67 research outputs found
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NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content.
- Author
- Publication venue
- eScholarship, University of California
- Publication date
- 01/07/2019
- Field of study
In mature neurons, postsynaptic N-methyl-D-aspartate receptors (NMDARs) are segregated into two populations, synaptic and extrasynaptic, which differ in localization, function, and associated intracellular cascades. These two pools are connected via lateral diffusion, and receptor exchange between them modulates synaptic NMDAR content. Here, we identify the phosphorylation of the PDZ-ligand of the GluN2B subunit of NMDARs (at S1480) as a critical determinant in dynamically controlling NMDAR synaptic content. We find that phosphorylation of GluN2B at S1480 maintains NMDARs at extrasynaptic membranes as part of a protein complex containing protein phosphatase 1 (PP1). Global activation of NMDARs leads to the activation of PP1, which mediates dephosphorylation of GluN2B at S1480 to promote an increase in synaptic NMDAR content. Thus, PP1-mediated dephosphorylation of the GluN2B PDZ-ligand modulates the synaptic expression of NMDARs in mature neurons in an activity-dependent manner, a process with profound consequences for synaptic and structural plasticity, metaplasticity, and synaptic neurotransmission
A communal catalogue reveals Earthâs multiscale microbial diversity
- Author
- Thompson L R
- Sanders Jon G
- McDonald Daniel
- Amir Amnon
- Ladau Joshua
- Locey Kenneth J
- Prill Robert J
- Tripathi Anupriya
- Gibbons Sean M
- Ackermann Gail
- Navas-Molina Jose A
- Janssen Stefan
- Kopylova Evguenia
- VĂĄzquez-Baeza Yoshiki
- GonzĂĄlez Antonio
- Morton James T
- Mirarab Siavash
- Zech Xu Zhenjiang
- Jiang Lingjing
- Haroon Mohamed F
- Kanbar Jad
- Zhu Qiyun
- Jin Song Se
- Kosciolek Tomasz
- Bokulich Nicholas A
- Lefler Joshua
- Brislawn Colin J
- Humphrey Gregory
- Owens Sarah M
- Hampton-Marcell Jarrad
- Berg-Lyons Donna
- McKenzie Valerie
- Fierer Noah
- Fuhrman Jed A
- Clauset Aaron
- Stevens Rick L
- Shade Ashley
- Pollard Katherine S
- Goodwin Kelly D
- Jansson Janet K
- Gilbert Jack A
- Knight Rob
- Rivera Jose L Agosto
- Al-Moosawi Lisa
- Alverdy John
- Amato Katherine R
- Andras Jason
- Angenent Largus T
- Antonopoulos Dionysios A
- Apprill Amy
- Armitage David
- Ballantine Kate
- BĂĄrta JirËĂ
- Baum Julia K
- Berry Allison
- Bhatnagar Ashish
- Bhatnagar Monica
- Biddle Jennifer F
- Bittner Lucie
- Boldgiv Bazartseren
- Bottos Eric
- Boyer Donal M
- Braun Josephine
- Brazelton William
- Brearley Francis Q
- Campbell Alexandra H
- Caporaso J Gregory
- Cardona Cesar
- Carroll JoLynn
- Cary S Craig
- Casper Brenda B
- Charles Trevor C
- Chu Haiyan
- Claar Danielle C
- Clark Robert G
- Clayton Jonathan B
- Clemente Jose C
- Cochran Alyssa
- Coleman Maureen L
- Collins Gavin
- Colwell Rita R
- Contreras MĂłnica
- Crary Benjamin B
- Creer Simon
- Cristol Daniel A
- Crump Byron C
- Cui Duoying
- Daly Sarah E
- Davalos Liliana
- Dawson Russell D
- Defazio Jennifer
- Delsuc Frédéric
- Dionisi Hebe M
- Dominguez-Bello Maria Gloria
- Dowell Robin
- Dubinsky Eric A
- Dunn Peter O
- Ercolini Danilo
- Espinoza Robert E
- Ezenwa Vanessa
- Fenner Nathalie
- Findlay Helen S
- Fleming Irma D
- Fogliano Vincenzo
- Forsman Anna
- Freeman Chris
- Friedman Elliot S
- Galindo Giancarlo
- Garcia Liza
- Garcia-Amado Maria Alexandra
- Garshelis David
- Gasser Robin B
- Gerdts Gunnar
- Gibson Molly K
- Gifford Isaac
- Gill Ryan T
- Giray Tugrul
- Gittel Antje
- Golyshin Peter
- Gong Donglai
- Grossart Hans-Peter
- Guyton Kristina
- Haig Sarah-Jane
- Hale Vanessa
- Hall Ross Stephen
- Hallam Steven J
- Handley Kim M
- Hasan Nur A
- Haydon Shane R
- Hickman Jonathan E
- Hidalgo Glida
- Hofmockel Kirsten S
- Hooker Jeff
- Hulth Stefan
- Hultman Jenni
- Hyde Embriette
- Ibåñez-Ălamo Juan Diego
- Jastrow Julie D
- Jex Aaron R
- Johnson L Scott
- Johnston Eric R
- Joseph Stephen
- Jurburg Stephanie D
- Jurelevicius Diogo
- Karlsson Anders
- Karlsson Roger
- Kauppinen Seth
- Kellogg Colleen T E
- Kennedy Suzanne J
- Kerkhof Lee J
- King Gary M
- Kling George W
- Koehler Anson V
- Krezalek Monika
- Kueneman Jordan
- Lamendella Regina
- Landon Emily M
- Lane-deGraaf Kelly
- LaRoche Julie
- Larsen Peter
- Laverock Bonnie
- Lax Simon
- Lentino Miguel
- Levin Iris I
- Liancourt Pierre
- Liang Wenju
- Linz Alexandra M
- Lipson David A
- Liu Yongqin
- Lladser Manuel E
- Lozada Mariana
- Spirito Catherine M
- MacCormack Walter P
- MacRae-Crerar Aurora
- Magris Magda
- MartĂn-Platero Antonio M
- MartĂn-Vivaldi Manuel
- MartĂnez L Margarita
- MartĂnez-Bueno Manuel
- Marzinelli Ezequiel M
- Mason Olivia U
- Mayer Gregory D
- McDevitt-Irwin Jamie M
- McDonald James E
- McGuire Krista L
- McMahon Katherine D
- McMinds Ryan
- Medina MĂłnica
- Mendelson Joseph R
- Metcalf Jessica L
- Meyer Folker
- Michelangeli Fabian
- Miller Kim
- Mills David A
- Minich Jeremiah
- Mocali Stefano
- Moitinho-Silva Lucas
- Moore Anni
- Morgan-Kiss Rachael M
- Munroe Paul
- Myrold David
- Neufeld Josh D
- Ni Yingying
- Nicol Graeme W
- Nielsen Shaun
- Nissimov Jozef I
- Niu Kefeng
- Nolan Matthew J
- Noyce Karen
- OâBrien Sarah L
- Okamoto Noriko
- Orlando Ludovic
- Castellano Yadira Ortiz
- Osuolale Olayinka
- Oswald Wyatt
- Parnell Jacob
- Peralta-SĂĄnchez
- Juan M
- Petraitis Peter
- Pfister Catherine
- Pilon-Smits Elizabeth
- Piombino Paola
- Pointing Stephen B
- Pollock F Joseph
- Potter Caitlin
- Prithiviraj Bharath
- Quince Christopher
- Rani Asha
- Ranjan Ravi
- Rao Subramanya
- Rees Andrew P
