Facing the COVID-19 pandemic with science and practice

The COVID-19 pandemic has led to a health system crisis, deaths and socioeconomic hardship. In order to minimize the consequences of the COVID-19 pandemic in the municipality of Lavras, a partnership was developed between the Lavras City Hall and the Universidade Federal de Lavras (UFLA). The present study aimed to describe the main prevention measures proposed in Lavras and to evaluate the community's perception of the management model towards COVID-19. A public online questionnaire, with 20 multiple-choice questions, about the measures to confront covid was submitted to the Google Forms platform from April 22nd to April 30th, 2020. The data regarding the strategies carried out to deal with COVID-19 was obtained from the published municipal ordinances. During the eight days that the questionnaire was applied, a total of 8,874 respondents from Lavras were obtained. Among these respondents, 31.64% (2,808) were men, 68.15% (6,047) were women, and 0.21% (19) declared "another option". When the participants were asked whether they are respecting the social distance measures, 7,452 (84.1%) of them answered "yes."Also, a total of 57.4% of the participants reported that the social distancing measures compromised their family income. However, despite the impact of this economic compromise on these families, 93.82% of the respondents believe that the measures applied are important. When analyzing the questionnaire responses, it was noticeable that despite residents suffering negative economic consequences, there was great popular approval of preventive measures, such as social distancing and the use of masks. In addition, it was possible to notice the population's trust in the measures recommended by professionals at UFLA and the city hall, highlighting the importance of establishing contact between authorities and the population during decision making

As práticas educativas seus respectivos impactos na prevenção da gravidez na adolescência / Educational practices and their respective impacts on the prevention of teen pregnancy

A gravidez na adolescência é considerada um problema de saúde pública que acarreta grandes problemas econômicos, gastos de saúde, interrupções aos estudos, além de complicações durante a gravidez que podem ser desencadeados tanto para a mãe como para o recém-nascido. O enfermeiro e o professor possuem papel importante no desenvolvimento de habilidades preventivas e educativas com os adolescentes. Desta forma, o presente trabalho tem por objetivo descrever as práticas educativas realizadas pelo enfermeiro na prevenção da gravidez na adolescência. Tendo como método a revisão sistemática, realizou-se buscas bibliográficas nas bases de dados: Google Acadêmico e Scielo (Scientific Eletronic Library Online), além de livros, teses e dissertações. Foram inclusos artigos na língua portuguesa, disponíveis eletronicamente na íntegra, que tinham como foco a prevenção da gravidez na adolescência por meio de práticas desenvolvidas pela enfermagem e que se encontram dentro do recorte temporal entre 2010 e 2020. Referente a atuação da enfermagem para a prevenção da gravidez na adolescência, a maioria dos artigos apresentavam essa abordagem. Foi possível concluir que, apesar de ser um tema de grande importância e que traz impacto para os serviços de saúde, ainda existe uma escassez de publicações e estudos voltados a este assunto, sendo necessário que sejam realizadas mais pesquisas dentro desta temática. A enfermagem é uma área de grande importância, suas ações e seus profissionais possuem grande potencial para contribuir significativamente para a redução das estatísticas nos casos da gravidez na adolescência. Ressalta-se também, a relevância da interação entre a educação e a saúde, afim de juntos, encontrarem novas formas e ações para interagir, orientar e lidar com o público adolescente, de forma a reduzir os índices de gravidez não planejada e abandono escolar

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

Aspiração Anestésica

A aspiração é um procedimento importante na Odontologia, poisevita o depósito intravascular do anestésico, diminuindo o risco decomplicações sistêmicas

