Constraints on the Galactic bar from the Hercules stream as traced with RAVE across the Galaxy

Non-axisymmetries in the Galactic potential (spiral arms and bar) induce kinematic groups such as the Hercules stream. Assuming that Hercules is caused by the effects of the outer Lindblad resonance of the Galactic bar, we model analytically its properties as a function of position in the Galaxy and its dependence on the bar's pattern speed and orientation. Using data from the RAVE survey we find that the azimuthal velocity of the Hercules structure decreases as a function of Galactocentric radius, in a manner consistent with our analytical model. This allows us to obtain new estimates of the parameters of the Milky Way's bar. The combined likelihood function of the bar's pattern speed and angle has its maximum for a pattern speed of Omega(b) = (1.89 +/- 0.08) x Omega(0), where Omega(0) is the local circular frequency. Assuming a solar radius of 8.05 kpc and a local circular velocity of 238 km s(-1), this corresponds to Omega(b) = 56 +/- 2km s(-1) kpc(-1). On the other hand, the bar's orientation phi(b) cannot be constrained with the available data. In fact, the likelihood function shows that a tight correlation exists between the pattern speed and the orientation, implying that a better description of our best fit results is given by the linear relation Omega(b)/Omega(0) = 1.91+0.0044 (phi(b)(deg) - 48), with standard deviation of 0.02. For example, for an angle of phi(b) = 30 deg the pattern speed is 54.0 +/- 0.5 km s(-1) kpc(-1). These results are not very sensitive to the other Galactic parameters such as the circular velocity curve or the peculiar motion of the Sun, and are robust to biases in distance

Thick disk kinematics from RAVE and the solar motion

Radial velocity surveys such as the Radial Velocity Experiment (RAVE) provide us with measurements of hundreds of thousands of nearby stars most of which belong to the Galactic thin, thick disk or halo. Ideally, to study the Galactic disks (both thin and thick) one should make use of the multi-dimensional phase-space and the whole pattern of chemical abundances of their stellar populations. In this paper, with the aid of the RAVE Survey, we study the thin and thick disks of the Milky Way, focusing on the latter. We present a technique to disentangle the stellar content of the two disks based on the kinematics and other stellar parameters such as the surface gravity of the stars. Using the Padova Galaxy Model, we checked the ability of our method to correctly isolate the thick disk component from the Galaxy mixture of stellar populations. We introduce selection criteria in order to clean the observed radial velocities from the Galactic differential rotation and to take into account the partial sky coverage of RAVE. We developed a numerical technique to statistically disentangle thin and thick disks from their mixture. We deduce the components of the solar motion relative to the Local Standard of Rest (LSR) in the radial and vertical direction, the rotational lag of the thick disk component relative to the LSR, and the square root of the absolute value of the velocity dispersion tensor for the thick disk alone. The analysis of the thin disk is presented in another paper. We find good agreement with previous independent parameter determinations. In our analysis we used photometrically determined distances. In the Appendix we show that similar values can be found for the thick disk alone as derived in the main sections of our paper even without the knowledge of photometric distances.Comment: accepted on A&A, please see companion paper "THIN disk kinem...

Chemical gradients in the Milky Way from the RAVE data

Aims. We aim at measuring the chemical gradients of the elements Mg, Al, Si, and Fe along the Galactic radius to provide new constraints on the chemical evolution models of the Galaxy and Galaxy models such as the Besancon model. Thanks to the large number of stars of our RAVE sample we can study how the gradients vary as function of the distance from the Galactic plane. Methods. We analysed three different samples selected from three independent datasets: a sample of 19 962 dwarf stars selected from the RAVE database, a sample of 10 616 dwarf stars selected from the Geneva-Copenhagen Survey (GCS) dataset, and a mock sample (equivalent to the RAVE sample) created by using the GALAXIA code, which is based on the Besancon model. The three samples were analysed by using the very same method for comparison purposes. We integrated the Galactic orbits and obtained the guiding radii (R-g) and the maximum distances from the Galactic plane reached by the stars along their orbits (Z(max)). We measured the chemical gradients as functions of R-g at different Z(max). Results. We found that the chemical gradients of the RAVE and GCS samples are negative and show consistent trends, although they are not equal: at Z(max) < 0.4 kpc and 4.5 < R-g(kpc) < 9.5, the iron gradient for the RAVE sample is d[Fe/H]/dR(g) = -0.065 dex kpc(-1), whereas for the GCS sample it is d[Fe/H]/dR(g) = -0.043 dex kpc(-1) with internal errors of +/-0.002 and +/-0.004 dex kpc(-1), respectively. The gradients of the RAVE and GCS samples become flatter at larger Z(max). Conversely, the mock sample has a positive iron gradient of d[Fe/H]/dR(g) = +0.053 +/- 0.003 dex kpc(-1) at Z(max) < 0.4 kpc and remains positive at any Z(max). These positive and unrealistic values originate from the lack of correlation between metallicity and tangential velocity in the Besancon model. In addition, the low metallicity and asymmetric drift of the thick disc causes a shift of the stars towards lower R-g and metallicity which, together with the thin-disc stars with a higher metallicity and R-g, generates a fictitious positive gradient of the full sample. The flatter gradient at larger Z(max) found in the RAVE and the GCS samples may therefore be due to the superposition of thin-and thick-disc stars, which mimicks a flatter or positive gradient. This does not exclude the possibility that the thick disc has no chemical gradient. The discrepancies between the observational samples and the mock sample can be reduced by i) decreasing the density; ii) decreasing the vertical velocity; and iii) increasing the metallicity of the thick disc in the Besancon model

