111 research outputs found
Single-trial multiwavelet coherence in application to neurophysiological time series
- Publication venue
- 'Institute of Electrical and Electronics Engineers (IEEE)'
- Publication date
- 01/01/2007
- Field of study
A method of single-trial coherence analysis is presented, through the application of continuous muldwavelets. Multiwavelets allow the construction of spectra and bivariate statistics such as coherence within single trials. Spectral estimates are made consistent through optimal time-frequency localization and smoothing. The use of multiwavelets is considered along with an alternative single-trial method prevalent in the literature, with the focus being on statistical, interpretive and computational aspects. The multiwavelet approach is shown to possess many desirable properties, including optimal conditioning, statistical descriptions and computational efficiency. The methods. are then applied to bivariate surrogate and neurophysiological data for calibration and comparative study. Neurophysiological data were recorded intracellularly from two spinal motoneurones innervating the posterior,biceps muscle during fictive locomotion in the decerebrated cat
Impaired transmission in the corticospinal tract and gait disability in spinal cord injured persons
- Author
- Publication venue
- 'American Physiological Society'
- Publication date
- 01/08/2010
- Field of study
Rehabilitation following spinal cord injury is likely to depend on recovery of corticospinal systems. Here we investigate whether transmission in the corticospinal tract may explain foot drop (inability to dorsiflex ankle) in persons with spinal cord lesion. The study was performed in 24 persons with incomplete spinal cord lesion (C1 to L1) and 15 healthy controls. Coherence in the 10- to 20-Hz frequency band between paired tibialis anterior muscle (TA) electromyographic recordings obtained in the swing phase of walking, which was taken as a measure of motor unit synchronization. It was significantly correlated with the degree of foot drop, as measured by toe elevation and ankle angle excursion in the first part of swing. Transcranial magnetic stimulation was used to elicit motor-evoked potentials (MEPs) in the TA. The amplitude of the MEPs at rest and their latency during contraction were correlated to the degree of foot drop. Spinal cord injured participants who exhibited a large foot drop had little or no MEP at rest in the TA muscle and had little or no coherence in the same muscle during walking. Gait speed was correlated to foot drop, and was the lowest in participants with no MEP at rest. The data confirm that transmission in the corticospinal tract is of importance for lifting the foot during the swing phase of human gait
The Adoption Challenge: An Analysis of Research Methods in JIBS
- Author
- Publication venue
- 'Academy of International Business'
- Publication date
- 01/01/2021
- Field of study
This study introduces the concepts of translational distance and complexity distance to explain challenges to adoption of research methods in JIBS. We examine three analytical techniques and data collection approaches: (1) Heckman models, (2) ethnographic studies, and (3) data collection equivalence procedures in survey-based research. We note that progress has been made to reduce translational and complexity distance for analytical techniques. However, concerns remain for data collection equivalence and ethnography as IB scholars are using increasingly advanced analytical techniques on less credible data
Biomarker counseling, disclosure of diagnosis and follow-up in patients with mild cognitive impairment:A European Alzheimer's Disease Consortium survey
- Author
- Alberto Lleó
- Alexandre de Mendonça
- Anne Koivisto
- Audrey Gabelle
- Bernard Hanseeuw
- Birgitte Bo Andersen
- Bruno Dubois
- David Robinson
- Elisabet Sánchez
- Elka Stefanova
- Flavio Nobili
- Gunhild Waldemar
- Görsev Yener
- Ildebrando Appollonio
- Isabel Santana
- Jacques Hugon
- Jakub Hort
- Katerina Sheardova
- Kristian S. Frederiksen
- Latchezar Traykov
- Lucrezia Hausner
- Luiza Spiru
- Lutz Frölich
- Marcel Olde Rikkert
- Mario Riverol
- Mathieu Ceccaldi
- Mercè Boada
- Milica G. Kramberger
- Nikolaos Scarmeas
- Olivier Rouaud
- Pierre‐Jean Ousset
- Prince M
- Robert Perneczky
- Sebastiaan Engelborghs
- Stephanie Sloan
- Thibaud Lebouvier
- Thomas R. Nielsen
- Timo Grimmer
- Tomasz Gabryelewicz
- van Maurik IS
- Vesna Jelic
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
Objectives: Mild cognitive impairment (MCI) is associated with an increased risk of further cognitive decline, partly depending on demographics and biomarker status. The aim of the present study was to survey the clinical practices of physicians in terms of biomarker counseling, management, and follow-up in European expert centers diagnosing patients with MCI. Methods: An online email survey was distributed to physicians affiliated with European Alzheimer's disease Consortium centers (Northern Europe: 10 centers; Eastern and Central Europe: 9 centers; and Southern Europe: 15 centers) with questions on attitudes toward biomarkers and biomarker counseling in MCI and dementia. This included postbiomarker counseling and the process of diagnostic disclosure of MCI, as well as treatment and follow-up in MCI. Results: The response rate for the survey was 80.9% (34 of 42 centers) across 20 countries. A large majority of physicians had access to biomarkers and found them useful. Pre- and postbiomarker counseling varied across centers, as did practices for referral to support groups and advice on preventive strategies. Less than half reported discussing driving and advance care planning with patients with MCI. Conclusions: The variability in clinical practices across centers calls for better biomarker counseling and better training to improve communication skills. Future initiatives should address the importance of communicating preventive strategies and advance planning
The effect of mild induced hypothermia on outcomes of patients after cardiac arrest: a systematic review and meta-analysis of randomised controlled trials
- Author
- A Janata
- A Langhelle
- A Schneider
- BS Abella
- C Coimbra
- CW Callaway
- D Atkins
- D Che
- DI Sessler
- E Kagawa
- E Lopez-de-Sa
- F Dumas
- Feng Mei Guo
- G Xiao
- Hai Bo Qiu
- Hypothermia after Cardiac Arrest Study Group
- I Laurent
- J Arrich
- J Bro-Jeppesen
- J Brok
- J Herlitz
- J Prior
- J Wetterslev
- J Wetterslev
- Jian Feng Xie
- Jian Xiao Chen
- JP Higgins
- K Mori
- K Thorlund
- M Diao
- MA Peberdy
- MR Sayre
- N Nielsen
- N Nielsen
- N Nielsen
- S Hachimi-Idrissi
- SA Bernard
- T Uray
- Xi Wen Zhang
- Yi Yang
- Ying Zi Huang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
QCD and strongly coupled gauge theories : challenges and perspectives
- Author
- A Accardi
- A Accardi
- A Accardi
- A Adams
- A Afanasev
- A Alexandru
- A Alexandru
- A Alexandru
- A Ali
- A Ali
- A Ali
- A Amato
- A Andronic
- A Andronic
- A Anisimov
- A Antognini
- A Antognini
- A Arvanitaki
- A Azatov
- A Banfi
- A Banfi
- A Barranco
- A Bazavov
- A Bazavov
- A Bazavov
- A Bazavov
- A Beraudo
- A Browman
- A Buzzatti
- A Bzdak
- A Bzdak
- A Calle-Cordon
- A Celis
- A Cheng
- A Chodos
- A Crivellin
- A Cucchieri
- A Czarnecki
- A Czarnecki
- A Denner
- A Deuzeman
- A Deuzeman
- A Deuzeman
- A Dobado
- A Donnachie
- A Donos
- A DotΘ
- A Drukier
- A Dumitru
- A Dumitru
- A Dumitru
- A Esposito
- A Forster
- A Francis
- A Freitas
- A Gal
- A Gouvea de
- A Gray
- A Grimbach
- A Gynther
- A Hameren van
- A Hameren van
- A Hasenfratz
- A Hoang
- A Hoang
- A H÷cker
- A Idilbi
- A Idilbi
- A Khodjamirian
- A Kisiel
- A Knecht
- A Knecht
- A Kovner
- A Kryjevski
- A Kulesza
- A Kurkela
- A Kurkela
- A Kurkela
- A Lenz
- A Li
- A Maas
- A Maas
- A Majumder
- A Majumder
- A Majumder
- A Menon
- A Mocsy
- A Mocsy
- A Morsch
- A Nyffeler
- A Orgogozo
- A Orgogozo
- A Ortiz
- A Patella
- A Paul
- A Pich
