Reply to ``Comment on ``Lateral Casimir Force beyond the Proximity Force Approximation'' ''

We reply to the comment arXiv:quant-ph/0702060 on our letter arXiv:quant-ph/0603120 [Phys. Rev. Lett. 96, 100402 (2006)]Comment: 1 pag

Lateral Casimir force beyond the Proximity Force Approximation

We argue that the appropriate variable to study a non trivial geometry dependence of the Casimir force is the lateral component of the Casimir force, which we evaluate between two corrugated metallic plates outside the validity of the Proximity Force Approximation (PFA). The metallic plates are described by the plasma model, with arbitrary values for the plasma wavelength, the plate separation and the corrugation period, the corrugation amplitude remaining the smallest length scale. Our analysis shows that in realistic experimental situations the Proximity Force Approximation overestimates the force by up to 30%.Comment: 4 pages. Identical to v1, which was accidentally replaced by a different paper (quant-ph/0610026

Casimir torque between corrugated metallic plates

We consider two parallel corrugated plates and show that a Casimir torque arises when the corrugation directions are not aligned. We follow the scattering approach and calculate the Casimir energy up to second order in the corrugation amplitudes, taking into account nonspecular reflections, polarization mixing and the finite conductivity of the metals. We compare our results with the proximity force approximation, which overestimates the torque by a factor 2 when taking the conditions that optimize the effect. We argue that the Casimir torque could be measured for separation distances as large as 1 $\mu{\rm m}.$Comment: 7 pages, 3 figures, contribution to QFEXT07 proceeding

ACE2 a double-edged sword?

Angiotensin-converting enzyme 2 (ACE2) is the binding protein/receptor used by the new SARS-CoV-2, which causes 2019 coronavirus disease (COVID-19), to enter host cells [1,2]. In 2003, Li and colleagues [3] at the Harvard Medical School, USA had previously described that a protein (spike proteins - S1 domain) da família do coronavirus binds efficiently to ACE2 [3,4]. From binding to ACE2, the virus envelope fuses into the host cell membrane allowing its genetic material entering the cell and replicate, triggering severe respiratory disease, including acute respiratory distress syndrome (ARDS), a devastating lung disease with high mortality rates (3060%).Sociedad Argentina de Fisiologí

Redução do uso da Cannabis Sativa nas pessoas com deficiência motora em treino de basquete em cadeiras de rodas: ensaio clinico randomizado

Introdução: as pessoas com deficiências têm anormalidade de estrutura ou função anatômica, fisiológica ou psicológica. Sendo que nas lesões crônicas e deficiências permanentes aumenta as taxas de prevalência de alterações mentais ou comportamentais. O uso de cannabis sativa nos esportes tornou-se questão polêmica proeminente e debatida pelas autoridades governamentais e por movimentos esportivos que lutam contra o doping no esporte. Objetivos: analisar o uso de Cannabis Sativa  e aspectos saúde no Treino de Basquete em Cadeiras de Rodas (BCR) das Pessoas com Deficiência Motora (PCD-M). Métodos: estudo experimental tipo ensaio clínico randomizado. A amostra foi triada da população do sexo masculino PCD-M, em  idade igual e superior a 18 anos até 55 anos, residentes na Baixada Cuiabana-MT, Brasil, sendo  recrutadas por sorteio (n=100), e randomizadas para avaliação (n=48), alocados em dois braços sendo experimental (GE n=21) e controle (GC n=27).  A coleta foi realizada por entrevista estruturada e avaliação clínica incluindo os aspectos sociodemográficos, hábitos de estilo de vida, autorrelatos de álcool e drogas. O treino de basquete foi feito duas vezes da semana às 2º e 4º feiras das 19h as 21h com @ 2 horas de tempo de duração. Para análise de dados foi utilizada a teste quiquadrado e cálculo estimativo do efeito da intervenção, com significância em p<0.05 e 95% de intervalo e confiança. Resultados: A idade média foi de 35 (±8,8) anos.  O tempo de prevalência das deficiências por etiologia Poliomielite foram superiores a 20 anos.  Foram encontrados eventos de aspecto mental e comportamental com uso (Cannabis sativa, 25%); alterações no aspecto físico (úlcera de pressão=21%, infecção de urina=40%); previdência social pública (zero auxílio percapita, 10%). Houve  melhora e o Número Necessário para Tratamento com Ulcera Pressão (NTT 3,0 e p=0.03); e redução de usuários de Cannabis Sativa (NNT= 5,50 e p=0.02) neste ensaio clínico. Conclusão:  houve melhora dos aspectos da clínica pós intervenção no GE denotando redução do uso de Cannabis Sativa melhora da condição de saúde na PCD-M. Então, as técnicas de preleção com motivação de equipe, dinâmicas de grupo, a compreensão das regras antidoping nos campeonato de BCR corroborou no equilíbrio do comportamento mental reduzindo consumo de Cannabis Sativa. Assim programas de esportes coletivos para PCD-M podem contribuir no tratamento redução de consumo de Cannabis Sativa e ser estratégia de equilíbrio comportamental e de ressignificação da vida

