71 research outputs found
Integrative analyses identify modulators of response to neoadjuvant aromatase inhibitors in patients with early breast cancer
- Author
- A Mackay
- AK Dunbier
- AK Dunbier
- Alan Mackay
- Alexey Larionov
- Anita K Dunbier
- Aradhana Rani
- Ash Nerurkar
- B Weigelt
- BP Coe
- C Curtis
- C Kent
- D Generali
- DG Albertson
- DS Tan
- Elena López-Knowles
- F Kreisel
- Helen Anderson
- HW Cheung
- IE Smith
- IE Smith
- J Hicks
- J Michael Dixon
- Jorge S Reis-Filho
- JS Foster
- K Lundgren
- L Osterberg
- LA Martin
- LA Martin
- LA Martin
- Lesley-Ann Martin
- LG Leon
- Lorna Renshaw
- M Dowsett
- M Mello-Grand
- M Scaltriti
- Mitch Dowsett
- MJ Ellis
- MT Weigel
- N Turner
- P Darbre
- P Lal
- Paul M Wilkerson
- Peter Osin
- PM Wilkerson
- PM Wilkerson
- PT Simpson
- R Beroukhim
- R Duprez
- R Katz-Brull
- R Natrajan
- R Natrajan
- R Natrajan
- Ricardo Ribas
- T Miyake
- T Troiani
- TK Lam
- William R Miller
- WR Miller
- WR Miller
- WR Miller
- WR Miller
- X Huo
- Y Zhao
- Z Ghazoui
- Zara Ghazoui
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Introduction
Aromatase inhibitors (AIs) are a vital component of estrogen receptor positive (ER+) breast cancer treatment. De novo and acquired resistance, however, is common. The aims of this study were to relate patterns of copy number aberrations to molecular and proliferative response to AIs, to study differences in the patterns of copy number aberrations between breast cancer samples pre- and post-AI neoadjuvant therapy, and to identify putative biomarkers for resistance to neoadjuvant AI therapy using an integrative analysis approach.
Methods
Samples from 84 patients derived from two neoadjuvant AI therapy trials were subjected to copy number profiling by microarray-based comparative genomic hybridisation (aCGH, n = 84), gene expression profiling (n = 47), matched pre- and post-AI aCGH (n = 19 pairs) and Ki67-based AI-response analysis (n = 39).
Results
Integrative analysis of these datasets identified a set of nine genes that, when amplified, were associated with a poor response to AIs, and were significantly overexpressed when amplified, including CHKA, LRP5 and SAPS3. Functional validation in vitro, using cell lines with and without amplification of these genes (SUM44, MDA-MB134-VI, T47D and MCF7) and a model of acquired AI-resistance (MCF7-LTED) identified CHKA as a gene that when amplified modulates estrogen receptor (ER)-driven proliferation, ER/estrogen response element (ERE) transactivation, expression of ER-regulated genes and phosphorylation of V-AKT murine thymoma viral oncogene homolog 1 (AKT1).
Conclusions
These data provide a rationale for investigation of the role of CHKA in further models of de novo and acquired resistance to AIs, and provide proof of concept that integrative genomic analyses can identify biologically relevant modulators of AI response
RET PLCγ Phosphotyrosine Binding Domain Regulates Ca2+ Signaling and Neocortical Neuronal Migration
- Author
- Branden Nelson
- BS Schmutzler
- C Canibano
- CB Guan
- D Natarajan
- DE Clapham
- DS Richardson
- E Arighi
- E Pozas
- G Paratcha
- GR Dressler
- GR Monteith
- HL Roderick
- I Plaza-Menacho
- J Anders
- J Mijatovic
- JP Golden
- JQ Zheng
- Katsutoshi Nakahata
- L Desfrere
- L Jiao
- LN Borodinsky
- M Coulpier
- M Jijiwa
- M Santoro
- M Takahashi
- M Uchida
- MG Borrello
- MJ Berridge
- MJ Berridge
- MJ Berridge
- MR Rusciano
- MS Airaksinen
- N Asai
- N Asai
- Nicolas Fritz
- P Runeberg-Roos
- P Uhlen
- Paola Rebellato
- Per Uhlén
- R Zhou
- RAM Daza
- S Bourane
- S Eketjall
- S Jain
- S Kjaer
- S Malmersjo
- S Manie
- S Seino
- SJ Cook
- Songbai Zhang
- T Fukuda
- T Saito
- T Watanabe
- T Yu
- T. Kalle Lundgren
- TK Lundgren
- VM Leppanen
- Publication venue
- Public Library of Science
- Publication date
- 15/02/2012
- Field of study
The receptor tyrosine kinase RET plays an essential role during embryogenesis in regulating cell proliferation, differentiation, and migration. Upon glial cell line-derived neurotrophic factor (GDNF) stimulation, RET can trigger multiple intracellular signaling pathways that in concert activate various downstream effectors. Here we report that the RET receptor induces calcium (Ca2+) signaling and regulates neocortical neuronal progenitor migration through the Phospholipase-C gamma (PLCγ) binding domain Tyr1015. This signaling cascade releases Ca2+ from the endoplasmic reticulum through the inositol 1,4,5-trisphosphate receptor and stimulates phosphorylation of ERK1/2 and CaMKII. A point mutation at Tyr1015 on RET or small interfering RNA gene silencing of PLCγ block the GDNF-induced signaling cascade. Delivery of the RET mutation to neuronal progenitors in the embryonic ventricular zone using in utero electroporation reveal that Tyr1015 is necessary for GDNF-stimulated migration of neurons to the cortical plate. These findings demonstrate a novel RET mediated signaling pathway that elevates cytosolic Ca2+ and modulates neuronal migration in the developing neocortex through the PLCγ binding domain Tyr1015
Immunotoxin Complementation of HAART to Deplete Persisting HIV-Infected Cell Reservoirs
- Author
- A Fauci
- C McCoig
- CF Barbas
- CM Coleman
- D Montefiori
- DD Richman
- DG Brooks
- E Dadachova
- E Dadachova
- EA Berger
- EA Berger
- EA Berger
- Edward A. Berger
- Glenn F. Rall
- H Fuchs
- H Goldstein
- I Pastan
- Ira Pastan
- J Jones
- J Verhoef
- JB Dinoso
- JB Dinoso
- JD Lundgren
- JM Brenchley
- JR Bailey
- K Strebhardt
- K Uberla
- KKA Van Rompay
- L Geeraert
- L McHugh
- L Shen
- L Zhang
- LM Walker
- M Buzon
- M Duvic
- M Onda
- M Onda
- M Stevenson
- MA Till
- MA Winters
- MD Marsden
- MD Marsden
- MJ Root
- O Ramilo
- P Ashorn
- P Ashorn
- P Ashorn
- P Aullo
- P Wolf
- PE Kennedy
- PE Kennedy
- PR Gorry
- R Stasi
- RC Gallo
- RJ Kreitman
- RJ Kreitman
- RL Murphy
- RT Davey
- RV Ramachandran
- RW Finberg
- S Broder
- S Johansson
- SH Pincus
- SH Pincus
- T Igarashi
- TK Bera
- TP Brennan
- TW Chun
- VK Chaudhary
- X Contreras
- Z Ambrose
- Publication venue
- Public Library of Science
- Publication date
- 01/06/2010
- Field of study
Direct Recognition of Fusobacterium nucleatum by the NK Cell Natural Cytotoxicity Receptor NKp46 Aggravates Periodontal Disease
- Author
- A Chalifour
- A Jewett
- A Moretta
- A Wilensky
- A Wilensky
- A Zeidel
- Asaf Wilensky
- B Agerberth
- C Gur
- CA Genco
- Chamutal Gur
- D Grenier
- D Polak
- David Polak
- DH Raulet
- DJ Shealy
- DT Graves
- DT Graves
- E Burns
- E Marcenaro
- EF Berbari
- FA Scannapieco
- G Schett
- GC Koo
- Gilad Bachrach
- Gili Halftek
- GJ Seymour
- H Okada
- Hagit Achdout
- I Frolov
- J Beck
- J Hanna
- James Carlyle
- JM Albandar