- A Pich
- A Pich
- A Pich
- A Pich
- A Pichlmaier
- A Pineda
- A Pineda
- A Pineda
- A Pineda
- A Pineda
- A Pineda
- A Pineda
- A Ramos
- A Ramos
- A Roeck De
- A Rothkopf
- A Salvio
- A Schmitt
- A Schmitt
- A Schmitt
- A Schmitt
- A Schmitt
- A Schmitt
- A Schwenk
- A Serebrov
- A Sibirtsev
- A Sternbeck
- A Thiel
- A Toia
- A Vairo
- A Vairo
- A Vuorinen
- A. Kalweit
- A. Mischke
- A. Pich
- A. S. Kronfeld
- A. Schmitt
- A. Vairo
- A. Vuorinen
- AA Andrianov
- AA Andrianov
- AA Khan
- AA Penin
- AA Penin
- AA Penin
- AA Petrov
- AB Balantekin
- AB Balantekin
- AB Larionov
- AB Zamolodchikov
- AC Aguilar
- AC Cordon
- AD Martin
- AD Martin
- AD Martin
- AE Bondar
- AE Nelson
- AE Snyder
- AH Mueller
- AH Mueller
- AJ Baltz
- AJ Buras
- AJ Buras
- AJ Buras
- AJ Buras
- AJ Buras
- AJ Buras
- AJ Buras
- AK Leibovich
- AL Fitzpatrick
- AL Fitzpatrick
- AM Bernstein
- AM Clogston
- AM Polyakov
- AM Polyakov
- AM Polyakov
- AM Poskanzer
- AP Bakulev
- AP Bakulev
- AP Bakulev
- AP Bakulev
- AP Serebrov
- AP Szczepaniak
- AR Zhitnitsky
- AS Arapoglu
- AS Gorsky
- AS Kronfeld
- AS Kronfeld
- AS Kronfeld
- AS Kronfeld
- AS Schwarz
- AT Davies
- AT Yue
- AV Anisovich
- AV Anisovich
- AV Anisovich
- AV Anisovich
- AV Anisovich
- AV Anisovich
- AV Belitsky
- AV Belitsky
- AV Belitsky
- AV Belitsky
- AV Efremov
- AV Kovalenko
- AV Kovalenko
- AV Manohar
- AV Manohar
- AV Manohar
- AV Manohar
- AV Radyushkin
- AV Radyushkin
- AV Radyushkin
- AV Radyushkin
- AV Smirnov
- AW Steiner
- AX El-Khadra
- AY Alekseev
- B Adeva
- B Adeva
- B Alver
- B Ananthanarayan
- B Batell
- B Bellazzini
- B Berdnikov
- B Bhattacharya
- B Bhattacharya
- B Blossier
- B Blossier
- B Dehnadi
- B Frois
- B Gong
- B Gong
- B Gong
- B Gong
- B Gong
- B Gong
- B Grzadkowski
- B Haskell
- B Haskell
- B Holdom
- B Holdom
- B Kubis
- B Lucini
- B Melić
- B Moussallam
- B Müller
- B Müller
- B MΣrkisch
- B Page
- B Pendleton
- B Pire
- B Plaster
- B Povh
- B Schenke
- B Schrempp
- B Sheikholeslami
- B Wu
- B. Ketzer
- BA Brown
- BA Burrington
- BA Dobrescu
- BA Kniehl
- BA Kniehl
- BA Thacker
- BB Back
- BB Brandt
- BC Regan
- BC Rislow
- BE Lautrup
- BG Zakharov
- BG Zakharov
- BJ Menadue
- BJ Owen
- BM Roberts
- BO Lange
- BR Holstein
- BS Chandrasekhar
- BU Musch
- C Alexandrou
- C Alexandrou
- C Alexandrou
- C Alexandrou
- C Alexandrou
- C Alexandrou
- C Alexandrou
- C Amsler
- C Anastasiou
- C Anzai
- C Aubin
- C Aubin
- C Aubin
- C Aubin
- C Aubin
- C Bernard
- C Bourrely
- C Csaki
- C Csaki
- C DeTar
- C Ditsche
- C Donato Di
- C Fernández-Ramírez
- C Fernández-Ramírez
- C Fernández-Ramírez
- C Fuchs
- C Gale
- C Gattringer
- C Gattringer
- C Gattringer
- C Gerschel
- C Hartnack
- C Jayalath
- C Lourenτo
- C Manuel
- C McNeile
- C McNeile
- C McNeile
- C Meng
- C Michael
- C Michael
- C Morningstar
- C Nunez
- C Pelissier
- C Rappold
- C Ratti
- C Shen
- C Shen
- C-H Chang
- C-M Chang
- C-Y Chen
- C. A. Salgado
- CA Baker
- CA Baker
- CA Meyer
- CA Salgado
- CB Lang
- CB Lang
- CB Lang
- CB Paranavitane
- CE Carlson
- CE Carlson
- CE Carlson
- CE Wolfe
- CG Boyd
- CG Callan
- CG Parthey
- CJ Bomhof
- CJ Morningstar
- CL Korpa
- CL Schat
- CM Arnesen
- CM Maekawa
- CP Herzog
- CP Herzog
- CR Allton
- CS Fischer
- CS Fischer
- CT Hill
- CT Sachrajda
- CTH Davies
- CW Bauer
- CW Bauer
- CW Bauer
- CW Bauer
- CW Bauer
- CW Bauer
- CW Bernard
- D Arean
- D Babusci
- D Bailin
- D Bak
- D Bandurin
- D Banerjee
- D Becirevic
- D Becirevic
- D Becirevic
- D Bernecker
- D Besak
- D Binosi
- D Binosi
- D Blaschke
- D Blaschke
- D Blaschke
- D Bodeker
- D Bodeker
- D Bodeker
- D Boer
- D Boito
- D Diakonov
- D Diakonov
- D Diakonov
- D Dubbers
- D Dubbers
- D Dudal
- D Elander
- D Espriu
- D Florian de
- D Florian de
- D Florian de
- D Forde
- D Gaiotto
- D Gotta
- D Grumiller
- D Guadagnoli
- D Jido
- D Kang
- D Kharzeev
- D Kharzeev
- D Kharzeev
- D Mateos
- D Melconian
- D Mohler
- D Molnar
- D Müller
- D Ng
- D Page
- D Pirjol
- D Pirjol
- D Pirjol
- D Ruic
- D Sahoo
- D Steineder
- D Steineder
- D Teaney
- D Tong
- D Zwanziger
- D Zwanziger
- D-Y Chen
- D. Keane
- DA Demir
- DB Kaplan
- DB Kaplan
- DB Kaplan
- DB Kaplan
- DB Kaplan
- DB Leinweber
- DB Leinweber
- DC McGlinchey
- DE Kharzeev
- DE Kharzeev
- DE Kharzeev
- DE Morrissey
- DG Yakovlev
- DJ Dean
- DJ Salvat
- DJ Schwarz
- DM Alde
- DM Alde
- DM Asner
- DS Armstrong
- DT Son
- DT Son
- DT Son
- DT Son
- DT Son
- DT Son
- DV Amelin
- DV Shirkov
- DW Sivers
- E Applebaum
- E Botta
- E Braaten
- E Braaten
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- E Braaten
- E Braaten
- E Braaten
- E Braaten
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- E Braaten
- E Braaten
- E Braaten
- E Braaten
- E Braaten
- E Braaten
- E Braaten
- E Braaten
- E Braaten
- E Conde
- E Dalgic
- E Eichten
- E Eichten
- E Epelbaum
- E Epelbaum
- E Ferreiro
- E Flowers
- E Franco
- E Frodermann
- E Golowich
- E Gregory
- E Gámiz
- E Iancu
- E Kiritsis
- E Kiritsis
- E Klempt
- E Kuflik
- E Laenen
- E Leader
- E Massot
- E Megias
- E Mereghetti
- E Perez
- E Poppitz
- E Rafael de
- E Schnedermann
- E Sezgin
- E Shintani
- E Shintani
- E Shintani
- E Shintani
- E Shuster
- E Witten
- E Witten
- E Witten
- E Witten
- E-M Ilgenfritz
- E. Kiritsis
- E. Pallante
- EB Gregory
- EC Poggio
- ED Skillman
- EE Jenkins
- EE Jenkins
- EE Kolomeitsev
- EG Ferreiro
- EJ Eichten
- EL Berger
- ER Berger
- ES Fraga
- F Antinori
- F Arleo
- F Arleo
- F Arleo
- F Arleo
- F Becattini
- F Berruto
- F Bezrukov
- F Bruckmann
- F Burger
- F Cachazo
- F Caravaglios
- F Cascioli
- F D'Eramo
- F D'Eramo
- F Diberder Le
- F Diberder Le
- F Dominguez
- F Englert
- F Feng
- F Gelis
- F Haas
- F Hautmann
- F Iocco
- F Jegerlehner
- F Jegerlehner
- F Jegerlehner
- F Karsch
- F Karsch
- F Karsch
- F Karsch
- F Lenz
- F Niecknig
- F Osterfeld
- F Preis
- F Preis
- F Steiner
- F Wilczek
- F-K Guo
- F-K Guo
- F-K Guo
- F-K Guo
- F. J. Llanes-Estrada
- FA Berends
- FA Dolan
- FA Dolan
- FE Close
- FE Wietfeldt
- FE Wietfeldt
- FJ Tackmann
- FJM Farley
- FL Shapiro
- FV Gubarev
- G Aarts
- G Aarts
- G Aarts
- G Aarts
- G Agakishiev
- G Altarelli
- G Amoros
- G Bali
- G Bell
- G Bell
- G Bellini
- G Bevilacqua
- G Bevilacqua
- G Bhanot
- G Bozzi
- G Buchalla
- G Buchalla
- G Burdman
- G Burdman
- G Cacciapaglia
- G Cacciapaglia
- G Colangelo
- G Colangelo
- G Colangelo
- G Corcella
- G Cullen
- G Cullen
- G D'Ambrosio
- G D'Ambrosio
- G Degrassi
- G Ecker
- G Ecker
- G Eichmann
- G Eichmann
- G Eichmann
- G Eichmann
- G Eichmann
- G Endrődi
- G Hiller
- G Hiller
- G Isidori
- G Jungman
- G Ossola
- G Ossola
- G Ossola
- G Ossola
- G Ovanesyan
- G Prezeau
- G Ricciardi
- G Ricciardi
- G Ricciardi
- G Ricciardi
- G Watt
- G Watt
- G Wlazłowski
- G-Z Xu
- G. M. von Hippel
- G. Odyniec
- G. Ricciardi
- GA Miller
- GA Miller
- GA Miller
- GA Miller
- GC Donald
- GC Giecold
- GC Nayak
- GC Nayak
- GC Nayak
- GC Nayak
- GD Moore
- GF Giudice
- GF Teramond de
- GJ Gounaris
- GJ Gounaris
- GJ Mathews
- GM Divitiis de
- GM Divitiis de
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- GM Divitiis de
- GP Engel
- GP Lepage
- GP Lepage
- GP Lepage
- GS Bali
- GS Bali
- GT Bodwin
- GT Bodwin
- GT Bodwin
- GT Bodwin
- GT Bodwin
- GT Bodwin
- GT Bodwin
- H Abuki
- H Chen
- H Chen
- H Flacher
- H Fujii
- H Fujii
- H Fujii
- H Fujii
- H Georgi
- H Georgi
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- H Hata
- H Jallouli
- H Johansson
- H Kowalski
- H Lenske
- H Leutwyler
- H Liu
- H Liu
- H Liu
- H Liu
- H Muther
- H Na
- H Na
- H Na
- H Neuberger
- H Neuberger
- H Ohki
- H Reinhardt
- H Sanchis-Alepuz
- H Satz
- H Satz
- H Song
- H Stoecker
- H-J Drescher
- H-K Guo
- H-N Li
- H-N Li
- H-N Li
- H-R Dong
- H-T Chen
- H-T Ding
- H-W Lin
- H-W Lin
- H-W Lin
- H-Y Cheng
- H-Y Cheng
- H. B. Meyer
- H. Sazdjian
- H. W. Lin
- H. Wittig
- HB Meyer
- HB Meyer
- HB Meyer
- HB Meyer
- HB Meyer
- HB Meyer
- HB Meyer
- HB Meyer
- HK Wohri
- HS Sharatchandra
- HT Ding
- I Balitsky
- I Balitsky