- Richardson Miles
- Riebesell Ulf
- Robinson Carol
- Rockne Karl J
- Rodriguezl Selena Marie
- Rohwer Forest
- Roundstone Wayne
- Safran Rebecca J
- Sangwan Naseer
- Sanz Virginia
- Schrenk Matthew
- Schrenzel Mark D
- Scott Nicole M
- Seger Rita L
- Seguin-Orlando Andaine
- Seldin Lucy
- Seyler Lauren M
- Shakhsheer Baddr
- Sheets Gabriela M
- Shen Congcong
- Shi Yu
- Shin Hakdong
- Shogan Benjamin D
- Shutler Dave
- Siegel Jeffrey
- Simmons Steve
- Sjöling Sara
- Smith Daniel P
- Soler Juan J
- Sperling Martin
- Steinberg Peter D
- Stephens Brent
- Stevens Melita A
- Taghavi Safiyh
- Tai Vera
- Tait Karen
- Tan Chia L
- Tas Neslihan
- Taylor D Lee
- Thomas Torsten
- Timling Ina
- Turner Benjamin L
- Urich Tim
- Ursell Luke K
- van der Lelie Daniel
- Van Treuren William
- van Zwieten Lukas
- Vargas-Robles Daniela
- Thurber Rebecca Vega
- Vitaglione Paola
- Walker Donald A
- Walters William A
- Wang Shi
- Wang Tao
- Weaver Tom
- Webster Nicole S
- Wehrle Beck
- Weisenhorn Pamela
- Weiss Sophie
- Werner Jeffrey J
- West Kristin
- Whitehead Andrew
- Whitehead Susan R
- Whittingham Linda A
- Willerslev Eske
- Williams Allison E
- Wood Stephen A
- Woodhams Douglas C
- Yang Yeqin
- Zaneveld Jesse
- Zarraonaindia Iratxe
- Zhang Qikun
- Zhao Hongxia
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 22/09/2000
- Field of study
Our growing awareness of the microbial worldâs importance and diversity contrasts starkly with our limited understanding of its fundamental structure. Despite recent advances in DNA sequencing, a lack of standardized protocols and common analytical frameworks impedes comparisons among studies, hindering the development of global inferences about microbial life on Earth. Here we present a meta-analysis of microbial community samples collected by hundreds of researchers for the Earth Microbiome Project. Coordinated protocols and new analytical methods, particularly the use of exact sequences instead of clustered operational taxonomic units, enable bacterial and archaeal ribosomal RNA gene sequences to be followed across multiple studies and allow us to explore patterns of diversity at an unprecedented scale. The result is both a reference database giving global context to DNA sequence data and a framework for incorporating data from future studies, fostering increasingly complete characterization of Earthâs microbial diversity
Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)
- Author
- Abora Rial-Villavecchia
- Adriana SĂĄnchez Serrano
- AdriĂĄn Sousa
- Aina Gomila Grange
- Ainhoa Sanjuan LĂłpez
- Ainhoa Urrutia Losada
- Alberto Gato DĂez
- Alberto Romero-Palacios
- Alberto Serrano MartĂnez
- Alejandra Duarte Borges
- Alejandro Araujo
- Alexander Rombauts
- Alexandra de la Vega
- Alexandre PĂ©rez GonzĂĄlez
- Alfonso Cabello Ăbeda
- Alfonso Lluna Carrascosa
- Alicia HernĂĄndez Torres
- Almudena HernĂĄndez Milian
- Ana Alberich Conesa
- Ana Correa Ruiz
- Ana Escoresca
- Ana Ferrer Ribera
- Ana Isabel Mariño Callejo
- Ana Isabel PelĂĄez Ballesta
- Ana Such Diaz
- Andrea MartĂn Plata
- André Barbosa Ventura
- Andrés Ruiz Sancho
- Ane Andrés Eisenhofer
- Anonymous
- Antonia Alcaraz
- Antonia SepĂșlveda Berrocal
- Antonio José Ruiz Reina
- Antonio Plata Ciezar
- Araceli GonzĂĄlez-Cuevas
- Arantzazu Mera Fidalgo
- Ariadna De Genover Gil
- Aroa Villoslada Gelabert
- Aychel Elena Roura Piloto
- Beatriz Diaz Pollan
- Beatriz Dietl
- Beatriz PĂ©rez-Monte MĂnguez
- Beatriz Sobrino Diaz
- Beigel
- BelĂ©n Loeches YagĂŒe
- Berenguer
- Bhimraj
- Blanca Alonso MartĂnez
- Blanca MartĂnez Cifre
- Blanca Pinilla
- Borja Gracia-Tello
- Campochiaro
- Capra
- Carlos Bea Serrano
- Carlos Dueñas Gutiérrez
- Carlos Enrique Sabbagh Fajardo
- Carlota Gudiol
- Carmen Aguayo Jiménez
- Carmen Herrero RodrĂguez
- Carmen Infante
- Carmen Yllera
- Carolina RoldĂĄn Fontana
- Channappanavar
- Chen
- Chen
- Chiara Fanciulli
- Clara MartĂnez Montes
- Clara Muñoz Aguirre
- Claudia GonzĂĄlez Rico
- Claudia Ălvarez-Pouso
- Claudio Bueno
- ConcepciĂłn GarcĂa-GarcĂa
- ConcepciĂłn Gonzalo
- Cristina BadĂa
- Cristina Cervera Acedo
- Cristina DĂez
- Cristina Lojo Cruz
- Cristina PelĂĄez Ballesta
- Cristina PĂ©rez GarcĂa
- Daniel Molina Morant
- Daniel Podzamczer
- Daniel Roger Zapata
- David Roa Alonso
- David Vinuesa GarcĂa
- Diana Piñar Cabezos
- Efrén Sånchez Vidal
- Elena Aranda Rife
- Elena Bereciartua Bastarrica
- Elena HellĂn-Valiente
- Elena MarĂn
- Elena Morcillo RodrĂguez
- Elena Salamanca-Rivera
- Elena Trigo Esteban
- Elena Ălvaro Alonso
- Eleni Patera
- Elisa Cordero-MatĂa
- Elisa GarcĂa VĂĄzquez
- Elizabet Petkova-Saiz
- EncarnaciĂłn Moral Escudero
- Enrique Bernal Morell
- Enrique MĂguez Rey
- Ester Saez de Adana Arroniz
- Esther Aznar Muñoz
- Esther Calbo
- Esther MartĂnez Birlanga
- Eva Jiménez Gonzålez de Buitrago
- Eva León Jiménez
- Eva Pilar GarcĂa Villalba
- Eva Talavera GarcĂa
- Evangelia Anna MarĂa Zioga
- Fadel
- Fernando de la Calle Prieto
- Fernando FernĂĄndez SĂĄnchez
- Francesc Escrihuela
- Francesca Gioia
- Francisco Anguita Santos
- Francisco Arnaiz de las Revillas
- Francisco Javier De la Hera FernĂĄndez
- Francisco Javier MartĂnez Marcos
- Francisco Javier RodrĂguez GĂłmez
- Francisco Muñoz Beamud
- Francisco Tejerina
- Fåtima Brañas Baztån
- Gabriela Abelenda-Alonso
- Gabriela Escudero LĂłpez
- Galadriel Pellejero
- Gaspar Duro Ruiz
- Gemma Mut Ramon
- Gemma Muñiz Nicolås
- Guan
- Guaraldi
- Guillem Policarpo Torres
- Guillermo Cuevas Tascon
- Gurutz Orbe NarvĂĄez
- GĂłmez LucĂa
- Harris
- Helem HaydeĂ© VĂlchez Rueda
- Helena AlbendĂn Iglesias
- HoffmannâLa Roche
- Horby
- Hortensia Ălvarez DĂaz
