322 research outputs found
Generation of Porous Particle Structures using the Void Expansion Method
The newly developed "void expansion method" allows for an efficient
generation of porous packings of spherical particles over a wide range of
volume fractions using the discrete element method. Particles are randomly
placed under addition of much smaller "void-particles". Then, the void-particle
radius is increased repeatedly, thereby rearranging the structural particles
until formation of a dense particle packing.
The structural particles' mean coordination number was used to characterize
the evolving microstructures. At some void radius, a transition from an
initially low to a higher mean coordination number is found, which was used to
characterize the influence of the various simulation parameters. For structural
and void-particle stiffnesses of the same order of magnitude, the transition is
found at constant total volume fraction slightly below the random close packing
limit. For decreasing void-particle stiffness the transition is shifted towards
a smaller void-particle radius and becomes smoother.Comment: 9 pages, 8 figure
Failure of Standard Conservation Laws at a Classical Change of Signature
The Divergence Theorem as usually stated cannot be applied across a change of
signature unless it is re-expressed to allow for a finite source term on the
signature change surface. Consequently all conservation laws must also be
`modified', and therefore insistence on conservation of matter across such a
surface cannot be physically justified. The Darmois junction conditions
normally ensure conservation of matter via Israel's identities for the jump in
the energy-momentum density, but not when the signature changes. Modified
identities are derived for this jump when a signature change occurs, and the
resulting surface effects in the conservation laws are calculated. In general,
physical vector fields experience a jump in at least one component, and a
source term may therefore appear in the corresponding conservation law. Thus
current is also not conserved. These surface effects are a consequence of the
change in the character of physical law. The only way to recover standard
conservation laws is to impose restrictions that no realistic cosmological
model can satisfy.Comment: 15pp, figures available on request from Charles Hellaby at
[email protected]
Stealth Branes
We discuss the brane world model of Dvali, Gabadadze and Porrati in which
branes evolve in an infinite bulk and the brane curvature term is added to the
action. If Z_2 symmetry between the two sides of the brane is not imposed, we
show that the model admits the existence of "stealth branes" which follow the
standard 4D internal evolution and have no gravitational effect on the bulk
space. Stealth branes can nucleate spontaneosly in a Minkowski bulk. This
process is described by the standard 4D quantum cosmology formalism with
tunneling boundary conditions for the brane world wave function. The notorious
ambiguity in the choice of boundary conditions is fixed in this case due to the
presence of the embedding spacetime. We also point to some problematic aspects
of models admitting stealth brane solutions.Comment: 24 pages; Final version, to appear in Phys. Rev. D. The discussion of
"embeddability obstruction" is removed (thanks to Takahiro Tanaka who
convinced us that there is no such obstruction
Ultrarelativistic black hole in an external electromagnetic field and gravitational waves in the Melvin universe
We investigate the ultrarelativistic boost of a Schwarzschild black hole
immersed in an external electromagnetic field, described by an exact solution
of the Einstein-Maxwell equations found by Ernst (the ``Schwarzschild-Melvin''
metric). Following the classical method of Aichelburg and Sexl, the
gravitational field generated by a black hole moving ``with the speed of
light'' and the transformed electromagnetic field are determined. The
corresponding exact solution describes an impulsive gravitational wave
propagating in the static, cylindrically symmetric, electrovac universe of
Melvin, and for a vanishing electromagnetic field it reduces to the well known
Aichelburg-Sexl pp-wave. In the boosting process, the original Petrov type I of
the Schwarzschild-Melvin solution simplifies to the type II on the impulse, and
to the type D elsewhere. The geometry of the wave front is studied, in
particular its non-constant Gauss curvature. In addition, a more general class
of impulsive waves in the Melvin universe is constructed by means of a
six-dimensional embedding formalism adapted to the background. A coordinate
system is also presented in which all the impulsive metrics take a continuous
form. Finally, it is shown that these solutions are a limiting case of a family
of exact gravitational waves with an arbitrary profile. This family is
identified with a solution previously found by Garfinkle and Melvin. We thus
complement their analysis, in particular demonstrating that such spacetimes are
of type II and belong to the Kundt class.Comment: 11 pages, REVTeX
Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in âs = 7 TeV pp collisions with the ATLAS detector
A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fbâ1 of protonâproton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results
Jet size dependence of single jet suppression in lead-lead collisions at sqrt(s(NN)) = 2.76 TeV with the ATLAS detector at the LHC
Measurements of inclusive jet suppression in heavy ion collisions at the LHC
provide direct sensitivity to the physics of jet quenching. In a sample of
lead-lead collisions at sqrt(s) = 2.76 TeV corresponding to an integrated
luminosity of approximately 7 inverse microbarns, ATLAS has measured jets with
a calorimeter over the pseudorapidity interval |eta| < 2.1 and over the
transverse momentum range 38 < pT < 210 GeV. Jets were reconstructed using the
anti-kt algorithm with values for the distance parameter that determines the
nominal jet radius of R = 0.2, 0.3, 0.4 and 0.5. The centrality dependence of
the jet yield is characterized by the jet "central-to-peripheral ratio," Rcp.