- I Balitsky
- I Bediaga
- I Bediaga
- I Bediaga
- I Bigi
- I Caprini
- I Caprini
- I Feige
- I Gahramanov
- I Giannakis
- I Giller
- I Helenius
- I Horvath
- I Kuznetsova
- I Sagert
- I Vitev
- IA Karpenko
- IB Khriplovich
- IB Khriplovich
- IB Khriplovich
- IC Cloet
- IC Cloet
- IG Aznauryan
- IG Aznauryan
- II Bigi
- IL Bogolubsky
- IO Cherednikov
- IO Cherednikov
- IO Cherednikov
- IO Cherednikov
- IR Klebanov
- IT Lorenz
- IV Danilkin
- IW Stewart
- IW Stewart
- IW Stewart
- IY Aref'eva
- J Alwall
- J Antoniadis
- J Arrington
- J Babington
- J Berges
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- J Boer de
- J Braun
- J Braun
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- J Collins
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- J Dudek
- J Dudek
- J Ellis
- J Engel
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- J Erler
- J Erler
- J Galloway
- J Gao
- J Gasser
- J Gasser
- J Gasser
- J Gasser
- J Gasser
- J Gasser
- J Gasser
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- J Giedt
- J Gomez
- J Greensite
- J Greensite
- J Greensite
- J Harada
- J Harada
- J Heinonen
- J Hirn
- J Hisano
- J Jalilian-Marian
- J Jalilian-Marian
- J Jalilian-Marian
- J Kang
- J Kim
- J Laiho
- J Liao
- J Maldacena
- J Maldacena
- J Menendez
- J Menendez
- J Nagata
- J Polchinski
- J Pumplin
- J Rapaport
- J Schaffner
- J Schaffner-Bielich
- J Schukraft
- J Schweizer
- J Shu
- J Siebenson
- J Stahov
- J Steinheimer
- J Thaler
- J Vries de
- J Vries de
- J Vries de
- J Xu
- J Xu
- J-H Kim
- J-J Wu
- J-P Blaizot
- J-W Qiu
- J-Y Chiu
- J-Y Chiu
- J-Z Li
- J. Erdmenger
- J. L. Goity
- J.-W. Qiu
- JA Formaggio
- JA Oller
- JA Tjon
- JB Kogut
- JB Kogut
- JC Collins
- JC Collins
- JC Collins
- JC Collins
- JC Collins
- JC Collins
- JC Collins
- JC Collins
- JC Collins
- JC Collins
- JC Collins
- JC Collins
- JC Collins
- JC Hardy
- JD Bjorken
- JD Jackson
- JD Weinstein
- JE Drut
- JF Donoghue
- JF Donoghue
- JF Gunion
- JF Kamenik
- JF Owens
- JI Kapusta
- JJ Dudek
- JJ Dudek
- JJ Dudek
- JJ Dudek
- JJ Dudek
- JJ Dudek
- JJ Hudson
- JJ Kelly
- JL Albacete
- JL Albacete
- JL Albacete
- JL Albacete
- JL Albacete
- JL Albacete
- JL Albacete
- JL Cardy
- JL Goity
- JL Goity
- JL Goity
- JL Goity
- JL Goity
- JL Goity
- JL Goity
- JL Goity
- JL Goity
- JL Hewett
- JM Bulava
- JM Campbell
- JM Maldacena
- JM Maldacena
- JM Pawlowski
- JO Andersen
- JP Blaizot
- JP Chen
- JP Ralston
- JP Silva
- JR Andersen
- JR Ellis
- JR Ellis
- JR Ellis
- JR Ellis
- JR Ellis
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- JR Gaunt
- JR Green
- JR Green
- JR Oppenheimer
- JS Bell
- JS Conway
- JS Nico
- JT Daub
- K Adcox
- K Agashe
- K Agashe
- K Agashe
- K Blum
- K Durstberger-Rennhofer
- K Dusling
- K Fukushima
- K Fukushima
- K Fukushima
- K Fukushima
- K Fuyuto
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- Publication venue
- Publication date
- 01/01/2014
- Field of study
We highlight the progress, current status, and open challenges of QCD-driven physics, in theory and in experiment. We discuss how the strong interaction is intimately connected to a broad sweep of physical problems, in settings ranging from astrophysics and cosmology to strongly coupled, complex systems in particle and condensed-matter physics, as well as to searches for physics beyond the Standard Model. We also discuss how success in describing the strong interaction impacts other fields, and, in turn, how such subjects can impact studies of the strong interaction. In the course of the work we offer a perspective on the many research streams which flow into and out of QCD, as well as a vision for future developments.Peer reviewe
Long-range angular correlations on the near and away side in p–Pb collisions at
- Author
- Abdiel Ramirez Reyes
- Adam Ryszard Kisiel
- Adam Tomasz Matyja
- Adam Wlodzimierz Jacholkowski
- Adam Szczepankiewicz
- Adela Kravcakova
- Aditya Nath Mishra
- Adrian Sevcenco
- Adriana Telesca
- Airton Deppman
- Ajay Kumar Dash
- Alberica Toia
- Alberto Baldisseri
- Alberto Collu
- Alberto Gago
- Alberto Masoni
- Alejandro Szanto de Toledo
- Alessandra Maria Mazzoni
- Alessandra Fantoni
- Alessandro De Falco
- Alessandro Feliciello
- Alessandro Grelli
- Alessandro Pesci
- Alexander Philipp Kalweit
- Alexander Akindinov
- Alexander Borissov
- Alexander Hansen
- Alexander Kluge
- Alexander Mamonov
- Alexander Nedosekin
- Alexander Ochirov
- Alexander Vinogradov
- Alexander Vodopianov
- Alexander Wilk
- Alexandr Tumkin
- Alexandre Alarcon do Passo Suaide
- Alexandre Nyanin
- Alexandre Rachevski
- Alexandre Shabetai
- Alexandru Florin Dobrin
- Alexandru Bercuci
- Alexei Kaidalov
- Alexei Khanzadeev
- Alexei Pavlinov
- Alexey Bogdanov
- Alexey Kuryakin
- Alexey Vyushin
- Alexis Jean Michel Mas
- Alfonso Tarazona Martinez
- Alfredo Musso
- Alice Zimmermann
- Alina Gabriela Grigoras
- Alis Rodriguez Manso
- Alla Maevskaya
- Alphonse Rademakers
- Amalia Pop
- Amaya Ofelia Casanova Diaz
- Ana Maria Marin
- Anais Annick Erica Bergognon
- Anand Kumar Dubey
- Anatoly Kolojvari
- Anders Garritt Knospe
- Anders Nils Erik Oskarsson
- Andras Gabor Agocs
- Andre Augustinus
- Andre Mischke
- Andrea Agostinelli
- Andrea Alici
- Andrea Dainese
- Andrea Danu
- Andrea Dubla
- Andrea Festanti
- Andrea Francescon
- Andrea Rossi
- Andreas Arend
- Andreas Morsch
- Andrei Geae Gheata
- Andrei Ionut Herghelegiu
- Andres Sandoval
- Andrew Marshall Adare
- Andrey Ivanov
- Andrey Kazantsev
- Andrey Reshetin
- Andrey Vasiliev
- Andrey Zarochentsev
- Andry Malala Rakotozafindrabe
- Andrzej Deloff
- Andrzej Rybicki
- Andzhey Asryan
- Angela Badala
- Anik Gupta
- Anitha Nyatha
- Anju Bhasin
- Ankita Goswami
- Anna Rita Reolon
- Annalisa De Caro
- Annalisa Mastroserio
- Annika Passfeld
- Anselmo Margotti
- Ante Bilandzic
- Anthony Timmins
- Antoine Xavier Lardeux
- Anton Alkin
- Anton Andronic
- Anton Jusko
- Antonin Maire
- Antonino Zichichi
- Antonio Carlos Oliveira Da Silva
- Antonio Di Mauro
- Antonio Juan Rubio Montero
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- Satish Sharma
- Satyajit Jena
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- Susanta Kumar Pal
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- Sven Gotovac
- Svetlana Kushpil
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- Tadeusz Antoni Dobrowolski
- Taebong Moon
- Taesoo Kim
- Takafumi Niida
- Taku Gunji
- Tapan Kumar Nayak
- Tatiana Karavicheva
- Tatjana Susa
- Tatsuya Chujo
- Teodor Siemiarczuk
- Terry Awes
- Thanushan Kugathasan
- Theo Alexander Broker
- Thomas Michael Cormier
- Thomas Dietel
- Thomas Humanic
- Thomas Peitzmann
- Thorsten Kollegger
- Tim Schuster
- Timo Gunther Breitner
- Timothy Symons
- Timur Pocheptsov
- Tinku Sinha
- Tiziano Virgili
- Tobias Krawutschke
- Tomas Robert Aronsson
- Tomasz Jan Pawlak
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- Tomi Samuli Raiha
- Tomoya Tsuji
- Torsten Alt
- Toru Sugitate
- Trine Spedstad Tveter
- Tuomo Esa Aukusti Kalliokoski
- Tuva Richert
- Tyler Allen Browning
- Udo Wolfgang Kebschull
- Ulrich Michael Frankenfeld
- Ulrich Fuchs
- Uwe Westerhoff
- Valentina Zaccolo
- Valeria Muccifora
- Valerie Barret
- Valerio Altini
- Valery Kondratiev
- Valery Punin
- Vardanush Papikyan
- Vasco Miguel Chibante Barroso
- Vasile Catanescu
- Vasily Kushpil
- Vedran Nikolic
- Venelin Anguelov
- Vera Loggins
- Vercellin Ermanno
- Veronica Canoa Roman
- Victor Trubnikov
- Vikas Singhal
- Vincenzo Paticchio
- Vitaly Loginov
- Vito Lenti
- Vito Manzari
- Vladimir Ivanov
- Vladimir Kaplin
- Vladimir Kovalenko
- Vladimir Nikulin
- Vladimir Peskov
- Vladimir Pospisil
- Vladimir Samsonov
- Vladimir Vechernin
- Vladimir Wagner
- Vladislav Grigoriev
- Vladislav Manko
- Vojtech Petracek
- Volker Lindenstruth
- Weilin Yu
- Werner Riegler
- Wiktor Stanislaw Peryt
- Wisla Carena
- Wladyslaw Henryk Trzaska
- Woo Jin Park
- Xavier Bernard Lopez
- Xianbao Yuan
- Xiangrong Zhu
- Xianguo Lu
- Xiaoming Zhang
- Xitzel Sanchez Castro
- Yaldo Chris G.