- Ignacio Pina
- Ignacio PĂ©rez Valero
- Ignacio Ălvarez RodrĂguez
- Inmaculada GonzĂĄlez-Cuello
- Inmaculada JarrĂn
- Inmaculada LĂłpez-Montesinos
- Inés Fernåndez Jiménez
- Inés Pérez Zapata
- Irene MartĂn Rubio
- Isabel A. PĂ©rez HernĂĄndez
- Isabel Asschert AgĂŒero
- Isabel Gutiérrez
- Isabel GutiĂ©rrez MartĂn
- Isabel RĂĄbago Lorite
- Isidoro FernĂĄndez Romero
- Israel Sevilla Moreno
- Itziar Arrieta-Aldea
- IvĂĄn PelegrĂn Senent
- Ivån Piñero
- Jara Llenas-GarcĂa
- Javier De la Torre Lima
- Javier Garrido
- Javier Martin Guerra
- JerĂłnimo PachĂłn
- Jessica Souto Higueras
- JesĂșs FortĂșn Abete
- JesĂșs RodrĂguez-Baño
- JesĂșs Ruiz AragĂłn
- Joan GĂłmez-Junyent
- Joel ElĂas Chara Cervantes
- Jon Ugalde Espiñeira
- Jordi CarratalĂ
- Jordi NiubĂł
- Jorge CalderĂłn Parra
- Jorge Calvo
- Jorge Parra Ruiz
- Jorge Valencia de la Rosa
- Josefina GarcĂa GarcĂa
- Josune Goikoetxea Agirre
- José A. Oteo Revuelta
- José Antonio Iribarren Loyarte
- José Javier Castrodeza Sanz
- José Joaquin Portu Zapirain
- José Luis Sierra-Monzón
- José M. Azcona Gutiérrez
- JosĂ© M. GarcĂa de Lomas Guerrero
- José Manuel Tafalla Torres
- JosĂ© MarĂa Reguera Iglesias
- JosĂ© MarĂa Robaina BordĂłn
- José Miguel Cisneros
- José Ramón Arribas
- Juan Berenguer
- Juan Berenguer
- Juan Carlos Gainzarain Arana
- Juan Carlos LĂłpez
- Juan Carlos Ramos Ramos
- Juan Diego Ruiz Mesa
- Juan GonzĂĄlez GarcĂa
- Juan GonzĂĄlez-Moreno
- Juan Mora Delgado
- Juan Pablo Avilés Parra
- Juan RamĂłn DomĂnguez Vicent
- Juan Salillas Hernando
- Juan Torres Macho
- Judit Villar-GarcĂa
- Julen Cadiñaños Loidi
- Julio GarcĂa RodrĂguez
- Justo Lajusticia Aisa
- JĂșlia Pareja Coca
- Karim Mohamed RamĂrez
- Laia Lorenzo-Esteller
- Laia Raich Montiu
- Laura Castelo Corral
- Laura GarcĂa Escudero
- Laura GarcĂa Pereña
- Laura Guio CarriĂłn
- Laura Parra GĂłmez
- Laura RodrĂguez FernĂĄndez
- Le
- Leire PĂ©rez-Latorre
- Lluis Planas Bibiloni
- Lorea Arteche Eguizabal
- Lourdes Bladé Vidal
- Lucia Boix Palop
- Lucia SuĂĄrez
- Lucia Valiente de Santis
- LucĂa Ramos Merino
- Luisa GonzĂĄlez-Iglesias
- Luz MartĂn Carbonero
- Ma del Carmen Liébana Martos
- Ma JesĂșs del Amor EspĂn
- Ma Luisa FernĂĄndez Ăvila
- Ma Teresa PĂ©rez RodrĂguez
- Maialen Ibarguren Pinilla
- Manuel Alejandro GĂĄlvez Bobadilla
- Manuela Aguilar-Guisado
- Margarita RamĂrez
- Mario Pérez Butragueño
- Mariona Tasias Pitarch
- Marta Arsuaga Vicente
- Marta AsĂn-Corrochano
- Marta DĂaz MenĂ©ndez
- Marta FernĂĄndez Morales
- Marta Ibarrola Hierro
- Marta Jiménez Escrig
- Marta Lamata Subero
- Marta Navarro VilasarĂł
- Marta Santos Peña
- MartĂn Guillermo
- MarĂa Antonia Ribot Sanso
- MarĂa Carmen Fariñas Ălvarez
- MarĂa D. del Toro
- MarĂa Erostarbe Gallardo
- MarĂa HernĂĄndez-Bonaga
- MarĂa Isabel Guirado Torrecillas
- MarĂa JesĂșs Bustinduy Odriozola
- MarĂa JosĂ© RĂos-Villegas
- MarĂa Lorena MarĂa Valle Feijoo Begoña RodrĂguez Ferreira
- MarĂa Luisa Machado Sicilia
- MarĂa Paz GarcĂa Butenegro
- MarĂa Pilar Toledano Sierra
- MarĂa Rivas-Carmenado
- MarĂa RodrĂguez Mayo
- MarĂa RuĂz Campuzano
- MarĂa Soledad GarcĂa de Carlos
- MarĂa Victoria FernĂĄndez-Baca
- MarĂa Yllescas
- MarĂa Ăngeles Garcinuño
- Mehta
- Melchor Riera Jaume
- Mercedes Clemente Presas
- Meritxell Gavalda Manso
- Meritxell Ortega Montoliu
- Miguel GĂłrgolas HernĂĄndez-Mora
- Miguel Pedromingo Kus
- Miguel Salvert LletĂ
- Miguel Torralba GonzĂĄlez de Suso
- Miguel Ăngel MorĂĄn RodrĂguez
- Mikel Temprano Gogenola
- Miquel Hortos Alsina
- Miquel Pujol
- Mohamed Kallouchi
- Montserrat Sanmarti Vilamala
- Montserrat Viqueira GonzĂĄlez
- MĂČnica Angerri Nadal
- Mónica Liébana Gómez
- Nerea Carrasco AntĂłn
- NicolĂĄs JimĂ©nez-GarcĂa
- Nicolås Merchante Gutiérrez
- Nieves de la Cruz Felipe
- Nieves Valcarce Pardeiro
- Olga Meca Birlanga
- Olga SĂĄnchez-Pernaute
- Onofre MartĂnez Madrid
- Oscar Sanz PelĂĄez
- Pablo Ryan
- Paloma Albiol Viñals
- Patricia Gonzålez Muñiz
- Patricia GonzĂĄlez-Ruano PĂ©rez
- Patricia Jiménez Aguilar
- Patricia MartĂnez MartĂn
- Paula Mendoza Roy
- Paula Santibañez Såenz
- Pedro Gil Divasson
- Pedro MartĂnez PĂ©rez-Crespo
- Pedro Ăngel Cuadros Tito
- Pere Comas Casanova
- Pilar MartĂn DĂĄvila
- Pilar Vizcarra
- Rafae Silvariño Fernåndez
- Raquel Ălvarez Franco
- Rebeca Longueira
- Regino RodrĂguez Ălvarez
- Reinaldo EspĂndola GĂłmez
- Ricardo Gil SĂĄnchez
- Rita Godoy Lorenzo
- RocĂo Montejano SĂĄnchez
- Rojas-Marte
- Rosa de Miguel Buckley
- Rosa Oltra Sempere
- Rosana Rouco Esteves Marques
- Rosario Castilla Ortiz
- Sabela SĂĄnchez Trigo
- Saioa Domingo Echaburu
- Salvador PĂ©rez-Galera
- Santiago Moreno Guillén
- Santiago PĂ©rez Parra
- Sara Lidia Kamel Rey
- Sara Vela Bernal
- Sara Velasco Fuentes
- Sergio España Cueto
- Sergio Gilaberte ReyzĂĄbal
- Sergio Manuel Santana BĂĄez
- Sergio PĂ©rez Pinto
- Sergio RomĂĄn Soto
- Silvana Fiorante
- Silvia GarcĂa MartĂnez
- Silvia SuĂĄrez
- Sonia Calzado Isbert
- Sonia GarcĂa Prieto
- Sonsoles Salto
- Tamara CaĂnzos Romero
- Teresa AldabĂł
- Teresa AldĂĄmiz-EchevarrĂa
- Teresa Giménez
- Vanesa Alende Castro
- Vicens DĂaz de Brito FernĂĄndez
- Vicente de la Rosa
- Violeta Ramos Sesma
- Virginia Almadana
- Virginia FernĂĄndez Espinilla
- Virginia Isern FernĂĄndez
- Virginia Naranjo Velasco
- VĂctor Asensi
- Xabier Kortajarena Urkola
- Xavier Sanz Salvador
- Ye
- Yolanda Meije Castillo
- Yuan
- Zaira R. Palacios Baena
- Zhang
- Zuriñe Ortiz de Zårate Ibarra
- Ăngel DomĂnguez-Castellano
- Ăngeles GarcĂa Flores
- Ăngeles Muñoz
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/08/2020
- Field of study
Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters.
Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs).
Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001).
Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio
A communal catalogue reveals Earth's multiscale microbial diversity
- Author
- Aaron Clauset
- Aaron R. Jex
- Alexandra H. Campbell
- Alexandra M. Linz
- Allison Berry
- Allison E. Williams
- Alyssa Cochran
- Amnon Amir
- Amy Apprill
- Andaine Seguin-Orlando
- Anders Karlsson
- Andrew P. Rees
- Andrew Whitehead
- Anna Forsman
- Anni Moore
- Anson V. Koehler
- Antje Gittel
- Antonio GonzĂĄlez
- Antonio M. MartĂn-Platero
- Anupriya Tripathi
- Asha Rani
- Ashish Bhatnagar
- Ashley Shade
- Aurora MacRae-Crerar
- Baddr Shakhsheer
- Bazartseren Boldgiv
- Beck Wehrle
- Benjamin B. Crary
- Benjamin D. Shogan
- Benjamin L. Turner
- Bharath Prithiviraj
- Bonnie Laverock
- Brenda B. Casper
- Brent Stephens
- Byron C. Crump
- Caitlin Potter
- Carol Robinson
- Catherine M. Spirito
- Catherine Pfister
- Cesar Cardona
- Chia L. Tan
- Chris Freeman
- Christopher Quince
- Colin J. Brislawn
- Colleen T. E. Kellogg
- Congcong Shen
- D. Lee Taylor
- Daniel A. Cristol
- Daniel McDonald
- Daniel P. Smith
- Daniel van der Lelie
- Daniela Vargas-Robles
- Danielle C. Claar
- Danilo Ercolini
- Dave Shutler
- David A. Lipson
- David A. Mills
- David Armitage
- David Garshelis
- David Myrold
- Diogo Jurelevicius
- Dionysios A. Antonopoulos
- Donal M. Boyer
- Donald A. Walker
- Donglai Gong
- Donna Berg-Lyons
- Douglas C. Woodhams
- Duoying Cui
- Elizabeth Pilon-Smits
- Elliot S. Friedman
- Embriette Hyde
- Emily M. Landon
- Eric A. Dubinsky
- Eric Bottos
- Eric R. Johnston
- Eske Willerslev
- Evguenia Kopylova
- Ezequiel M. Marzinelli
- F. Joseph Pollock
- Fabian Michelangeli
- Folker Meyer
- Forest Rohwer
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- Tomasz Kosciolek
- Torsten Thomas
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- Ulf Riebesell
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- Vanessa Ezenwa
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- Vera Tai
- Vincenzo Fogliano
- Virginia Sanz
- Walter P. MacCormack
- Wayne Roundstone
- Wenju Liang
- William A. Walters
- William Brazelton
- William Van Treuren
- Wyatt Oswald
- Yadira Ortiz Castellano
- Yeqin Yang
- Yingying Ni
- Yongqin Liu
- Yoshiki VĂĄzquez-Baeza
- Yu Shi
- Zhenjiang Zech Xu
- Publication venue
- Publication date
- 01/01/2017
- Field of study
Our growing awareness of the microbial world's importance and diversity contrasts starkly with our limited understanding of its fundamental structure. Despite recent advances in DNA sequencing, a lack of standardized protocols and common analytical frameworks impedes comparisons among studies, hindering the development of global inferences about microbial life on Earth. Here we present a meta-analysis of microbial community samples collected by hundreds of researchers for the Earth Microbiome Project. Coordinated protocols and new analytical methods, particularly the use of exact sequences instead of clustered operational taxonomic units, enable bacterial and archaeal ribosomal RNA gene sequences to be followed across multiple studies and allow us to explore patterns of diversity at an unprecedented scale. The result is both a reference database giving global context to DNA sequence data and a framework for incorporating data from future studies, fostering increasingly complete characterization of Earth's microbial diversity.Peer reviewe
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
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- Guerrero JE
- Guerrero-Lopez F
- Guerrero-LĂłpez F
- Guervilly C
- Guidet B
- Guillamon LN
- Guillen JA
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- Gul F
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- Gupta D
- Gupta O
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- Gutierrez LA
- Gutiérrez-Pizarraya A
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- Gómez-Jiménez C
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- HernĂĄndez A
- HernĂĄndez AA
- HernĂĄndez AA
- HernĂĄndez AA
- HernĂĄndez AA
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- HernĂĄndez AA
- HernĂĄndez G
- HernĂĄndez-Tejedor A
- Herpain A
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- Herrera AN
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- Hewitt H
- Heyne T
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- Hidalgo C
- Hikasa Y
- Hillier SD
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- Himpe D
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- Hirata A
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- Hodgson LE
- Hodgson LE
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- Horstmann C
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- Houzé S
- Houzé S
- Howes D
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- Hrachovina M
- Hraiech S
- Hravnak M
- Hu HC
- Hua Y
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- Huang CH
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- Huang WC
- Hubbard A
- Huber W
- Huddart S
- Hull AM
- Hung CY
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- Huot B
- Husheer SL
- Hutchings S
- Hutchison R
- Hwang GS
- Hwang GS
- Ibañes PG
- Ibsen M
- Idei M
- Idei M
- Idone FA
- Iesu E
- Iesu E
- Iglesias-Santiago A
- Ignacio ML
- Iida A
- Iijima H
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- IPREA Study Group
- Irazabal JM
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- Itenov TS
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- Jaffal K
- Jamali S
- Jang BH
- Janotka M
- Janotka M
- Janotka M
- Jansen D
- Jansen N
- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
- Jardim JJ
- Jardim M
- Jareño A
- Javadpour S
- Jayasinghe S
- Jean-Baptiste S
- Jean-Baptiste S
- Jensen AE
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- Jeon YD
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- Jeong IY
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- Jibaja M
- Jimenez-Herrera MF
- Jiménez GJ
- Jo YH
- Joachim J
- Jochmans S
- John G
- Jonas M
- Jonas M
- Jonas M
- Jones C
- Joshi R
- Joshi V
- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
- Juan WC
- Juanas CA
- Judickas S
- Juez A
- Juliarena A
- Jun IG
- Jun IG
- Jung K
- Jung KW
- Junior JM
- Kaczirek K
- Kaese S
- Kalani N
- Kalenka A
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- Kamali E
- Kaminsky GE
- Kaneko M
- Kang M
- Kang M
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- Kang PL
- Kang PL
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- Kang Y
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- Kappler F
- Kara A