- JM Albandar
- JS Orange
- K Kobayashi
- K Putsep
- L Moretta
- Lior Shapira
- LL Lanier
- M Elboim
- M Romero-Reyes
- Moran Elboim
- N Wegner
- O Mandelboim
- Ofer Mandelboim
- P de Pablo
- P Stashenko
- PE Kolenbrander
- PJ Baker
- PJ Baker
- Q Lu
- R Assuma
- R Biassoni
- R Gazit
- R Gorska
- R Lorini
- S Offenbacher
- S Sivori
- Stella Chaushu
- T Dodman
- T Hildebrand
- T Lundgren
- T Nakashima
- T Wu
- TE Van Dyke
- TE Van Dyke
- TI Arnon
- TI Arnon
- TI Arnon
- TI Arnon
- TK Varma
- WE Moore
- Y Houri-Haddad
- Y Houri-Haddad
- Y Houri-Haddad
- YW Han
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
Periodontitis is a common human chronic inflammatory disease that results in the destruction of the tooth attachment apparatus and tooth loss. Although infections with periopathogenic bacteria such as Porphyromonas gingivalis (P. gingivalis) and Fusobacterium nucleatum (F. nucleatum) are essential for inducing periodontitis, the nature and magnitude of the disease is determined by the host's immune response. Here, we investigate the role played by the NK killer receptor NKp46 (NCR1 in mice), in the pathogenesis of periodontitis. Using an oral infection periodontitis model we demonstrate that following F. nucleatum infection no alveolar bone loss is observed in mice deficient for NCR1 expression, whereas around 20% bone loss is observed in wild type mice and in mice infected with P. gingivalis. By using subcutaneous chambers inoculated with F. nucleatum we demonstrate that immune cells, including NK cells, rapidly accumulate in the chambers and that this leads to a fast and transient, NCR1-dependant TNF-α secretion. We further show that both the mouse NCR1 and the human NKp46 bind directly to F. nucleatum and we demonstrate that this binding is sensitive to heat, to proteinase K and to pronase treatments. Finally, we show in vitro that the interaction of NK cells with F. nucleatum leads to an NCR1-dependent secretion of TNF-α. Thus, the present study provides the first evidence that NCR1 and NKp46 directly recognize a periodontal pathogen and that this interaction influences the outcome of F. nucleatum-mediated periodontitis
Phase structures of the black Dp-D(p + 4)-brane system in various ensembles I: thermal stability
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
- Abeysekara AU
- Abramo LR
- Abramowski A
- Abreu P
- Acernese F
- Acero F
- Ackermann M
- Ackley K
- Ackley K
- Adams C
- Adams J
- Adams SM
- Adams T
- Addesso P
- Adhikari RX
- Adya VB
- Affeldt C
- Afrough M
- Agarwal B
- Agathos M
- Agatsuma K
- Aggarwal N
- Aglietta M
- Agliozzo C
- Agudo I
- Aguiar OD
- Aguilar JA
- Aharonian F
- Ahlers M
- Ahrens M
- Aiello L
- Ain A
- Ajith P
- Akras S
- Al Samarai I
- Albert A
- Albert A
- Albuquerque IFM
- Albury JM
- Alcaniz JS
- Alexander KD
- Alfaro R
- Alighieri S Di Serego
- Allam S
- Allekotte I
- Allen B
- Allen G
- Allison J
- Allison JR
- Allocca A
- Almela A
- Altin PA
- Altmann D
- Alvarez C
- Alvarez JD
- Alvarez M Dovale
- Alvarez-Muiz J
- Amati L
- Amato A
- An T
- Ananyeva A
- Anastasi GA
- Anchordoqui L
- Andeen K
- Anderson JP
- Anderson SB
- Anderson T
- Anderson WG
- Andrada B
- Andre M
- Andreoni I
- Andreoni I
- Andringa S
- Angelova SV
- Anghinolfi M
- Angner EO
- Angus CR
- Annis J
- Ansseau I
- Antier S
- Anton G
- Antonelli LA
- Antonelli LA
- Anupama GC
- Aoki K
- Aoki W
- Appert S
- Aptekar RL
- Arai K
- Arakawa M
- Aramo C
- Araya MC
- Arcavi I
- Arceo R
- Ardid M
- Areeda JS
- Aresu G
- Argan A
- Argelles C
- Arnaud N
- Array LWA Long Wavelength
- Array MWA Murchison Widefield
- Arrieta M
- Arsene N
- Arteaga-Velzquez JC
- Artola R
- Arun KG
- Asakura Y
- Asaoka Y
- Ascenzi S
- Ashall C
- Ashley MCB
- Ashton G
- Asorey H
- Assis P
- Ast M
- Aston SM
- Astone P
- Atallah DV
- ATLAS
- Atwood WB
- Aubert J-J
- Aubert P
- Aublin J
- Auffenberg J
- Aufmuth P
- Aulbert C
- AultONeal K
- Austin C
- Avgitas T
- Avila G
- Avila-Alvarez A
- Awad A Kuotb
- Axani S
- Baar S
- Babak S
- Bachetti M
- Backes M
- Bacon P
- Bader MKM
- Badescu AM
- Bae S
- Bagherpour H
- Bai X
- Bailes M
- Baker PT
- Balaceanu A
- Balanutsa PV
- Balasubramanian A
- Balbinot E
- Baldaccini F
- Baldini L
- Ballardin G
- Ballmer SW
- Bally J
- Balzer A
- Banagiri S
- Banerji M
- Bannister KW
- Barayoga JC
- Barbarino C
- Barbato F
- Barber AS
- Barbiellini G
- Barbiellini G
- Barclay SE
- Baret B
- Barish BC
- Barker D
- Barkett K
- Barnard M
- Barnes J
- Barone F
- Barr B
- Barrios-Marti J
- Barron JP
- Barsotti L
- Barsuglia M
- Barta D
- Barthelmy SD
- Bartlett J
- Bartos I
- Barway S
- Barway S
- Barwick SW
- Basa S
- Bassiri R
- Basti A
- Bastieri D
- Batch JC
- Bauer FE
- Bauer FE
- Baum V
- Bawaj M
- Bay R
- Bayley JC
- Bazzan M
- Bazzano A
- Bchele M
- Beardmore AP
- Beardsley A
- Beatty JJ
- Becerril A
- Becherini Y
- Bechtol K
- Becker KH
- Becsy B
- Beer C
- Bejger M
- Belahcene I
- Belhorma B
- Bell AS
- Bellazzini R
- Bellido JA
- Bellm E
- Belmont-Moreno E
- Benetti S
- Benkhali F Ait
- Benoit-Levy A
- BenZvi SY
- Berat C
- Berenji B
- Berge D
- Berger BK
- Berger E
- Bergmann G
- Berisso M Gomez
- Berley D
- Bernal A
- Bernardini E
- Bernardini MG
- Bernhard S
- Bernrhr K
- Bero JJ
- Beroiz M
- Berry CPL
- Bersanetti D
- Bertaina ME
- Bertin E
- Bertin V
- Bertolini A
- Berton M
- Bertou X
- Bessell MS
- Besson DZ
- Beswick R
- Betzwieser J
- Bhagwat S
- Bhalerao V
- Bhandare R
- Bhattacharya D
- Biagi S
- Biermann PL
- Bilenko IA
- Billingsley G
- Billman CR
- Binder G
- Bindig D
- Birch J
- Birney R
- Birnholtz O
- Biscans S
- Biscoveanu S
- Bisht A
- Bissaldi E
- Bissaldi E
- Biteau J
- Bitossi M
- Biwer C
- Bizouard MA
- Blackburn JK
- Blackburn L
- Blackman J
- Blackwell R
- Blaess SG
- Blagorodnova N
- Blair CD
- Blair DG
- Blair RM
- Blanchard P
- Blanco A
- Bland PA
- Blandford RD
- Blaufuss E
- Blazek J
- Bleve C
- Bloemen S
- Bloom ED
- Blot S
- Bock O
- Bode N
- Boer M
- Bogaert G
- Bohacova M
- Bohe A
- Bohm C
- Boisson C
- Bolmont J
- Bond IA
- Bondu F
- Bonifazi C
- Bonilla E
- Bonino R
- Bonnand R
- Bonnefoy S
- Bonoli S
- Booler T
- Boom BA
- Bordas P
- Bork R
- Bormuth R
- Borner M
- Borodai N
- Bos F
- Boschi V
- Bose D
- Bose S
- Boser S
- Bossie K
- Botner O
- Bottacini E
- Bottcher M
- Botti AM
- Botticella MT
- Bouffanais Y
- Bourbeau E
- Bourbeau J
- Bourret S
- Bouwhuis MC
- Bozzi A
- Bozzo E
- Brack J
- Bradaschia C
- Bradascio F
- Brady PR
- Branchesi M
- Brancus I
- Brandt S
- Brau JE
- Braun J
- Braun J
- Bravo O Martinez
- Brayeur L
- Breeveld AA
- Bregeon J
- Bregeon J
- Brenzke M
- Bretz H-P
- Bretz T
- Briant T
- Bridgeman A
- Briechle FL
- Briggs MS
- Brillet A
- Brinkmann M
- Brisbois C
- Brisson V
- Brnzas H