- Yannick Denis Zoccarato
- Yaping Wang
- Yaroslav Berdnikov
- Yasuo Miake
- Yasuto Hori
- Yaxian Mao
- Yevgen Martynov
- Yifei Wang
- Yogendra Viyogi
- Yong Wook Baek
- Yorito Yamaguchi
- You Zhou
- Youngil Kwon
- Yury Kharlov
- Yury Kucheriaev
- Yury Pestov
- Yury Sibiriak
- Yury Vinogradov
- Yves Roland Schutz
- Yvonne Chiara Pachmayer
- Zabulon Vilakazi
- Zaida Conesa del Valle
- Zhongbao Yin
- Zubayer Ahammed
- Zuzana Harmanova
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2013
- Field of study
Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector
- Author
- Aaboud Morad
- Aad Georges
- Abbott Brad
- Abdinov Ovsat
- Abeloos Baptiste
- Abidi Syed
- AbouZeid Ossama
- Abraham Nicola
- Abramowicz Halina
- Abreu Henso
- Abreu Ricardo
- Abulaiti Yiming
- Acharya Bobby
- Adachi Shunsuke
- Adamczyk Leszek
- Adelman Jahred
- Adersberger Michael
- Adye Tim
- Affolder Tony
- Afik Yoav
- Agatonovic-Jovin Tatjana
- Agheorghiesei Catalin
- Aguilar-Saavedra Juan
- Ahlen Steven
- Ahmadov Faig
- Aielli Giulio
- Akatsuka Shunichi
- Akerstedt Henrik
- Akilli Ece
- Akimov Andrei
- Alberghi Gian
- Albert Justin
- Albicocco Pietro
- Alconada Verzini Maria
- Alderweireldt Sara
- Aleksa Martin
- Aleksandrov Igor
- Alexa Calin
- Alexander Gideon
- Alexopoulos Theodoros
- Alhroob Muhammad
- Ali Babar
- Aliev Malik
- Alimonti Gianluca
- Alison John
- Alkire Steven
- Allbrooke Benedict
- Allen Benjamin
- Allport Phillip
- Aloisio Alberto
- Alonso Alejandro
- Alonso Francisco
- Alpigiani Cristiano
- Alshehri Azzah
- Alstaty Mahmoud
- Alvarez Gonzalez Barbara
- Alviggi Mariagrazia
- Amadio Brian
- Amaral Coutinho Yara
- Amelung Christoph
- Amidei Dante
- Amor Dos Santos Susana
- Amoroso Simone
- Anastopoulos Christos
- Ancu Lucian
- Andari Nansi
- Andeen Timothy
- Anders Christoph
- Anders John
- Anderson Kelby
- Andreazza Attilio
- Andrei George
- Angelidakis Stylianos
- Angelozzi Ivan
- Angerami Aaron
- Anisenkov Alexey
- Anjos Nuno
- Annovi Alberto
- Antel Claire
- Antonelli Mario
- Antonov Alexey
- Antrim Daniel
- Anulli Fabio
- Aoki Masato
- Aperio Bella Ludovica
- Arabidze Giorgi
- Arai Yasuo
- Araque Juan
- Araujo Ferraz Victor
- Arce Ayana
- Ardell Rose
- Arduh Francisco
- Arguin Jean-Francois
- Argyropoulos Spyridon
- Arik Metin
- Armbruster Aaron
- Armitage Lewis
- Arnaez Olivier
- Arnold Hannah
- Arratia Miguel
- Arslan Ozan
- Artamonov Andrei
- Artoni Giacomo
- Artz Sebastian
- Asai Shoji
- Asbah Nedaa
- Ashkenazi Adi
- Asquith Lily
- Assamagan Ketevi
- Astalos Robert
- Atkinson Markus
- Atlay Naim
- Augsten Kamil
- Avolio Giuseppe
- Axen Bradley
- Ayoub Mohamad
- Azuelos Georges
- Baas Alessandra
- Baca Matthew
- Bachacou Henri
- Bachas Konstantinos
- Backes Moritz
- Bagnaia Paolo
- Bahmani Marzieh
- Bahrasemani Sina
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- Baldin Evgenii
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- Barkeloo Jason
- Barklow Timothy
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- Baroncelli Antonio
- Barone Gaetano
- Barr Alan
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- Bartoldus Rainer
- Barton Adam
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- Basalaev Artem
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- Becker Maurice
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- Büscher Volker
- C-Q Changqiao
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- Calvet Samuel
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- Caminal Armadans Roger
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- Casadei Diego
- Casado Maria
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- Christodoulou Valentinos
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- Coniavitis Elias
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- Connelly Ian
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- Da Cunha Sargedas De Sousa Mario
- Da Via Cinzia
- Dabrowski Wladyslaw
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- Dale Orjan
- Dallaire Frederick
- Dallapiccola Carlo
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- Dassoulas James
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- de Asmundis Riccardo
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- De Cecco Sandro
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- De la Torre Hector
- De Lorenzi Francesco
- De Maria Antonio
- De Pedis Daniele
- De Salvo Alessandro
- De Sanctis Umberto
- De Santo Antonella
- De Vasconcelos Corga Kevin
- De Vivie De Regie Jean-Baptiste
- De Kaushik
- Debbe Ramiro
- Debenedetti Chiara
- Dedovich Dmitri
- Dehghanian Nooshin
- Deigaard Ingrid
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- Delgove David
- Deliot Frederic
- Delitzsch Chris
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- della Volpe Domenico
- Delmastro Marco
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- Demichev Mikhail
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- Denisov Sergey
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- Derkaoui Jamal
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- Di Clemente William
- Di Donato Camilla
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- Di Nardo Roberto
- Di Petrillo Karri
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- Dolezal Zdenek
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- Doyle Tony
- Drechsler Eric
- Dris Manolis
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- Duschinger Dirk
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- Duvnjak Damir
- Dyndal Mateusz
- Dziedzic Bartosz
- Díez Cornell Sergio
- Dührssen Michael
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- Eckardt Christoph
- Ecker Katharina
- Edgar Ryan
- Eifert Till
- Eigen Gerald
- Einsweiler Kevin
- Ekelof Tord
- El Kacimi Mohamed
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- Ellajosyula Venugopal
- Ellert Mattias
- Elles Sabine
- Ellinghaus Frank
- Elliot Alison
- Ellis Nicolas
- Elmsheuser Johannes
- Elsing Markus
- Emeliyanov Dmitry
- Enari Yuji
- Ennis Joseph
- Epland Matthew
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- Ernst Michael
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- Escalier Marc
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- Estrada Pastor Oscar
- Etienvre Anne-Isabelle
- Etzion Erez
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- Ezhilov Alexey
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- Farthouat Philippe
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- Faucci Giannelli Michele
- Favareto Andrea
- Fawcett William
- Fayard Louis
- Fedin Oleg
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- Feigl Simon
- Feligioni Lorenzo
- Feng Cunfeng
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- Fenyuk Alexander
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- Ferrere Didier
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- Filipčič Andrej
- Filthaut Frank
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- Fiolhais Miguel
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- Flowerdew Michael
- Forcolin Giulio
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- Forti Alessandra
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- Franchini Matteo
- Franchino Silvia
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- Frate Meghan
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- Freeborn David
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- Freund Benjamin
- Froidevaux Daniel
- Frost James
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- Fusayasu Takahiro
- Fuster Juan
- Förster Fabian
- Gabizon Ofir
- Gabrielli Alessandro
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- Gach Grzegorz
- Gadatsch Stefan
- Gadomski Szymon
- Gagliardi Guido
- Gagnon Louis
- Galea Cristina
- Galhardo Bruno
- Gallas Elizabeth
- Gallop Bruce
- Gallus Petr
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- Gan Kk
- Ganguly Sanmay
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- Gao Yongsheng
- Garay Walls Francisca
- Garcia-Sciveres Maurice
- García Navarro José
- García Pascual Juan
- García Carmen
- Gardner Robert
- Garelli Nicoletta
- Garonne Vincent
- Gascon Bravo Alberto
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- Gaudio Gabriella
- Gavrilenko Igor
- Gay Colin
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- Gee Norman
- Geisen Jannik
- Geisen Marc
