1,108 research outputs found

    Loss of heterozygosity in multistage carcinogenesis of esophageal carcinoma at high-incidence area in Henan Province, China

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    Aim: Microsatellites are the repeated DNA sequences scattered widely within the genomes and closely linked with many important genes. This study was designed to characterize the changes of microsatellite DNA loss of heterozygosity (LOH) in esophageal carcinogenesis. Methods: Allelic deletions in 32 cases of matched precancerous, cancerous and normal tissues were examined by syringe microdissection under an anatomic microscope and microsatellite polymorphism analysis using 15 polymorphic markers on chromosomes 3p, 5q, 6p, 9p, 13q, 17p, 17q and 18q. Results: Microsatellite DNA LOH was observed in precancerous and cancerous tissues, except D9S1752. The rate of LOH increased remarkably with the lesions progressed from basal cell hyperplasia (BCH) to squamous cell carcinoma (SCC) (P60%). LOH loci were different in precancerous and cancerous tissues. LOH in D3S1234 and TP53 was the common event in different lesions from the same patients. Conclusion: Microsatellite DNA LOH occurs in early stage of human esophageal carcinogenesis, even in BCH. With the lesion progressed, gene instability increases, the accumulation of this change may be one of the important mechanisms driving precancerous lesions to cancer. © 2005 The WJG Press and Elsevier Inc. All rights reserved.published_or_final_versio

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    BACKGROUND & OBJECTIVE: Local lymph node and blood metastasis could occur at early stage of esophageal squamous cell carcinoma (ESCC), which may be the key factors of its recurrence and poor prognosis. However, the mechanism of ESCC metastasis is unclear. This study was to analyze the genetic changes in primary lesion and lymph node metastases of ESCC, to screen for and locate ESCC metastasis-related genes. METHODS: Genomic alterations in 15 pairs of primary lesions and matched metastatic lymph nodes of ESCC were analyzed by comparative genomic hybridization (CGH). RESULTS: In the 15 pairs of tissues, the most common chromosomal alterations were the gains of 3q, 8q, 6p, 20p, 5p, 18p, 2p, 2q and 1q, and the losses of 10p, 10q, 17p, 18q, 4p and 13q. Of these changes, the most significant finding was the gain of 6p with a frequency of 47% in metastatic lymph nodes and 13% in primary lesions, and the gain of 20p with a frequency of 73% in metastatic lymph nodes and 33% in primary lesions. The second interesting finding was the loss of 10p with a frequency of 53% in metastatic lymph nodes and 13% in primary lesions, and the loss of 10q with a frequency of 47% in metastatic lymph nodes and 13% in primary lesions. CONCLUSION: The gains of 6p and 20p and the losses of 10p and 10q are common genomic alterations in primary lesion and lymph node metastases of ESCC, which may code ESCC metastasis-related genes.èƒŒæ™Żèˆ‡ç›źçš„:éŁŸçźĄç™Œæ—©æœŸćŻç™Œç”Ÿć±€éƒšæ·‹ć·Žæˆ–èĄ€èĄŒèœ‰ç§»,é€™æ˜Żć°Žè‡ŽćŸ©ç™Œć’Œé ćŽć·źçš„äž»èŠćŽŸć› ă€‚äœ†æ˜Ż,éŁŸçźĄç™Œèœ‰ç§»ç™Œç”Ÿçš„ćˆ†ć­æ©Ÿćˆ¶ć°šäžæž…æ„šă€‚æœŹç ”ç©¶æ—šćœšćˆ†æžéŁŸçźĄç™ŒćŽŸç™Œç¶ć’Œæ·‹ć·Žç”èœ‰ç§»ç¶è…«ç˜€çŽ°èƒžæŸ“è‰Čé«”èźŠćŒ–çš„ç‰čćŸ,ć°‹æ‰Ÿæˆ–ćźšäœèˆ‡éŁŸçźĄç™Œèœ‰ç§»ç›žé—œćŸș曠,ćŠ æ·±ć°ć…¶èœ‰ç§»æ©Ÿćˆ¶çš„äș†è§Łă€‚æ–čæł•:æ‡‰ç”šæŻ”èŒƒćŸșć› ç”„é›œäș€æŠ€èĄ“(comparativegenomichybridization,CGH)ćˆ†æž15äŸ‹éŁŸçźĄç™Œæ‚Łè€…ćŽŸç™Œç¶ć’Œć…¶ć°æ‡‰çš„æ·‹ć·Žç”èœ‰ç§»ç¶çš„æŸ“è‰Č體ćŸș曠甄æ”čèźŠă€‚ç”æžœ:æœ€ćžžèŠ‹æŸ“è‰Č體DNA拷èČæ•žćąžćŠ çš„éƒšäœæ˜Ż3q,8q,6p,20p,5p,18p,2p,2q,1q;ćžžèŠ‹çš„æŸ“è‰Č體DNA拷èČæ•žäžŸć€±çš„éƒšäœæ˜Ż10p,10q,17p,18q,4p,13q。慶䞭,æœ€æœ‰æ„çŸ©çš„ç™ŒçŸæ˜Ż6p汞抠(ćŽŸç™Œç¶:2/15,13%,蜉移灶:7/15,47%),20p汞抠(ćŽŸç™Œç¶:5/15,33.3%,蜉移灶:11/15,73.3%)。第äșŒć€‹ç™ŒçŸæ˜Ż10päžŸć€±(ćŽŸç™Œç¶:2/15,13.3%,蜉移灶:8/15,53%),10qäžŸć€±(ćŽŸç™Œç¶:2/15,13.3%,蜉移灶:7/15,46.6%)ă€‚ç”è«–:éŁŸçźĄç™ŒćŽŸç™Œç¶ć’Œæ·‹ć·Žç”èœ‰ç§»ç¶çŽ°èƒžæŸ“è‰Č體ćŸș曠甄æ”čèźŠæœ€éĄŻè‘—çš„éƒšäœæ˜Ż6p,20p的汞抠撌10p,10qçš„äžŸć€±;這äș›éƒšäœćŻèƒœć­˜ćœšèˆ‡éŁŸçźĄç™ŒçŽ°èƒžæ·‹ć·Žç”èœ‰ç§»ç›žé—œçš„ćŸș曠。link_to_subscribed_fulltex