Measurement of the cross-section and charge asymmetry of WW bosons produced in proton-proton collisions at s=8\sqrt{s}=8 TeV with the ATLAS detector

This paper presents measurements of the $W^+ \rightarrow \mu^+\nu$ and $W^- \rightarrow \mu^-\nu$ cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables, submitted to EPJC. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13

Search for chargino-neutralino production with mass splittings near the electroweak scale in three-lepton final states in √s=13 TeV pp collisions with the ATLAS detector

A search for supersymmetry through the pair production of electroweakinos with mass splittings near the electroweak scale and decaying via on-shell W and Z bosons is presented for a three-lepton final state. The analyzed proton-proton collision data taken at a center-of-mass energy of √s=13  TeV were collected between 2015 and 2018 by the ATLAS experiment at the Large Hadron Collider, corresponding to an integrated luminosity of 139  fb−1. A search, emulating the recursive jigsaw reconstruction technique with easily reproducible laboratory-frame variables, is performed. The two excesses observed in the 2015–2016 data recursive jigsaw analysis in the low-mass three-lepton phase space are reproduced. Results with the full data set are in agreement with the Standard Model expectations. They are interpreted to set exclusion limits at the 95% confidence level on simplified models of chargino-neutralino pair production for masses up to 345 GeV

A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism

Obesity and type 2 diabetes mellitus are global emergencies and long noncoding RNAs (lncRNAs) are regulatory transcripts with elusive functions in metabolism. Here we show that a high fraction of lncRNAs, but not protein-coding mRNAs, are repressed during diet-induced obesity (DIO) and refeeding, whilst nutrient deprivation induced lncRNAs in mouse liver. Similarly, lncRNAs are lost in diabetic humans. LncRNA promoter analyses, global cistrome and gain-of-function analyses confirm that increased MAFG signaling during DIO curbs lncRNA expression. Silencing Mafg in mouse hepatocytes and obese mice elicits a fasting-like gene expression profile, improves glucose metabolism, de-represses lncRNAs and impairs mammalian target of rapamycin (mTOR) activation. We find that obesity-repressed LincIRS2 is controlled by MAFG and observe that genetic and RNAi-mediated LincIRS2 loss causes elevated blood glucose, insulin resistance and aberrant glucose output in lean mice. Taken together, we identify a MAFG-lncRNA axis controlling hepatic glucose metabolism in health and metabolic disease

Direct Observation of Single Amyloid-β(1-40) Oligomers on Live Cells: Binding and Growth at Physiological Concentrations

Understanding how amyloid-β peptide interacts with living cells on a molecular level is critical to development of targeted treatments for Alzheimer's disease. Evidence that oligomeric Aβ interacts with neuronal cell membranes has been provided, but the mechanism by which membrane binding occurs and the exact stoichiometry of the neurotoxic aggregates remain elusive. Physiologically relevant experimentation is hindered by the high Aβ concentrations required for most biochemical analyses, the metastable nature of Aβ aggregates, and the complex variety of Aβ species present under physiological conditions. Here we use single molecule microscopy to overcome these challenges, presenting direct optical evidence that small Aβ(1-40) oligomers bind to living neuroblastoma cells at physiological Aβ concentrations. Single particle fluorescence intensity measurements indicate that cell-bound Aβ species range in size from monomers to hexamers and greater, with the majority of bound oligomers falling in the dimer-to-tetramer range. Furthermore, while low-molecular weight oligomeric species do form in solution, the membrane-bound oligomer size distribution is shifted towards larger aggregates, indicating either that bound Aβ oligomers can rapidly increase in size or that these oligomers cluster at specific sites on the membrane. Calcium indicator studies demonstrate that small oligomer binding at physiological concentrations induces only mild, sporadic calcium leakage. These findings support the hypothesis that small oligomers are the primary Aβ species that interact with neurons at physiological concentrations

A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism

Obesity and type 2 diabetes mellitus are global emergencies and long noncoding RNAs (lncRNAs) are regulatory transcripts with elusive functions in metabolism. Here we show that a high fraction of lncRNAs, but not protein-coding mRNAs, are repressed during diet-induced obesity (DIO) and refeeding, whilst nutrient deprivation induced lncRNAs in mouse liver. Similarly, lncRNAs are lost in diabetic humans. LncRNA promoter analyses, global cistrome and gain-of-function analyses confirm that increased MAFG signaling during DIO curbs lncRNA expression. Silencing Mafg in mouse hepatocytes and obese mice elicits a fasting-like gene expression profile, improves glucose metabolism, de-represses lncRNAs and impairs mammalian target of rapamycin (mTOR) activation. We find that obesity-repressed LincIRS2 is controlled by MAFG and observe that genetic and RNAi-mediated LincIRS2 loss causes elevated blood glucose, insulin resistance and aberrant glucose output in lean mice. Taken together, we identify a MAFG-lncRNA axis controlling hepatic glucose metabolism in health and metabolic disease

Search for direct stau production in events with two hadronic tau-leptons in root s=13 TeV pp collisions with the ATLAS detector

A search for the direct production of the supersymmetric partners ofτ-leptons (staus) in final stateswith two hadronically decayingτ-leptons is presented. The analysis uses a dataset of pp collisions corresponding to an integrated luminosity of139fb−1, recorded with the ATLAS detector at the LargeHadron Collider at a center-of-mass energy of 13 TeV. No significant deviation from the expected StandardModel background is observed. Limits are derived in scenarios of direct production of stau pairs with eachstau decaying into the stable lightest neutralino and oneτ-lepton in simplified models where the two staumass eigenstates are degenerate. Stau masses from 120 GeV to 390 GeV are excluded at 95% confidencelevel for a massless lightest neutralino