- Brocato E
- Brockill P
- Broderick JW
- Broida JE
- Bron S
- Brooks AF
- Brooks D
- Brostean-Kaiser J
- Brout D
- Brown DA
- Brown DD
- Brown IS
- Bruijn R
- Brun F
- Brun P
- Brunett S
- Brunner J
- Bruun SH
- Bryan M
- Buchanan CC
- Buchholz P
- Buckley DAH
- Buckley-Geer E
- Budnev NM
- Buehler R
- Bueno A
- Bufano F
- Buffa F
- Buikema A
- Buitink S
- Bulgarelli A
- Bulger J
- Bulik T
- Bulik T
- Bulla M
- Bulten HJ
- Buonanno A
- Burgay M
- Burgess JM
- Burgman A
- Burhonov O
- Burke DL
- Burns E
- Burrows DN
- Buscemi M
- Buskulic D
- Buson S
- Bustillo J Caldern
- Busto J
- Butler NR
- Butler RE
- Buttu M
- Buy C
- Byer RL
- Caballero-Garcia MD
- Caballero-Mora KS
- Caballero-Mora KS
- Cabero M
- Cabral J
- Caccianiga L
- Cadonati L
- Cagnoli G
- Cahillane C
- Callister TA
- Calloni E
- CALTECH GROWTH JAGWAR
- Cameron RA
- Camilo F
- Camp JB
- Campana S
- Camuccio R
- Cancio A
- Canepa M
- Canfora F
- Canizares P
- Cannella C
- Cannizzaro G
- Cannon KC
- Cano Z
- Cao H
- Cao J
- Cao XL
- Capaccioli M
- Capano CD
- Capasso M
- Capistrn T
- Capocasa E
- Capone A
- Capozzi D
- Cappellaro E
- Caputo R
- Caramete L
- Caraveo P
- Caraveo PA
- Carbognani F
- Carboni G
- Cardenas B Vargas
- Cardillo M
- Caria T
- Caride S
- Carlin JL
- Carney MF
- Caroff S
- Carosi A
- Carr J
- Carramiana A
- Carretti E
- Cartier R
- Caruso R
- Carver T
- Casadio C
- Casado A Lopez
- Casanova S
- Casanova S
- Casasola V
- Casella P
- Casentini C
- Casey J
- Casier M
- Castander FJ
- Castangia P
- Castellina A
- Castellon A
- Castellon JL Nilo
- Castillo J Alvarez
- Castillo M
- Castro JM Gonzalez
- Castro ML Diaz
- Castro-Tirado AJ
- Casu S
- Catalani F
- Cataldi G
- Cattaneo PW
- Caudill S
- Cavagli M
- Cavalier F
- Cavalieri R
- Cavazzuti E
- Cazon L
- Cella G
- Celli S
- Cenko SB
- Cepeda CB
- Cerd-Durn P
- Ceron JM Castro
- Cerretani G
- Cerruti M
- Cerutti AC Cobos
- Cesarini E
- Chakraborty N
- Chamberlin SJ
- Chambers KC
- Chan M
- Chandra P
- Chang S-W
- Chang Z
- Chao S
- Charlton P
- Chase E
- Chassande-Mottin E
- Chatterjee D
- Chatterjee D
- Chatziioannou K
- Chaves RCG
- Chavez AG
- Chavushyan V
- Cheeseboro BD
- Chekhtman A
- Chen A
- Chen G
- Chen HY
- Chen L
- Chen T-W
- Chen TX
- Chen X
- Chen Y
- Chen Y
- Chen YB
- Chen YP
- Chenevez J
- Cheng H-P
- Cherry ML
- Cheung CC
- Cheung E
- Chevalier J
- Chia H
- Chiang J
- Chiarusi T
- Chincarini A
- Chinellato JA
- Chirkin D
- Chiummo A
- Chmiel T
- Cho HS
- Cho M
- Choi C
- Choi J-S
- Chornock R
- Chow JH
- Christensen N
- Christov A
- Chu Q
- Chua AJK
- Chua S
- Chudoba J
- Chung AKW
- Chung S
- Ciani G
- Cikota A
- Ciolfi R
- Ciprini S
- Circella M
- Cirelli CE
- Cirone A
- Clara F
- Clark JA
- Clark K
- Clark P
- Clarke TE
- Classen L
- Clay RW
- Clearwater P
- Cleva F
- Cleveland WH
- Cline T
- Cobb BE
- Cocchieri C
- Coccia E
- Coelho JAB
- Coelho P
- Coenders S
- Cohadon P-F
- Cohen D
- Cohen-Tanugi J
- Colafrancesco S
- Colafrancesco S
- Colalillo R
- Colazo C
- Coleiro A
- Coleman A
- Colla A
- Collaboration ALMA
- Collaboration ANTARES
- Collaboration BOOTES
- Collaboration CALET
- Collaboration DLT40
- Collaboration HAWC
- Collaboration HESS
- Collaboration IceCube
- Collaboration IKI-GW Follow-up
- Collaboration Insight-Hxmt
- Collaboration IPN
- Collaboration KU
- Collaboration LOFAR
- Collaboration MASTER
- Collaboration Pi Sky
- Collaboration Pierre Auger
- Collaboration Swift
- Collaboration VINROUGE
- Collette CG
- Collica L
- Collin GH
- Colmenero E Romero
- Coluccia MR
- Cominsky LR
- Cominsky LR
- Conceicao R
- Concu R
- Condon B
- Coniglione R
- Connaughton V
- Conrad J
- Conrad JM
- Consolati G
- Consortium TZAC
- Constancio M
- Conti L
- Contreras F
- Cook DO
- Cook ER
- Cooke J
- Cooper MJ
- Cooper SJ
- Copperwheat C
- Corban P
- Corbitt TR
- Cordero-Carrion I
- Corley KR
- Cornish N
- Corongiu A
- Corral-Santana JM
- Corsi A
- Cortese S
- Costa CA
- Costa CF Da Silva
- Costa E
- Costa-Duarte MV
- Costantin D
- Costantini H
- Cotti U
- Cotzomi J
- Coughlin M
- Coughlin MW
- Coughlin SB
- Coulon J-P
- Coulter DA
- Countryman ST
- Courvoisier TJ-L
- Coutu S
- Couvares P
- Covas PB
- Covault CE
- Covino S
- Cowan EE
- Coward DM
- Coward DM
- Cowart MJ
- Cowen DF
- Cowperthwaite P
- Coyle P
- Coyne DC
- Coyne R
- Crawford S
- Creighton JDE
- Creighton TD
- Creusot A
- Cripe J
- Crisp H
- Crocce M
- Cronin J
- Cross R
- Crosse B
- Crowder SG
- Cucchiara A
- Cui W
- Cui WW
- Cullen TJ
- Cumming A
- Cunha CE
- Cunniffe R
- Cunningham L
- Cuoco A
- Cuoco E
- Cusumano G
- Cutter R
- Cwiek A
- Cwiok M
- Czyrkowski H
- D'Al A
- D'Amico F
- D'Amico S
- D'Ammando F
- D'Andrea CB
- D'Antonio S
- D'Avanzo P
- D'Elia V
- D'Olivo JC
- Da Costa LN
- Dabrowski R
- Dadina M
- Dal Canton T
- Daniel B
- Danilishin SL
- Danzmann K
- Dasgupta A
- Dasso S
- Dattilo V
- Daumiller K
- Dave I
- Davids ID
- Davier M
- Davis C
- Davis D
- Daw EJ
- Dawson BR
- Day B
- Day JA
- Day M
- De Almeida RM
- De Andre JPAM
- De Bonis G
- De Carvalho W Rodrigues
- De Cesare G
- De Cia A
- De Clercq C
- De Gois JS
- De Gregorio-Monsalvo I
- De Jong M
- De Jong SJ
- De la Fuente E
- De laurentis M
- De Leon C
- De Leon S Coutio
- De Mauro G
- De Mitri I
- De Naurois M
- de Oliveira C Mendes
- De Oliveira J
- De Oliveira MA Leigui
- de Oliveira R Lopes
- De Palma F
- De Pasquale M
- De Pietri R
- De Ridder S
- De Rosa R
- De Rossi C
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- Miller AA
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- Moskalenko IV
- Moskvitin AS
- Mostaf M
- Motohara K
- Moulai M
- Moulin E
- Mours B
- Moussa A
- Mow-Lowry CM
- Mrka S
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- Mueller G
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- Mueller S
- Muir AW
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- Mukherjee Arunava
- Mukherjee D
- Mukherjee S
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- Munch J
- Mundell CG
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- Murach T
- Murata KL
- Muratore M
- Murguia-Berthier A
- Murphy T
- Murray PG
- Mussa R
- Myers ST
- Nagai H
- Nagashima H
- Nagayama T
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- Nakahira S
- Nakajima M
- Nakamura Y
- Nakaoka T
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- Nakarmi P
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- Nakata F
- Nang Y
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- Neilsen E
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- Oikonomou F
- Ojha R
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- Ostrowski M
- Ottaway DJ
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- Padilla N
- Padovani M
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- Page MA
