Health Tourism Contribution to the Structural Dynamics of the Territorial Systems with Tourism Functionality

AbstractThe study aims to identify the role of health tourism (SPA) in developing the territorial systems, characterized by the tourism functionality, in Romania, for the period 2000-2012, a period marked by spectacular transformations, especially for this economic sector. Tourism has now become a true economic engine, generating an increase in the functional complexity of the territorial system, which is based on exploiting tourism resources. To quantify how tourism has contributed to the economic development of these territorial systems in Romania a database of NACE codes was set up, specific for the tourism activity, for the period 2000-2012, for territorial mainframe systems with functionality resort. Based on this statistical support analyzes on the evolution of the number of companies, number of employees, turnover and profit were made. The results show the important role of health tourism in generating multiplier effects on other components of the economic subsystem. They were defined two categories of territorial systems: territorial systems where tourism plays a complementary role function and territorial systems in which health tourism has a preeminent role in the local economy

Multiple sclerosis and SARS-CoV-2 infection

Universitatea de Medicină și Farmacie „Grigore T. Popa” Iași, România, Clinica I Oftalmologie, Spitalul Clinic Județean de Urgență „Sf. Spiridon”, Iași, RomâniaSummary. We analyzed the case of a patient with multiple sclerosis associated with SARS-CoV-2 infection. The clinical appearance of the ophthalmologist does not justify the decrease in AV, which is why it is recommended to perform an MRI in an emergency. The patient accuses the decrease in visual acuity in the left eye. The appearance described is suggestive for multiple sclerosis. PCR testing was positive. After 14 days PCR test was negative but the ophthalmological evolution was unfavorable. Intravenous emergency treatment with Solumedrol was initiated for 5 days. The particularity of the case is due to the fulminant onset of multiple sclerosis in the context of SARS-CoV-2 infection and the unfavorable evolution in terms of AV, despite early treatment.Introducere. Pacientă, în vârstă de 16 ani, se prezintă în Clinica I Oftalmologie a Spitalului „Sf. Spiridon”, Iași, acuzând scăderea acuității vizuale la ochiul stâng cu debut acut. Pacienta nu prezintă alte antecedente personale patologice. AVOD=1 fc, AVOS= pmm., PIOAO=12mmHg. La examinarea polului anterior, nu se constată elemente patologice. La examinarea polului posterior, discul optic este normal colorat, are contur net, C/D=0,1, artere și vene cu calibru normal, maculă fără leziuni. Aspectul clinic oftalmologic nu justifică scăderea AV, motiv pentru care se recomandă efectuarea unui RMN în urgență. Se identifică leziuni în hipersemnal T2 și FLAIR cu restricție de difuzie localizată periventricular pe partea dreaptă, în contrast cu cornul posterior al ventriculului lateral drept cu diametru de 17/15 mm și două în centri senzoriali, una mai mare de 9,6mm parietal drept în substanța albă, periventricular, talamic drept, 9,6 mm în medulla oblongata de 13 mm. Aspectul descris este sugestiv pentru scleroză multiplă. Testarea PCR pentru SARS-CoV-2 a avut rezultat pozitiv, pacienta fiind asimptomatică. S-a format o echipă multidisciplinară alcătuită din oftalmologi, neurologi și medici infecționiști și s-a inițiat tratamentul în urgență intravenos cu Solumedrol timp de 5 zile, continuat cu Medrol per os. Evoluție. După 14 zile, testul PCR pentru SARSCoV- 2 s-a negativat, însă evoluția oftalmologică a fost nefavorabilă. Pacienta se prezintă după 3 luni, în urgență, acuzând percepția unui scotom central la OD. AVOD=0,6, iar AVOS a rămas pmm. La RMN leziunile au aspect staționar. După tratamentul intravenos cu Solumedrol 3 zile și per os cu Medrol, scotomul central de la OD se reduce în dimensiuni și AVOD se îmbunătățește la 0,8 fcnc. Discuții: Rămâne în discuție deschisă dacă infecția cu SARS-CoV-2 la persoane nevaccinate poate precipita debutul fulminant al unor patologii în stare latentă. Concluzii. Particularitatea cazului se datorează debutului fulminant al sclerozei multiple în contextul infecției cu SARS-CoV-2 și evoluției nefavorabile din punct de vedere al AV, în ciuda tratamentului instaurat precoce

Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV

Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

Juxtaposing BTE and ATE – on the role of the European insurance industry in funding civil litigation

One of the ways in which legal services are financed, and indeed shaped, is through private insurance arrangement. Two contrasting types of legal expenses insurance contracts (LEI) seem to dominate in Europe: before the event (BTE) and after the event (ATE) legal expenses insurance. Notwithstanding institutional differences between different legal systems, BTE and ATE insurance arrangements may be instrumental if government policy is geared towards strengthening a market-oriented system of financing access to justice for individuals and business. At the same time, emphasizing the role of a private industry as a keeper of the gates to justice raises issues of accountability and transparency, not readily reconcilable with demands of competition. Moreover, multiple actors (clients, lawyers, courts, insurers) are involved, causing behavioural dynamics which are not easily predicted or influenced. Against this background, this paper looks into BTE and ATE arrangements by analysing the particularities of BTE and ATE arrangements currently available in some European jurisdictions and by painting a picture of their respective markets and legal contexts. This allows for some reflection on the performance of BTE and ATE providers as both financiers and keepers. Two issues emerge from the analysis that are worthy of some further reflection. Firstly, there is the problematic long-term sustainability of some ATE products. Secondly, the challenges faced by policymakers that would like to nudge consumers into voluntarily taking out BTE LEI

