Pharmaco-economic assessment of the HMGCoA reductase inhibitors

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Aspects of Roaccutane prescription in South Africa

A nationwide postmarketing surveillanc-e study on the use and outcomes of use of isotretinoin has been conducted in South Africa A representative sample of prescribers of the drug was identified from drug utilisation data and the overall doctor response rate was 90,1 %. A total of 766 patients was enrolled in the study, of which 728 were analysable for safety and efficacy. More than half the patients prescribed isotretinoin were women, of whom only 48,25% were practising some form of contraception. The mean overall dosage prescribed was 0,64 mg/kg/day and the mean overall duration of therapy prescribed was 15,5 weeks. The mean dose and duration of therapy prescribed by dermatologists was significantly higher than that prescribed by general practitioners. Potentially dangerous drug interactions involving the concomitant use of isotretinoin with tetracyclines, vitamin A and oral contraceptives together with antibiotics were noted. Mucocutaneous drying effects were the most common adverse events and the incidence of these effects decreased with continuation of therapy. The known effectiveness of the drug was confirmed by the results of the study

Long‐term Production and Profitability from Grazing Cattle in the Northern Mixed GrassPrairie

Conventional wisdom among rangeland professionals has been that for long‐term sustainability of grazing livestock operations, rangeland should be kept in high good to low excellent range condition. Our objective was to analyze production parameters, economic costs, returns, and profit using data generated over a thirty‐four year period (1969‐2002) from grazing a Clayey range site in the mixed‐grass prairie of western South Dakota with variable stocking rates required to maintain pastures in low‐fair, good, and excellent range condition classes. Cattle weights were measured at turnout and at the end of the grazing season. Gross income per acre was calculated by multiplying total gain per acre times price using historical National Agricultural Statistics Services feeder cattle prices. Annual variable costs were estimated from a historical yearling cattle budget developed by South Dakota State University (SDSU) agricultural economists. All economic values were adjusted to a constant dollar using the Bureau of Labor Statistics’ Consumer Price Index. Stocking rate, average daily gain, total gain, net profit, gross revenue, and annual costs per acre varied among range condition classes. Net income for low‐fair range condition ($11.18 per acre) and good range condition ($11.86 per acre) were not different, but both were greater (P \u3c 0.01) than excellent range condition ($ 9.31 per acre). Over the life of the study, real profit (adjusted for inflation) steadily increased (P \u3c 0.01) for the low‐fair and good treatments while it remained level for the excellent treatment. Neither drought nor wet springs impacted profit differently for the three treatments. These results support generally observed rancher behavior regarding range condition: to maintain their rangeland in a lower range condition than would be normally recommend by rangeland professionals. Ecosystem goods and services of increasing interest to society and associated with high range condition, such as floristic diversity, hydrologic function, and wildlife cover, come at an opportunity cost to the rancher

Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector

A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results

Jet size dependence of single jet suppression in lead-lead collisions at sqrt(s(NN)) = 2.76 TeV with the ATLAS detector at the LHC

Measurements of inclusive jet suppression in heavy ion collisions at the LHC provide direct sensitivity to the physics of jet quenching. In a sample of lead-lead collisions at sqrt(s) = 2.76 TeV corresponding to an integrated luminosity of approximately 7 inverse microbarns, ATLAS has measured jets with a calorimeter over the pseudorapidity interval |eta| < 2.1 and over the transverse momentum range 38 < pT < 210 GeV. Jets were reconstructed using the anti-kt algorithm with values for the distance parameter that determines the nominal jet radius of R = 0.2, 0.3, 0.4 and 0.5. The centrality dependence of the jet yield is characterized by the jet "central-to-peripheral ratio," Rcp. Jet production is found to be suppressed by approximately a factor of two in the 10% most central collisions relative to peripheral collisions. Rcp varies smoothly with centrality as characterized by the number of participating nucleons. The observed suppression is only weakly dependent on jet radius and transverse momentum. These results provide the first direct measurement of inclusive jet suppression in heavy ion collisions and complement previous measurements of dijet transverse energy imbalance at the LHC.Comment: 15 pages plus author list (30 pages total), 8 figures, 2 tables, submitted to Physics Letters B. All figures including auxiliary figures are available at http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/HION-2011-02