- Pai A
- Pai SA
- Pal-Singh A
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- Palashov O
- Palatiello M
- Palatka M
- Palazzi E
- Palczewski T
- Paliya VS
- Palliyaguru N
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- Pallot D
- Pallotta J
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- Paneque D
- Pang B
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- Pankow C
- Pannarale F
- Pant BC
- Panter M
- Paoletti F
- Paoletti F
- Paoli A
- Papa MA
- Papenbreer P
- Paragi Z
- Parente G
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- Pascucci D
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- Paul T
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- Paz-Chinchn F
- Pea-Rodriguez J
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- Pech M
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- Pekowsky L
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- Pele A
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- Pepper JA
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- Perri LM
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- Perrina C
- Perrodin D
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- Pescalli A
- Pesce-Rollins M
- Peters C
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- Petrera S
- Petrucci P-O
- Peyaud B
- Pfeiffer HP
- Phelps M
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- Pian E
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- Piergiovanni F
- Pierog T
- Pierro V
- Pignata G
- Pike S
- Pilia M
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- Pinard L
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- Piran T
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- Piranomonte S
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- Piron F
- Pirronello V
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- Pita S
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- Pittori C
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- Podsiadlowski P
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- Poh J
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- Pollmann A Obertacke
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- Popolizio P
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- Porowski C
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- Puppo P
- Qi H
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- Qu JL
- Quataert E
- Quel EJ
- Querchfeld S
- Querel R
- Quetschke V
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- Quinn L
- Quinn S
- Quinones C
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- Quirrenbach A
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- Rabus M
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- Racusin J
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- Raja S
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- Ramirez KE
- Ramirez-Ruiz E
- Ramos-Buades A
- Ramos-Pollan R
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- RATIR RIMAS
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- Regimbau T
- Rei L
- Reichart DE
- Reid S
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- Reimer A
- Reimer A
- Reimer O
- Reimer O
- Reitze DH
- Relethford B
- Relich M
- Ren W
- Ren Z
- Renaud M
- Renzi V
- Reposeur T
- Resconi E
- Resmi L
- Rest A
- Reva IV
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- Reynolds T
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- Rhode W
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- Rivera A Ramirez
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- Rizi V
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- Roberts OJ
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- Robie R
- Robinet F
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- Rossi A
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- Rowell G
- Rowlinson A
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- Roy R
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- Saito S
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- Sakamaki A
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- Sakellariadou M
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- Salamida F
- Salazar H
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- Saleem M
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- Sarmiento-Cano C
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- Scholten O
- Schonbeck A
- Schoneberg S
- Schoorlemmer H
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- Schreiber E
- Schroder FG
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- Schulze S
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- Scott J
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- Sellers D
- Selsing J
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- Sentenac D
- Sequino V
- Sergeev A
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- Serino M
- Serra G
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- Steinlechner J
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- Suarez-Duran M
- Suchyta E
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- Taddia F
- Tagliaferri G
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- Takahashi I
- Takahashi J
- Takahashi M
- Takahashi T
- Takao Y
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- Tamura T
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- Tan Y
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- Tao C
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- Ter-Antonyan S
- Terai T
- Terliuk A
- Terreran G
- Terrier R
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- Testa V
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- Thrane E
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- Tingay SJ
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- Tiziani D
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- Tonnis C
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- Torii S
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- Torres-Flores S
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- Torrie CI
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- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Impaired dendritic cell maturation and IL-10 production following H. pylori stimulation in gastric cancer patients
- Author
- A Kandulski
- A Langenkamp
- A Lundgren
- B Li
- C Ménétrier-Caux
- Chang-Hung Kuo
- Chih-Hsing Hung
- D Bimczok
- D Velin
- Deng-Chyang Wu
- E Takeshima
- Fang-Jung Yu
- HF Ismail
- I-Chen Wu
- J Banchereau
- J Bornschein
- JY Kao
- JY Kao
- K Mahnke
- KA Eaton
- KM Fock
- Lin-Li Chang
- M Karin
- M Moser
- M Rescigno
- M Zhang
- MA Naarding
- MP Bergman
- PJ Sansonetti
- PJ Schuler
