JAVATRACEIT!: software didáctico de apoyo a la docencia en Java

El objetivo de este trabajo es dar a conocer una nueva herramienta didáctica de apoyo a la docencia en asignaturas con contenidos curriculares que incluyan Java como lenguaje de programación. En concreto, JAVATRACEIT! proporciona un entorno integrado de desarrollo adaptado a Java, que permite la compilación y el análisis de código ejecutable gracias a la implementación de un sencillo depurador y optimizador, que permiten al alumno conocer el estado de un programa en todo momento

AIBench: framework de programación para la enseñanza de técnicas de IA en tercer ciclo

En este trabajo se presenta AIBench, un framework que agiliza la codificación, ejecución, prueba y optimización de técnicas de Inteligencia Artificial (IA). AIBench está pensado para su utilización por parte de alumnos de tercer ciclo, involucrados en programas de doctorado donde se imparten materias que implican la comprensión e implementación de distintas técnicas de IA. La finalidad del framework desarrollado es liberar al alumno de las labores de programación repetitivas y propensas a errores que están relacionadas, entre otras, con la entrada de datos, diálogos de configuración de parámetros o presentación de resultados, permitiéndole centrarse únicamente en los algoritmos objeto de estudio

Proxectos de deseño e desenvolvemento de elementos medioambientalmente sostibles: deseñando con responsabilidade medioambiental

Banco de experiencias de Aprendizaxe Servizo. Convocatoria 2020/202

Stroma-Mediated Resistance to S63845 and Venetoclax through MCL-1 and BCL-2 Expression Changes Induced by miR-193b-3p and miR-21-5p Dysregulation in Multiple Myeloma.

BH3-mimetics targeting anti-apoptotic proteins such as MCL-1 (S63845) or BCL-2 (venetoclax) are currently being evaluated as effective therapies for the treatment of multiple myeloma (MM). Interleukin 6, produced by mesenchymal stromal cells (MSCs), has been shown to modify the expression of anti-apoptotic proteins and their interaction with the pro-apoptotic BIM protein in MM cells. In this study, we assess the efficacy of S63845 and venetoclax in MM cells in direct co-culture with MSCs derived from MM patients (pMSCs) to identify additional mechanisms involved in the stroma-induced resistance to these agents. MicroRNAs miR-193b-3p and miR-21-5p emerged among the top deregulated miRNAs in myeloma cells when directly co-cultured with pMSCs, and we show their contribution to changes in MCL-1 and BCL-2 protein expression and in the activity of S63845 and venetoclax. Additionally, direct contact with pMSCs under S63845 and/or venetoclax treatment modifies myeloma cell dependence on different BCL-2 family anti-apoptotic proteins in relation to BIM, making myeloma cells more dependent on the non-targeted anti-apoptotic protein or BCL-XL. Finally, we show a potent effect of the combination of S63845 and venetoclax even in the presence of pMSCs, which supports this combinatorial approach for the treatment of MM

Divulgación en tiempos de pandemia: el poder de las webs

Trabajo presentado en el simposio Micromundo Aprendizaje-Servicio para el descubrimiento de antibiótico

Systolic blood pressure and the risk of kidney replacement therapy and mortality in patients with chronic kidney disease stage 4-5

Introduction In patients with chronic kidney disease stage 4 and 5 (CKD stages 4-5) without dialysis and arterial hypertension, it is unknown if the values of systolic blood pressure (SBP) considered in control <120 mmHg are associated with kidney replacement therapy (KRT) and mortality. Methods In this retrospective cohort study, hypertensive CKD stages 4-5 patients attending the Renal Health Clinic at the Hospital Civil de Guadalajara were enrolled. We divided them into those that achieved SBP 120 mmHg), the uncontrolled group. Our primary objective was to analyze the association between the controlled group and KRT; the secondary objective was the mortality risk, and if there were subgroups of patients that achieved more benefit. Data were analyzed using Stata software, version. 15.1. Results During 2017 to 2022 a total 275 hypertensive CKD stages 4-5 patients met the inclusion criteria for the analysis, 62 in the controlled group and 213 in the uncontrolled group; mean age 61 years, 49.82% were male, SBP was significantly lower in the controlled group (111 mmHg) compared to the uncontrolled group (140 mmHg), eGFR was similar between groups (20.41 ml/min/1.73m2). There was a tendency to increase the mortality risk in the uncontrolled group (HR 6.47 [0.78-53.27]; p= 0.082) and an association by the Kaplan-Meir analysis (Log-rank p= 0.043). The subgroup analysis for risk of KRT in the controlled group revealed that patients ≥ 61 years had a lower risk of KRT (HR 0.87 [95% CI, 0-76-0.99]; p=0.03, p of interaction = 0.005), but no differences were found in the subgroup analysis for mortality. In a follow-up of 1.34 years, no association was found in the risk of KRT according to the controlled or uncontrolled groups in a multivariate Cox analysis. Conclusion In a retrospective cohort of patients with CKD stages 4-5 and hypertension, SBP >120 mmHg was not associated with risk of KRT but could be associated with the risk of death. Clinical trials are required in this group of patients to demonstrate the impact of reaching the SBP goals recommended by the KDIGO guidelines

