Die Rezeption Karl Barths und der dialektischen Theologie in der russischen Religionsphilosophie

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Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.

The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD

Graphene-Based Nanocomposites for Energy Storage

Since the first report of using micromechanical cleavage method to produce graphene sheets in 2004, graphene/graphene-based nanocomposites have attracted wide attention both for fundamental aspects as well as applications in advanced energy storage and conversion systems. In comparison to other materials, graphene-based nanostructured materials have unique 2D structure, high electronic mobility, exceptional electronic and thermal conductivities, excellent optical transmittance, good mechanical strength, and ultrahigh surface area. Therefore, they are considered as attractive materials for hydrogen (H2) storage and high-performance electrochemical energy storage devices, such as supercapacitors, rechargeable lithium (Li)-ion batteries, Li–sulfur batteries, Li–air batteries, sodium (Na)-ion batteries, Na–air batteries, zinc (Zn)–air batteries, and vanadium redox flow batteries (VRFB), etc., as they can improve the efficiency, capacity, gravimetric energy/power densities, and cycle life of these energy storage devices. In this article, recent progress reported on the synthesis and fabrication of graphene nanocomposite materials for applications in these aforementioned various energy storage systems is reviewed. Importantly, the prospects and future challenges in both scalable manufacturing and more energy storage-related applications are discussed

Jüdische Beamten-Zeitung /

A magazine for Jewish officials, published by the organization of officials of the Jewish community of Berlin.Recataloging - edited the recordEdited bib. record (300, 506, PRS fields); linked to microfilm record; updated HOL and item recordsLibrary has v. 1, no. 3; v. 2, no. 2/3-4/5, 8.B26 and B175 had originally been separate. At some point, they were combined and the record for B175 was deleted. Since the titles of B26, B26.1 and B175 were all so distinct and there was no indication that B26 was the successor of B175, I separated these periodicals and returned B175 to its original call number

Distinct Mechanisms Mediate Naïve and memory CD8 T-cell tolerance

Peripheral tolerance to developmentally regulated antigens is necessary to sustain tissue homeostasis. We have now devised an inducible and reversible system that allows interrogation of T-cell tolerance induction in endogenous naïve and memory CD8 T cells. Our data show that peripheral CD8 T-cell tolerance can be preserved through two distinct mechanisms, antigen addiction leading to anergy for naïve T cells and ignorance for memory T cells. Induction of antigen in dendritic cells resulted in substantial expansion and maintenance of endogenous antigen-specific CD8 T cells. The self-reactive cells initially exhibited effector activity but eventually became unresponsive. Upon antigen removal, the antigen-specific population waned, resulting in development of a self-specific memory subset that recalled to subsequent challenge. In striking contrast to naïve CD8 T cells, preexisting antigen-specific memory CD8 T cells failed to expand after antigen induction and essentially ignored the antigen despite widespread expression by dendritic cells. The inclusion of inflammatory signals partially overcame memory CD8 T-cell ignorance of self-antigen. Thus, peripheral CD8 T-cell tolerance for naïve CD8 T cells depended on the continuous presence of antigen, whereas memory CD8 T cells were prohibited from autoreactivity in the absence of inflammation

Data underlying the publication: "Spatial dependency in abundance of Queen conch, Aliger gigas, in the Caribbean, indicates the importance of surveying deep-water distributions"

Evaluate how the spatial distribution of a heavily exploited marine gastropod (i.e., Queen conch) varies in response to a number of known biotic and abiotic variables within and between sites that vary in environmental conditions. A novel towed video system complemented belt transects to estimate adult queen conch densities throughout its depth range. Bayesian hierarchical spatial models (Integrated Nested Laplace approximations) modeled distribution patterns of adult conch and indicated that the general patchy distribution pattern and the lack of strong generic location over-crossing relationships between abiotic and biotic factors and adult conch abundance and distribution is likely to at least partly due to this spatial dependency and location-specific factors, that affect different parts of the conch life-history

Optimization of a Novel Preferential Covered Stent through Bench Experiments and in Vitro Platelet Activation Studies

10.1021/acsbiomaterials.9b00763ACS BIOMATERIALS SCIENCE & ENGINEERING5116216-6230complete