- R Rad
- R Rad
- S Andres
- S Backert
- S Kabir
- S Keep
- S Suerbaum
- Sheng-Wen Wang
- SI Gringhuis
- T Ito
- TK Means
- V Necchi
- Y Shi
- Ye-Pin Chen
- Yu-Chung Su
- Z Shen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
International Consensus Statement on Rhinology and Allergy: Rhinosinusitis
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- Zuckerman JD
- Zurlo JJ
- Zuskin E
- Čulig J
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2021
- Field of study
Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICAR‐RS‐2021 as well as updates to the original 140 topics. This executive summary consolidates the evidence‐based findings of the document. Methods: ICAR‐RS presents over 180 topics in the forms of evidence‐based reviews with recommendations (EBRRs), evidence‐based reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICAR‐RS‐2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidence‐based management algorithm is provided. Conclusion: This ICAR‐RS‐2021 executive summary provides a compilation of the evidence‐based recommendations for medical and surgical treatment of the most common forms of RS
Global variation in anastomosis and end colostomy formation following left-sided colorectal resection
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- Chen Cy
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- Chidambaram S
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- Clegg-Lamptey Jn
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- De La Medina AR
- de Leó
- De Leon MZP
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- Deichsel F
- Del Basso C
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- Delgado Msftl
- Dell A
- Dempster E
- Denewar A
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- Deputy M
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- Despotidis V
- Desta S
- Deutschmann P
- Devadasar Gh
- Dharamshi Ha
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- Diab A
- Diaconescu B
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- Dias S
- Diaz-Jover P
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- Djivoh F
- Domini E
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- Donoghue D
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- El Sayed GS
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- El-Sagheer N
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- Elbe P
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- Elkelany A
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- Elkorashy Am
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- Farinella E
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- Farooq T
- Farouk Sam
- Farquharson A
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- Farrugia A
- Faruq A
- Fathy Am
- Fattah Aa
- Fatuga A
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- Faturoti O
- Faure A
- Fautz T
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- Fawzy A
- Feidantsis T
- Felipe Co
- Fergany A
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- Koh C
- Koh H
- Koh Py
- Koh S
- Koh S
- Kojo Att
- Kojo Att
- Kojo Att
- Kolosov A
- Komolafe O
- Kondrotas P
- Kong C
- Kong Sn
- Kong V
- Kong V
- Konstantina K
- Kontos M
- Kordorwu Hek
- Korkolis D
- Kosai Nr
- Kosai Nr
- Kose E
- Koskenvuo L
- Kostov E
- Kotb Ahe
- Kotecha D
- Koto Mz
- Kotobi H
- Koumpa F
- Kouraklis G
- Kourdouli A
- Kourdouli A
- Kretzmann H
- Krishna K
- Kruspi S
- Kufeji D
- Kulasabanathan K
- Kuliavas J
- Kumar B
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- Kumwenda D
- Kushwaha S
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- Kusi K
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- Kwakyeafriyie P
- Kwatiwani C
- Kwizera S
- Kwok Sh
- Kyereh M
- Kyriazanos I
- Kyrou G
- Kyziridis D
- Ló
- L&apos
- La Brocca A
- la Medina AR
- la Medina AR
- la Medina AR
- Labib P
- Ladukas A
- Lafferty K
- Lagunavicius K
- Lai Ac
- Lakhani Sm
- Lakshmi Hn
- Lam Fy
- Lam Jcy
- Lam Wh
- Lamanna Gl
- Lanau Miv
- Lando J
- Landolfo G
- Landolfo G
- Lap G
- Lapitan Mc
- Lapitan Mc
- Larsen Jw
- Lasek A
- Lasheen A
- Lasheen Kt
- Latif A
- Laufer Lav
- Laugzemys E
- Laugzemys E
- Laurie K
- Lauzikas G
- Law Jh
- Lawal A
- Lawal Ao
- Lawal T
- Lawal Ta
- Lawani I
- Lawther R
- Lazzari G
- Lazzari V
- Leal A
- Leal M
- Lecompte Jf
- Lee C
- Lee Ex
- Lee F
- Lee K
- Lee Kc
- Lee Ky
- Lee Tsb
- Lemaire Sb
- Leone N
- Leong Fqh
- Leppä
- Leppä
- Leroux J
- Leung Kw
- Leung Mf
- Leusink A
- Lewis J
- Li Ws
- Licari L
- Lieske B
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- Liew I
- Liew I
- Lilford R
- Lilford R
- Lilford Rj
- Lim G
- Lim H
- Lim J
- Lim Pj
- Lim Sj
- Lim Sj
- Lim Sy
- Limache S
- Limaye N
- Limoges B
- Lintin L
- Lipnickas V
- Litvin A
- Liu Q
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- Livesey A
- Livingston M
- Ljuhar D
- Lo Conte A
- Loaloa Mr
- Lockey J
- Lohse Has
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- Loizides S
- Lokman Maa
- Longstaff L
- Lopez Ce
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- Lopez M
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- Lorenzon L
- Lossius Wj
- Loughran D
- Low X
- Luc Ar
- Luck J
- Luck J
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- Luglio G
- Lund J
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- Lundgren Po
- Luque Gb
- Luque L
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- Lytras D
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- Má
- Mé
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- Mañ
- Ma J
- Mabitsela Me
- Mabrouk M
- Macchiavello R
- Macchitella Y
- Macchitella Y
- Macdermid E
- Macdonald A
- Macdonald E
- Macdonald L
- Maceviciute K
- Macfarlane A
- Machaca M
- Maciejec L
- Madiba T
- Madkor Mh
- Maffioli A
- Maffioli A
- Magdy A
- Magdy B
- Magdy E
- Magdy H
- Magdy M
- Magdy S
- Magee C
- Maghrabi A
- Maghrabi Aa
- Magri D
- Mahamood Ab
- Mahanty S
- Maharaj G
- Mahdi A
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- Maher Me
- Mahmoud B
- Mahmoud H
- Mahmoud M
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- Mahmoud Mi
- Mahmoud S
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- Mahmud K
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- Maison K
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- Mangan C
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- Maniscalco A
- Mann T
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- Manriquez-Reyes M
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- Mansour B
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- Mansuri A
- Mao P
- Mapasse D
- Maple N
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- Marey A
