426 research outputs found

    AN ANALYSIS OF USMC SERVICE CONTRACTS UNDER THE SIMPLIFIED ACQUISITION THRESHOLD, AND THE EFFECTS CAUSED BY CONTINUING RESOLUTIONS

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    Daily operations within the United States Marine Corps (USMC) are reliant upon the effective and uninterrupted operations of services contracts in both garrison and field environments. From fiscal years 2010–2021, the federal government began the fiscal year with a continuing resolution (CR) in 11 out of 12 years. With the consistency of budget uncertainties at the onset of every fiscal year, purchasing and operations are affected resulting in interruptions to services. Additionally, across the Marine Corps, there is no organizational level standard operating procedures (SOP) for budget execution under a CR. Meshing CRs and the lack of standardization across the organization has potential to affect the deliverability of services. Analyzing data received from a Purchase Request Builder across fiscal years with and without CRs can develop a better understanding of what types of services, dollar amounts, and time are affected most by CRs. This project aims to better identify and understand efficiencies that can be implemented to affect services contracting when operating under a CR and provides recommendations that increase effectiveness of using unit and contracting professionals.Captain, United States Marine CorpsCaptain, United States Marine CorpsApproved for public release. Distribution is unlimited

    “Triple Bottom Line” as “Sustainable Corporate Performance”: A Proposition for the Future

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    Based upon a review of corporate performance, corporate financial performance and corporate social performance, we propose that the concept of ―triple bottom line‖ (TBL) as ―sustainable corporate performance‖ (SCP) should consist of three measurement elements, namely: (i) financial, (ii) social and (iii) environmental. TBL as SCP is proposed to be derived from the interface between them. We also propose that the content of each of these measurement elements may vary across contexts and over time. Furthermore, TBL as SCR should be interpreted to be a relative concept that is dynamic and iterative. Continuous monitoring needs to be performed, adapting the content of the measurement elements to changes that evolve across contexts and over time in the marketplace and society. TBL as SCP may be seen as a function of time and context. Keywords: triple bottom line; sustainable corporate performance; corporate social performance; financial performanc

    A decade of radio imaging the relativistic outflow in the peculiar X-ray binary Circinus X-1

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    We present observations of the neutron star X-ray binary and relativistic jet source Circinus X-1 made at 4.8 and 8.6 GHz with the Australia Telescope Compact Array during a time interval of almost 10 years. The system shows significant variations in the morphology and brightness of the radio features on all timescales from days to years. Using the time delay between the successive brightening of the different components of the radio emission we were able to provide further evidence for the relativistic nature of the arcsec scale outflow, with an apparent velocity beta_app >= 12. No compelling evidence for an evolution of the orientation of the jet axis was found. We also place an upper limit on the proper motion of the system which is consistent with previous optical studies. Besides the previously reported radio flares close to the orbital phase 0.0 (interpreted as enhanced accretion at periastron passage), we also identified outbursts with similar properties near the orbital phase 0.5. The global spectral index revealed a preferentially steep spectrum over the entire period of monitoring with a mean value and standard deviation alpha=-0.9 +/- 0.6 (F_nu ~ nu^{alpha}), which became significantly flatter during the outbursts. Polarization was detected in one third of the epochs and in one case Faraday rotation close to the core of the system was measured.Comment: Accepted for publication in MNRA

    Red-flag sepsis and SOFA identifies different patient population at risk of sepsis-related deaths on the general ward