Penilaian Kinerja Keuangan Koperasi di Kabupaten Pelalawan

This paper describe development and financial performance of cooperative in District Pelalawan among 2007 - 2008. Studies on primary and secondary cooperative in 12 sub-districts. Method in this stady use performance measuring of productivity, efficiency, growth, liquidity, and solvability of cooperative. Productivity of cooperative in Pelalawan was highly but efficiency still low. Profit and income were highly, even liquidity of cooperative very high, and solvability was good

Search for stop and higgsino production using diphoton Higgs boson decays

Results are presented of a search for a "natural" supersymmetry scenario with gauge mediated symmetry breaking. It is assumed that only the supersymmetric partners of the top-quark (stop) and the Higgs boson (higgsino) are accessible. Events are examined in which there are two photons forming a Higgs boson candidate, and at least two b-quark jets. In 19.7 inverse femtobarns of proton-proton collision data at sqrt(s) = 8 TeV, recorded in the CMS experiment, no evidence of a signal is found and lower limits at the 95% confidence level are set, excluding the stop mass below 360 to 410 GeV, depending on the higgsino mass

Severe early onset preeclampsia: short and long term clinical, psychosocial and biochemical aspects

Preeclampsia is a pregnancy specific disorder commonly defined as de novo hypertension and proteinuria after 20 weeks gestational age. It occurs in approximately 3-5% of pregnancies and it is still a major cause of both foetal and maternal morbidity and mortality worldwide1. As extensive research has not yet elucidated the aetiology of preeclampsia, there are no rational preventive or therapeutic interventions available. The only rational treatment is delivery, which benefits the mother but is not in the interest of the foetus, if remote from term. Early onset preeclampsia (<32 weeks’ gestational age) occurs in less than 1% of pregnancies. It is, however often associated with maternal morbidity as the risk of progression to severe maternal disease is inversely related with gestational age at onset2. Resulting prematurity is therefore the main cause of neonatal mortality and morbidity in patients with severe preeclampsia3. Although the discussion is ongoing, perinatal survival is suggested to be increased in patients with preterm preeclampsia by expectant, non-interventional management. This temporising treatment option to lengthen pregnancy includes the use of antihypertensive medication to control hypertension, magnesium sulphate to prevent eclampsia and corticosteroids to enhance foetal lung maturity4. With optimal maternal haemodynamic status and reassuring foetal condition this results on average in an extension of 2 weeks. Prolongation of these pregnancies is a great challenge for clinicians to balance between potential maternal risks on one the eve hand and possible foetal benefits on the other. Clinical controversies regarding prolongation of preterm preeclamptic pregnancies still exist – also taking into account that preeclampsia is the leading cause of maternal mortality in the Netherlands5 - a debate which is even more pronounced in very preterm pregnancies with questionable foetal viability6-9. Do maternal risks of prolongation of these very early pregnancies outweigh the chances of neonatal survival? Counselling of women with very early onset preeclampsia not only comprises of knowledge of the outcome of those particular pregnancies, but also knowledge of outcomes of future pregnancies of these women is of major clinical importance. This thesis opens with a review of the literature on identifiable risk factors of preeclampsia

Search for heavy resonances decaying to two Higgs bosons in final states containing four b quarks

A search is presented for narrow heavy resonances X decaying into pairs of Higgs bosons (H) in proton-proton collisions collected by the CMS experiment at the LHC at root s = 8 TeV. The data correspond to an integrated luminosity of 19.7 fb(-1). The search considers HH resonances with masses between 1 and 3 TeV, having final states of two b quark pairs. Each Higgs boson is produced with large momentum, and the hadronization products of the pair of b quarks can usually be reconstructed as single large jets. The background from multijet and t (t) over bar events is significantly reduced by applying requirements related to the flavor of the jet, its mass, and its substructure. The signal would be identified as a peak on top of the dijet invariant mass spectrum of the remaining background events. No evidence is observed for such a signal. Upper limits obtained at 95 confidence level for the product of the production cross section and branching fraction sigma(gg -> X) B(X -> HH -> b (b) over barb (b) over bar) range from 10 to 1.5 fb for the mass of X from 1.15 to 2.0 TeV, significantly extending previous searches. For a warped extra dimension theory with amass scale Lambda(R) = 1 TeV, the data exclude radion scalar masses between 1.15 and 1.55 TeV

Measurement of associated Z plus charm production in proton-proton collisions at root s=8TeV

A study of the associated production of a Z boson and a charm quark jet (Z + c), and a comparison to production with a b quark jet (Z + b), in pp collisions at a centre-of-mass energy of 8 TeV are presented. The analysis uses a data sample corresponding to an integrated luminosity of 19.7 fb(-1), collected with the CMS detector at the CERN LHC. The Z boson candidates are identified through their decays into pairs of electrons or muons. Jets originating from heavy flavour quarks are identified using semileptonic decays of c or b flavoured hadrons and hadronic decays of charm hadrons. The measurements are performed in the kinematic region with two leptons with pT(l) > 20 GeV, vertical bar eta(l)vertical bar 25 GeV and vertical bar eta(jet)vertical bar Z + c + X) B(Z -> l(+)l(-)) = 8.8 +/- 0.5 (stat)+/- 0.6 (syst) pb. The ratio of the Z+c and Z+b production cross sections is measured to be sigma(pp -> Z+c+X)/sigma (pp -> Z+b+X) = 2.0 +/- 0.2 (stat)+/- 0.2 (syst). The Z+c production cross section and the cross section ratio are also measured as a function of the transverse momentum of theZ boson and of the heavy flavour jet. The measurements are compared with theoretical predictions.Peer reviewe