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- Margaritis M
- Mariani A
- Marinkovic B
- Marinos C
- Marks E
- Marples L
- Marret Jb
- Marshall Dc
- Martian Bv
- Martin A
- Mas R
- Mason C
- Mata Lps
- Matheu A
- Mathew Sw
- Matos-Puig R
- Matta Jjh
- Mattar O
- Matter Sm
- Mauro L
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- McGarvie S
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- McMorran D
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- Mejia Agv
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- Mendizabal Caa
- Mendoza I
- Menegussi J
- Mensah E
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- Mentula P
- Meqbil J
- Mericliler M
- Merlini D
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- Mesbah N
- Meshref A
- Metwally Mm
- Migliore M
- Miguel Gps
- Mihaljevic Al
- Mihanovic J
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- Mijuskovic B
- Mikalauskas S
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- Mikuckyte D
- Mikwar Z
- Milligan W
- Milligan W
- Mingrone P
- Minguez G
- Minocha A
- Minocha A
- Miranda C
- Mircea H
- Mirghani D
- Mironescu A
- Mironescu A
- Mironescu As
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- Mirza A
- Mirza S
- Mistry A
- Mitrasinovic S
- Mitroudi M
- Mitroudis N
- Mittal A
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- Miyasato Hs
- Mizzi C
- Mizzi S
- Mlotshwa M
- Moaty M
- Mochet S
- Modolo Mm
- Modolo Mm
- Modolo Mm
- Moe Tt
- Mogan Yp
- Moghazy Me
- Mohamed A
- Mohamed A
- Mohamed Am
- Mohamed Ar
- Mohamed B
- Mohamed F
- Mohamed I
- Mohamed M
- Mohamed Ma
- Mohamed Maeh
- Mohamed Mm
- Mohamed O
- Mohamed Sr
- Mohameden A
- Mohammad A
- Mohammad A
- Mohammed A
- Mohammed A
- Mohammed Ae
- Mohammed Ar
- Mohammed H
- Mohammed Mm
- Mohammed Mmh
- Mohammed S
- Mohan H
- Mohan M
- Mohan M
- Mok Yt
- Mokhtar A
- Molina G
- Mollo Mc
- Monaghan E
- Monaghan E
- Monrad-Hansen Pw
- Montejo Msg
- Monteleone M
- Monteleone M
- Montes I
- Montes I
- Montrimaite M
- Montrimaite M
- Moodley Y
- Moore R
- Moore R
- Mora Jjv
- Morais Pab
- Morales C
- Moran Aer
- Morandi E
- Moreira G
- Moreno Sc
- Morgan C
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- Morshedy Em
- Morsi A
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- Mosad A
- Mosalum O
- Mostafa Ha
- Mostafa M
- Mostafa M
- Mousa M
- Moussa O
- Moustafa A
- Mouttalib S
- Mowafy B
- Mphatsoe Am
- Mshelbwala P
- Msiska N
- Msosa V
- Msosa V
- Muddebihal U
- Mukin Adf
- Muktar U
- Mukuzunga C
- Muller C
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- Munera A
- Munhoz Mm
- Munipalle Pc
- Muntean L
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- Muralha N
- Murphy J
- Murray A
- Murutoglu B
- Musa Aek
- Musleh A
- Musowoya J
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- Musyoka Ck
- Mutabazi Az
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- Mutlu D
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- Muzio E
- Myers J
- Mykoniatis I
- Næ
- Nabawi A
- Nada F
- Nadeem N
- Nadkarni S
- Nagy Gs
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- Nair H
- Nanthakumaran S
- Napolitano L
- Napolitano L
- Naqvi Sa
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- Naranjo Aristizã
- Narayanan R
- Narayanan R
- Narvestad Jk
- Nashaat A
- Nashat M
- Nasher O
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- Nasir A
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- Nasr A
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- Nassif D
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- Natalie H
- Nataraja R
- Natili A
- Navarro A
- Nawara C
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- Nayel Ar
- Nazir M
- Ndajiwo A
- Ndajiwo A
- Ndegwa W
- Ndlovu Sr
- Ndwambi P
- Ne&apos
- Negida A
- Negoi I
- Nel D
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- Neo Yn
- Neo Yt
- Neophytou C
- Nepogodiev D
- Nepogodiev D
- Nepogodiev D
- Nepogodiev D
- Nesaratnam A
- Nessa A
- Nestorovic M
- Nevieraite V
- Newton T
- Ng S
- Ng Yk
- Ng Zh
- Ngayu N
- Ngwa Te
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- Nicholson L
- Nighat B
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- Nikberg M
- Nikoloudis N
- Nikoloudis N
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- Niranjan N
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- Niyirera E
- Njokanma I
- Nnajiuba H
- Nocito A
- Nocito A
- Nofal E
- Noor F
- Normile C
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- North As
- Notarnicola M
- Notarnicola M
- Nouh T
- Nouh T
- Noukpozounkou B
- Novak A
- Nowers J
- Nsengimana Vjp
- Nsengiyumva C
- Ntirenganya F
- Nur&apos
- Nurqistan Hd
- Nwabuoku E
- Nwinee V
- Nwokoro C
- Nyberg J
- Nymo L
- O&apos
- O&apos
- O&apos
- O&apos
- O&apos
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- Obute Rd
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- Odeyemi B
- Odeyemi B
- Odutola O
- Ogunsua O
- Ogunyemi A
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- Ohene-Yeboah M
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- Olajide To
- Olaolorun A
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- Olori S
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- Omar Aa
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- Ortiz N
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- Oshati O
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- Owusu F
- Owusu F
- Ozben V
- Ozkan Bb
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- Pabla G
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- Padmore G
- Pagano G
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- Palma Af
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- Papaskarlatos Ia
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- Parreno-Sacdalan Md
- Parseliunas A
- Parthiban S
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- Pastora J
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- Patoulias I
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- Preckailaite E
- Primavesi F
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- Puma Cmh
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- Raza A
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- Razmdjou S
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- Recinos G
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- Redota Map
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- Sahel S
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- Sallinen V
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- Salma M
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- Salma U
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- Sam Zh
