Colour-Difference Assessment for Driving Headlight Simulation

In high quality driving simulation applications, such as headlight simulation, colorimetric validity is essential. In virtual testing of headlight systems, it is important that the WYSIWYG (What You See Is What You Get) paradigm is respected for product quality headlight assessment. Indeed, if a slightly reddish orange colour is displayed instead of the typical orange of halogen lighting, the effect for driver comfort or traffic safety can be critical. The lighting specialist should accept a headlight which doesn't have the right colour. Previous studies have shown that there is a significant colour difference between virtual and real environments. Nevertheless, in virtual headlight testing the rendered colour fidelity has to fit industrial assessment. This study therefore deals with the colour-difference perceptibility that is the ability of an observer to detect a difference between two colours and, more precisely, on the acceptability of the perceived difference. We propose in this paper a psychophysical function for colour difference acceptability which fits well with the measured data. The colour acceptability function was implemented in a driving simulator for high validity headlight assessment. Driver acceptability experimentation was carried out using Renault's headlight driving simulation equipped with a fullcab and a 210° cylindrical display screen

Color-difference assessment and enhancement for driving headlight simulation

Real-time headlight simulation in driving conditions is used by most car manufacturers to assure the quality, cost, and delivery of headlight engineering design. An important parameter judged by the headlight assessment team is color restitution; indeed, this parameter has to meet the standard of “lamps for road vehicles.” Therefore, the goal of this study was the color assessment and enhancement of a driving headlight simulator. For this purpose, this study was conducted in two phases: the process of constructing two color acceptability scales that directly reflect the perception of two different populations (experts and “naive”), and the assessment of a method based on the chromatic adaptation transform (CAT) for reducing the color difference between real and virtual environments. In the first phase, we conducted two psychophysical experiments (i.e., one for each population), in which the observers had to report their degree of satisfaction about the color difference. These two experiments enabled the creation of two acceptability scales for headlight simulation. In the second phase, we compared the performance of different chromatic transformations; as a result of this comparison, we advise the use of the CAT02 transformation, in order to reduce the color difference for headlight assessment in driving simulation experiments.ANRT (Association Nationale de la Recherche et de la Technologie) and Renaul

Colour-Difference Assessment for Driving Headlight Simulation

In high quality driving simulation applications, such as headlight simulation, colorimetric validity is essential. In virtual testing of headlight systems, it is important that the WYSIWYG (What You See Is What You Get) paradigm is respected for product quality headlight assessment. Indeed, if a slightly reddish orange colour is displayed instead of the typical orange of halogen lighting, the effect for driver comfort or traffic safety can be critical. The lighting specialist should accept a headlight which doesn't have the right colour. Previous studies have shown that there is a significant colour difference between virtual and real environments. Nevertheless, in virtual headlight testing the rendered colour fidelity has to fit industrial assessment. This study therefore deals with the colour-difference perceptibility that is the ability of an observer to detect a difference between two colours and, more precisely, on the acceptability of the perceived difference. We propose in this paper a psychophysical function for colour difference acceptability which fits well with the measured data. The colour acceptability function was implemented in a driving simulator for high validity headlight assessment. Driver acceptability experimentation was carried out using Renault's headlight driving simulation equipped with a fullcab and a 210° cylindrical display screen

Colorimétrie appliquée à la simulation de phare de voiture

Afin d’optimiser les temps de conception d’un système d’une voiture (phare, système de freinage, etc.), les industries utilisent de manière de plus en plus régulière des logiciels de simulation et de Conception Assistée par Ordinateur (CAO). Ces derniers permettent la visualisation en temps réel de ces systèmes sous diverses conditions (analyse de la résistance à la pression, à la chaleur, etc.). Le Centre de Réalité Virtuelle et de Simulation Immersive (CRVSI) de Renault dispose d’outils de conception et de maquettage virtuel (CAVE, simulateur dynamique, etc.). Ces derniers s’intègrent dans le cycle de la conception des véhicules en offrant aux utilisateurs la possibilité d’interagir, en temps réel, avec des maquettes virtuelles. Dans le cadre spécifique de la simulation des phares d’une voiture, il est important d’étudier la représentativité des couleurs affichées. Il est en effet primordial que, pour un outil de validation, la restitution des couleurs soit au plus proche de la réalité physique (phare halogène, LED, Xenon, etc.). La colorimétrie offre plusieurs outils permettant de calculer une différence colorimétrique. Nous avons ainsi étudié l’uniformité colorimétrique des métriques CIE76, CIE94 et CIEDE2000 afin d’une part, de proposer des coefficients de pondération pour la teinte et la chroma et, d’autre part, de comparer les résultats de chacune afin de déterminer celle qui uniformise le mieux l’espace CIELAB pour la simulation d’éclairage

