Genetic determinants of haemolysis in sickle cell anaemia

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/97446/1/bjh12245.pd

Gradient Optics of subwavelength nanofilms

Propagation and tunneling of light through subwavelength photonic barriers, formed by dielectric layers with continuous spatial variations of dielectric susceptibility across the film are considered. Effects of giant heterogeneity-induced non-local dispersion, both normal and anomalous, are examined by means of a series of exact analytical solutions of Maxwell equations for gradient media. Generalized Fresnel formulae, visualizing a profound influence of gradient and curvature of dielectric susceptibility profiles on reflectance/transmittance of periodical photonic heterostructures are presented. Depending on the cutoff frequency of the barrier, governed by technologically managed spatial profile of its refractive index, propagation or tunneling of light through these barriers are examined. Nonattenuative transfer of EM energy by evanescent waves, tunneling through dielectric gradient barriers, characterized by real values of refractive index, decreasing in the depth of medium, is shown. Scaling of the obtained results for different spectral ranges of visible, IR and THz waves is illustrated. Potential of gradient optical structures for design of miniaturized filters, polarizers and frequency-selective interfaces of subwavelength thickness is considered

A Genome-Wide Association Study of Total Bilirubin and Cholelithiasis Risk in Sickle Cell Anemia

Serum bilirubin levels have been associated with polymorphisms in the UGT1A1 promoter in normal populations and in patients with hemolytic anemias, including sickle cell anemia. When hemolysis occurs circulating heme increases, leading to elevated bilirubin levels and an increased incidence of cholelithiasis. We performed the first genome-wide association study (GWAS) of bilirubin levels and cholelithiasis risk in a discovery cohort of 1,117 sickle cell anemia patients. We found 15 single nucleotide polymorphisms (SNPs) associated with total bilirubin levels at the genome-wide significance level (p value <5×10−8). SNPs in UGT1A1, UGT1A3, UGT1A6, UGT1A8 and UGT1A10, different isoforms within the UGT1A locus, were identified (most significant rs887829, p = 9.08×10−25). All of these associations were validated in 4 independent sets of sickle cell anemia patients. We tested the association of the 15 SNPs with cholelithiasis in the discovery cohort and found a significant association (most significant p value 1.15×10−4). These results confirm that the UGT1A region is the major regulator of bilirubin metabolism in African Americans with sickle cell anemia, similar to what is observed in other ethnicities

Basic Judaism.

New Yorkix, 172 p.; 20 cm

The Prophet\u27s Wife

Sunday, October 16, 2011 (2:00-3:30PM) The Prophet\u27s Wife by Milton Steinberg Discussion led by Dr. Monica Osborne, English Dept. The Lord said unto Hosea: Go, take unto thee a wife of harlotry and children of harlotry; for the land doth commit great harlotry, departing from the Lord. HOSEA 1:2From the moment young Hosea saw the maiden Gomer dancing at the Festival of Booths, he loved her. It was the most beautiful vision he had ever seen, and he would never forget it, despite the scornful laughter of his older brother Iddo, despite the lack of piety of Gomer s household, and despite her admission that she did not love him. And so Hosea marries Gomer, in a troubled land where idol-worshiping neighbors offer up their daughters purity in the sacred groves, where arrogant high priests will stop at nothing to silence troublesome prophets, and where the blood of brothers can be the strongest bond, or the most destructive.When Milton Steinberg died in 1950, he left one manuscript tantalizingly unfinished. Like As a Driven Leaf, it is grand in scope, while told as a compelling personal tale. Set against a backdrop of unrest in ancient Israel, The Prophet s Wife is a stirring portrait of the biblical prophet Hosea, his passionate and free-spirited wife Gomer, and a people seduced by the lures of power and idolatry to betray their faith.https://digitalcommons.lmu.edu/jewishbookgroup/1041/thumbnail.jp