- Karachi F
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- Karbing DS
- Karsten E
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- Kashyap R
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- Katira BH
- Kavanagh BP
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- Kayaaslan B
- Kayambu G
- Kazutoshi F
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- Khine H
- Kim DJ
- Kim HJ
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- Kim KS
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- Kim MH
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- Kirakli C
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- Kirwan CJ
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- Kleinpell R
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- Kobayashi A
- Koco E
- Kodate A
- Kodate A
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- Kokkini S
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- Komuro T
- Kondili E
- Kongpolprom N
- Kooner G
- Kostalas M
- Kosuk ME
- Kotsopoulos A
- Kou PS
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- Kox M
- Kraegpoeth A
- Krenn CG
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- Kristof J
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- Kubota K
- Kuebler WM
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- Kumari BK
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- Kunze-Szikszay N
- Kurmukov IA
- Kurth T
- Kurtz P
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- Lacerda P
- Laerkner E
- Lafaurie M
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- Lagos R
- Lahmer T
- Lai CC
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- Lischinsky A
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- Lukaszewicz AC
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- Saitou N
- Sakai Y
- Sakieva FI
- Sakuma M
- Sakuraya M
- Sales G
- Salgado DR
- Salluh J
- Sampath S
- Sampath S
- Sampley S
- Sampson D
- Samuels T
- Samy W
- Sanchez A
- Sanchez JA
- Sanchez-Orézzoli MG
- Sandiumenge A
- Sandiumenge A
- Sandroni C
- Sani D
- Santacruz C
- Santana JD
- Santana JD
- Santana MC
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- Santana PS
- Santana PS
- Santana SR
- Santana SR
- Santiago AI
- Santiago AI
- Santos F
- Sanui M
- Sanz ER
- Sanz ER
- Sanz ER
- Sanz ER
- Sanz ER
- Sanz ER
- Sanz NM
- Sanz NM
- Sanz NM
- Sato K
- Savi C
- Savin I
- Savvidou S
- Sawamura A
- Sawamura A
- Sawamura A
- Sawamura A
- Scala S
- Scales DC
- Scanziani E
- Scanziani E
- Schaller SJ
- Schlaepfer P
- Schleifer J
- Schmid RM
- Schmidt M
- Schneider AG
- Schoenenberger JA
- Schortgen F
- Schortgen F
- Schortgen F
- Schröder T
- Schuepbach R
- Schultz MJ
- Schultz MJ
- Schwarz C
- Schwarze S
- Schwerdtfeger K
- Sciurti R
- Scott SH
- SedlĂĄk P
- Seemann R
- Seet E
- Sekhri K
- Seldon T
- Sellés MD
- Sendid B
- Senussi T
- Serati Z
- Serbource-Goguel J
- Sergey S
- Serpytis M
- Serra J
- Sesana G
- Shah A
- Shah H
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- Sheils MA
- Shekerdemian LS
- Shekerdemian LS
- Sherif H
- Shi ZH
- Shimanskiy V
- Shimony JS
- Shin WJ
- Shin WJ
- Shinotsuka CR
- Shlyk I
- Shu CW
- Shuinotsuka C
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- Shum HP
- Sibley S
- Siddiqui SS
- Sidhu P
- Sigcha MS
- Sigera CS
- Signouret T
- Sigurta A
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- Singer M
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- Singer M
- Singh H
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- Sipylaite J
- Sirisena N
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- Siu K
- Sjövall F
- Skinner L
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- Skrifvars M
- Skrifvars MB
- Smekal D
- Snelson C
- Snyder AZ
- Sobhanian S
- Soeffker G
- Soilemezi E
- Soilemezi E
- Soilemezi E
- Sokolova E
- Solanki S
- Soler EA
- SolligÄrd E
- Solé-Violån J
- Somhorst P
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- Song I
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- Song YG
- Sonneville R
- Sosa M
- Sossou A
- Sousa SC
- Soussi S
- Souza VA
- Spadaro S
- Spadaro S
- Spahn DR
- Spatenkova V
- Spazzadeschi A
- Spijkstra JJ
- Spronk PE
- Spronk PE
- Sprung CL
- St Georgeâs University of London
- Stamm J
- Stamouli M
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- Starczewska M
- Staszewsky L
- Stauffert N
- Stella A
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- Stiphout C
- Stocchetti N
- Stocchetti N
- Stougianni M
- Street H
- Stretti F
- Struijs A
- Stubbs C
- Stubbs C
- Student Research Committee - Shiraz University of Medical Sciences
- StĂŒmpfle R
- StĂŒmpfle R
- Su F
- Su L
- Su PL
- Su PL
- Suchomel P
- Suh GJ
- Suh GJ
- Suh GJ
- Suh GY
- Suh JW
- Sullivan E
- Sun WZ
- Sun XM
- Sung D
- Suwanpasu S
- Suzuki S
- Suzuki T
- Swart M
- Sy O
- Sydow K
- Sylla P
- SĂĄez VC
- SĂĄnchez B
- SĂĄnchez B
- SĂĄnchez EC
- SĂĄnchez MJ
- SĂĄnchez MJ
- SĂĄnchez MJ
- SĂĄnchez MJ
- SĂĄnchez MJ
- SĂĄnchez MJ
- SĂĄnchez PC
- SĂĄnchez PC
- SĂĄnchez-Elvira LA
- Tabatabaei HR
- Tabei SH
- Taccone F
- Taccone FS
- Taccone FS
- Taccone FS
- Taccone FS
- Taccone FS
- Taccone FS
- Taccone FS
- Taggu A
- Taggu A
- Takahashi H
- Takaki S
- Takaki S
- Takeda M
- Takeda M
- Takei T
- Takei T
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- Thomas B
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- Thévenin D
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- Timsit JF
- Tirkkonen J
- Tirumala S
- Tjepkema-Cloostermans MC
- Tobar M
- Tofiño AL
- Toh CH
- Tokyo Womens Medical University
- Tomas E
- Tomas E
- Tomic I
- Tominaga N
- TomĂĄs MA
- Tonelotto BF
- Tonetti T
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- Topcu L
- Tormos P
- Torner MM
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- Torrance HD
- Torrent RL
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- Tsukahara K
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- Tsutui T
- Tucci MR
- Tudor BA
- Tuinman PR
- Tullo L
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- Vallverdu M
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- VallverdĂș I
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- van den Boogaard M
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- van der Hoeven JG
- van der Hoeven JG
- van der Voort PH
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- van Ieperen SN
- Van Logten T
- van Nes M
- van Putten MJ
- van Thiel RJ
- van Wijk A
- Vandijck D
- Vaneker I
- Vanhuyse F
- Vaporidi K
- Vaquerizo C
- Varas GM
- Varas JL
- Varea MM
- Vargiolu A
- Varma A
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- Vatsik MV
- Vazquez D
- Vedage D
