264 research outputs found

    Socio-legal status and experiences of forced labour among asylum seekers and refugees in the UK

    Get PDF
    Socio-legal status determines the differential rights to residence, work and social welfare that accrue to migrants depending on their particular immigration status. This paper presents analysis of original empirical data generated in qualitative interviews with migrants who had both made a claim for asylum and experienced conditions of forced labour in the UK. Following an outline of the divergent socio-legal statuses assigned to individual migrants within the asylum system, early discussions in the paper offer a summary of key aspects and indicators of forced labour. Subsequent sections highlight the significance of socio-legal status in constructing such migrants as inherently vulnerable to severe exploitation. It is concluded that immigration policy and, more particularly, the differential socio-legal statuses that it structures at various stages of the asylum process, helps to create the conditions in which severe exploitation and forced labour are likely to flourish among asylum seekers and refugees in the UK

    DMPP-4: Candidate sub-Neptune mass planets orbiting a naked-eye star

    Get PDF
    We present radial velocity measurements of the very bright (V5.7V\sim5.7) nearby F star, DMPP-4 (HD 184960). The anomalously low Ca II H&K emission suggests mass loss from planets orbiting a low activity host star. Periodic radial velocity variability with 10\sim 10 ms1^{-1} amplitude is found to persist over a >4>4 year timescale. Although the non-simultaneous photometric variability in four TESS sectors supports the view of an inactive star, we identify periodic photometric signals and also find spectroscopic evidence for stellar activity. We used a posterior sampling algorithm that includes the number of Keplerian signals, NpN_\textrm{p}, as a free parameter to test and compare (1) purely Keplerian models (2) a Keplerian model with linear activity correlation and (3) Keplerian models with Gaussian processes. A preferred model, with one Keplerian and quasi-periodic Gaussian process indicates a planet with a period of Pb=3.49820.0027+0.0015P_\textrm{b} = 3.4982^{+0.0015}_{-0.0027} d and corresponding minimum mass of mbsini=12.21.9+1.8m_\textrm{b}\,\textrm{sin}\,i = 12.2^{+1.8}_{-1.9} M_\oplus. Without further high time resolution observations over a longer timescale, we cannot definitively rule out the purely Keplerian model with 2 candidates planets with Pb=2.45700.0462+0.0026P_\textrm{b} = 2.4570^{+0.0026}_{-0.0462} d, minimum mass mbsini=8.01.5+1.1m_\textrm{b}\,\textrm{sin}\,i = 8.0^{+1.1}_{-1.5} M_\oplus and Pc=5.41960.0030+0.6766P_\textrm{c} = 5.4196^{+0.6766}_{-0.0030} d and corresponding minimum mass of mbsini=12.21.6+1.4m_\textrm{b}\,\textrm{sin}\,i = 12.2^{+1.4}_{-1.6} M_\oplus. The candidate planets lie in the region below the lower-envelope of the Neptune Desert. Continued mass loss may originate from the highly irradiated planets or from an as yet undetected body in the system.Comment: 19 pages, 11 figures. Accepted for publication in MNRA

    Pharmacokinetic/pharmacodynamic modelling approaches in paediatric infectious diseases and immunology.

    Get PDF
    Pharmacokinetic/pharmacodynamic (PKPD) modelling is used to describe and quantify dose-concentration-effect relationships. Within paediatric studies in infectious diseases and immunology these methods are often applied to developing guidance on appropriate dosing. In this paper, an introduction to the field of PKPD modelling is given, followed by a review of the PKPD studies that have been undertaken in paediatric infectious diseases and immunology. The main focus is on identifying the methodological approaches used to define the PKPD relationship in these studies. The major findings were that most studies of infectious diseases have developed a PK model and then used simulations to define a dose recommendation based on a pre-defined PD target, which may have been defined in adults or in vitro. For immunological studies much of the modelling has focused on either PK or PD, and since multiple drugs are usually used, delineating the relative contributions of each is challenging. The use of dynamical modelling of in vitro antibacterial studies, and paediatric HIV mechanistic PD models linked with the PK of all drugs, are emerging methods that should enhance PKPD-based recommendations in the future

    Are There Gains to Joining a Union? Evidence from Mexico

    Get PDF
    Union density in Mexico has been in decline since the 1980s. This article provides evidence on the worker compensation gains (losses) made by males upon joining (leaving) a union. These are estimated using a nationally representative labour market survey covering 2005q1–2016q1. The transitions between non‐union and union status are investigated using a difference‐in‐difference estimator. The findings suggest that joining a union is associated with modest wage gains, contrary to what the literature has shown for most industrialized nations. However, in contrast to this, some union leavers are found to experience a decrease in wages. This article also contributes to the wider literature by providing the first estimates of the longitudinal gain (loss) associated with joining (leaving) a union with respect to non‐wage benefits. The findings show joining (leaving) a union increases (decreases) the probability of being in receipt of legally guaranteed benefits such as bonuses and paid holidays. This suggests that although union density may be in decline, unions still have an important role to play in voicing worker's preferences with respect to compensation and ensuring that employers comply with the law

    Putting knowledge to work in clinical practice: understanding experiences of preceptorship as outcomes of interconnected domains of learning.