Color-difference assessment and enhancement for driving headlight simulation

Real-time headlight simulation in driving conditions is used by most car manufacturers to assure the quality, cost, and delivery of headlight engineering design. An important parameter judged by the headlight assessment team is color restitution; indeed, this parameter has to meet the standard of “lamps for road vehicles.” Therefore, the goal of this study was the color assessment and enhancement of a driving headlight simulator. For this purpose, this study was conducted in two phases: the process of constructing two color acceptability scales that directly reflect the perception of two different populations (experts and “naive”), and the assessment of a method based on the chromatic adaptation transform (CAT) for reducing the color difference between real and virtual environments. In the first phase, we conducted two psychophysical experiments (i.e., one for each population), in which the observers had to report their degree of satisfaction about the color difference. These two experiments enabled the creation of two acceptability scales for headlight simulation. In the second phase, we compared the performance of different chromatic transformations; as a result of this comparison, we advise the use of the CAT02 transformation, in order to reduce the color difference for headlight assessment in driving simulation experiments.ANRT (Association Nationale de la Recherche et de la Technologie) and Renaul

Lipid Remodeling in Hepatocyte Proliferation and Hepatocellular Carcinoma.

BACKGROUND AND AIMS: Hepatocytes undergo profound metabolic rewiring when primed to proliferate during compensatory regeneration and in hepatocellular carcinoma (HCC). However, the metabolic control of these processes is not fully understood. In order to capture the metabolic signature of proliferating hepatocytes, we applied state-of-the-art systems biology approaches to models of liver regeneration, pharmacologically and genetically activated cell proliferation, and HCC. APPROACH AND RESULTS: Integrating metabolomics, lipidomics, and transcriptomics, we link changes in the lipidome of proliferating hepatocytes to altered metabolic pathways including lipogenesis, fatty acid desaturation, and generation of phosphatidylcholine (PC). We confirm this altered lipid signature in human HCC and show a positive correlation of monounsaturated PC with hallmarks of cell proliferation and hepatic carcinogenesis. CONCLUSIONS: Overall, we demonstrate that specific lipid metabolic pathways are coherently altered when hepatocytes switch to proliferation. These represent a source of targets for the development of therapeutic strategies and prognostic biomarkers of HCC.J.L.G., Z.H. and M.V. are funded by the Medical Research Council (MRC grant MC UP A90 1006 & MC PC 13030). J.L.G. and Z.H. are supported by the Imperial Biomedical Research Centre, NIHR. M.A., A.V-P., F.O., Q.M.A. and M.V. are members of the EPoS consortium, which is funded by the Horizon 2020 Framework Program of the European Union under Grant Agreement 634413. F.O. is supported by MRC program grants (MR/K0019494/1 and MR/R023026/1). J.L is supported by MRC PhD studentship and a CRUK program grant (C18342/A23390). M.V. and A.V-P. are supported by MRC MDU and MRC DMC (MC UU 12012/2). Q.M.A. received additional research support from The Liver Research Trust and is a Newcastle NIHR Biomedical Research Centre investigator. M.A., M.V., A.V-P. and J.L.G. received research support from the Evelyn Trust and the NIHR Cambridge Biomedical Research Centre (Gastroenterology Theme)

Quantitative modelling of human liver reveals dysregulation of glycosphingolipid pathways in nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) is an increasingly prevalent disease that is associated with multiple metabolic disturbances, yet the metabolic pathways underlying its progression are poorly understood. Here, we studied metabolic pathways of the human liver across the full histological spectrum of NAFLD. We analyzed whole liver tissue transcriptomics and serum metabolomics data obtained from a large, prospectively enrolled cohort of 206 histologically characterized patients derived from the European NAFLD Registry and developed genome-scale metabolic models (GEMs) of human hepatocytes at different stages of NAFLD. We identified several metabolic signatures in the liver and blood of these patients, specifically highlighting the alteration of vitamins (A, E) and glycosphingolipids, and their link with complex glycosaminoglycans in advanced fibrosis. Furthermore, we derived GEMs and identified metabolic signatures of three common NAFLD-associated gene variants (PNPLA3, TM6SF2, and HSD17B13). The study demonstrates dysregulated liver metabolic pathways which may contribute to the progression of NAFLD.</p

Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically-characterised cohort

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