- Geisler Manuel
- Gellerstedt Karl
- Gemme Claudia
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- Geß{}ner Gregor
- Ghasemi Sara
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- Giagu Stefano
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- Giannetti Paola
- Gibson Stephen
- Gignac Matthew
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- Gillberg Dag
- Gilles Geoffrey
- Gingrich Douglas
- Giordani MarioPaolo
- Giorgi Filippo
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- Giromini Paolo
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- Gkaitatzis Stamatios
- Gkialas Ioannis
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- Glasman Claudia
- Glatzer Julian
- Glaysher Paul
- Glazov Alexandre
- Goblirsch-Kolb Maximilian
- Godlewski Jan
- Goldfarb Steven
- Golling Tobias
- Golubkov Dmitry
- Gomes Agostinho
- Goncalves Gama Rafael
- Goncalves Pinto Firmino Da Costa Joao
- Gonella Giulia
- Gonella Laura
- Gongadze Alexi
- Gonnella Francesco
- Gonski Julia
- Gonzalez-Sevilla Sergio
- González de la Hoz Santiago
- Gonçalo Ricardo
- Goossens Luc
- Gorbounov Petr
- Gordon Howard
- Gorini Benedetto
- Gorini Edoardo
- Gorišek Andrej
- Goshaw Alfred
- Gostkin Mikhail
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- Goudet Christophe
- Goujdami Driss
- Goussiou Anna
- Govender Nicolin
- Gozani Eitan
- Grabowska-Bold Iwona
- Gradin Per
- Gramling Johanna
- Gramstad Eirik
- Grancagnolo Sergio
- Gratchev Vadim
- Gravila Paul
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- Gray Heather
- Greenwood Zeno
- Grefe Christian
- Gregersen Kristian
- Gregor Ingrid-Maria
- Grenier Philippe
- Grevtsov Kirill
- Griffiths Justin
- Grillo Alexander
- Grimm Kathryn
- Grinstein Sebastian
- Gris Philippe
- Grivaz Jean-Francois
- Groh Sabrina
- Gross Eilam
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- Guan Wen
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- Guest Daniel
- Gueta Orel
- Gui Bin
- Guido Elisa
- Guillemin Thibault
- Guindon Stefan
- Gul Umar
- Gumpert Christian
- Guo Jun
- Guo Wen
- Guo Yicheng
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- Gustavino Giuliano
- Gutelman Benjamin
- Gutierrez Ortiz Nicolas
- Gutierrez Phillip
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- Guyot Claude
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- Gwenlan Claire
- Gwilliam Carl
- Gössling Claus
- Haas Andy
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- Hadavand Haleh
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- Hadef Asma
- Hageböck Stephan
- Hagihara Mutsuto
- Hakobyan Hrachya
- Haleem Mahsana
- Haley Joseph
- Halladjian Garabed
- Hallewell Gregory
- Hamacher Klaus
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- Hamano Kenji
- Hamilton Andrew
- Hamity Guillermo
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- Hanawa Keita
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- Handl David
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- Hanke Paul
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- Hasegawa Yoji
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- Hauser Reiner
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- Havener Laura
- Havranek Miroslav
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- Hawkings Richard
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- Hays Jonathan
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- Heinrich Jochen
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- Helary Louis
- Held Alexander
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- Helsens Clement
- Henderson Robert
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- Herbert Geoffrey
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- Hernández Jiménez Yesenia
- Herr Holger
- Herten Gregor
- Hertenberger Ralf
- Hervas Luis
- Herwig Theodor
- Hesketh Gavin
- Hessey Nigel
- Hetherly Jeffrey
- Higashino Satoshi
- Higón-Rodriguez Emilio
- Hildebrand Kevin
- Hill Ewan
- Hill John
- Hiller Karl
- Hillier Stephen
- Hils Maximilian
- Hinchliffe Ian
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- Hirschbuehl Dominic
- Hiti Bojan
- Hladik Ondrej
- Hlaluku Dingane
- Hoad Xanthe
- Hobbs John
- Hod Noam
- Hodgkinson Mark
- Hodgson Paul
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- Hoeferkamp Martin
- Hoenig Friedrich
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- Holzbock Michael
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- Honda Shunsuke
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- Hooberman Benjamin
- Hopkins Walter
- Horii Yasuyuki
- Horton Arthur
- Hostachy Jean-Yves
- Hostiuc Alexandru
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- Howarth James
- Hoya Joaquin
- Hrabovsky Miroslav
- Hrdinka Julia
- Hristova Ivana
- Hrivnac Julius
- Hryn'ova Tetiana
- Hrynevich Aliaksei
- Hsu Pai-hsien
- Hsu Shih-Chieh
- Hu Qipeng
- Hu Shuyang
- Huang Yanping
- Hubacek Zdenek
- Hubaut Fabrice
- Huegging Fabian
- Huffman Todd
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- Huhtinen Mika
- HUNTER Robert
- Huo Peng
- Huseynov Nazim
- Huston Joey
- Huth John
- Hyneman Rachel
- Iacobucci Giuseppe
- Iakovidis Georgios
- Ibragimov Iskander
- Iconomidou-Fayard Lydia
- Idrissi Zineb
- Iengo Paolo
- Igonkina Olga
- Iizawa Tomoya
- Ikegami Yoichi
- Ikeno Masahiro
- Ilchenko Yuriy
- Iliadis Dimitrios
- Ilic Nikolina
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- Introzzi Gianluca
- Ioannou Pavlos
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- Iordanidou Kalliopi
- Ippolito Valerio
- Isacson Max
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- Ishino Masaya
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- Ito Fumiaki
- Iturbe Ponce Julia
- Iuppa Roberto
- Iwasaki Hiroyuki
- Izen Joseph
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- Jakobs Karl
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- JAMIN David
- Jana Dilip
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- Janus Michel
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- Jarlskog Göran
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- Jiggins Stephen
- Jimenez Pena Javier
- Jin Shan
- Jinaru Adam
- Jinnouchi Osamu
- Jivan Harshna
- Johansson Per
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- Yamatani Masahiro
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- Zanzi Daniele
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- Zemaityte Gabija
- Zemla Andrzej
- Zeng Jian
- Zeng Qi
- Zenin Oleg
- Zerwas Dirk
- Zhang Dengfeng
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- Zhang Huijun
- Zhang Jinlong
- Zhang Lei
- Zhang Liqing
- Zhang Matt
- Zhang Peng
- Zhang Rui
- Zhang Ruiqi
- Zhang Xueyao
- Zhang Yu
- Zhang Zhiqing
- Zhao Xiandong
- Zhao Yongke
- Zhao Zhengguo
- Zhemchugov Alexey
- Zhou Bing
- Zhou Chen
- Zhou Li
- Zhou Maosen
- Zhou Mingliang
- Zhou Ning
- Zhou You
- Zhu Cheng
- Zhu Hongbo
- Zhu Junjie
- Zhu Yingchun
- Zhuang Xuai
- Zhukov Konstantin
- Zibell Andre
- Zieminska Daria
- Zimine Nikolai
- Zimmermann Christoph
- Zimmermann Stephanie
- Zinonos Zinonas
- Zinser Markus
- Ziolkowski Michael
- Zobernig Georg
- Zoccoli Antonio
- Zou Rui
- zur Nedden Martin
- Zwalinski Lukasz
- Åkesson Torsten
- Šfiligoj Tina
- Ženiš Tibor
- Živković Lidija
- Άlvarez Piqueras Damián
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements
Stroke genetics informs drug discovery and risk prediction across ancestries
- Author
- Aamodt Anne H
- Aamodt Anne H
- Abedi Vida
- Adams Hieab
- Adebajo Olayinka J
- Adeoye Abiodun M
- Afzal Shoaib
- Ago Tetsuro
- Agunloye Atinuke
- Akinyemi Joshua
- Akinyemi Rufus
- Akpa Onoja
- Akpa Onoja
- Akpalu Albert
- Almgren Peter
- Alvarez-Sabin Jose
- Amin Najaf
- Amouyel Philippe
- Anderson Christopher D
- Anderson Christopher D
- Anderson Christopher D
- Aparicio Hugo J
- Arenillas Juan Francisco
- Armasu Sebastian M
- Armstrong Nicole D
- Arnett Donna K
- Arulogun Oyedunni
- Attia John
- Ay Hakan
- Bae Hee-Joon
- Bakker Mark K
- Bammler Theo K
- Bartz Traci M
- Bastarache Lisa
- Beiser Alexa S
- Beiser Alexa S
- Bell Steven
- Benavente Oscar R
- Benn Marianne
- Bennett David A
- Berr Claudine
- Bevan Steve
- Bis Joshua C
- Bis Joshua C
- Bis Joshua C
- Blay Natalia
- Boerwinkle Eric
- Boncoraglio Giorgio B
- Bordes Constance
- Borte Sigrid
- Braekkan Sigrid K
- Brody Jennifer A
- Brouwers Paul JAM
- Brown Robert D