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    Controversy exists regarding the best diagnostic and screening tool for sepsis outside the intensive care unit (ICU). Sequential organ failure assessment (SOFA) score has been shown to be superior to systemic inflammatory response syndrome (SIRS) criteria, however, the performance of “Red Flag sepsis criteria” has not been tested formally. The aim of the study was to investigate the ability of Red Flag sepsis criteria to identify the patients at high risk of sepsis-related death in comparison to SOFA based sepsis criteria. We also investigated the comparison of Red Flag sepsis to quick SOFA (qSOFA), SIRS, and national early warning score (NEWS) scores and factors influencing patient mortality. Patients were recruited into a 24-hour point-prevalence study on the general wards and emergency departments across all Welsh acute hospitals. Inclusion criteria were: clinical suspicion of infection and NEWS 3 or above in-line with established escalation criteria in Wales. Data on Red Flag sepsis and SOFA criteria was collected together with qSOFA and SIRS scores and 90-day mortality. 459 patients were recruited over a 24-hour period. 246 were positive for Red Flag sepsis, mortality 33.7% (83/246); 241 for SOFA based sepsis criteria, mortality 39.4% (95/241); 54 for qSOFA, mortality 57.4% (31/54), and 268 for SIRS, mortality 33.6% (90/268). 55 patients were not picked up by any criteria. We found that older age was associated with death with OR (95% CI) of 1.03 (1.02–1.04); higher frailty score 1.24 (1.11–1.40); DNA-CPR order 1.74 (1.14–2.65); ceiling of care 1.55 (1.02–2.33); and SOFA score of 2 and above 1.69 (1.16–2.47). The different clinical tools captured different subsets of the at-risk population, with similar sensitivity. SOFA score 2 or above was independently associated with increased risk of death at 90 days. The sequalae of infection-related organ dysfunction cannot be reliably captured based on routine clinical and physiological parameters alone

    Sepsis-related deaths in the at-risk population on the wards: attributable fraction of mortality in a large point-prevalence study

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    Objective Sepsis mortality is reported to be high worldwide, however recently the attributable fraction of mortality due to sepsis (AFsepsis) has been questioned. If improvements in treatment options are to be evaluated, it is important to know what proportion of deaths are potentially preventable or modifiable after a sepsis episode. The aim of the study was to establish the fraction of deaths directly related to the sepsis episode on the general wards and emergency departments. Results 839 patients were recruited over the two 24-h periods in 2016 and 2017. 521 patients fulfilled SEPSIS-3 criteria. 166 patients (32.4%) with sepsis and 56 patients (17.6%) without sepsis died within 90 days. Out of the 166 sepsis deaths 12 (7.2%) could have been directly related to sepsis, 28 (16.9%) possibly related and 96 (57.8%) were not related to sepsis. Overall AFsepsis was 24.1%. Upon analysis of the 40 deaths likely to be attributable to sepsis, we found that 31 patients (77.5%) had the Clinical Frailty Score ≄ 6, 28 (70%) had existing DNA-CPR order and 17 had limitations of care orders (42.5%)

    Combined Hybridization Capture and Shotgun Sequencing for Ancient DNA Analysis of Extinct Wild and Domestic Dromedary Camel

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    The performance of hybridization capture combined with next-generation sequencing (NGS) has seen limited investigation with samples from hot and arid regions until now. We applied hybridization capture and shotgun sequencing to recover DNA sequences from bone specimens of ancient-domestic dromedary (Camelus dromedarius) and its extinct ancestor, the wild dromedary from Jordan, Syria, Turkey and the Arabian Peninsula, respectively. Our results show that hybridization capture increased the percentage of mitochondrial DNA (mtDNA) recovery by an average 187-fold and in some cases yielded virtually complete mitochondrial (mt) genomes at multifold coverage in a single capture experiment. Furthermore, we tested the effect of hybridization temperature and time by using a touchdown approach on a limited number of samples. We observed no significant difference in the number of unique dromedary mtDNA reads retrieved with the standard capture compared to the touchdown method. In total, we obtained 14 partial mitochondrial genomes from ancient-domestic dromedaries with 17–95% length coverage and 1.27–47.1-fold read depths for the covered regions. Using whole-genome shotgun sequencing, we successfully recovered endogenous dromedary nuclear DNA (nuDNA) from domestic and wild dromedary specimens with 1–1.06-fold read depths for covered regions. Our results highlight that despite recent methodological advances, obtaining ancient DNA (aDNA) from specimens recovered from hot, arid environments is still problematic. Hybridization protocols require specific optimization, and samples at the limit of DNA preservation need multiple replications of DNA extraction and hybridization capture as has been shown previously for Middle Pleistocene specimens

