Retiro temprano de esteroides en una cohorte de trasplante renal tratada con tacrolimus, mofetil micofenolato y basiliximab

Antecedentes: No hay suficiente evidencia sobre la frecuencia de rechazo agudo y la funci�n del injerto en los pacientes con retiro temprano de esteroides (RTE). El objetivo del presente estudio es comparar el efecto del RTE sobre la tasa de filtrado glomerular (TFG), la supervivencia/rechazo del injerto en receptores de una cohorte de tratados con tacrolimus/mofetil micofenolato, comparada con un grupo control. Material y m�todos: Cohorte retrospectiva en 60 receptores de bajo riesgo inmunol�gico entre diciembre de 2005 y julio de 2010. Cohorte del estudio (C-RTE; N = 32), el RTE se hizo el 5� d�a mientras recib�an tacrolimus/mofetil micofenolato. La cohorte control (C-C, N = 28) recibi� prednisona/tacrolimus/mofetil micofenolato. Las variables cl�nicas, bioqu�micas e histol�gicas fueron evaluadas al inicio del estudio, y a los 3, 6 y 12 meses de seguimiento. Se utiliz� Kaplan-Meier y el modelo de riesgos proporcionales de Cox para evaluar la supervivencia. Las comparaciones entre cohortes fueron hechas por la t de Student y ?�. Resultados: Durante el seguimiento, la C-C muestra presi�n sangu�nea significativamente mayor tanto sist�lica (125 � 10 frente a 114 � 8) como diast�lica (81 � 8 frente a 72 � 7), glucosa s�rica (96 � 13 frente a 86 � 10), triglic�ridos (177 � 61 frente a 129 � 34), colesterol total (183 � 43 frente a 148 � 34) y colesterol LDL (100 � 22 frente a 87 � 25). La C-C present� una mayor proporci�n de uso de antihipertensivos (57 frente a 13 %) y de estatinas (27 frente a 9 %). La TFGe fue mejor en la C-RTE que en la C-C (85,4 � 20,6 frente a 70,6 � 17,0, p = 0,004). La frecuencia de rechazo agudo fue menor en la C-RTE. Conclusiones: La supervivencia del injerto, la TFG, la tasa de rechazo agudo y el perfil metab�lico fueron mejores en la C-RTE que en la C-C

Search for doubly charged Higgs bosons in like-sign dilepton final states at root s=7 TeV with the ATLAS detector

A search for doubly charged Higgs bosons decaying to pairs of electrons and/or muons is presented. The search is performed using a data sample corresponding to an integrated luminosity of 4.7 fb(-1) of pp collisions at root s = 7 TeV collected by the ATLAS detector at the LHC. Pairs of prompt, isolated, high-p(T) leptons with the same electric charge (e(+/-)e(+/-), e(+/-)mu, mu(+/-)mu(+/-)) are selected, and their invariant mass distribution is searched for a narrow resonance. No significant excess over Standard Model background expectations is observed, and limits are placed on the cross section times branching ratio for pair production of doubly charged Higgs bosons. The masses of doubly charged Higgs bosons are constrained depending on the branching ratio into these leptonic final states. Assuming pair production, coupling to left-handed fermions, and a branching ratio of 100% for each final state, masses below 409 GeV, 375 GeV, and 398 GeV are excluded for e(+/-)e(+/-), e(+/-)mu(+/-),and mu(+/-)mu(+/-), respectively

Measurements of the Total and Differential Higgs Boson Production Cross Sections Combining the H??????? and H???ZZ*???4??? Decay Channels at s\sqrt{s}=8??????TeV with the ATLAS Detector

Measurements of the total and differential cross sections of Higgs boson production are performed using 20.3~fb$^{-1}$ of $pp$ collisions produced by the Large Hadron Collider at a center-of-mass energy of $\sqrt{s} = 8$ TeV and recorded by the ATLAS detector. Cross sections are obtained from measured $H \rightarrow \gamma \gamma$ and $H \rightarrow ZZ ^{*}\rightarrow 4\ell$ event yields, which are combined accounting for detector efficiencies, fiducial acceptances and branching fractions. Differential cross sections are reported as a function of Higgs boson transverse momentum, Higgs boson rapidity, number of jets in the event, and transverse momentum of the leading jet. The total production cross section is determined to be $\sigma_{pp \to H} = 33.0 \pm 5.3 \, ({\rm stat}) \pm 1.6 \, ({\rm sys}) \mathrm{pb}$. The measurements are compared to state-of-the-art predictions.Measurements of the total and differential cross sections of Higgs boson production are performed using 20.3  fb-1 of pp collisions produced by the Large Hadron Collider at a center-of-mass energy of s=8  TeV and recorded by the ATLAS detector. Cross sections are obtained from measured H→γγ and H→ZZ*→4ℓ event yields, which are combined accounting for detector efficiencies, fiducial acceptances, and branching fractions. Differential cross sections are reported as a function of Higgs boson transverse momentum, Higgs boson rapidity, number of jets in the event, and transverse momentum of the leading jet. The total production cross section is determined to be σpp→H=33.0±5.3 (stat)±1.6 (syst)  pb. The measurements are compared to state-of-the-art predictions.Measurements of the total and differential cross sections of Higgs boson production are performed using 20.3 fb$^{-1}$ of $pp$ collisions produced by the Large Hadron Collider at a center-of-mass energy of $\sqrt{s} = 8$ TeV and recorded by the ATLAS detector. Cross sections are obtained from measured $H \rightarrow \gamma \gamma$ and $H \rightarrow ZZ ^{*}\rightarrow 4\ell$ event yields, which are combined accounting for detector efficiencies, fiducial acceptances and branching fractions. Differential cross sections are reported as a function of Higgs boson transverse momentum, Higgs boson rapidity, number of jets in the event, and transverse momentum of the leading jet. The total production cross section is determined to be $\sigma_{pp \to H} = 33.0 \pm 5.3 \, ({\rm stat}) \pm 1.6 \, ({\rm sys}) \mathrm{pb}$. The measurements are compared to state-of-the-art predictions