Angiotensin-(1-7): an anti-inflammatory and pro-resolutive peptide

In recent decades the renin-angiotensin system has been established itself as a complex regulatory mechanism composed of different pathways involved in the control of physiological functions and, when for long term inappropriately activated, it is involved in the pathophysiology of different diseases. Among its biologically active peptides, angiotensin-(1-7) and its receptor Mas, represent an important counter-regulatory mechanism due to their antihypertensive, anti-inflammatory, anti-proliferative and antifibrotic effects. In this review, we present data that besides demonstrating the antiinflammatory effect, indicate that angiotensin-(1-7) has a crucial additional effect on the return to tissue homeostasis, that is to promote resolution of the inflammatory process. These studies point angiotensin-(1-7) or activation of Mas receptor as important therapeutic targets for the treatment of inflammatory diseases.En las últimas décadas, el sistema renina-angiotensina se ha establecido como un mecanismo regulador complejo compuesto de diferentes vías involucradas no solo en el control de funciones fisiológicas sino también en la fisiopatología de diferentes enfermedades cuando se activa de manera inapropiada y a largo plazo. Entre sus péptidos biológicamente activos, la angiotensina-(1-7) y su receptor Mas representan un mecanismo contrarregulador importante debido a efectos antihipertensivos, antiinflamatorios, antiproliferativos y antifibróticos. En esta revisión presentamos datos que, además de demostrar el efecto antiinflamatorio, indican que la angiotensina-(1-7) tiene un efecto adicional crucial en el retorno a la homeostasis del tejido, que es promover la resolución del proceso inflamatorio. Estos estudios apuntan a la angiotensina-(1-7) y/o la activación del receptor Mas, como importantes blancos terapéuticos para el tratamiento de enfermedades inflamatorias.Sociedad Argentina de Fisiologí

Measurement of the cross-section and charge asymmetry of WW bosons produced in proton-proton collisions at s=8\sqrt{s}=8 TeV with the ATLAS detector

This paper presents measurements of the $W^+ \rightarrow \mu^+\nu$ and $W^- \rightarrow \mu^-\nu$ cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables, submitted to EPJC. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13

Search for chargino-neutralino production with mass splittings near the electroweak scale in three-lepton final states in √s=13 TeV pp collisions with the ATLAS detector

A search for supersymmetry through the pair production of electroweakinos with mass splittings near the electroweak scale and decaying via on-shell W and Z bosons is presented for a three-lepton final state. The analyzed proton-proton collision data taken at a center-of-mass energy of √s=13  TeV were collected between 2015 and 2018 by the ATLAS experiment at the Large Hadron Collider, corresponding to an integrated luminosity of 139  fb−1. A search, emulating the recursive jigsaw reconstruction technique with easily reproducible laboratory-frame variables, is performed. The two excesses observed in the 2015–2016 data recursive jigsaw analysis in the low-mass three-lepton phase space are reproduced. Results with the full data set are in agreement with the Standard Model expectations. They are interpreted to set exclusion limits at the 95% confidence level on simplified models of chargino-neutralino pair production for masses up to 345 GeV

Search for squarks and gluinos in events with isolated leptons, jets and missing transverse momentum at s√=8 TeV with the ATLAS detector

The results of a search for supersymmetry in final states containing at least one isolated lepton (electron or muon), jets and large missing transverse momentum with the ATLAS detector at the Large Hadron Collider are reported. The search is based on proton-proton collision data at a centre-of-mass energy s√=8 TeV collected in 2012, corresponding to an integrated luminosity of 20 fb−1. No significant excess above the Standard Model expectation is observed. Limits are set on supersymmetric particle masses for various supersymmetric models. Depending on the model, the search excludes gluino masses up to 1.32 TeV and squark masses up to 840 GeV. Limits are also set on the parameters of a minimal universal extra dimension model, excluding a compactification radius of 1/R c = 950 GeV for a cut-off scale times radius (ΛR c) of approximately 30