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- Vergani G
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- Vezzani A
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- Villarreal E
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- Vincent JL
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- Vinje LJ
- Vinsonneau C
- Vitaller S
- Vittone F
- Vogelaers D
- Voiriot G
- Volker T
- Volta CA
- Volta CA
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- Wada T
- Wada T
- Waldauf P
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- Wang CH
- Wang H
- Wann SR
- Wann SR
- Wann SR
- Wann SR
- Wathanawatthu T
- Wee S
- Welte T
- Welters I
- Wetz A
- Weyer CM
- White C
- Wiesner O
- Wijayatilake DS
- Wildenberg L
- Wilks M
- Wilson ME
- WIND study group
- WIND study group
- WIND study group
- Winder-Rhodes S
- Witter T
- Wolf M
- Wolff M
- Wong Y
- Wood B
- Wood CA
- Wood D
- Wood M
- Wray J
- Xie Z
- Xini A
- Xini A
- Xiol EA
- Xu M
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- Yaguchi A
- Yaguchi A
- Yamaguchi O
- Yamaguchi O
- Yamaguchi Y
- Yamaguchi Y
- Yamamoto H
- Yamamoto N
- Yaman G
- Yamashita K
- Yamazaki A
- Yan WW
- Yan WW
- Yang JH
- Yang JS
- Yang YL
- Yasuda H
- Yatabe T
- Yebenes JC
- Yeh YC
- Yemets H
- Yergaliyeva A
- Yılmaz G
- Yilmazer F
- Yodice P
- Yokoyama M
- Yonis H
- Yonis H
- Yonis H
- Yoon SZ
- Yoruk F
- Yoshida K
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshihiro S
- Yoshitake E
- You KM
- Youn AM
- Young A
- Yu KM
- Yumoto T
- Yuzawa J
- Yuzawa J
- Zabaletta WJ
- Zabini D
- Zahorec M
- Zaien I
- Zakynthinos S
- Zanello M
- Zani D
- Zarantonello F
- Zayas B
- Zepeda EM
- Zeroual N
- Zerva L
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- Zhou JC
- Zhou JC
- Zhou JX
- Zhovnir V
- Zibandah N
- Zijlstra F
- Zimmerman J
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- Zogheib E
- Zullino V
- Zwaag J
- ZĂœkovĂĄ I
- Ălvarez JT
- Ălvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
The management of acute venous thromboembolism in clinical practice. Results from the European PREFER in VTE Registry
- Author
- Abbadie F
- Achkar A
- Ackroyd A
- Adamczyk A
- Adarraga Cansino Md
- Addala A
- Adnet F
- Agarwal G
- Ageno W
- Agnelli G
- Agnelli G
- Al Ahmad W
- Al-Refaie F
- Alexandra Jf
- Alikhan R
- Allameddine A
- Altarriba Es
- Amado FernĂĄndez C
- Amitrano M
- Amore M
- Angelini E
- Antignani Pl
- Aquilanti S
- Aranda Blazquez R
- Arden C
- Arellano Rodrigo E
- Armengou Arxe A
- Arone A
- Asaro G
- Attanzio Mt
- Attinasi V
- Austin A
- Axthelm C
- Axthelm P
- Bakhai A
- Balbarini A
- Ballaz Quincoces A
- Banfi E
- Banyai M
- Barcellona D
- Barillari G
- Bartolini C
- Barton T
- Bartone M
- Bauersachs R
- Bauersachs R
- Beato PĂ©rez Jl
- Bedate DĂaz P
- Belhassane A
- Bellanuova I
- Bellisi M
- Bellizzi A
- Benaroya B
- Bergmann K
- Berremili T
- Beschorner U
- Bianchi M
- Bianchini G
- Binias Kh
- Birr V
- Blanco-Molina Ma
- Boari B
- Body R
- Bonnin C
- Boral M
- Bortoluzzi C
- Bosler F
- Bramlage P
- Bratsch H
- Brauer G
- Bresin Durand Mg
- Brisot D
- Brodmann M
- Brousse C
- Brucoli C
- Burghard S
- Calandra G
- Calvo Mijares N
- Camporese G
- Canafoglia L
- Cancellieri E
- Cannavacciuolo F
- Caprioli C
- Carlizza A
- Carnovali M
- Carrasco ExpĂłsito M
- Carrasco Mas A
- Carugati A
- Casarsa C
- Castellote Mc
- Castrodeza Sanz R
- Catalini R
- Cavazza S
- Cayman C
- Cazaubon M
- Cañas Alcåntara I
- Cenci C
- Ceresa F
- Cereto Castro F
- Chacko J
- Champion O
- Chandra D
- Chanut M
- Charters F
- Chevalet P
- Church A
- Ciampa A
- Ciarambino T
- Cillari E
- Cisneros de la Fuente E
- Clemente M
- Clements J
- Clifford P
- Cohen At
- Connault J
- Constans J
- Conti F
- Cordeanu M
- Cosmi B
- Couturaud F
- Cox D
- Crouch M
- Crowther M
- D'Alessandro A
- D'Angelo A
- D'Antoni S
- Davies E
- Davies M
- de Ancos Aracil C
- De Bartolomeo G
- De Campora P
- de Daborenea GonzĂĄlez Md
- De Dedker L
- De Franciscis S
- De Gaudenzi E
- de la Fuente Aguado J
- De La Fuente T
- de las Revillas Fa
- De Santis F
- De Tommaso I
- Decoulx E
- del Carmen FernĂĄndez-CapitĂĄn M
- del Toro Cervera J
- Delgado Bregel Jl
- Delpin S
- Demann C
- Demmig A
- Derrien B
- Di Francesco L
- Di Maggio R
- Di Micco P
- Di Michele D
- Di Minno G
- Di Nisio M
- Di Salvo M
- Diamand Jm
- Diard A
- Dimitri S
- Donadio F
- Douadi Y
- Drebes A
- Dres P
- Dupas S
- Durant C
- DĂez FernĂĄndez F
- DâAvino M
- Eberhad Rieker E
- Eberlein U
- Edhery S
- Eischer L
- Elias HernĂĄndez T
- Emter E
- Enea I
- Enger F
- Eschenburg J
- Eschenburg Ju
- Ewad H
- Fabbian F
- Falanga A
- Falvo N
- Farcas Taralunga C
- Felis S
- FernĂĄndez Iglesias A
- Ferrari E
- Ferri Bataler R
- Fiore V
- Fontanella A
- Forkmann L
- Franco E
- Frank J
- Frank U
- Franklin S
- Frausini G
- Freischmidt H
- Fritsche I
- Fronk Em
- Fuorlo M
- Gaillard C
- Gallerani M
- Gamberini S
- Garcia Ma
- GarcĂa GarcĂa Jm
- GarcĂa Loizaga A
- GarcĂa-Bragado Dalmau F
- Garrigues D
- Gassauer M
- George J
- Gerofke H
- Ghirarduzzi A
- Ghizzi G
- Gianniello F
- Gibbs C
- Gillet Jl
- Giordana P
- Girke F
- Gitt Ak
- Giudice G
- Goebels Mc
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- GonzĂĄlez Porras Jr
- GonzĂĄlez Lg
- Grange C
- Grare F
- Grenot Mc
- GrĂŒn-Himmelmann K
- Guarnera G
- Guercini F
- Guggenbichler S
- Guil GarcĂa M
- Gupta S
- Gutierrez Ja
- Hadj Henni A
- Hartmann K
- Heilberger P
- Heinsius A
- Held M
- Herman G
- Hernando LĂłpez E
- Herold J
- Hertrich F
- Heuser S
- Hidden-Henic V
- Hirschl M
- Holmes J
- Holtea D
- Hommel H
- Hottin D
- HĂ€rtel D
- HĂŒtte G
- Imbert B
- Imberti D
- Iosub Di
- Iozzi E
- Irvine N
- Jackson-Voyzey E
- Jacquinandi V
- Jakob D
- Jara Palomares L
- Jaras Mj
- Jeanneret C
- Jiménez Castro D
- JimĂ©nez-RodrĂguez Madridejos R
- Jones N
- Joya Seijo D
- Jungandreas K
- Jurus C
- Jörg Gr
- Kalka C
- Kallat A
- Karcher J
- Karl-Wollweber S
- Keilhau Da
- Kerr P
- Kesteven P
- Kittel K
- Knittel M
- Knolinski T
- Kopplin U
- Kroschel U
- Kröger K
- KubicekâHofmann C
- Köhler C
- Körner I
- La Forgia S
- La Regina M
- Lacoste A
- Lacut K
- Laeis P
- Landolfi R
- Laroche Jp
- Lecumberri R
- Lench T
- Leschke M
- Lester W
- Lewis M
- LluĂs Padierna M
- Lodigiani C
- Lorenzo HernĂĄndez A
- Lowe G
- Lutz A
- LĂłpez Castellanos Gt
- López Jiménez L
- LĂłpez Gt
- LĂłpez-SĂĄez Jb
- LĂŒbbert G
- Madridano Cobo O
- Mainez Saiz C
- Mancuso G
- Manfredini R
- Manzano Espinosa L
- Marchena Yglesias Pj
- Marconi L
- Marcucci R
- Marencke Gh
- Margheriti R
- Marongiu S
- Marra A
- Marrocco F
- Martin M
- Martinelli I
- MartĂn del Pozo M
- MartĂnez N
- Masotti L
- Mazollier C
- McCormack T
- McCoye A
- McGrane F
- Mearelli F
- Mearns B
- Melibovsky L
- Mersel T