- Brumpton Ben M
- Brumpton Ben M
- Buring Julie E
- Bustamante Mariana
- Butterworth Adam S
- Cain Anael
- Campos Francisco
- Camps-Renom Pol
- Carcel-Marquez Jara
- Caro Ilana
- Carrera Caty
- Carty Cara L
- Caso Valeria
- Castillo Jose
- Chasman Daniel I
- Chauhan Ganesh
- Chen Junshi
- Chen Junshi
- Chen Ming-Huei
- Chen Pei-Hsin
- Chen Wei Min
- Chen Wei-Min
- Chen Yiping
- Chen Zhengming
- Cheng Yu-Ching
- Cho Kelly
- Choi Seung Hoan
- Chong Michael R
- Chowhan Ayesha
- Christensen Kaare
- Clarke Robert
- Cole John W
- Collins Rory
- Correa Adolfo
- Cotlarciuc Ioana
- Cruchaga Carlos
- Cullell Natalia
- Curtze Sami
- Curtze Sami
- Cushman Mary
- Damrauer Scott M
- Danesh John
- Dartigues Jean-Francois
- de Andrade Mariza
- de Bakker Paul IW
- de Cid Rafael
- de Cid Rafael
- de Jager Phil L
- de Jager Phil L
- de Jager Phil L
- de Kort Paul L
- de Laat Karlijn F
- de Laat Karlijn F
- de Leeuw Frank-Erik
- de Leeuw Frank-Erik
- Debette Stephanie
- Delavaran Hossein
- Deleuze Jean-Francois
- Delgado Pilar
- Delgado Pilar
- Delgado-Mederos Raquel
- den Heijer Tom
- den Hoed Marcel
- DeStefano Anita L
- Dhar Rajat
- Diaz-Navarro Rosa
- Dichgans Martin
- Dorr Marcus
- Duan Qing
- Ellekjaer Hanne
- Endres Matthias
- Engelter Stefan T
- Engstrom Gunnar
- Esko Tonu
- Esko Tonu
- Evans Michele K
- Fairhurst-Hunter Zammy
- Fakunle Adekunle G
- Falcone Guido J
- Fernandez-Cadenas Israel
- Ferreira Leslie E
- Ferreira Leslie E
- Fongang Bernard
- Ford Ian
- Fornage Myriam
- Franca Paulo HC
- Frantz Stefan
- Frazer Kelly A
- Freijo Marimar
- Frikke-Schmidt Ruth
- Fritsche Lars G
- Furie Karen L
- Gabrielsen Maiken E
- Gabrielsen Maiken E
- Gallego-Fabrega Cristina
- Gallego-Fabrega Cristina
- Gasca Natalie C
- Gasca Natalie C
- Geerlings Mirjam I
- Geerlings Mirjam I
- Geerlings Mirjam I
- Georgakis Marios K
- Germain Marine
- Ghanbari Mohsen
- Gieger Christian
- Giese Anne-Katrin
- Giese Anne-Katrin
- Giulianini Franco
- Gons Rob AR
- Gordon William
- Gottesman Rebecca F
- Gottesman Rebecca F
- Gottesman Rebecca F
- Grabe Hans J
- Gravel Simon
- Gretarsdottir Solveig
- Grewal Raji P
- Gudnason Vilmundur
- Gudnason Vilmundur
- Guo Yu
- Gurpreet Wander S
- Gustafsson Stefan
- Habib Naomi
- Hachiya Tsuyoshi
- Haessler Jeffrey
- Haessler Jeffrey
- Haeusler Karl Georg
- Hagen Knut
- Hamsten Anders
- Hansen John-Bjarne
- Harris Tamara B
- Hassan Ahamad
- Hata Jun
- Havulinna Aki S
- He Jing
- He Yunye
- Heath Alicia K
- Heath Alicia K
- Heckbert Susan R
- Heit John A
- Heitsch Laura
- Heuch Ingrid
- Heuschmann Peter Ulrich
- Hill Michael
- Ho Yuk-Lam
- Holliday Elizabeth G
- Hopewell Jemma C
- Howard George
- Howson Joanna MM
- Hozawa Atsushi
- Hsu Fang-Chi
- Huffman Jennifer E
- Hveem Kristian
- Hveem Kristian
- Hyacinth Hyacinth I
- Ibanez Laura
- Ibrahim Manal
- Ikram Mohammad A
- Ikram Mohammad K
- Ilinca Andreea
- Ingelsson Erik
- Ingelsson Martin
- Inouye Michael
- Irvin Marguerite R
- Irvin Marguerite R
- Irvin Marguerite R
- Iwasaki Motoki
- Jackson Rebecca D
- Jackson Rebecca D
- Jacob Mina A
- Jee Yon Ho
- Jenkins Carolyn
- Jensen Gorm B
- Jeon Christina E
- Jern Christina
- Jian Xueqiu
- Jimenez-Conde Jordi
- Johnson Andrew D
- Johnson Julie A
- Jood Katarina
- Jousilahti Pekka
- Judy Renae L
- Jukema J Wouter
- Jung Keum Ji
- Jurgenson Tuuli
- Kabrhel Christopher
- Kaffashian Sara
- Kalra Lalit
- Kamanu Frederick K
- Kamatani Yoichiro
- Kamouchi Masahiro
- Kamstrup Pia R
- Kanai Masahiro
- Kappelle L Jaap
- Keene Keith L
- Kim Bong-Jo
- Kim Bong-Jo
- Kim Jihye
- Kim Young Jin
- Kinnunen Janne
- Kissela Brett M
- Kitazono Takanari
- Kittner Steven J
- Kjartansson Olafur
- Kleindorfer Dawn O
- Kleinschnitz Christoph
- Kleinschnitz Christoph
- Kloss Manja
- Knol Maria J
- Koido Masaru
- Komolafe Morenikeji
- Konuma Takahiro
- Kooperberg Charles
- Kooperberg Charles
- Kooperberg Charles
- Korv Janika
- Koudstaal Peter J
- Kraft Peter
- Krebs Kristi
- Kristoffersen Espen S
- Krupinski Jerzy
- Kubo Michiaki
- Kumar Amit
- Labovitz Daniel L
- Lacaze Paul
- Lange Leslie A
- Langefeld Carl D
- Langenberg Claudia
- Lathrop G Mark
- Launer Lenore J
- Laurie Cathy C
- Le Grand Quentin
- Le Grand Quentin
- Le Grand Quentin
- Lee Jin-Moo
- Lee Keon-Joo
- Lee Tsong-Hai
- Lemmens Robin
- Lemmons Robin
- Leonard Hampton L
- Lepik Kaido
- Levi Christopher R
- Lewis Adam J
- Lewis Cathryn M
- Leys Didier
- Li Jiang
- Li Liming
- Li Linxin
- Liaw Yi-Ching
- Liaw Yung-Po
- Liman Thomas
- Lin Kuang
- Lin Wei-Yu
- Lind Lars
- Lindgren Arne G
- Lindgren Cecilia M
- Lindstrom Sara
- Linkohr Birgit
- Lioutas Vasileios
- Liu Yong Mei
- Lledos Miquel
- Llucia-Carol Laia
- Longstreth WT
- Lopez Oscar L
- Lopez-Cancio Elena
- Lorentzen Erik
- Luijckx Gert-Jan
- Lv Jun
- MacDonald James
- Magi Reedik
- Magnusson Patrik K
- Maguire Jane
- Makoto Hirata
- Malik Rainer
- Manichaikul Ani
- Markus Hugh S
- Marston Nicholas A
- Marti-Fabregas Joan
- Martinez-Majander Nicolas
- Martinsen Amy E
- Matsuda Koichi
- Mayerhofer Ernst
- McArdle Patrick F
- McCauley Bryan M
- McDonough Caitrin W
- McKnight Barbara
- Meitinger Thomas
- Melander Olle
- Menon Vilas
- Menon Vilas
- Meschia James F
- Metspalu Andres
- Milani Lili
- Millan Monica
- Millwood Iona Y
- Minegishi Naoko
- Mishra Aniket
- Mitchell Braxton D
- Molina Carlos A
- Montaner Joan
- Montellano Felipe A
- Morange Pierre-Emmanuel
- Morisaki Takayuki
- Morris Andrew P
- Mosley Thomas H
- Muino Elena
- Muller-Nurasyid Martina
- Munoz-Narbona Lucia
- Murakami Yoishinori
- Nagai Akiko
- Nagai Akiko
- Nalls Mike A
- Namba Shinichi
- Nederkoorn Paul J
- Nederkoorn Paul J
- Nelis Mari
- Nielsen Jonas B
- Nielsen Jonas B
- Niiranen Teemu J
- Ninomiya Toshiharu
- Nordestgaard Borge G
- Nordestgaard Borge G
- Norrving Bo
- Nygaard Marianne
- O'Donnell Chris J
- O'Donnell Martin J
- Obach Victor
- Obiako Reginald
- Ogbole Godwin
- Ogishima Soichi
- Okada Yukinori
- Olalere Abimbola
- Onland-Moret N Charlotte
- Onland-Moret N Charlotte
- Onland-Moret N Charlotte
- Osaigbovo Godwin
- Ovbiagele Bruce
- Owolabi Lukman
- Owolabi Mayowa O
- Pankow James S
- Pankratz Nathan
- Parati Eugenio A
- Pare Guillaume
- Parodi Livia
- Pattee Jack W
- Peddareddygari Leema Reddy
- Pedersen Linda M
- Pedersen Nancy L
- Pera Joanna
- Perola Markus
- Peters Annette
- Peto Richard
- Pezzini Alessandro
- Pileggi Silvana
- Posner Daniel C
- Pozarickij Alfred
- Prasad Kameshwar
- Prats-Sanchez Luis
- Psaty Bruce M
- Pulit Sara L
- Putaala Jukka
- Puurunen Marja K
- Rabionet Raquel
- Rannikmae Kristiina
- Reiner Alexander
- Reiner Alexander P
- Rexrode Kathryn M
- Riaz Moeen
- Riba-Llena Iolanda
- Ribases Marta
- Ribo Marc
- Rice Kenneth
- Rich Stephen S
- Ridker Paul M
- Rissanen Ina L
- Rolfs Arndt
- Romero Jose R
- Roquer Jaume
- Rosand Jonathan
- Rosendaal Frits R
- Roshchupkin Gennady V
- Ross Owen A
- Rost Natalia S
- Rothwell Peter M
- Rotter Jerome I
- Rudd Anthony G
- Ruff Christian T
- Ruigrok Ynte M
- Rundek Tatjana
- Rutten-Jacobs Loes
- Sabatine Marc S
- Sacco Ralph L
- Saillour-Glenisson Florence
- Sakaue Saori
- Sale Michele M
- Saleheen Danish
- Salomaa Veikko
- Sandset Else Charlotte
- Sanghera Dharambir K
- Sapkota Bishwa R
- Sarfo Fred S
- Sargurupremraj Muralidharan
- Sargurupremraj Muralidharan
- Sarin Antti-Pekka
- Sarju Ralhan
- Sarnowski Chloe
- Sasaki Makoto
- Satizabal Claudia L
- Satoh Mamoru
- Sattar Naveed
- Sawada Norie
- Schmidt Carsten O
- Schmidt Dan
- Schmidt Reinhold
- Schminke Ulf
- Schnohr Peter
- Schnohr Peter
- Segura Tomas
- Serrano-Heras Gemma
- Seshadri Sudha
- Sharma Pankaj
- Shi Mingyang
- Shimizu Atsushi
- Shiroma Eric J
- Sibolt Gerli
- Sigurdsson Asgeir
- Sigurdsson Sigurdur
- Simonsick Eleanor M
- Skogholt Anne H
- Sloane Kelly L
- Slowik Agnieszka
- Smith Albert
- Smith Erin N
- Smith Nicholas L
- Sobrino Tomas
- Sobue Kenji
- Soderholm Martin
- Soriano-Tarraga Carolina
- Srinivasasainagendra Vinodh
- Stanne Tara M
- Stefansson Kari
- Stevens Becky
- Stine O Colin
- Stott David J
- Strauch Konstantin
- Strbian Daniel
- Suchon Pierre
- Sudlow Cathie LM
- Sumoy Lauro
- Sun Yan V
- Sung Yun Ju
- Sutoh Yoichi
- Takai Takako
- Tanaka Hideo
- Tang Weihong
- Tanislav Christian
- Tanno Kozo
- Tatlisumak Turgut
- Taylor Kent D
- Taylor Kent D
- Teumer Alexander
- Thijs Vincent NS
- Thomas Laurent F
- Thomassen Jesper Qvist
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Tiainen Marjaana
