ge}{\rm V}|\eta |\lt 1.9{{\sigma }_{W+Z}}=8.5\pm 1.7$ pb and is compared to next-to-leading-order calculations. The selected events are further used to study jet grooming techniques
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