665 research outputs found
Reinforcement determines the timing dependence of corticostriatal synaptic plasticity in vivo
Plasticity at synapses between the cortex and striatum is considered critical for learning novel actions. However, investigations of spike-timing-dependent plasticity (STDP) at these synapses have been performed largely in brain slice preparations, without consideration of physiological reinforcement signals. This has led to conflicting findings, and hampered the ability to relate neural plasticity to behavior. Using intracellular striatal recordings in intact rats, we show here that pairing presynaptic and postsynaptic activity induces robust Hebbian bidirectional plasticity, dependent on dopamine and adenosine signaling. Such plasticity, however, requires the arrival of a reward-conditioned sensory reinforcement signal within 2 s of the STDP pairing, thus revealing a timing-dependent eligibility trace on which reinforcement operates. These observations are validated with both computational modeling and behavioral testing. Our results indicate that Hebbian corticostriatal plasticity can be induced by classical reinforcement learning mechanisms, and might be central to the acquisition of novel actions
The Local Bubble and Interstellar Material Near the Sun
The properties of interstellar matter (ISM) at the Sun are regulated by our
location with respect to the Local Bubble (LB) void in the ISM. The LB is
bounded by associations of massive stars and fossil supernovae that have
disrupted natal ISM and driven intermediate velocity ISM into the LB interior
void. The Sun is located in such a driven ISM parcel. The Local Fluff has a
bulk velocity of 19 km/s in the LSR, and an upwind direction towards the center
of the gas and dust ring formed by the Loop I supernova remnant interaction
with the LB. When the ram pressure of the LIC is included in the total LIC
pressure, and if magnetic thermal and cosmic ray pressures are similar, the LIC
appears to be in pressure equilibrium with the local hot bubble plasma.Comment: Proceedings of Symposium on the Composition of Matter, honoring
Johannes Geiss on the occasion of his 80th birthday. Space Science Reviews
(in press
Pulsar Timing and its Application for Navigation and Gravitational Wave Detection
Pulsars are natural cosmic clocks. On long timescales they rival the
precision of terrestrial atomic clocks. Using a technique called pulsar timing,
the exact measurement of pulse arrival times allows a number of applications,
ranging from testing theories of gravity to detecting gravitational waves. Also
an external reference system suitable for autonomous space navigation can be
defined by pulsars, using them as natural navigation beacons, not unlike the
use of GPS satellites for navigation on Earth. By comparing pulse arrival times
measured on-board a spacecraft with predicted pulse arrivals at a reference
location (e.g. the solar system barycenter), the spacecraft position can be
determined autonomously and with high accuracy everywhere in the solar system
and beyond. We describe the unique properties of pulsars that suggest that such
a navigation system will certainly have its application in future astronautics.
We also describe the on-going experiments to use the clock-like nature of
pulsars to "construct" a galactic-sized gravitational wave detector for
low-frequency (f_GW ~1E-9 - 1E-7 Hz) gravitational waves. We present the
current status and provide an outlook for the future.Comment: 30 pages, 9 figures. To appear in Vol 63: High Performance Clocks,
Springer Space Science Review
Ground state properties of a Tonks-Girardeau Gas in a periodic potential
In this paper, we investigate the ground-state properties of a bosonic
Tonks-Girardeau gas confined in a one-dimensional periodic potential. The
single-particle reduced density matrix is computed numerically for systems up
to bosons. Scaling analysis of the occupation number of the lowest
orbital shows that there are no Bose-Einstein Condensation(BEC) for the
periodically trapped TG gas in both commensurate and incommensurate cases. We
find that, in the commensurate case, the scaling exponents of the occupation
number of the lowest orbital, the amplitude of the lowest orbital and the
zero-momentum peak height with the particle numbers are 0, -0.5 and 1,
respectively, while in the incommensurate case, they are 0.5, -0.5 and 1.5,
respectively. These exponents are related to each other in a universal
relation.Comment: 9 pages, 10 figure
Mutations in MAP3K7 that Alter the Activity of the TAK1 Signaling Complex Cause Frontometaphyseal Dysplasia.
Frontometaphyseal dysplasia (FMD) is a progressive sclerosing skeletal dysplasia affecting the long bones and skull. The cause of FMD in some individuals is gain-of-function mutations in FLNA, although how these mutations result in a hyperostotic phenotype remains unknown. Approximately one half of individuals with FMD have no identified mutation in FLNA and are phenotypically very similar to individuals with FLNA mutations, except for an increased tendency to form keloid scars. Using whole-exome sequencing and targeted Sanger sequencing in 19 FMD-affected individuals with no identifiable FLNA mutation, we identified mutations in two genes-MAP3K7, encoding transforming growth factor β (TGF-β)-activated kinase (TAK1), and TAB2, encoding TAK1-associated binding protein 2 (TAB2). Four mutations were found in MAP3K7, including one highly recurrent (n = 15) de novo mutation (c.1454C>T [ p.Pro485Leu]) proximal to the coiled-coil domain of TAK1 and three missense mutations affecting the kinase domain (c.208G>C [p.Glu70Gln], c.299T>A [p.Val100Glu], and c.502G>C [p.Gly168Arg]). Notably, the subjects with the latter three mutations had a milder FMD phenotype. An additional de novo mutation was found in TAB2 (c.1705G>A, p.Glu569Lys). The recurrent mutation does not destabilize TAK1, or impair its ability to homodimerize or bind TAB2, but it does increase TAK1 autophosphorylation and alter the activity of more than one signaling pathway regulated by the TAK1 kinase complex. These findings show that dysregulation of the TAK1 complex produces a close phenocopy of FMD caused by FLNA mutations. Furthermore, they suggest that the pathogenesis of some of the filaminopathies caused by FLNA mutations might be mediated by misregulation of signaling coordinated through the TAK1 signaling complex
Measurement of (anti)deuteron and (anti)proton production in DIS at HERA
The first observation of (anti)deuterons in deep inelastic scattering at HERA
has been made with the ZEUS detector at a centre-of-mass energy of 300--318 GeV
using an integrated luminosity of 120 pb-1. The measurement was performed in
the central rapidity region for transverse momentum per unit of mass in the
range 0.3<p_T/M<0.7. The particle rates have been extracted and interpreted in
terms of the coalescence model. The (anti)deuteron production yield is smaller
than the (anti)proton yield by approximately three orders of magnitude,
consistent with the world measurements.Comment: 26 pages, 9 figures, 5 tables, submitted to Nucl. Phys.
Measurement of the B0-anti-B0-Oscillation Frequency with Inclusive Dilepton Events
The - oscillation frequency has been measured with a sample of
23 million \B\bar B pairs collected with the BABAR detector at the PEP-II
asymmetric B Factory at SLAC. In this sample, we select events in which both B
mesons decay semileptonically and use the charge of the leptons to identify the
flavor of each B meson. A simultaneous fit to the decay time difference
distributions for opposite- and same-sign dilepton events gives ps.Comment: 7 pages, 1 figure, submitted to Physical Review Letter
Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector
A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results
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