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- Samaniego Cs
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- Schiavone R
- Schivo D
- Schmid R
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- Semeda N
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- Senanayake Kj
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- Senanayake W
- Septiem Jg
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- Setiawan J
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- Sfougaris D
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- Shah A
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- Shahbaz Ar
- Shaheen A
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- Shahzad N
- Shaikh N
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- Shalabi A
- Shalaby A
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- Shamasneh A
- Shamsedine Aw
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- Snyder E
- Sobnach S
- Sodde P
- Soeselo Da
- Sokratous A
- Solaini L
- Soldevila-Verdeguer C
- Soley R
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- Soliman Na
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- Sollazzo V
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- Souaibou Yi
- Souaibou Yi
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- Sproule L
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- Sreedharan A
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- Sriram A
- Sroor F
- Sruogiene Ez
- Staerkle Rf
- Starr N
- Stasinou T
- Steccanella F
- Stefanopoulos A
- Stephen A
- Stewart D
- Stock S
- Stock S
- Stoddart M
- Stoddart M
- Stoddart M
- Stourton F
- Strazdas A
- Strupas K
- Strupas K
- Strupas K
- Stuva J
- Stuva Jpg
- Styles K
- Suá
- Suarez A
- Suarez Aab
- Subocius A
- Suleiman Si
- Summerour V
- Sund M
- Sund M
- Sunderland G
- Sundstrom Sm
- Suresh S
- Sutandi N
- Sutanto Epr
- Sutton P
- Sutton P
- Suyadi A
- Swann J
- Swaroop M
- Swaroop M
- Syibrah Kz
- Sykes M
- Szczap A
- Szeto Ccl
- Szeto Kj
- Tabiri S
- Tabiri S
- Tabiri S
- Tabiri S
- Tabiri S
- Tabiri S
- Tackie E
- Taddei A
- Tade A
- Tafazal H
- Taha Ems
- Tahboub H
- Taher Aa
- Taher M
- Taher Mm
- Taieb C
- Taiwo A
- Taiwo O
- Taiwo O
- Talaat M
- Tale F
- Tale L
- Talukder S
- Talukder S
- Talving P
- Talving P
- Tammam A
- Tan C
- Tan Cl
- Tan Cy
- Tan Jj
- Tan Jk
- Tan Ksk
- Tan Rck
- Tan Yk
- Tan Yw
- Tanase A
- Tanase A
- Tang A
- Tang L
- Tani Si
- Tansoker I
- Tarek A
- Tarek A
- Tarek D
- Targa S
- Tariq S
- Tata Md
- Tatagiba Ls
- Tawfik Ba
- Tawfik G
- Tawfik G
- Taylor F
- Teasdale E
- Teasdale E
- Teasdale E
- Teasdale E
- Tedeschi U
- Tedjaatmadja C
- Telfah Mm
- Tembo T
- Temoche E
- Tennakoon A
- Teo Sy
- Ter Ez
- Tessera G
- Teufelberger G
- Tew Yy
- Tew Yy
- Tewari S
- Th&apos
- Thabet W
- Thalgaspitiya Spb
- Tham Jc
- Thanusan V
- Tharmalingam S
- Theodosopoulos T
- Thollot A
- Thomas E
- Thompson B
- Thomson P
- Thorarinsdottir H
- Thorarinsdottir H
- Thorell A
- Thorell A
- Thorsen K
- Thurairaja R
- Ticona Wa
- Tierney G
- Tilston Tw
- Timothy Ok
- Ting Jrs
- To K
- To K
- Todd O
- Toeema Ag
- Tolba H
- Tolg C
- Tolonen M
- Tolotra Tec
- Tori Sa
- Torrance Hd
- Torrance Hd
- Torres Cpg
- Torres Sg
- Toto Ö
- Tou S
- Townsend D
- Tracy J
- Trompetto M
- Tselos A
- Tshisola Sk
- Tugnoli G
- Tugnoli G
- Tun Ak
- Tun M
- Tun M
- Turati L
- Turati L
- Turkustani S
- Turner M
- Tutino R
- Tverskis Z
- Tyler R
- Tyler R
- Tze Rge
- Tze Rge
- Tzikos G
- Uš
- Ubhi Hk
- Ubiali P
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- Ukwenya Y
- Uluş
- Ulusahin M
- Upadhyaya V
- Upchurch E
- Urbanavicius L
- Urbonas T
- Urbonas T
- Urniež
- Urniezius Z
- Urquizu Mc
- Usaityte A
- Utter M
- Uzabumwana N
- Vaicius A
- Valcarcel-Saldañ
- Valioulis I
- Van Der Naald N
- Van Duren B
- Van Niekerk M
- Van Straten S
- Varcada M
- Vargas M
- Varkalys K
- Vartanoglu T
- Vartic M
- Vartic M
- Vasquez G
- Vasquez I
- Veen T
- Vega Gmm
- Vega Gmm
- Velá
- Velá
- Velasquez R
- Vella-Baldacchino M
- Venclauskas L
- Vendramin E
- Venskutonis D
- Venskutonis D
- Venskutonis D
- Venskutonis D
- Venugopal C
- Verbeek A
- Vergara Alc
- Verjee A
- Vermaas M
- Veronese E
- Viš
- Vianna P
- Vicario E
- Vico Td
- Vida Lc
- Vida Lc
- Vilč
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- Villalobos S
- Villegas Mi
- Vimalachandran D
- Vincent J
- Violi P
- Vivekanantham S
- Vlachogiorgos A
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- Vth Le
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- Wakefield R
- Walę
- Waleed H
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- Walker N
- Walls L
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- Walsh U
- Waqar M
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- Ward S
- Warda M
- Warren O
- Warren O
- Warwick Am
- Waterman A
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- Weber P
- Weinstein Ms
- Werder G
- Wheeler J
- Whewell H
- Whitaker J
- White R
- White T
- Whitehurst K
- Wiborg J
- Widiastini Ta
- Widmer Lw
- Wijayarathna Ls
- Wild Jrl
- Williams E
- Williams G
- Williams O
- Williams O
- Williamson A
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- Wilson L
- Wilson M
- Wilson M
- Wilson Ms
- Wilson Msj
- Wimalge Pmsn
- Winstanley J
- Witherspoon P
- Wogensen F
- Wogensen F
- Wogensen F
- Woin E
- Wold Tb
- Wolf B
- Wolf B
- Wondimu S
- Wondoh P
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- Wong Cy
- Wong F
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- Wood G
- Woodward H
- Worku M
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- Yavuz Ma
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- Yifieyeh A
- Yildirim R
- Yip C
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- Yoganathan P
- Yolcu S
- Yong Co
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- Younis A
- Youssef D
- Youssef H
- Youssef M
- Youssif Jh
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- Zachariades Dc
- Zadoroznas A
- Zahran D
- Zakaria E
- Zakaria M
- Zakaria Y
- Zaki A
- Zakir M
- Zalabia Mf
- Zamarin K
- Zammit S
- Zampitis N
- Zani A
- Zani A
- Zani A
- Zanini N
- Zanini N
- Zapata F
- Zarb C
- Zardab A
- Zegarra S
- Zeidan S
- Zerihun Ab
- Zhang Z
- Zheng F
- Zidan H
- Zidan H
- Zidan M
- Zielinski M
- Ziff O
- Zikry M
- Zil-E-Ali A
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskiene R
- Zimmermann Ef
- Zohair A
- Zorrilla Cd
- Zuber M
- Zuber M
- Zuk G
- Zulkifli A
- Zumbü
- Publication venue
- 'Wiley'
- Publication date
- 27/11/2018
- Field of study
Background
End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection.
Methods
This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model.
Results
In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001).