- Tiedt Steffen
- Tiwari Hemant K
- Tomppo Liisa
- Torres-Aguila Nuria P
- Touze Emmanuel
- Traylor Matthew
- Tregouet David-Alexandre
- Trompet Stella
- Tsugane Shoichiro
- Tuladhar Anil Man
- Turman Constance
- Turnbull Iain
- Tybjaerg-Hansen Anne
- Tzourio Christophe
- Uitterlinden Andre G
- Ungethum Kathrin
- Uvere Ezinne
- Valdimarsson Einar M
- van der Laan Sander W
- van der Lee Sven J
- van Dijk Ewoud J
- van Dijk Ewoud J
- van Dijk Gert W
- van Duijn Cornelia M
- van Hylckama Vlieg Astrid
- van Norden Anouk GW
- van Oostenbrugge Robert J
- van Rooij Frank GW
- van Setten Jessica
- van Setten Jessica
- van Vugt Marion
- van Vugt Marion
- Vaura Felix C
- Verma Shefali S
- Verma Shefali S
- Vermeer Sarah E
- Vibo Riina
- Visser Marieke C
- Vives-Bauza Cristofol
- Volker Uwe
- Volzke Henry
- Vonk Jet MJ
- Wahab Kolawole
- Wakai Kenji
- Walters Matthew
- Walters Robin G
- Wang Chen
- Wang Lu
- Wang Ruiqi
- Wareham Nicholas J
- Wassertheil-Smoller Sylvia
- Weir David
- Wennberg Patrik
- Wermer Marieke JH
- Wiggins Kerri L
- Willer Cristen J
- Williams Stephen R
- Wilson James G
- Wilson Peter WF
- Winsvold Bendik Slagsvold
- Wolfe Charles DA
- Wong Quenna
- Woo Daniel
- Worrall Bradford B
- Xu Huichun
- Yaffe Kristine
- Yamaji Taiki
- Yang Chaojie
- Yang Chengran
- Yang Qiong
- Yonova-Doing Ekaterina
- Yoon Kyungheon
- Yu Canqing
- Yusuf Salim
- Zand Ramin
- Zhou Wei
- Zonderman Alan B
- Zwart John-Anker
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis3, and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach4, we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry5. Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two
- Author
- Abassi Yama
- Abelin Jennifer G
- Abolhalaj Milad
- Abraham Tara S
- Adam Ammar
- Adams David
- Adams Homer
- Adams Sarah F
- Adamus Tomasz
- Addepalli Murali
- Addepalli Murali
- Adjei Alex A
- Agapova Larissa
- Agarwala Sanjiv
- Ager Casey
- Aggarwal Charu
- Agnello Giulia
- Agudo Judith
- Aguilar Ethan G
- Aguilera Todd
- Ahamadi Malidi
- Ahn Yong-Oon
- Ahrens Eric T
- Aizer Ayal
- Ajina Reham
- Akerley Wallace
- Al-Muftah Mariam
- Albershardt Tina C
- Albershardt Tina C
- Albrekt Ann-Sofie
- Alekar Shilpa
- Alemany Ramon
- Alemany Ramon
- Alexander Brian
- Allbritton Omaira
- Allen Clint T
- Alley Evan W
- Allison James
- Allison James
- Allison James
- Alston Tesha
- Alt Jürgen
- Alters Susan
- Amatulli Michael
- Anand Snjezana
- Anand Snjezana
- Anand Snjezana
- Anderson Clark
- Anderson Mark
- Andersson Bengt
- Andre Pascale
- Andtbacka Robert H I
- Andtbacka Robert H I
- Angiuoli Sam
- Ansari Tameem
- Anthony Scott
- Antonarakis Emmanuel S
- Antonia Scott J
- Anwar Firoz
- Aquino-Michaels Keston
- Archer Jacob F
- Arina Ainhoa
- Armand Philippe
- Armenta Paul
- Armet Caroline M
- Arnoux Thomas
- Ascarateil Stephane
- Askmyr David
- Atkins Michael
- Atkins Michael B
- Atkinson Victoria
- Au Katrina
- Autio Karen A
- Awad Mark
- Bagarazzi Mark
- Bai Dina
- Baia Gilson
- Baird Jason
- Bajaj Anshika
- Balatoni Timea
- Balboni Tracy
- Balch Leslie
- Bang Andrew
- Bao Riyue
- Bao Yangyi
- Bao Yangyi
- Barakat David
- Barberi Theresa
- Barker Christopher A
- Barnea Eytan
- Barras David
- Bartkowiak Todd
- Bartlett David
- Bartlett David
- Bartlett David
- Bartlett David
- Barton Sunjay M
- Barve Minal
- Bauer Todd
- Bauer Todd W
- Bauman Julie
- Baumgaertner Petra
- Bauml Joshua
- Beceren-Braun Figen
- Beck Kristen
- Becker Annette
- Beckers Johannes
- Beckett Michael A
- Bedognetti Davide
- Bedognetti Davide
- Bedognetti Davide
- Bell Bryan
- Bell Charles J M
- Bell Peter
- Beltran Pedro
- Bender Lewis H
- Bender Steven
- Bennett Mark K
- Benz Steven
- Bera Tapan
- Berglund Peter
- Berglund Peter
- Berkey Sara
- Bernatchez Chantale
- Berry John S
- Berzofsky Jay A
- Bhardwaj Nina
- Bian Zhen
- Bianco Alberto
- Biediger Ronald J
- Bifulco Carlo
- Bigley Alison
- Bingham Patrick
- Biniszkiewicz Detlev M
- Bischoff Helge
- Blake Zoe
- Blake Zoe
- Blakely Collin
- Blazar Bruce R
- Blogowski Wojciech
- Bloom Anja C
- Boehm Jesse
- Bokovanov Vladimir
- Bommareddy Praveen K
- Bommareddy Praveen K
- Bommareddy Praveen K
- Bommareddy Praveen K
- Booth Jamie
- Bornschlegl Svetlana
- Bose Nandita
- Bossenmaier Birgit
- Boughorbel Sabri
- Boyer Jean
- Bramante Simona
- Branstetter Daniel
- Brech Dorothee
- Brenin David
- Broaddus V. C
- Brockstedt Dirk G
- Brockstedt Dirk G
- Brody Joshua
- Bronson Roderick
- Brooks Alan
- Brooks Alan D
- Broucek Joseph
- Brown Alice
- Brown Brian
- Brown Brittany
- Brown Gail L
- Brown Sheila
- Bruce Jeffrey N
- Brunet Laura R
- Bruno Tullia C
- Bryan Jennifer
- Bryant Richard
- Buchbinder Elizabeth
- Bucsek Mark
- Budhu Sadna
- Budhu Sadna
- Budkowska Marta
- Bueno Raphael
- Buettner Florian
- Buettner Nico
- Bullock Kim
- Bullock Kim
- Burova Elena
- Burrill Joel
- Bussler Holm
- Butterfield Lisa H
- Butterfield Lisa H
- Byrne-Steele Miranda
- Cagney Daniel
- Calderon Hugo
- Callahan Margaret K
- Campesato Luis F
- Campogan Dwayne
- Cao Felicia
- Capasso Cristian
- Capasso Cristian
- Caplazi Patrick
- Cappuccini Federica
- Carcaboso Angel M
- Carlino Matteo S
- Carpi Sara
- Carrasco Ruben
- Carrera Diego A
- Carrero Rosa M S
- Carson Dennis A
- Castellini Laura
- Cathomas Richard
- Cauvin Annick
- Cauwenberghs Sandra
- Caux Christophe
- Cebon Jonathan S
- Ceccarelli Michele
- Celis Esteban
- Cerignoli Fabio
- Cerullo Vincenzo
- Cerullo Vincenzo
- Cervera-Carrascón Víctor
- Cesareni Gianni
- Cha John
- Cha John
- Cha John
- Champion Brian
- Chan Anissa S H
- Chan Chanty
- Chan Chanty
- Chan Ivan
- Chan Leo
- Chan Timothy A
- Chang Alfred E
- Chang Alfred E
- Chang Joe
- Chang Nancy N
- Chang Thomas
- Chanuc Fabien
- Chapelin Fanny
- Chaplin Jenny
- Chappel Scott C
- Charych Deborah H
- Charych Deborah H
- Chaudhuri Amitabha
- Chaussabel Damien
- Chen Ada
- Chen Ada
- Chen Gang
- Chen Jason
- Chen Jason
- Chen Xiaomu
- Chen Xin
- Chen Xiufen
- Chen Yu
- Chen Yu
- Chenchik Alex
- Chheda Zinal
- Chiang Eugene
- Chikina Maria
- Chittenden Thomas
- Chiu Hsiling
- Cho Charles
- Chongyung Fang
- Chou Margaret
- Choueiri Toni K
- Choy Carmen
- Clark Joseph I
- Clavijo Paul E
- Clifton Guy T
- Clynes Raphael
- Cobbold Mark
- Cobbold Mark
- Cobbold Mark
- Coder Brandon
- Coffman Robert L
- Cohen Cyrille
- Cohen Ezra E W
- Cohen Roger
- Colen Rivka
- Colevas A. D
- Collins Natalie
- Colrain Jillian
- Coltharp Carla
- Concha-Benavente Fernando
- Connolly Eileen P
- Conwell Darwin
- Conwell Darwin
- Corrales Leticia P
- Corrales Leticia P
- Coukos George
- Coukos George
- Coussens Lisa M
- Coussens Lisa M
- Craggs Graham
- Craig Andrew
- Crittenden Marka
- Cron Kyle R
- Cronstein Bruce N
- Crooks James
- Crosby Andrea
- Crosignani Stefano
- Crowder Robert
- Cruickshank Scott
- Csuka Orsolya
- Curbishley Stuart
- Curiel Tyler
- Curran Emily
- Curran Michael
- Curti Brendan
- Curti Brendan
- Da Costa Andre
- Dai Fu
- Dai Jie
- Dai Peihong
- Dalgleish Angus
- Dalvie Deepak
- Daniels Gregory A
- Daud Adil
- David Justin M
- Davies Bronwyn
- de Boisferon Marc H
- de Groot Patricia
- de Gruijl Tanja
- De Henau Olivier
- de Leon Laura
- De Maeseneire Coraline
- De Sanctis Francesco
- de Silva Suresh
- Deacon Donna
- Deacon Donna H
- DeBenedette Mark
- DeBenedette Mark
- Declerck Paul
- Decock Julie
- Decock Julie
- DeFalco Jeff
- Dela Cruz Filemon
- Delgoffe Greg
- Delgoffe Greg M
- Delgoffe Greg M
- Delgoffe Greg M
- Delogu Lucia
- Delorenzi Mauro
- Demaria Sandra
- Demaria Sandra
- Deng Liang
- Deng Weiwen
- Deng Wentao
- Denies Sofie
- Denis Caroline
- Desbien Anthony L
- deVries Michele
- Dhupkar Pooja
- Diab Adi
- Diab Adi
- Diab Adi
- Diaz Luis
- DiCostanzo AriCeli
- Diede Scott J
- Dietz Allan B
- Dillhoff Mary
- Dillon Patrick
- Dilworth Ryan
- Dimberg Anna
- Ding Yueyun
- Doberstein Stephen K
- Dobkin Julie
- Doener Fatma
- Dolegowska Barbara
- Doleschall Zoltan
- Doman Thompson
- Dominguez George
- Donahue Renee
- Donahue Renee
- Dorsey Frank C
- Dovedi Simon
- Downs-Canner Stephanie
- Drake Charles
- Drake Charles G
- Drake Charles G
- Driessens Gregory
- Driscoll Kyla
- Druker Brian J
- Dubensky Thomas W
- Dubensky Thomas W
- Dudimah Duafalia
- Duff Susan
- Dumontet Charles
- Dunai Cordelia
- Dunai Cordelia
- Dutcher Janice P
- Duttagupta Priyanka
- Duvvuri Uma
- Dyson Mike
- D’Apuzzo Massimo
- Ebner Peggy
- Edwards Robert
- Edwards Robert P
- Edwards Robert P