- Milesi V
- Millón Caño Ja
- Miserey G
- Mismetti P
- Modeliar Remond Ss
- Mommi V
- Monreal Bosch M
- Monreal M
- Montagna Es
- Monte Secades R
- Mora LujĂĄn Jm
- Moral Moral P
- Moreno Flores A
- Moriarty A
- Morretti T
- Morris W
- Mortensen K
- Mos L
- Moysidis T
- Mugno F
- Muñoz RodrĂguez Fj
- Narayanan M
- Nedey C
- Nelles H
- Nestler K
- Neumeister A
- Nieto RodrĂguez Ja
- Nitti C
- Nou M
- NĂșñez FernĂĄndez Mj
- Oettler W
- Olivieri O
- Oncala Sibajas E
- Onesta M
- Oo N
- Orlandini F
- Ortiz de Saracho J
- Ott I
- Otto A
- Ouvry P
- Pagliara V
- Paiella L
- Pala P
- Palasciano G
- Palla A
- Paoletti O
- Paolucci G
- Parisi R
- Parra Caballero P
- Pasca S
- Pasin M
- Pasligh M
- PatanĂš F
- Pedrajas Navas Jm
- Pennacchioni M
- Pepe C
- Pernod G
- Pertermann A
- Perticone F
- Peter Marschang P
- Peuch B
- Pfister R
- Piccinni Gc
- Pichot O
- Pierri F
- Piloquet Fx
- Pindur P
- Pinto A
- Piovella F
- Pivetti G
- Pizzini Am
- Placentino M
- Poli D
- Pons MartĂn del Campo I
- Porreca E
- Portillo SĂĄnchez J
- Poulain V
- Pourhassan S
- Predel D
- Prisco D
- Pudollek T
- PĂ©rez Rus G
- Quere I
- Quezada Loaiza A
- Quintavalla R
- Ramthor M
- Rancan E
- Ray P
- Reed M
- Reimer D
- Rennebaum C
- Reppel M
- Reynaldo P
- Ria L
- Richter R
- Rief P
- Riera Mestre A
- Rifai A
- Rivera Gallego A
- RodrĂguez BeltrĂĄn Em
- RoldĂĄn Schilling V
- Romero Pizarro Y
- Roncero LĂĄzaro A
- Rose P
- Rossetto V
- RothenbĂŒcher G
- Rothhagen B
- Rovinelli M
- Roy Pm
- Rubino P
- Rudolff S
- Ruiz J
- Rupoli S
- Russo V
- Saby Jc
- Saccullo G
- Sada S
- Saja K
- Sala G
- Salmi R
- Salvi A
- Samaden A
- San RomĂĄn TerĂĄn Cm
- Sangiuolo R
- Santalla Valle Ea
- Santini C
- Schafnitzl W
- Schellong S
- Schenone A
- Schiller M
- Schlosser A
- Schmeink P
- Schmeink T
- Schmidt J
- Schnabl S
- Schneider H
- Schnupp S
- Schulze M
- SchÀfer A
- Schön N
- Sciacqua A
- Sechtem U
- Sedl S
- Serra R
- Severino S
- Sevestre Ma
- Signorelli Ss
- Silvestri E
- Silvestris F
- Simon F
- Simonot-Lalandec E
- Siniscalchi V
- Siragusa S
- Sivakumaran M
- Sohal M
- Sollazzo V
- Solomons G
- Sonnenschein K
- Sorvillo S
- Stachowitz J
- Staub D
- Stephan D
- Stoshikj S
- Strafino C
- StĂŒcker M
- Sultanzadeh Sj
- Suriñach Caralt Jm
- SĂĄnchez Fuentes D
- Sånchez Muñoz-Torrero Jf
- SĂĄnchez Ălvarez J
- Talerico A
- Testa S
- Thachil J
- Thieme M
- Tiefenbacher C
- Tirado Miranda R
- Tissot A
- TodolĂ Parra Ja
- Tonello C
- Tosi F
- Tropeano P
- Tsantilas D
- Tufano A
- Usandizaga de Antonio E
- Vallarelli S
- Vaquero de Sedas M
- Venton T
- Verdecchia P
- Vetrano V
- Vieth P
- ViganĂČ S
- Villalta Blanch J
- Villalta S
- Villanueva Montes Ma
- Villaverde Ălvarez I
- Vincentelli Gm
- Violo C
- Vital-Durand D
- Vodoungnon H
- Voigts B
- vom Dahl J
- von Bilderling P
- von Maltik T
- Wakeling J
- Walby C
- Waldron M
- Watt S
- Weber H
- Weinmann S
- Weinrich K
- Werner N
- Werno Hs
- Werth S
- Weyer M
- Willcock W
- Willich Sn
- Wirtz P
- Wittig I
- Wittig K
- Wucherpfennig P
- Zafar A.
- Zanatta N
- Zierock P
- Zingaretti O
- Zorzi F
- zur Nieden T
- Publication venue
- 'Georg Thieme Verlag KG'
- Publication date
- 01/01/2017
- Field of study
Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in Europe. Data from real-world registries are necessary, as clinical trials do not represent the full spectrum of VTE patients seen in clinical practice. We aimed to document the epidemiology, management and outcomes of VTE using data from a large, observational database. PREFER in VTE was an international, non-interventional disease registry conducted between January 2013 and July 2015 in primary and secondary care across seven European countries. Consecutive patients with acute VTE were documented and followed up over 12 months. PREFER in VTE included 3,455 patients with a mean age of 60.8 ± 17.0 years. Overall, 53.0 % were male. The majority of patients were assessed in the hospital setting as inpatients or outpatients (78.5 %). The diagnosis was deep-vein thrombosis (DVT) in 59.5 % and pulmonary embolism (PE) in 40.5 %. The most common comorbidities were the various types of cardiovascular disease (excluding hypertension; 45.5 %), hypertension (42.3 %) and dyslipidaemia (21.1 %). Following the index VTE, a large proportion of patients received initial therapy with heparin (73.2 %), almost half received a vitamin K antagonist (48.7 %) and nearly a quarter received a DOAC (24.5 %). Almost a quarter of all presentations were for recurrent VTE, with >80 % of previous episodes having occurred more than 12 months prior to baseline. In conclusion, PREFER in VTE has provided contemporary insights into VTE patients and their real-world management, including their baseline characteristics, risk factors, disease history, symptoms and signs, initial therapy and outcomes
Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).
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- A'Court C.
- Aaroe H.
- Abd El-Aziz A.
- Abdalla Saad J.
- Abdel-Qader M.
- Abdelrahman H.
- Abdul A.
- Abe M. (Masahiko)
- Abe M. (Masatake)
- Abe M. (Mitsunori)
- Abe S.
- Abe Y.
- Abhayaratna W.
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- Abraham S.
- Abu-Mahfouz M.
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- Accetta Gabriele
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- Adachi S.
- Adachi S. (Sen)
- Adachi S. (Susumu)
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- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2018
- Field of study
Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and â„1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (nâ=â5069) or prospectively (nâ=â5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (â€6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; pâ=â0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)
Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries
- Author
- Aamir Faiqa Binte
- Aamir Syed Roohan
- Ababneh Adnan
- Abbal Muhammad Anas
- Abbas Ahmed M
- Abbas Mostafa
- Abd-Albain Montasir A
- Abdalei Abdulwahab
- Abdalla Ahmed
- Abdalla Ahmed Yassir
- Abdalla Mohamed Galal Ali
- Abdalla Zainab
- Abdallah Mohamed M
- Abdalmahmoud Noon Ezzeldien
- Abdalsadeg Rowa
- Abdelaal Ahmed M
- Abdelbagi Alnazeer Y
- Abdelbaky Mostafa
- Abdelbaset Doaa
- AbdElbaset Esraa
- Abdelbast Menhag
- Abdelfatah Mohammed Abdelnasser
- Abdelgawad Samia
- Abdelhamid Mohamed M
- Abdeljaber Mahmoud
- Abdelkhalig Mubarak
- Abdelmaksoud Mohamed
- Abdelmeguid Rana
- Abdelmelek Dhia Errahmane
- Abdelnaeam Samah
- Abdelnasser Mohammad K
- Abdelrahim Najwa
- Abdelrahman Amira
- Abdelrahman Ayman
- Abdelsalam Hebatalla
- Abdelsamed Enas Abdelbaset
- Abdelwahab Khaled
- Abdoun Meriem