    Disparities and risks of sexually transmissible infections among men who have sex with men in China: a meta-analysis and data synthesis.

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    BACKGROUND: Sexually transmitted infections (STIs), including Hepatitis B and C virus, are emerging public health risks in China, especially among men who have sex with men (MSM). This study aims to assess the magnitude and risks of STIs among Chinese MSM. METHODS: Chinese and English peer-reviewed articles were searched in five electronic databases from January 2000 to February 2013. Pooled prevalence estimates for each STI infection were calculated using meta-analysis. Infection risks of STIs in MSM, HIV-positive MSM and male sex workers (MSW) were obtained. This review followed the PRISMA guidelines and was registered in PROSPERO. RESULTS: Eighty-eight articles (11 in English and 77 in Chinese) investigating 35,203 MSM in 28 provinces were included in this review. The prevalence levels of STIs among MSM were 6.3% (95% CI: 3.5-11.0%) for chlamydia, 1.5% (0.7-2.9%) for genital wart, 1.9% (1.3-2.7%) for gonorrhoea, 8.9% (7.8-10.2%) for hepatitis B (HBV), 1.2% (1.0-1.6%) for hepatitis C (HCV), 66.3% (57.4-74.1%) for human papillomavirus (HPV), 10.6% (6.2-17.6%) for herpes simplex virus (HSV-2) and 4.3% (3.2-5.8%) for Ureaplasma urealyticum. HIV-positive MSM have consistently higher odds of all these infections than the broader MSM population. As a subgroup of MSM, MSW were 2.5 (1.4-4.7), 5.7 (2.7-12.3), and 2.2 (1.4-3.7) times more likely to be infected with chlamydia, gonorrhoea and HCV than the broader MSM population, respectively. CONCLUSION: Prevalence levels of STIs among MSW were significantly higher than the broader MSM population. Co-infection of HIV and STIs were prevalent among Chinese MSM. Integration of HIV and STIs healthcare and surveillance systems is essential in providing effective HIV/STIs preventive measures and treatments. TRIAL REGISTRATION: PROSPERO NO: CRD42013003721

