IRAC Imaging of Lockman Hole

IRAC imaging of a 4'7x4'7 area in the Lockman Hole detected over 400 galaxies in the IRAC 3.6 micron and 4.5 micron bands, 120 in the 5.8 micron, and 80 in the 8 micron bandin 30 minutes of observing time. Color-color diagrams suggest that about half of these galaxies are at redshifts 0.6<z<1.3 with about a quarter at higher redshifts (z>1.3). We also detect IRAC counterparts for 6 of the 7 SCUBA sources and all 9 XMM sources in this area. The detection of the counterparts of the SCUBA sources and galaxies at z>1.3 demonstrates the ability of IRAC to probe the universe at very high redshifts.Comment: 11 pages, 2 figures. accepted by ApJS, Spizter Special Issu

Remarkable Disk and Off-nuclear Starburst Activity in the "Tadpole Galaxy" as revealed by the Spitzer Space Telescope

We present ground-based optical and Spitzer infrared imaging observations of the interacting galaxy UGC 10214, the "Tadpole Galaxy" (z = 0.0310), focusing on the star formation activity in the nuclear, disk, spiral arms and tidal tail regions. The major findings of this study are that the Tadpole is actively forming stars in the main disk outside of the nucleus and in the tidal plume, with an estimated mean star formation rate of ~2 to 4 M_sun/yr. The most prominent sites of mid-infrared emission define a "ring" morphology that, combined with the overall morphology of the system, suggest the interaction may belong to the rare class of off-center collisional ring systems that form both shock-induced rings of star formation and tidal plumes. The nuclear emission is solely powered by older stars, with little evidence for ongoing star formation at the center of the Tadpole. Extra-nuclear star formation accounts for >50% of the total star formation in the disk and spiral arms, featuring infrared-bright 'hot spots' that exhibit strong PAH emission, whose band strength is comparable to that of late-type star-forming disk galaxies. The tidal tail, which extends 2 arcmin (~75 kpc) into the intergalactic medium, is populated by super massive star clusters likely triggered by the galaxy-galaxy interaction that has distorted UGC 10214 into its current "tadpole" shape.Comment: to appear in the January 2006 (vol 131) issue of the Astronomical Journal; high quality graphics are located here: http://spider.ipac.caltech.edu/staff/jarrett/tadpole.htm

The evolution of the dust temperatures of galaxies in the SFR–M∗plane up to z ~ 2

We study the evolution of the dust temperature of galaxies in the SFR−M ∗ plane up to z ∼ 2 using far-infrared and submillimetre observations from the Herschel Space Observatory taken as part of the PACS Evolutionary Probe (PEP) and Herschel Multi-tiered Extragalactic Survey (HerMES) guaranteed time key programmes. Starting from a sample of galaxies with reliable star-formation rates (SFRs), stellar masses (M ∗ ) and redshift estimates, we grid the SFR−M ∗ parameter space in several redshift ranges and estimate the mean dust temperature (T dust ) of each SFR–M ∗ −z bin. Dust temperatures are inferred using the stacked far-infrared flux densities (100–500μm) of our SFR–M ∗ −z bins. At all redshifts, the dust temperature of galaxies smoothly increases with rest-frame infrared luminosities (L IR ), specific SFRs (SSFR; i.e., SFR/M ∗ ), and distances with respect to the main sequence (MS) of the SFR−M ∗ plane (i.e., Δlog(SSFR) MS = log[SSFR(galaxy)/SSFR MS (M ∗ ,z)]). The T dust −SSFR and T dust – Δlog(SSFR) MS correlations are statistically much more significant than the T dust −L IR one. While the slopes of these three correlations are redshift-independent, their normalisations evolve smoothly from z = 0 and z ∼ 2. We convert these results into a recipe to derive T dust from SFR, M ∗ and z, valid out to z ∼ 2 and for the stellar mass and SFR range covered by our stacking analysis. The existence of a strong T dust −Δlog(SSFR) MS correlation provides us with several pieces of information on the dust and gas content of galaxies. Firstly, the slope of the T dust −Δlog(SSFR) MS correlation can be explained by the increase in the star-formation efficiency (SFE; SFR/M gas ) with Δlog(SSFR) MS as found locally by molecular gas studies. Secondly, at fixed Δlog(SSFR) MS , the constant dust temperature observed in galaxies probing wide ranges in SFR and M ∗ can be explained by an increase or decrease in the number of star-forming regions with comparable SFE enclosed in them. And thirdly, at high redshift, the normalisation towards hotter dust temperature of the T dust −Δlog(SSFR) MS correlation can be explained by the decrease in the metallicities of galaxies or by the increase in the SFE of MS galaxies. All these results support the hypothesis that the conditions prevailing in the star-forming regions of MS and far-above-MS galaxies are different. MS galaxies have star-forming regions with low SFEs and thus cold dust, while galaxies situated far above the MS seem to be in a starbursting phase characterised by star-forming regions with high SFEs and thus hot dust

Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway

This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2009 Orton et al.BACKGROUND: The Epidermal Growth Factor Receptor (EGFR) activated Extracellular-signal Regulated Kinase (ERK) pathway is a critical cell signalling pathway that relays the signal for a cell to proliferate from the plasma membrane to the nucleus. Deregulation of the EGFR/ERK pathway due to alterations affecting the expression or function of a number of pathway components has long been associated with numerous forms of cancer. Under normal conditions, Epidermal Growth Factor (EGF) stimulates a rapid but transient activation of ERK as the signal is rapidly shutdown. Whereas, under cancerous mutation conditions the ERK signal cannot be shutdown and is sustained resulting in the constitutive activation of ERK and continual cell proliferation. In this study, we have used computational modelling techniques to investigate what effects various cancerous alterations have on the signalling flow through the ERK pathway. RESULTS: We have generated a new model of the EGFR activated ERK pathway, which was verified by our own experimental data. We then altered our model to represent various cancerous situations such as Ras, B-Raf and EGFR mutations, as well as EGFR overexpression. Analysis of the models showed that different cancerous situations resulted in different signalling patterns through the ERK pathway, especially when compared to the normal EGF signal pattern. Our model predicts that cancerous EGFR mutation and overexpression signals almost exclusively via the Rap1 pathway, predicting that this pathway is the best target for drugs. Furthermore, our model also highlights the importance of receptor degradation in normal and cancerous EGFR signalling, and suggests that receptor degradation is a key difference between the signalling from the EGF and Nerve Growth Factor (NGF) receptors. CONCLUSION: Our results suggest that different routes to ERK activation are being utilised in different cancerous situations which therefore has interesting implications for drug selection strategies. We also conducted a comparison of the critical differences between signalling from different growth factor receptors (namely EGFR, mutated EGFR, NGF, and Insulin) with our results suggesting the difference between the systems are large scale and can be attributed to the presence/absence of entire pathways rather than subtle difference in individual rate constants between the systems.This work was funded by the Department of Trade and Industry (DTI), under their Bioscience Beacon project programme. AG was funded by an industrial PhD studentship from Scottish Enterprise and Cyclacel

Mid-infrared spectroscopy of infrared-luminous galaxies at z~0.5-3

We present results on low-resolution mid-infrared (MIR) spectra of 70 infrared-luminous galaxies obtained with the Infrared Spectrograph (IRS) onboard Spitzer. We selected sources from the European Large Area Infrared Survey (ELAIS) with S15 > 0.8 mJy and photometric or spectroscopic z > 1. About half of the sample are QSOs in the optical, while the remaining sources are galaxies, comprising both obscured AGN and starbursts. We classify the spectra using well-known infrared diagnostics, as well as a new one that we propose, into three types of source: those dominated by an unobscured AGN (QSOs), obscured AGN, and starburst-dominated sources. Starbursts concentrate at z ~ 0.6-1.0 favored by the shift of the 7.7-micron PAH band into the selection 15 micron band, while AGN spread over the 0.5 < z < 3.1 range. Star formation rates (SFR) are estimated for individual sources from the luminosity of the PAH features. An estimate of the average PAH luminosity in QSOs and obscured AGN is obtained from the composite spectrum of all sources with reliable redshifts. The estimated mean SFR in the QSOs is 50-100 Mo yr^-1, but the implied FIR luminosity is 3-10 times lower than that obtained from stacking analysis of the FIR photometry, suggesting destruction of the PAH carriers by energetic photons from the AGN. The SFR estimated in obscured AGN is 2-3 times higher than in QSOs of similar MIR luminosity. This discrepancy might not be due to luminosity effects or selection bias alone, but could instead indicate a connection between obscuration and star formation. However, the observed correlation between silicate absorption and the slope of the near- to mid-infrared spectrum is compatible with the obscuration of the AGN emission in these sources being produced in a dust torus.Comment: 32 pages, 24 figures, 15 tables, accepted for publication in MNRA

HERUS: the far-IR/submm spectral energy distributions of local ULIRGs and photometric atlas

