Prospectus, February 21, 1996

https://spark.parkland.edu/prospectus_1996/1005/thumbnail.jp

Prospectus, May 1, 1996

https://spark.parkland.edu/prospectus_1996/1014/thumbnail.jp

Prospectus, November 8, 1995

https://spark.parkland.edu/prospectus_1995/1028/thumbnail.jp

Prospectus, March 6, 1996

https://spark.parkland.edu/prospectus_1996/1007/thumbnail.jp

GABAA receptor subtype involvement in addictive behaviour

GABAA receptors form the major class of inhibitory neurotransmitter receptors in the mammalian brain. This review sets out to summarise the evidence that variations in genes encoding GABAA receptor isoforms are associated with aspects of addictive behaviour in humans, while animal models of addictive behaviour also implicate certain subtypes of GABAA receptor. In addition to outlining the evidence for the involvement of specific subtypes in addiction, we summarise the particular contributions of these isoforms in control over the functioning of brain circuits, especially the mesolimbic system, and make a first attempt to bring together evidence from several fields to understanding potential involvement of GABAA Receptor Subtypes in addictive behaviour. While the weight of the published literature is on alcohol dependency, the underlying principles outlined are relevant across a number of different aspects of addictive behaviour

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Journal of Supply Chain Management

Articles :1. A Supply Chain Perspective on Strategic Foothold Moves in Emerging Markets2. Learning from Conformance Quality Failures That Triggered Product Recalls : The Role of Direct and Indirect Experience3. Responses to Supplier-Induced Disruptions : A Fuzzy-Set Analysis4. A New Paradigm for Systematic Literature Reviews in Supply Chain Managementii+85p.;21x28c