- Abdulali Fatima
- Abdulaziz Mohamed
- Abdulla Dheba Almukhtar
- Abdullah Bahiyah
- Abdullah Bahiyah
- Abdullah Walaa
- Abdullahi Habiba Ibrahim
- Abdulrahman Ahmed
- Abdulrasheed Lubabatu
- Abdulwahed Eman
- Abdulwahed Eman
- Abeysirigunawardana Dewmi
- Abidin Muhammad Fihmi Zainal
- Abiola Olukayode
- Abiyere Henry
- Abodina Ahmed Mohammed
- Aboelela Reham
- AboElfarh Hadeer Elsaeed
- Aboudlal Husein
- AbouHiekal Osama
- Aboulfotouh Ahmed
- Abozid Anwaar
- Abubaker Noora
- Abubaker Noora
- Abufanas Asma
- Abughanima Mahmoud
- Abuhashem Shehab
- Abulafia Daniel
- Abushaala Fatima
- Abushanab Khaled
- AbuShawareb Issa
- Abuuqteish Hamza
- Abuzaho Amany
- Achem Arome
- Adam Eithar
- Adam Mohammed
- Adam Mohammed A
- Addalla Mohamed
- Addley Jordan
- Adeleye Gbadebo
- Adeniyi Adebayo
- Adewole Nathaniel
- Adeyemo Olabisi
- Adeyeye Ademola
- Adeyeye Ademola
- Adly Michael
- Adnan Siti Nasyirah Nisya
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adze Joel Amwe
- Afeikhena Ehis
- Agida Teddy
- Agilla Hamza
- Agnew Emilie
- Agu Joy Onyekachi
- Ahmad Zatul Akmar
- Ahmed Abdalla
- Ahmed Ahmed
- Ahmed Ahmed
- Ahmed Alaaaldeen
- Ahmed Entisar
- Ahmed Habeeba
- Ahmed Hatem
- Ahmed Reem
- Ahmed Rehab
- Ahmed Rihab
- Ahmed Rogia Ahmed Abdalla
- Ahmed Ruaa
- Ahmed Sharwany
- Ahmed Uzair
- Ahmed Wahiba
- Ahmeed Sultan
- Airede Lydia Regina
- Aitchison Lori
- Ajredini Mirac
- Ajulo Adeshina A
- Akaba Godwin
- Akasha Mazin
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- Akbuz Seyma Orcan
- Akdere Hakan
- Akın Bilge
- Akkaya Ege Nur
- Akpamgbo Chukwunonso Nnamdi
- Akwaisah Ayoub
- Al Hammoud Amr
- Al Rawashdeh Toka â â
- Al-Baw Mahmoud
- Al-Dahdouh Mosheer
- Al-Haek Safaâ
- Al-Hazaimeh Mo'ath
- Al-issawi Dima
- Al-Issawi Subhi
- Al-jammal Maryam
- Al-Juaifari Maytham A
- Al-Mwajeh Tesneem
- Al-Omary Sohaib
- Al-Quossi Mohammed
- Al-Shambaty Yasir Babkir Ali
- Al-Shami Qotadah
- Al-Smirat Heba
- Al-Tahayneh Sief-Addeen
- Al-Touny Aiman
- Al-Touny Shimaa
- Al-zawaydeh Alia
- Alaa Ali
- Alabed Ebtihal
- Alagelli Fatma
- Alagoz Ahmet Can
- Alameen Hind
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- Alamlih Laith
- Alaqoubi Retaj
- Alarabi Rehab
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- Alathameen Nassar
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- Albanopoulos Konstantinos
- Albarhomy Osama
- Albarki Aisha
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- Alboon Mosab
- Alboridy Muneera
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- Aldeges Marwan
- Aldreawi Mohammed
- Alflite Asil Omar Saleh
- Alfrijat Tamam
- Alfrjani Tariq
- Algabbasi Salima
- Algatanesh Nassib
- Alhadad Qamrah
- Alhaddad Hoda Salem
- Alhaleem Ayah
- Alhaleeq Saif
- Alharam Abtisam
- Alhashimi Abdulhadi Mohammed Alhadi
- Alhassan Monzer
- Alhudhairy Sara
- Ali Ahmed
- Ali Aml
- Ali Doua
- Ali Eithar M
- Ali Iqra Fatima Munawar
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- Ali Muhammad
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- Aljamal Sarah
- Alkaraja Layth
- Alkaseek Akram
- Alkazali Mustafa
- Alkchr Hayat Ben Hasan Mohamed A A
- Alkhatib Abed Alazeez
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- Almahroush Marin
- Almakki Doha Mohammed Ahmed
- Alnajjar Lara
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- Altahir Mohamed
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- Altughar Bushra
- Alvarez Matias
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- Amin Mostafa K
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- Keskin Abdil Yetkin
- Khadrawi Mohammad
- Khafifi Khaled
- Khairallah Nour Salah
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- Zaed Moahmed
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- Zaheer Adil
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- Zapsalis Konstantinos
- Zargar Kamran
- Zarzour Mohamed A
- Zeng Raymond
- Zeng Raymond
- Zengin Kagan
- Zertuche Juventino Tadeo Guerrero
- Zhang Caitlin
- Zhang Edward
- Zhang Shane
- Zhang Yichi
- Zhao Hailin
- Zheng Helen
- Zhou Karen
- Zhou Yida
- Ziergiebel Felix
- Zou Peishan
- Zuylekom Kate Van
- Zuylekom Katie Van
- Zwain Yasir Adnan
- Zyul'korneeva Sof'ya
- âAladna âAbdallah
- âAljoumaa âAbdullah
- âNawfal âHamdi
- âNiazi âAmmar
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely
Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.
- Author
- A. Abd El-Aziz
- A. Abdul
- A. Agakhanyan
- A. Aggarwala
- A. Agrawal
- A. Al Mulla
- A. Al Naeemi
- A. Alfieri
- A. Ali
- A. Altun
- A. Alvarez D'Amelio
- A. Andersson
- A. Argena
- A. Austria
- A. Aydinlar
- A. Babyesiza
- A. Barai
- A. Barreau
- A. Barszcz
- A. Bartes
- A. Bazzoni Ruiz
- A. Beattie
- A. Bianchi
- A. Biernacka
- A. Black
- A. Blenkhorn
- A. Branjovich Tijuan
- A. Bremmelgaard
- A. Brown
- A. Browne
- A. Capucci
- A. Caspar
- A. Catanchin
- A. Chmielowski
- A. Choi
- A. Cieszynska
- A. Conde Y Bolado
- A. Connelly
- A. Cortada Cabrera
- A. Davids
- A. De Blasio
- A. De Wolf
- A. Dickerson
- A. Domenech Borras
- A. Dumikyan
- A. Edin
- A. Egilsson
- A. El-Etreby
- A. Elbahry
- A. Elorriaga Madariaga
- A. Espallargas
- A. Ewert
- A. Fearon
- A. Fedorowsky
- A. Ferreira-Jardim
- A. Ferrer
- A. Filippi
- A. Fleck
- A. Flynn
- A. Forero
- A. Frankiewicz
- A. Fujisawa
- A. Gallagher
- A. Ganatra
- A. Gegenhuber
- A. Gieroba
- A. Gilliland
- A. Giombolini
- A. Gonzales Segovia
- A. Grande Ruiz
- A. Grau
- A. Grytzmann
- A. Gubanov
- A. Guerrero Molina
- A. Guinand
- A. Haideri
- A. Hajimirsadeghi
- A. HallarÄker
- A. Halpin
- A. Hay
- A. Heer
- A. Heyse
- A. Horak
- A. Hot-Bjelac
- A. Howitt
- A. Iglesias Garcia
- A. Ishihara
- A. Ivanov
- A. Iñiguez Romo
- A. Jackun-Podlesna
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- A. Markiewicz
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- Ajay K. Kakkar
- Ajay K. Kakkar
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- Dan Atar
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- David Fitzmaurice
- Dayi Hu
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- Y.H. Sun
- Y.H. Yin
- Y.J. Yang
- Y.J. Yang
- Y.K. On
- Y.M. Chen
- Y.M. Lee
- Y.M. Sohn
- Y.R. Jeon
- Y.S. Oh
- Y.S. Son
- Y.S. Zhao
- Y.Y. Liu
- Ying Wang
- Yoichi Nakamura
- Yong Wang
- Yoshihisa Fujiura
- Yoshitake Fujiura
- Yuhei Shiga
- Yuichiro Nakamura
- Yukihiro Koretsune
- Yukio Shiga
- Z. Babjakova
- Z. Boda
- Z. Djaidani
- Z. Lajkowski
- Z. Laszlo
- Z. May
- Z. Monhart
- Z. Ongen
- Z. Radics
- Z.C. Lu
- Z.H. Zhou
- Z.M. Yang
- Publication venue
- Indian Heart J
- Publication date
- 01/01/2018
- Field of study
BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362
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