We present the Herschel-SPIRE photometric atlas for a complete flux limited sample of 43 local ultraluminous infrared galaxies (ULIRGs), selected at 60 μm by IRAS, as part of the HERschel ULIRG Survey (HERUS). Photometry observations were obtained using the SPIRE instrument at 250, 350, and 500 μm. We describe these observations, present the results, and combine the new observations with data from IRAS to examine the far-infrared spectral energy distributions (SEDs) of these sources. We fit the observed SEDs of HERUS objects with a simple parametrized modified blackbody model, where temperature and emissivity β are free parameters. We compare the fitted values to those of non-ULIRG local galaxies, and find, in agreement with earlier results, that HERUS ULIRGs have warmer dust (median temperature T = 37.9 ± 4.7 K compared to 21.3 ± 3.4 K) but a similar β distribution (median β = 1.7 compared to 1.8) to the Herschel reference sample (HRS, Cortese et al. 2014) galaxies. Dust masses are found to be in the range of 107.5–109 M⊙, significantly higher than that of HRS sources. We compare our results for local ULIRGs with higher redshift samples selected at 250 and 850 μm. These latter sources generally have cooler dust and/or redder 100-to-250  μm colours than our 60 μm-selected ULIRGs. We show that this difference may in part be the result of the sources being selected at different wavelengths rather than being a simple indication of rapid evolution in the properties of the population

Single hadron response measurement and calorimeter jet energy scale uncertainty with the ATLAS detector at the LHC

The uncertainty on the calorimeter energy response to jets of particles is derived for the ATLAS experiment at the Large Hadron Collider (LHC). First, the calorimeter response to single isolated charged hadrons is measured and compared to the Monte Carlo simulation using proton-proton collisions at centre-of-mass energies of sqrt(s) = 900 GeV and 7 TeV collected during 2009 and 2010. Then, using the decay of K_s and Lambda particles, the calorimeter response to specific types of particles (positively and negatively charged pions, protons, and anti-protons) is measured and compared to the Monte Carlo predictions. Finally, the jet energy scale uncertainty is determined by propagating the response uncertainty for single charged and neutral particles to jets. The response uncertainty is 2-5% for central isolated hadrons and 1-3% for the final calorimeter jet energy scale.Comment: 24 pages plus author list (36 pages total), 23 figures, 1 table, submitted to European Physical Journal

Measurement of χ c1 and χ c2 production with s√ = 7 TeV pp collisions at ATLAS

The prompt and non-prompt production cross-sections for the χ c1 and χ c2 charmonium states are measured in pp collisions at s√ = 7 TeV with the ATLAS detector at the LHC using 4.5 fb−1 of integrated luminosity. The χ c states are reconstructed through the radiative decay χ c → J/ψγ (with J/ψ → μ + μ −) where photons are reconstructed from γ → e + e − conversions. The production rate of the χ c2 state relative to the χ c1 state is measured for prompt and non-prompt χ c as a function of J/ψ transverse momentum. The prompt χ c cross-sections are combined with existing measurements of prompt J/ψ production to derive the fraction of prompt J/ψ produced in feed-down from χ c decays. The fractions of χ c1 and χ c2 produced in b-hadron decays are also measured

OpenMS – An open-source software framework for mass spectrometry

<p>Abstract</p> <p>Background</p> <p>Mass spectrometry is an essential analytical technique for high-throughput analysis in proteomics and metabolomics. The development of new separation techniques, precise mass analyzers and experimental protocols is a very active field of research. This leads to more complex experimental setups yielding ever increasing amounts of data. Consequently, analysis of the data is currently often the bottleneck for experimental studies. Although software tools for many data analysis tasks are available today, they are often hard to combine with each other or not flexible enough to allow for rapid prototyping of a new analysis workflow.</p> <p>Results</p> <p>We present OpenMS, a software framework for rapid application development in mass spectrometry. OpenMS has been designed to be portable, easy-to-use and robust while offering a rich functionality ranging from basic data structures to sophisticated algorithms for data analysis. This has already been demonstrated in several studies.</p> <p>Conclusion</p> <p>OpenMS is available under the Lesser GNU Public License (LGPL) from the project website at <url>http://www.openms.de</url>.</p

Measurement of the production cross section for W-bosons in association with jets in pp collisions at s=7 TeV with the ATLAS detector

This Letter reports on a first measurement of the inclusive W + jets cross section in proton-proton collisions at a centre-of-mass energy of 7 TeV at the LHC, with the ATLAS detector. Cross sections, in both the electron and muon decay modes of the W-boson, are presented as a function of jet multiplicity and of the transverse momentum of the leading and next-to-leading jets in the event. Measurements are also presented of the ratio of cross sections sigma (W + >= n)/sigma(W + >= n - 1) for inclusive jet multiplicities n = 1-4. The results, based on an integrated luminosity of 1.3 pb(-1), have been corrected for all known detector effects and are quoted in a limited and well-defined range of jet and lepton kinematics. The measured cross sections are compared to particle-level predictions based on perturbative QCD. Next-to-leading order calculations, studied here for n <= 2, are found in good agreement with the data. Leading-order multiparton event generators, normalized to the NNLO total cross section, describe the data well for all measured jet multiplicitie