NEOTROPICAL CARNIVORES: a data set on carnivore distribution in the Neotropics

Mammalian carnivores are considered a key group in maintaining ecological health and can indicate potential ecological integrity in landscapes where they occur. Carnivores also hold high conservation value and their habitat requirements can guide management and conservation plans. The order Carnivora has 84 species from 8 families in the Neotropical region: Canidae; Felidae; Mephitidae; Mustelidae; Otariidae; Phocidae; Procyonidae; and Ursidae. Herein, we include published and unpublished data on native terrestrial Neotropical carnivores (Canidae; Felidae; Mephitidae; Mustelidae; Procyonidae; and Ursidae). NEOTROPICAL CARNIVORES is a publicly available data set that includes 99,605 data entries from 35,511 unique georeferenced coordinates. Detection/non-detection and quantitative data were obtained from 1818 to 2018 by researchers, governmental agencies, non-governmental organizations, and private consultants. Data were collected using several methods including camera trapping, museum collections, roadkill, line transect, and opportunistic records. Literature (peer-reviewed and grey literature) from Portuguese, Spanish and English were incorporated in this compilation. Most of the data set consists of detection data entries (n = 79,343; 79.7%) but also includes non-detection data (n = 20,262; 20.3%). Of those, 43.3% also include count data (n = 43,151). The information available in NEOTROPICAL CARNIVORES will contribute to macroecological, ecological, and conservation questions in multiple spatio-temporal perspectives. As carnivores play key roles in trophic interactions, a better understanding of their distribution and habitat requirements are essential to establish conservation management plans and safeguard the future ecological health of Neotropical ecosystems. Our data paper, combined with other large-scale data sets, has great potential to clarify species distribution and related ecological processes within the Neotropics. There are no copyright restrictions and no restriction for using data from this data paper, as long as the data paper is cited as the source of the information used. We also request that users inform us of how they intend to use the data

Characterisation of microbial attack on archaeological bone

As part of an EU funded project to investigate the factors influencing bone preservation in the archaeological record, more than 250 bones from 41 archaeological sites in five countries spanning four climatic regions were studied for diagenetic alteration. Sites were selected to cover a range of environmental conditions and archaeological contexts. Microscopic and physical (mercury intrusion porosimetry) analyses of these bones revealed that the majority (68%) had suffered microbial attack. Furthermore, significant differences were found between animal and human bone in both the state of preservation and the type of microbial attack present. These differences in preservation might result from differences in early taphonomy of the bones. © 2003 Elsevier Science Ltd. All rights reserved

Reduced Cancer Incidence in Huntington's Disease: Analysis in the Registry Study

Background: People with Huntington's disease (HD) have been observed to have lower rates of cancers. Objective: To investigate the relationship between age of onset of HD, CAG repeat length, and cancer diagnosis. Methods: Data were obtained from the European Huntington's disease network REGISTRY study for 6540 subjects. Population cancer incidence was ascertained from the GLOBOCAN database to obtain standardised incidence ratios of cancers in the REGISTRY subjects. Results: 173/6528 HD REGISTRY subjects had had a cancer diagnosis. The age-standardised incidence rate of all cancers in the REGISTRY HD population was 0.26 (CI 0.22-0.30). Individual cancers showed a lower age-standardised incidence rate compared with the control population with prostate and colorectal cancers showing the lowest rates. There was no effect of CAG length on the likelihood of cancer, but a cancer diagnosis within the last year was associated with a greatly increased rate of HD onset (Hazard Ratio 18.94, p < 0.001). Conclusions: Cancer is less common than expected in the HD population, confirming previous reports. However, this does not appear to be related to CAG length in HTT. A recent diagnosis of cancer increases the risk of HD onset at any age, likely due to increased investigation following a cancer diagnosis

Clinical and genetic characteristics of late-onset Huntington's disease

Background: The frequency of late-onset Huntington's disease (&gt;59 years) is assumed to be low and the clinical course milder. However, previous literature on late-onset disease is scarce and inconclusive. Objective: Our aim is to study clinical characteristics of late-onset compared to common-onset HD patients in a large cohort of HD patients from the Registry database. Methods: Participants with late- and common-onset (30–50 years)were compared for first clinical symptoms, disease progression, CAG repeat size and family history. Participants with a missing CAG repeat size, a repeat size of ≤35 or a UHDRS motor score of ≤5 were excluded. Results: Of 6007 eligible participants, 687 had late-onset (11.4%) and 3216 (53.5%) common-onset HD. Late-onset (n = 577) had significantly more gait and balance problems as first symptom compared to common-onset (n = 2408) (P &lt;.001). Overall motor and cognitive performance (P &lt;.001) were worse, however only disease motor progression was slower (coefficient, −0.58; SE 0.16; P &lt;.001) compared to the common-onset group. Repeat size was significantly lower in the late-onset (n = 40.8; SD 1.6) compared to common-onset (n = 44.4; SD 2.8) (P &lt;.001). Fewer late-onset patients (n = 451) had a positive family history compared to common-onset (n = 2940) (P &lt;.001). Conclusions: Late-onset patients present more frequently with gait and balance problems as first symptom, and disease progression is not milder compared to common-onset HD patients apart from motor progression. The family history is likely to be negative, which might make diagnosing HD more difficult in this population. However, the balance and gait problems might be helpful in diagnosing HD in elderly patients