    Nuclear energy in the public sphere: Anti-nuclear movements vs. industrial lobbies in Spain (1962-1979)

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    The final publication is available at Springer via http://dx.doi.org/10.1007/s11024-014-9263-0This article examines the role of the Spanish Atomic Forum as the representative of the nuclear sector in the public arena during the golden years of the nuclear power industry from the 1960s to 1970s. It focuses on the public image concerns of the Spanish nuclear lobby and the subsequent information campaigns launched during the late 1970s to counteract demonstrations by the growing and heterogeneous anti-nuclear movement. The role of advocacy of nuclear energy by the Atomic Forum was similar to that in other countries, but the situation in Spain had some distinguishing features. Anti-nuclear protest in Spain peaked in 1978 paralleling the debates of a new National Energy Plan in Congress, whose first draft had envisaged a massive nuclearization of the country. We show how the approval of the Plan in July 1979, with a significant reduction in the nuclear energy component, was influenced by the anti-nuclear protest movements in Spain. Despite the efforts of the Spanish Atomic Forum to counter its message, the anti-nuclear movement was strengthened by reactions to the Three Mile Island accident in March 1979

    Renal biopsy findings among Indigenous Australians: a nationwide review

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    Australia's Indigenous people have high rates of chronic kidney disease and kidney failure. To define renal disease among these people, we reviewed 643 renal biopsies on Indigenous people across Australia, and compared them with 249 biopsies of non-Indigenous patients. The intent was to reach a consensus on pathological findings and terminology, quantify glomerular size, and establish and compare regional biopsy profiles. The relative population-adjusted biopsy frequencies were 16.9, 6.6, and 1, respectively, for Aboriginal people living remotely/very remotely, for Torres Strait Islander people, and for non-remote-living Aboriginal people. Indigenous people more often had heavy proteinuria and renal failure at biopsy. No single condition defined the Indigenous biopsies and, where biopsy rates were high, all common conditions were in absolute excess. Indigenous people were more often diabetic than non-Indigenous people, but diabetic changes were still present in fewer than half their biopsies. Their biopsies also had higher rates of segmental sclerosis, post-infectious glomerulonephritis, and mixed morphologies. Among the great excess of biopsies in remote/very remote Aborigines, females predominated, with younger age at biopsy and larger mean glomerular volumes. Glomerulomegaly characterized biopsies with mesangiopathic changes only, with IgA deposition, or with diabetic change, and with focal segmental glomerulosclerosis (FSGS). This review reveals great variations in biopsy rates and findings among Indigenous Australians, and findings refute the prevailing dogma that most indigenous renal disease is due to diabetes. Glomerulomegaly in remote/very remote Aboriginal people is probably due to nephron deficiency, in part related to low birth weight, and probably contributes to the increased susceptibility to kidney disease and the predisposition to FSGS

    Ocean Solutions to Address Climate Change and Its Effects on Marine Ecosystems

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    The Paris Agreement target of limiting global surface warming to 1.5–2∘C compared to pre-industrial levels by 2100 will still heavily impact the ocean. While ambitious mitigation and adaptation are both needed, the ocean provides major opportunities for action to reduce climate change globally and its impacts on vital ecosystems and ecosystem services. A comprehensive and systematic assessment of 13 global- and local-scale, ocean-based measures was performed to help steer the development and implementation of technologies and actions toward a sustainable outcome. We show that (1) all measures have tradeoffs and multiple criteria must be used for a comprehensive assessment of their potential, (2) greatest benefit is derived by combining global and local solutions, some of which could be implemented or scaled-up immediately, (3) some measures are too uncertain to be recommended yet, (4) political consistency must be achieved through effective cross-scale governance mechanisms, (5) scientific effort must focus on effectiveness, co-benefits, disbenefits, and costs of poorly tested as well as new and emerging measures
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