Natural History of MYH7-Related Dilated Cardiomyopathy

BACKGROUND Variants in myosin heavy chain 7 (MYH7) are responsible for disease in 1% to 5% of patients with dilated cardiomyopathy (DCM); however, the clinical characteristics and natural history of MYH7-related DCM are poorly described. OBJECTIVES We sought to determine the phenotype and prognosis of MYH7-related DCM. We also evaluated the influence of variant location on phenotypic expression. METHODS We studied clinical data from 147 individuals with DCM-causing MYH7 variants (47.6% female; 35.6 +/- 19.2 years) recruited from 29 international centers. RESULTS At initial evaluation, 106 (72.1%) patients had DCM (left ventricular ejection fraction: 34.5% +/- 11.7%). Median follow-up was 4.5 years (IQR: 1.7-8.0 years), and 23.7% of carriers who were initially phenotype-negative developed DCM. Phenotypic expression by 40 and 60 years was 46% and 88%, respectively, with 18 patients (16%) first diagnosed at <18 years of age. Thirty-six percent of patients with DCM met imaging criteria for LV noncompaction. During follow-up, 28% showed left ventricular reverse remodeling. Incidence of adverse cardiac events among patients with DCM at 5 years was 11.6%, with 5 (4.6%) deaths caused by end-stage heart failure (ESHF) and 5 patients (4.6%) requiring heart transplantation. The major ventricular arrhythmia rate was low (1.0% and 2.1% at 5 years in patients with DCM and in those with LVEF of <= 35%, respectively). ESHF and major ventricular arrhythmia were significantly lower compared with LMNA-related DCM and similar to DCM caused by TTN truncating variants. CONCLUSIONS MYH7-related DCM is characterized by early age of onset, high phenotypic expression, low left ventricular reverse remodeling, and frequent progression to ESHF. Heart failure complications predominate over ventricular arrhythmias, which are rare. (C) 2022 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation

Healthcare workers hospitalized due to COVID-19 have no higher risk of death than general population. Data from the Spanish SEMI-COVID-19 Registry

Aim To determine whether healthcare workers (HCW) hospitalized in Spain due to COVID-19 have a worse prognosis than non-healthcare workers (NHCW). Methods Observational cohort study based on the SEMI-COVID-19 Registry, a nationwide registry that collects sociodemographic, clinical, laboratory, and treatment data on patients hospitalised with COVID-19 in Spain. Patients aged 20-65 years were selected. A multivariate logistic regression model was performed to identify factors associated with mortality. Results As of 22 May 2020, 4393 patients were included, of whom 419 (9.5%) were HCW. Median (interquartile range) age of HCW was 52 (15) years and 62.4% were women. Prevalence of comorbidities and severe radiological findings upon admission were less frequent in HCW. There were no difference in need of respiratory support and admission to intensive care unit, but occurrence of sepsis and in-hospital mortality was lower in HCW (1.7% vs. 3.9%; p = 0.024 and 0.7% vs. 4.8%; p<0.001 respectively). Age, male sex and comorbidity, were independently associated with higher in-hospital mortality and healthcare working with lower mortality (OR 0.211, 95%CI 0.067-0.667, p = 0.008). 30-days survival was higher in HCW (0.968 vs. 0.851 p<0.001). Conclusions Hospitalized COVID-19 HCW had fewer comorbidities and a better prognosis than NHCW. Our results suggest that professional exposure to COVID-19 in HCW does not carry more clinical severity nor mortality

Post-Franco Theatre

In the multiple realms and layers that comprise the contemporary Spanish theatrical landscape, “crisis” would seem to be the word that most often lingers in the air, as though it were a common mantra, ready to roll off the tongue of so many theatre professionals with such enormous ease, and even enthusiasm, that one is prompted to wonder whether it might indeed be a miracle that the contemporary technological revolution – coupled with perpetual quandaries concerning public and private funding for the arts – had not by now brought an end to the evolution of the oldest of live arts, or, at the very least, an end to drama as we know it

Temas Socio-Jurídicos. Volumen 18 No. 39 Diciembre 2000

En la presente edición, la número 39 de la Revista Temas Socio-Jurídicos, colocamos a disposición de nuestros lectores los ensayos elaborados por los profesores y estudiantes de la Facultad de Derecho de la Universidad Autónoma de Bucaramanga, durante el segundo semestre del presente año 2000. La crisis institucional de la nación inquieta de especial manera a la comunidad académica que se expresa en propuestas, análisis o a veces con simples manifestaciones de perplejidad, que son las que se postulan por los distintos voceros de esta, nuestra escuela jurídica, que este medio escrito las acoge, recopila y divulga para incentivar el debate. Reiteramos la convocatoria a los profesores, estudiantes y egresados a vincularse con sus escritos al desarrollo y proyección de este instrumento de comunicación entre la academia y la comunidad, que sin reticencias ni reparos censurantes deja al criterio del lector el lacerante estímulo de la crítica, en procura de generar a través de la controversia dialéctica un ámbito propicio para el desarrollo intelectual de quienes despliegan el placer de escribir.In this edition, number 39 of the Socio-Legal Issues Magazine, we place at the disposal of our readers the essays prepared by the professors and students of the Faculty of Law of the Autonomous University of Bucaramanga, during the second semester of the current year 2000 The institutional crisis of the nation is particularly worrying way to the academic community that expresses itself in proposals, analyzes or sometimes with simple expressions of perplexity, which are the ones that are postulated by the different spokesmen of this, our legal school, that this written medium welcomes, compiles and disseminates to encourage the debate. We reiterate the call to professors, students and graduates to link with their writings to the development and projection of this instrument of communication between the academy and the community, which without reluctance or censorious objections leaves to the reader's discretion the lacerating stimulus of criticism, in seeks to generate through dialectical controversy a favorable environment for the intellectual development of those who display the pleasure of writing