- Eickhoff Jens
- Eisenhower Mary
- El Alaoui Meddy
- El Alaoui Said
- Eles Klara
- Ellies Lesley
- Elnaggar Omar
- Elvecrog James
- Emberley Ethan
- Emerling Daniel
- Eng Charis
- Engelhard Victor H
- English Jessie
- Enstrom Amanda
- Eremeev Artem
- Eriksson Emma
- Eriksson Emma
- Eriksson Emma
- Ertelt Kathleen
- Eswarappa Rajesh
- Evans Elizabeth
- Evans Kathy
- Facciabene Andrea
- Facciabene Andrea
- Facciabene Andrea
- Facciponte John
- Facciponte John
- Falchook Gerald
- Fantini Massimo
- Fantini Massimo
- Fantini Massimo
- Farkas Emil
- Farren Matthew
- Faustman Denise
- Fa’ak Faisal
- Fa’ak Faisal
- Femel Julia
- Feng JunLi
- Feng Yan
- Feng Zipei
- Feola Sara
- Fernandez Christian
- Fernando Ingrid
- Ferris Robert L
- Ferris Robert L
- Ferris Robert L
- Ferris Robert L
- Fesenkova Valentyna
- Field Jessica J
- Fisher Kerry
- Fisher Terry
- Fitzharris Bernie
- Flano Emilio
- Flechtner Jessica B
- Flies Dallas B
- Flynn Patrick
- Fogler William
- Fong Lawrence
- Formenti Silvia C
- Formenti Silvia C
- Foster Cathie
- Foster Rosemary
- Fotin-Mleczek Mariola
- Fox Bernard
- Francica Brian
- Francis Julie-Ann
- Frangou Costa
- Franklin Marilyn
- Franklin Wilbur
- Frascaro Federica
- Fraser Kathryn
- Frederix Kim
- Freimark Bruce
- Freimark Bruce
- Freimark Bruce
- Frey Alan
- Fridman Leticia
- Friedman Alan
- Friedman David
- Fromm George
- Früh Martin
- Fu Yang-Xin
- Fu Yichun
- Fu Yichun
- Fuertes Marraco Silvia A
- Fugle Caroline W
- Fuhrmann Steven
- Fukaya Satoshi
- Fulton Noreen
- Fuoco Claudia
- Fusciello Manlio
- Fuseri Nicolas
- Gabitzsch Elizabeth
- Gabrail Nashat
- Gabrilovich Dmitry
- Gajewski Thomas
- Gajewski Thomas F
- Gajewski Thomas F
- Gajewski Thomas F
- Gajewski Thomas F
- Gajewski Thomas F
- Gajewski Thomas F
- Galeassi Nadejda
- Gamble Alicia
- Gamble Alicia
- Gameiro Sofia
- Gameiro Sofia R
- Gandhi Anita
- Gao Chan
- Gardai Shyra J
- Gardner Kellie
- Gartrell Robyn
- Gartrell Robyn
- Gartrell Robyn
- Gasmi Billel
- Gastineau Dennis A
- Gaughan Elizabeth
- Gauthier Audrey
- Gauthier Kelsey S
- Geissler Michael
- Gergel Ivan
- Geukens Nick
- Gfeller David
- Ghadially Hormas
- Ghamsari Lila
- Ghandi Leena
- Ghisoli Maurizio
- Giaccia Amato
- Gibney Geoffrey
- Giffin Louise
- Gillies Stephen D
- Giri Sanjeev
- Gladstone Douglas
- Glickman Laura H
- Gnad-Vogt Ulrike
- Godwin John
- Gomes Bruno
- Gong Jian
- Gong Jian
- Gonzales Rodney J M
- Gooding William
- Gooding William
- Goodman Reid
- Gopal Ajay
- Gordon Keith
- Gordon Nancy
- Gottschalk Stephen
- Gough Michael
- Gowda Nagaraj
- Goyal Sharad
- Graff Jeremy
- Graham Charles
- Graves Edward
- Gray Michael
- Gray Michael
- Greasley Samantha
- Greenberg Norman
- Greiff Lennart
- Greiner John W
- Grenga Italia
- Grenga Italia
- Gressett Monica M
- Griesinger Frank
- Grigoryeva Olga
- Grigsby Iwen
- Grivas Petros
- Grogan Elizabeth W
- Grogan Jane
- Grose Mark
- Grose Mark
- Grose Mark
- Grosh William
- Gross Matt
- Gross Matt
- Grossenbacher Steven K
- Grossmann Kenneth
- Gruber Harry
- Gu Xuemin
- Guenther Garret
- Guerriero Jennifer
- Gugel Elena G
- Guiducci Cristina
- Guirado Elizabeth
- Gulley James L
- Gunatilaka Leslie A A
- Guo Jie
- Guo Zeng-qing
- Gupta Ravi
- Gupta Sachin
- Gupta Sumati
- Gustafson Michael P
- Gutierrez Andres A
- Guttridge Denis
- Guy Emily I
- Guzman Wilson
- Hagihara Katsunobu
- Hagner Patrick
- Hailemichael Yared
- Hailemichael Yared
- Haining W. N
- Hale Diane F
- Hall Gerald
- Hallmeyer Sigrun
- Hamdy Freddie
- Hammond Scott A
- Han Jian
- Han Yanyan
- Hank Jacquelyn A
- Hanks Brent A
- Hanson Bill
- Harari Paul M
- Harbell Michael
- Hardin Mark O
- Hardwick James
- Harrington Kevin
- Harris Jaryse
- Harris-Bookman Sarah
- Hart Philip
- Hasapidis Jeannette
- Hassan Raffit
- Havel Jonathan
- Havunen Riikka
- Havunen Riikka
- Hayashi Tomoko
- Haymaker Cara
- Haynes Heather
- Heinze Clinton
- Hellmann Matthew D
- Hellmann Matthew D
- Hellmann Matthew D
- Hellström Ann-Charlotte
- Helming Laura
- Hemmi Silvio
- Hemminki Akseli
- Hemminki Akseli
- Hemminki Otto
- Hendrickx Wouter
- Hendrickx Wouter
- Hendrickx Wouter
- Henrich Ian
- Heo Dae S
- Herbert Garth S
- Herbst Ronald
- Heron Dwight
- Herranz Mireia U
- Hess Kenneth R
- Heymach John
- Higuchi Tomoe
- Hilbe Wolfgang
- Hill Adrian
- Hill Andrew G
- Hill Jonathan A
- Hillringhaus Lars
- Hipp Madeleine
- Hirschhorhn-Cymerman Daniel
- Ho Po
- Hoch Ute
- Hoch Ute
- Hoch Ute
- Hodge James
- Hodge James
- Hodge James W
- Hodi F. S
- Hodi F. S
- Hodi F. S
- Hofmeister Robert
- Holland Pamela M
- Hollevoet Kevin
- Hollingsworth Robert E
- Hollingsworth Robert E
- Holmgaard Rikke
- Holtzhausen Alisha
- Honarmand Somayeh
- Hong Bang-Xing
- Hong David
- Hong Henoch S
- Hong Peter
- Horst Basil
- Horton Brendan
- Horvath Szabolcs
- Hotson Andrew
- Hou Jinlin
- Hou Xiaohong
- Hou Yafei
- Howell Alan
- Hu Yangyang
- Hu Yangyang
- Hu-Lieskovan Siwen
- Hua Hong
- Huang Fei
- Huang Jing
- Huang Shiang
- Huang Shiang
- Huang Tony
- Huang Yuanhiu
- Huang Yuanhiu
- Hudson Thomas E
- Huelsmann Erica
- Huffman Austin P
- Humeau Laurent
- Hunt Donald F
- Hunt Donald F
- Hurt Elaine
- Hurt Elaine
- Hurwitz Michael
- Hutchins Jeff
- Hutchins Jeff
- Hutchins Jeff
- Hwu Patrick
- Hwu Wen-Jen
- Hylander Bonnie
- Ibrahim Nageatte
- Illingworth Sam
- Infante Jeffrey
- Ioffe Ella
- Irmler Martin
- Irving Bryan A
- Irving Bryan A
- Izaki Daisuke
- Jablons David
- Jablonski Sandra
- Jackson Doreen O
- Jackson Natalie
- Jacobson Caron
- Jacques Judy
- Jaen Juan C
- Jaen Juan C
- Jahan Naznin
- Jahan Thierry
- Jaini Ritika
- Jaiswal Ashvin
- Jameson Michael B
- Jang Dadi
- Janku Filip
- Janne Pasi A
- Janssen Louise
- Jarblad-Leja Justyna
- Jeraj Robert
- Jessen Katti
- Jhawar Sachin
- Jhawar Sachin
- Jia Dan T
- Jin Ming
- Johnson Brian
- Johnson Bruce D
- Johnson Karen
- Johnson Melissa L
- Jolly Douglas
- Joly Nathalie
- Jonas Adria
- Jones Frank
- Jones Jeremy
- Jones Sian
- Joshi Bharat H
- Ju Xiaoming
- Kadenhe-Chiweshe Angela
- Kaiser Stephen
- Kalinski Pawel
- Kalinski Pawel
- Kalinski Pawel
- Kalinski Pawel
- Kallen Karl-Josef
- Kalos Michael
- Kane Lawrence P
- Kanerva Anna
- Kang Kai
- Kangas Takashi O
- Kanne David B
- Kantrowitz Joel
- Kapp Kerstin
- Kapralova Marina
- Kariolis Mihalis
- Karlsson-Parra Alex
- Karpathy Roberta
- Karpov Andrey
- Kasibhatla Shailaja
- Kasler Miklos
- Katibah George
- Katibah George
- Kaufman David R
- Kaufman Howard L
- Kaufman Howard L
- Kaufman Howard L
- Kaufman Howard L
- Kaufman Howard L
- Kaufman Howard L
- Kaufman Howard L
- Kauh John S
- Kavanaugh W. M
- Kavanaugh W. M
- Keam Bhumsuk
- Kern Jeffrey
- Khalil Danny N
- Khong Hiep
- Khong Hung
- Khuat Lam T
- Khuat Lam T
- Kibel Adam S
- Kidder Koby
- Kim Chul-Ho
- Kim Dong-Wan
- Kim Dongkyoon
- Kim Seulki
- Kim Seungwon
- Kim Soyeon
- Kim Tae M
- Kindler Hedy L
- Kindt Erick
- Kirk Peter
- Kirksey Yolanda
- Kitaura Kazutaka
- Kleinerman Eugenie S
- Kler Jasdeep
- Kline Justin
- Klinke David J
- Klinkhardt Ute
- Klippel Anke
- Kluger Harriet
- Knapp Alyssa
- Knudson Karin M
- Knudson Karin M
- Koch Sven D
- Kodumudi Krithika
- Kohanbash Gary
- Kohlhapp Frederick
- Kohlhapp Frederick
- Kolarkar Shalini
- Kollmeier Jens
- Komar Hannah
- Komar Hannah M
- Komarov Andrey
- Konakova Marina
- Koong Albert
- Korman Alan J
- Kornbluth Richard S
- Kortylewski Marcin
- Kortylewski Marcin
- Kosaka Yoko
- Kosoff Rachelle
- Kostarelos Kostas
- Koti Madhuri
- Kotlan Beatrix
- Koziol Marie E
- Kradjian Giorgio
- Krasovskaia Liudmila
- Kraus Manfred
- Kraynyak Kim
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- Zeng Xue
- Zha Yuanyuan
- Zhang Danhui
- Zhang Jing
- Zhang Ping
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- Zhang Winter
- Zhang Yanping
- Zhao Fei
- Zhao Leyna
- Zhao Xingli
- Zheng Lianxing
- Zheng Wenxin
- Zheng Xianxian
- Zheng Yi
- Zhong Hong
- Zhou Li
- Zhou Xiangjun
- Zippelius Alfred
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zou Jun
- Zuba-Surma Ewa
- Zubkova Olga
- Zureikat Amer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Background
The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd.
Methods
We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background.
Results
First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001).
Conclusions
In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival
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