Jet production is found to be suppressed by approximately a factor of two in
the 10% most central collisions relative to peripheral collisions. Rcp varies
smoothly with centrality as characterized by the number of participating
nucleons. The observed suppression is only weakly dependent on jet radius and
transverse momentum. These results provide the first direct measurement of
inclusive jet suppression in heavy ion collisions and complement previous
measurements of dijet transverse energy imbalance at the LHC.Comment: 15 pages plus author list (30 pages total), 8 figures, 2 tables,
submitted to Physics Letters B. All figures including auxiliary figures are
available at
http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/HION-2011-02
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Parallel computing in information retrieval - An updated review
The progress of parallel computing in Information Retrieval (IR) is reviewed. In particular we stress the importance of the motivation in using parallel computing for Text Retrieval. We analyse parallel IR systems using a classification due to Rasmussen [1] and describe some parallel IR systems. We give a description of the retrieval models used in parallel Information Processing.. We describe areas of research which we believe are needed
Improving Genetic Prediction by Leveraging Genetic Correlations Among Human Diseases and Traits
Genomic prediction has the potential to contribute to precision medicine. However, to date, the utility of such predictors is limited due to low accuracy for most traits. Here theory and simulation study are used to demonstrate that widespread pleiotropy among phenotypes can be utilised to improve genomic risk prediction. We show how a genetic predictor can be created as a weighted index that combines published genome-wide association study (GWAS) summary statistics across many different traits. We apply this framework to predict risk of schizophrenia and bipolar disorder in the Psychiatric Genomics consortium data, finding substantial heterogeneity in prediction accuracy increases across cohorts. For six additional phenotypes in the UK Biobank data, we find increases in prediction accuracy ranging from 0.7 for height to 47 for type 2 diabetes, when using a multi-trait predictor that combines published summary statistics from multiple traits, as compared to a predictor based only on one trait. © 2018 The Author(s)
Genome-wide association study identifies 30 Loci Associated with Bipolar Disorder
This paper is dedicated to the memory of Psychiatric Genomics Consortium (PGC) founding member and Bipolar disorder working group co-chair Pamela Sklar. We thank the participants who donated their time, experiences and DNA to this research, and to the clinical and scientific teams that worked with them. We are deeply indebted to the investigators who comprise the PGC. The views expressed are those of the authors and not necessarily those of any funding or regulatory body. Analyses were carried out on the NL Genetic Cluster Computer (http://www.geneticcluster.org ) hosted by SURFsara, and the Mount Sinai high performance computing cluster (http://hpc.mssm.edu).Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P<1x10-4 in an additional 9,412 cases and 137,760 controls. Eight of the 19 variants that were genome-wide significant (GWS, p < 5x10-8) in the discovery GWAS were not GWS in the combined analysis, consistent with small effect sizes and limited power but also with genetic heterogeneity. In the combined analysis 30 loci were GWS including 20 novel loci. The significant loci contain genes encoding ion channels, neurotransmitter transporters and synaptic components. Pathway analysis revealed nine significantly enriched gene-sets including regulation of insulin secretion and endocannabinoid signaling. BDI is strongly genetically correlated with schizophrenia, driven by psychosis, whereas BDII is more strongly correlated with major depressive disorder. These findings address key clinical questions and provide potential new biological mechanisms for BD.This work was funded in part by the Brain and Behavior Research Foundation, Stanley Medical Research Institute, University of Michigan, Pritzker Neuropsychiatric Disorders Research Fund L.L.C., Marriot Foundation and the Mayo Clinic Center for Individualized Medicine, the NIMH Intramural Research Program; Canadian Institutes of Health Research; the UK Maudsley NHS Foundation Trust, NIHR, NRS, MRC, Wellcome Trust; European Research Council; German Ministry for Education and Research, German Research Foundation IZKF of MĂŒnster, Deutsche Forschungsgemeinschaft, ImmunoSensation, the Dr. Lisa-Oehler Foundation, University of Bonn; the Swiss National Science Foundation; French Foundation FondaMental and ANR; Spanish Ministerio de EconomĂa, CIBERSAM, Industria y Competitividad, European Regional Development Fund (ERDF), Generalitat de Catalunya, EU Horizon 2020 Research and Innovation Programme; BBMRI-NL; South-East Norway Regional Health Authority and Mrs. Throne-Holst; Swedish Research Council, Stockholm County Council, Söderström Foundation; Lundbeck Foundation, Aarhus University; Australia NHMRC, NSW Ministry of Health, Janette M O'Neil and Betty C Lynch
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