    Observation of a ppb mass threshoud enhancement in \psi^\prime\to\pi^+\pi^-J/\psi(J/\psi\to\gamma p\bar{p}) decay

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    The decay channel ψâ€Č→π+π−J/ψ(J/Ïˆâ†’Îłppˉ)\psi^\prime\to\pi^+\pi^-J/\psi(J/\psi\to\gamma p\bar{p}) is studied using a sample of 1.06×1081.06\times 10^8 ψâ€Č\psi^\prime events collected by the BESIII experiment at BEPCII. A strong enhancement at threshold is observed in the ppˉp\bar{p} invariant mass spectrum. The enhancement can be fit with an SS-wave Breit-Wigner resonance function with a resulting peak mass of M=1861−13+6(stat)−26+7(syst)MeV/c2M=1861^{+6}_{-13} {\rm (stat)}^{+7}_{-26} {\rm (syst)} {\rm MeV/}c^2 and a narrow width that is Γ<38MeV/c2\Gamma<38 {\rm MeV/}c^2 at the 90% confidence level. These results are consistent with published BESII results. These mass and width values do not match with those of any known meson resonance.Comment: 5 pages, 3 figures, submitted to Chinese Physics

    Observation of the electromagnetic doubly OZI-suppressed decay J/ψ→ϕπ0J/\psi \rightarrow \phi \pi^{0}

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    Using a sample of 1.311.31 billion J/ψJ/\psi events accumulated with the BESIII detector at the BEPCII collider, we report the observation of the decay J/ψ→ϕπ0J/\psi \rightarrow \phi\pi^{0}, which is the first evidence for a doubly Okubo-Zweig-Iizuka suppressed electromagnetic J/ψJ/\psi decay. A clear structure is observed in the K+K−K^{+} K^{-} mass spectrum around 1.02 GeV/c2c^2, which can be attributed to interference between J/ψ→ϕπ0J/\psi \rightarrow \phi\pi^{0} and J/ψ→K+K−π0J/\psi \rightarrow K^{+}K^{-}\pi^{0} decays. Due to this interference, two possible solutions are found. The corresponding measured values of the branching fraction of J/ψ→ϕπ0J/\psi \to \phi\pi^{0} are [2.94±0.16(stat.)±0.16(syst.)]×10−6[2.94 \pm 0.16\text{(stat.)} \pm 0.16\text{(syst.)}] \times 10^{-6} and [1.24±0.33(stat.)±0.30(syst.)]×10−7[1.24 \pm 0.33\text{(stat.)} \pm 0.30\text{(syst.)}] \times 10^{-7}.Comment: 7 pages, 4 figures, published in Phys. Rev.

    Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector

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    Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente

    Observation of associated near-side and away-side long-range correlations in √sNN=5.02  TeV proton-lead collisions with the ATLAS detector

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    Two-particle correlations in relative azimuthal angle (Δϕ) and pseudorapidity (Δη) are measured in √sNN=5.02  TeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1  Όb-1 of data as a function of transverse momentum (pT) and the transverse energy (ÎŁETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Δη|<5) “near-side” (Δϕ∌0) correlation that grows rapidly with increasing ÎŁETPb. A long-range “away-side” (Δϕ∌π) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ÎŁETPb, is found to match the near-side correlation in magnitude, shape (in Δη and Δϕ) and ÎŁETPb dependence. The resultant Δϕ correlation is approximately symmetric about π/2, and is consistent with a dominant cos⁥2Δϕ modulation for all ÎŁETPb ranges and particle pT
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