545 research outputs found
Setting limits on Effective Field Theories: the case of Dark Matter
The usage of Effective Field Theories (EFT) for LHC new physics searches is
receiving increasing attention. It is thus important to clarify all the aspects
related with the applicability of the EFT formalism in the LHC environment,
where the large available energy can produce reactions that overcome the
maximal range of validity, i.e. the cutoff, of the theory. We show that this
does forbid to set rigorous limits on the EFT parameter space through a
modified version of the ordinary binned likelihood hypothesis test, which we
design and validate. Our limit-setting strategy can be carried on in its
full-fledged form by the LHC experimental collaborations, or performed
externally to the collaborations, through the Simplified Likelihood approach,
by relying on certain approximations. We apply it to the recent CMS mono-jet
analysis and derive limits on a Dark Matter (DM) EFT model. DM is selected as a
case study because the limited reach on the DM production EFT Wilson
coefficient and the structure of the theory suggests that the cutoff might be
dangerously low, well within the LHC reach. However our strategy can also be
applied to EFT's parametrising the indirect effects of heavy new physics in the
Electroweak and Higgs sectors
Structural Changes of the Paraflagellar Rod during Flagellar Beating in Trypanosoma cruzi
, the agent of Chagas disease, is a protozoan member of the Kinetoplastidae family characterized for the presence of specific and unique structures that are involved in different cell activities. One of them is the paraflagellar rod (PFR), a complex array of filaments connected to the flagellar axoneme. Although the function played by the PFR is not well established, it has been shown that silencing of the synthesis of its major proteins by either knockout of RNAi impairs and/or modifies the flagellar motility.Here, we present results obtained by atomic force microscopy (AFM) and transmission electron microscopy (TEM) of replicas of quick-frozen, freeze-fractured, deep-etched and rotary-replicated cells to obtain detailed information of the PFR structures in regions of the flagellum in straight and in bent state. The images obtained show that the PFR is not a fixed and static structure. The pattern of organization of the PFR filament network differs between regions of the flagellum in a straight state and those in a bent state. Measurements of the distances between the PFR filaments and the filaments that connect the PFR to the axoneme as well as of the angles between the intercrossed filaments supported this idea.Graphic computation based on the information obtained allowed the proposal of an animated model for the PFR structure during flagellar beating and provided a new way of observing PFR filaments during flagellar beating
Capacitação e intervenções de técnicos de farmácia na dispensação de medicamentos em Atenção Primária à Saúde
Interpreting LHC SUSY searches in the phenomenological MSSM
We interpret within the phenomenological MSSM (pMSSM) the results of SUSY
searches published by the CMS collaboration based on the first ~1 fb^-1 of data
taken during the 2011 LHC run at 7 TeV. The pMSSM is a 19-dimensional
parametrization of the MSSM that captures most of its phenomenological
features. It encompasses, and goes beyond, a broad range of more constrained
SUSY models. Performing a global Bayesian analysis, we obtain posterior
probability densities of parameters, masses and derived observables. In
contrast to constraints derived for particular SUSY breaking schemes, such as
the CMSSM, our results provide more generic conclusions on how the current data
constrain the MSSM.Comment: 15 pages, 7 figures; minor revision, some references and a comment on
prior dependence added; version accepted by JHE
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente
Performance of the CMS Cathode Strip Chambers with Cosmic Rays
The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device
in the CMS endcaps. Their performance has been evaluated using data taken
during a cosmic ray run in fall 2008. Measured noise levels are low, with the
number of noisy channels well below 1%. Coordinate resolution was measured for
all types of chambers, and fall in the range 47 microns to 243 microns. The
efficiencies for local charged track triggers, for hit and for segments
reconstruction were measured, and are above 99%. The timing resolution per
layer is approximately 5 ns
Seabird Modulations of Isotopic Nitrogen on Islands
The transport of nutrients by migratory animals across ecosystem boundaries can significantly enrich recipient food webs, thereby shaping the ecosystems’ structure and function. To illustrate the potential role of islands in enabling the transfer of matter across ecosystem boundaries to be gauged, we investigated the influence of seabirds on nitrogen input on islands. Basing our study on four widely differing islands in terms of their biogeography and ecological characteristics, sampled at different spatial and temporal intervals, we analyzed the nitrogen isotopic values of the main terrestrial ecosystem compartments (vascular plants, arthropods, lizards and rodents) and their relationship to seabird values. For each island, the isotopic values of the ecosystem were driven by those of seabirds, which ultimately corresponded to changes in their marine prey. First, terrestrial compartments sampled within seabird colonies were the most enriched in δ15N compared with those collected at various distances outside colonies. Second, isotopic values of the whole terrestrial ecosystems changed over time, reflecting the values of seabirds and their prey, showing a fast turnover throughout the ecosystems. Our results demonstrate that seabird-derived nutrients not only spread across the terrestrial ecosystems and trophic webs, but also modulate their isotopic values locally and temporally on these islands. The wealth of experimental possibilities in insular ecosystems justifies greater use of these model systems to further our understanding of the modalities of trans-boundary nutrient transfers
Regulated Expression of ADAMTS-12 in Human Trophoblastic Cells: A Role for ADAMTS-12 in Epithelial Cell Invasion?
Metastatic carcinoma cells exploit the same molecular machinery that allows human placental cytotrophoblasts to develop an invasive phenotype. As altered expression levels of ADAMTS (A Disintegrin And Metalloproteinase with ThromboSpondin repeats) subtypes have been associated with cancer progression, we have examined the function and regulation of members of this gene family in epithelial cell invasion using cultures of highly invasive extravillous cytotrophoblasts and the poorly invasive JEG-3 cytotrophoblast cell line as model systems. Of the multiple ADAMTS subtypes identified in first trimester human placenta and these two trophoblastic cell types, only ADAMTS-12 was preferentially expressed by extravillous cytotrophoblasts. Transforming growth factor-β1 and interleukin-1β, two cytokines that promote and restrain cytotrophoblast invasion in vitro, were also found to differentially regulate trophoblastic ADAMTS-12 mRNA levels. Loss- or gain-of-function studies confirmed that ADAMTS-12, independent of its proteolytic activity, plays a specific, non-redundant role in trophoblast invasion. Furthermore, we demonstrated that ADAMTS-12 regulated cell-extracellular matrix adhesion and invasion through a mechanism involving the αvβ3 integrin heterodimer. This study identifies a novel biological role for ADAMTS-12, and highlights the importance and complexity of its non-proteolytic domain(s) pertaining to its function
TrkA is amplified in malignant melanoma patients and induces an anti-proliferative response in cell lines
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