Conclusion
Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone
The Seventeenth Data Release of the Sloan Digital Sky Surveys: Complete Release of MaNGA, MaStar, and APOGEE-2 Data
- Author
- Abdurro'uf
- Accetta K
- Aerts C
- Aguirre VS
- Ahumada R
- Ajgaonkar N
- Ak NF
- Alam S
- Alfaro PV
- Almeida A
- Anders F
- Anderson SF
- Andrews BH
- Anguiano B
- Aquino-Ortiz E
- Aragon-Salamanca A
- Argudo-Fernandez M
- Ata M
- Aubert M
- Avila-Reese V
- Badenes C
- Barba RH
- Barger K
- Barrera-Ballesteros JK
- Beaton RL
- Beers TC
- Belfiore F
- Bender CF
- Bernardi M
- Bershady MA
- Beutler F
- Bidin CM
- Bird JC
- Bizyaev D
- Blanc GA
- Blanton MR
- Boardman NF
- Bolton AS
- Boquien M
- Borissova J
- Bovy J
- Brandt WN
- Brown J
- Brownstein JR
- Brusa M
- Buchner J
- Bundy K
- Burchett JN
- Bureau M
- Burgasser A
- Cabang TK
- Campbell S
- Cano-Diaz M
- Cappellari M
- Carlberg JK
- Carrera R
- Cash J
- Chen W-H
- Chen Y-P
- Cherinka B
- Chiappini C
- Chitham JI
- Choi PD
- Chojnowski SD
- Chung H
- Clerc N
- Cohen RE
- Comerford JM
- Comparat J
- Covey K
- Crane JD
- Cruz-Gonzalez I
- Culhane C
- Cunha K
- da Costa L
- Dai YS
- Damke G
- Darling J
- Davidson JW
- Davies R
- Dawson K
- de la Macorra A
- De Lee N
- de Oliveira GLS
- Di Mille F
- Diamond-Stanic AM
- Donor J
- Duckworth C
- Dwelly T
- Eisenstein DJ
- Elsworth YP
- Emsellem E
- Eracleous M
- Escoffier S
- Fan X
- Farr E
- Feng S
- Fernandez-Trincado JG
- Feuillet D
- Filipp A
- Fillingham SP
- Frinchaboy PM
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- Galbany L
- Garcia RA
- Garcia-Hernandez DA
- Garma-Oehmichen L
- Ge J
- Geisler D
- Gelfand J
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- Gibson BJ
- Goddy J
- Godoy-Rivera D
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- Green PJ
- Greener M
- Grier CJ
- Griffith E
- Guo H
- Guy J
- Hadjara M
- Harding P
- Hasselquist S
- Hayes CR
- Hearty F
- Hill L
- Hogg DW
- Holtzman JA
- Horta D
- Hsieh B-C
- Hsu C-H
- Hsu Y-H
- Huber D
- Huertas-Company M
- Hutchinson B
- Hwang HS
- Ibarra-Medel HJ
- Ilha GS
- Imig J
- Jaekle W
- Jayasinghe T
- Ji X
- Johnson JA
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- Jonsson H
- Katkov I
- Khalatyan A
- Kinemuchi K
- Kisku S
- Knapen JH
- Kneib J-P
- Kollmeier JA
- Kong M
- Kounkel M
- Kreckel K
- Krishnarao D
- Lacerna I
- Lane RR
- Langgin R
- Lavender R
- Law DR
- Lazarz D
- Leung H-H
- Leung HW
- Lewis HM
- Li C
- Li R
- Lian J
- Liang F-H
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- Lin Y-T
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- Longa-Pena P
- Lopez-Coba C
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- Mackereth JT
- Mahadevan S
- Majewski SR
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- Maraston C
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- Masseron T
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- Mathur S
- McDermid RM
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- Merloni A
- Merrifield M
- Meszaros S
- Miglio A
- Minniti D
- Minsley R
- Monachesi A
- Moon J
- Mosser B
- Mulchaey J
- Muna D
- Munoz RR
- Myers AD
- Myers N
- Nadathur S
- Nair P
- Nandra K
- Neumann J
- Newman JA
- Nidever DL
- Nikakhtar F
- Nitschelm C
- O'Connell JE
- Olney R
- Oravetz D
- Ortigoza-Urdaneta M
- Osorio Y
- Otter J
- Pace ZJ
- Padilla N
- Pan H-A
- Pan K
- Parikh T
- Parker J
- Peirani S
- Penny S
- Percival WJ
- Perez-Fournon I
- Pinsonneault M
- Poidevin F
- Poovelil VJ
- Price-Whelan AM
- Prieto CA
- Queiroz AB de A
- Raddick MJ
- Ramirez KP
- Ray A
- Rembold SB
- Riddle N
- Riffel R
- Riffel RA
- Rix H-W
- Robin AC
- Rodriguez-Puebla A
- Rojas FAS
- Roman-Lopes A
- Roman-Zuniga C
- Rose B
- Ross AJ
- Rossi G
- Rubin KHR
- Salvato M
- Sanchez HD
- Sanchez SF
- Sanchez-Gallego JR
- Sanderson R
- Sarceno E
- Sarmiento R
- Sayres C
- Sazonova E
- Schaefer AL
- Schiavon R
- Schlegel DJ
- Schneider DP
- Schultheis M
- Schwope A
- Serenelli A
- Serna J
- Shao Z
- Shapiro G
- Sharma A
- Shen Y
- Shetrone M
- Shu Y
- Simon JD
- Skrutskie MF
- Smethurst R
- Smith V
- Sobeck J
- Spoo T
- Sprague D
- Stark D
- Stassun KG
- Steinmetz M
- Stello D
- Stone-Martinez A
- Storchi-Bergmann T
- Stringfellow GS
- Stutz A
- Su Y-C
- Taghizadeh-Popp M
- Talbot MS
- Tayar J
- Telles E
- Teske J
- Thakar A
- Theissen C
- Thomas D
- Tkachenko A
- Tojeiro R
- Toledo HH
- Troup NW
- Trump JR
- Trussler J
- Turner J
- Tuttle S
- Unda-Sanzana E
- Valentini M
- Valenzuela O
- Vargas-Gonzalez J
- Vargas-Magana M
- Vazquez-Mata JA
- Villanova S
- Vincenzo F
- Wake D
- Wanderley FC
- Warfield JT
- Washington JD
- Weaver BA
- Weijmans A-M
- Weinberg DH
- Weiss A
- Westfall KB
- Wild V
- Wilde MC
- Wilson JC
- Wilson M
- Wilson RF
- Wolf J
- Wood-Vasey WM
- Yan R
- Zamora O
- Zasowski G
- Zhang K
- Zhao C
- Zheng Z
- Zheng Z
- Zhu K
- Publication venue
- 'American Astronomical Society'
- Publication date
- Field of study
This paper documents the seventeenth data release (DR17) from the Sloan Digital Sky Surveys; the fifth and final release from the fourth phase (SDSS-IV). DR17 contains the complete release of the Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey, which reached its goal of surveying over 10,000 nearby galaxies. The complete release of the MaNGA Stellar Library accompanies this data, providing observations of almost 30,000 stars through the MaNGA instrument during bright time. DR17 also contains the complete release of the Apache Point Observatory Galactic Evolution Experiment 2 survey that publicly releases infrared spectra of over 650,000 stars. The main sample from the Extended Baryon Oscillation Spectroscopic Survey (eBOSS), as well as the subsurvey Time Domain Spectroscopic Survey data were fully released in DR16. New single-fiber optical spectroscopy released in DR17 is from the SPectroscipic IDentification of ERosita Survey subsurvey and the eBOSS-RM program. Along with the primary data sets, DR17 includes 25 new or updated value-added catalogs. This paper concludes the release of SDSS-IV survey data. SDSS continues into its fifth phase with observations already underway for the Milky Way Mapper, Local Volume Mapper, and Black Hole Mapper surveys
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