The Generationing of Power: A Comparison of Child-Parent and Sibling Relations in Scotland

The paper concentrates on an exploration of power relations within families. The paper discusses parental power in relation to legitimacy, household resources and children’s anticipated reactions of adult discipline. The nature of sibling power is highlighted before exploring the reciprocal expectations of sibling and child-parent interactions. The paper ends by suggesting that the generationing of power relations can lead to differing degrees of backstage and frontstage performances within the home

On the Static Diffie-Hellman Problem on Elliptic Curves over Extension Fields

We show that for any elliptic curve E(Fqn ), if an adversary has access to a Static Diffie-Hellman Problem (Static DHP) oracle, then by making O(q1− 1/n+1) Static DHP oracle queries during an initial learning phase, for fixed n > 1 and q → ∞ the adversary can solve any further instance of the Static DHP in heuristic time O˜(q1− 1/n+1). Our proposal also solves the Delayed Target DHP as defined by Freeman, and naturally extends to provide algorithms for solving the Delayed Target DLP, the One-More DHP and One-More DLP, as studied by Koblitz and Menezes in the context of Jacobians of hyperelliptic curves of small genus. We also argue that for any group in which index calculus can be effectively applied, the above problems have a natural relationship, and will always be easier than the DLP. While practical only for very small n, our algorithm reduces the security provided by the elliptic curves defined over Fp2 and Fp4 proposed by Galbraith, Lin and Scott at EUROCRYPT 2009, should they be used in any protocol where a user can be made to act as a proxy Static DHP oracle, or if used in protocols whose security is related to any of the above problems

The Physical Processes of CME/ICME Evolution

As observed in Thomson-scattered white light, coronal mass ejections (CMEs) are manifest as large-scale expulsions of plasma magnetically driven from the corona in the most energetic eruptions from the Sun. It remains a tantalizing mystery as to how these erupting magnetic fields evolve to form the complex structures we observe in the solar wind at Earth. Here, we strive to provide a fresh perspective on the post-eruption and interplanetary evolution of CMEs, focusing on the physical processes that define the many complex interactions of the ejected plasma with its surroundings as it departs the corona and propagates through the heliosphere. We summarize the ways CMEs and their interplanetary CMEs (ICMEs) are rotated, reconfigured, deformed, deflected, decelerated and disguised during their journey through the solar wind. This study then leads to consideration of how structures originating in coronal eruptions can be connected to their far removed interplanetary counterparts. Given that ICMEs are the drivers of most geomagnetic storms (and the sole driver of extreme storms), this work provides a guide to the processes that must be considered in making space weather forecasts from remote observations of the corona.Peer reviewe

Glucose management for exercise using continuous glucose monitoring: should sex and prandial state be additional considerations? Reply to Yardley JE and Sigal RJ [letter]

Oral diseases are a significant global health problem across all countries and populations. With about 3.5 billion cases (2017), more people are affected than by any other disease group. The main oral diseases comprise tooth decay of permanent and deciduous teeth, severe periodontal disease, and oral and lip cancer. With a largely unchanged high global prevalence, but significantly growing population sizes, the pressure on health systems is increasing, particularly in low- and middle-income countries.Nonetheless, in many countries oral health has insufficient priority as a key health topic, including the global health policy discourse of German and international stakeholders. One of the fundamental challenges is ensuring universal and equitable access to basic oral healthcare services for all and without financial hardship (Universal Health Coverage).This paper provides an introductory overview of the global trends for the main oral diseases, which are generally characterized by stark inequalities. Opportunities for improving the situation through population-wide risk reduction and preventive approaches, access to oral healthcare, and policy options are highlighted. In addition, a range of relevant global (oral) health topics with potential for tangible change are discussed. Lastly, the reform areas of the Lancet Series on Oral Health from 2019 are presented and recommendations for the German and international global health policy discourse are provided