    Get PDF
    AIM: To explore how preceptor support can assist newly qualified nurses (NQNs) to put knowledge to work across interconnected forms of knowledge when delegating to health care assistants (HCAs). BACKGROUND: Current literature on preceptorship in nursing has failed to explore how competence is underpinned by knowledge frameworks in clinical practice. DESIGN: An ethnographic case study in three hospital sites in England (2011-2014). METHODS: Data collection included participant observation, interviews with 33 newly qualified nurses, 10 HCAs and 12 ward managers. Data were analysed using thematic analysis. A tool to assist NQNs to delegate and supervise NQNs during the preceptorship period was developed and piloted with thirteen NQNs in the same sites. A process evaluation was undertaken. FINDINGS: Focusing on a key task for NQNS, delegation to HCAs, we argue that preceptorship can support NQNs as they put knowledge to work in the transition from qualifying student to NQN. In supportive ward cultures, limited access to formal preceptorship can be bolstered by team support. NQNs in less supportive ward cultures may have both a greater need for preceptorship and have fewer compensatory mechanisms available to them when formal preceptorship is not available. We argue that organisational learning contexts and individual learning styles (interconnected domains of learning) are key to understanding effective preceptorship. CONCLUSIONS: We suggest that putting knowledge to work early in their careers with preceptorship support may assist NQNs to develop confidence and competence in delegation and supervision of health care assistants. This article is protected by copyright. All rights reserved

    The pains of desistance

    Get PDF
    Desistance is generally presented in a positive light, with themes of ‘making good’ and generativity recurring in the literature. This article reports on two qualitative studies exploring the desistance journeys of two different groups of ex-offenders, drawing attention to the pains of this process. It examines the possible consequences of these ‘pains of desistance’ and how they are linked to three spheres of desistance: act-desistance; identity desistance; and relational desistance. The attempt to achieve act-desistance often led to the pain of isolation for our interviewees, while the clash between the need to achieve identity desistance and a lack of relational desistance (especially on the meso- and macro-levels) meant that they suffered the pain of goal failure. The pains of isolation and goal failure combined to lead to the further pain of hopelessness. Those interviewed were indeed ‘going straight’, but taking this path led many to a limited and often diminished life

    "The solution needs to be complex." Obese adults' attitudes about the effectiveness of individual and population based interventions for obesity

    Get PDF
    BackgroundPrevious studies of public perceptions of obesity interventions have been quantitative and based on general population surveys. This study aims to explore the opinions and attitudes of obese individuals towards population and individual interventions for obesity in Australia.MethodsQualitative methods using in-depth semi-structured telephone interviews with a community sample of obese adults (Body Mass Index ≥30). Theoretical, purposive and strategic recruitment techniques were used to ensure a broad sample of obese individuals with different types of experiences with their obesity. Participants were asked about their attitudes towards three population based interventions (regulation, media campaigns, and public health initiatives) and three individual interventions (tailored fitness programs, commercial dieting, and gastric banding surgery), and the effectiveness of these interventions.ResultsOne hundred and forty two individuals (19-75 years) were interviewed. Participants strongly supported non-commercial interventions that were focused on encouraging individuals to make healthy lifestyle changes (regulation, physical activity programs, and public health initiatives). There was less support for interventions perceived to be invasive or high risk (gastric band surgery), stigmatising (media campaigns), or commercially motivated and promoting weight loss techniques (commercial diets and gastric banding surgery).ConclusionObese adults support non-commercial, non-stigmatising interventions which are designed to improve lifestyles, rather than promote weight loss

    Utilization of data below the analytical limit of quantitation in pharmacokinetic analysis and modeling: promoting interdisciplinary debate

    Get PDF
    Traditionally, bioanalytical laboratories do not report actual concentrations for samples with results below the LOQ (BLQ) in pharmacokinetic studies. BLQ values are outside the method calibration range established during validation and no data are available to support the reliability of these values. However, ignoring BLQ data can contribute to bias and imprecision in model-based pharmacokinetic analyses. From this perspective, routine use of BLQ data would be advantageous. We would like to initiate an interdisciplinary debate on this important topic by summarizing the current concepts and use of BLQ data by regulators, pharmacometricians and bioanalysts. Through introducing the limit of detection and evaluating its variability, BLQ data could be released and utilized appropriately for pharmacokinetic research
    corecore