An evolutionary approach to the delimitation of labour market areas: an empirical application for Chile

An evolutionary approach to the delimitation of labour market areas: an empirical application for Chile. Spatial Economic Analysis. Labour market areas (LMAs) are argued to represent a more appropriate policy framework than administrative units for the analysis of spatial labour market activity. This article develops LMAs for Chile by applying an evolutionary computation approach. This innovative approach defines LMAs through an optimization process by maximization of internal cohesion, subject to restrictions of minimum levels of self-containment and population. To evaluate the appropriateness of the LMAs, comparative analyses are performed between alternative delimitations based on different parameter configurations of the proposed method versus administrative boundaries and the most widely used method for official LMA delimitation, the travel-to-work areas method

An XMM-Newton view of FeK{\alpha} in HMXBs

We present a comprehensive analysis of the whole sample of available XMM-Newton observations of High Mass X-ray Binaries (HMXBs) until August, 2013, focusing on the FeK{\alpha} emission line. This line is a key tool to better understand the physical properties of the material surrounding the X-ray source within a few stellar radii (the circumstellar medium). We have collected observations from 46 HMXBs, detecting FeK{\alpha} in 21 of them. We have used the standard classification of HMXBs to divide the sample in different groups. We find that: (1) FeK{\alpha} is centred at a mean value of 6.42 keV. Considering the instrumental and fits uncertainties, this value is compatible with ionization states lower than FeXVIII. (2) The flux of the continuum is well correlated with the flux of the line, as expected. Eclipse observations show that the Fe fluorescence emission comes from an extended region surrounding the X-ray source. (3) FeK{\alpha} is narrow (width lower than 0.15keV), reflecting that the reprocessing material does not move at high speeds. We attempt to explain the broadness of the line in terms of three possible broadening phenomena: line blending, Compton scattering and Doppler shifts (with velocities of the reprocessing material V=1000-2000 km/s). (4) The equivalent hydrogen column (NH) directly correlates with the EW of FeK{\alpha}, displaying clear similarities to numerical simulations. It highlights the strong link between the absorbing and the fluorescent matter. The obtained results clearly point to a very important contribution of the donors wind in the FeK{\alpha} emission and the absorption when the donor is a supergiant massive star.Comment: Accepted for publication in A&A. 13 pages, 16 figures + Appendice

Time Reversal Violation from the entangled B0-antiB0 system

We discuss the concepts and methodology to implement an experiment probing directly Time Reversal (T) non-invariance, without any experimental connection to CP violation, by the exchange of "in" and "out" states. The idea relies on the B0-antiB0 entanglement and decay time information available at B factories. The flavor or CP tag of the state of the still living neutral meson by the first decay of its orthogonal partner overcomes the problem of irreversibility for unstable systems, which prevents direct tests of T with incoherent particle states. T violation in the time evolution between the two decays means experimentally a difference between the intensities for the time-ordered (l^+ X, J/psi K_S) and (J/psi K_L, l^- X) decays, and three other independent asymmetries. The proposed strategy has been applied to simulated data samples of similar size and features to those currently available, from which we estimate the significance of the expected discovery to reach many standard deviations.Comment: 17 pages, 2 figures, 6 table

Electromagnetic Form Factors of a Massive Neutrino

Electromagnetic form factors of a massive neutrino are studied in a minimally extended standard model in an arbitrary $R_{\xi}$ gauge and taking into account the dependence on the masses of all interacting particles. The contribution from all Feynman diagrams to the charge, magnetic, and anapole form factors, in which the dependence on the masses of all particles as well as on gauge parameters is accounted for exactly, are obtained for the first time in explicit form. The asymptotic behavior of the magnetic form factor for large negative squares of the momentum of an external photon is analyzed and expression for the anapole moment of a massive neutrino is derived. The results are generalized to the case of mixing between various generations of the neutrino. Explicit expressions are obtained for the charge, magnetic, and electric dipole and anapole transition form factors as well as for the transition electric dipole moment.Comment: 16 pares with 5 figures in pdf forma

Inside the metropolis: the articulation of Spanish metropolitan areas into local labor markets

In this article, we delimit local labor markets (LLMs) in order to analyze the internal structure and organization of Spanish metropolitan areas. LLMs are defined as self-contained and cohesive areas in terms of commuting flows. Unlike the conventional approach to polycentrism based on the analysis of commuting flows that begins with the identification of subcenters, our analytical strategy does assume any a priori structure and is compatible with the relationship between places of work and residence having other locational and spatial organization patterns. The analysis is performed at three different scales of detail linked to three self-containment levels for the LLMs delimited and three population groups (total, males, and females). The results show that metropolitan areas are complex, fuzzy, multidimensional spaces, where the conditions of spatial organization are manifested in different ways depending on the parameters and variables used.This work was supported by the Spanish Ministry of Economy and Competitiveness [grant numbers CSO2011-29943-C03-01, CSO2011-29943-C03-02, CSO2014-55780-C3-1-P, and CSO2014-55780-C3-2-P (National R&D&I Plan)]

Theory and phenomenology of two-Higgs-doublet models

We discuss theoretical and phenomenological aspects of two-Higgs-doublet extensions of the Standard Model. In general, these extensions have scalar mediated flavour changing neutral currents which are strongly constrained by experiment. Various strategies are discussed to control these flavour changing scalar currents and their phenomenological consequences are analysed. In particular, scenarios with natural flavour conservation are investigated, including the so-called type I and type II models as well as lepton-specific and inert models. Type III models are then discussed, where scalar flavour changing neutral currents are present at tree level, but are suppressed by either specific ansatze for the Yukawa couplings or by the introduction of family symmetries. We also consider the phenomenology of charged scalars in these models. Next we turn to the role of symmetries in the scalar sector. We discuss the six symmetry-constrained scalar potentials and their extension into the fermion sector. The vacuum structure of the scalar potential is analysed, including a study of the vacuum stability conditions on the potential and its renormalization-group improvement. The stability of the tree level minimum of the scalar potential in connection with electric charge conservation and its behaviour under CP is analysed. The question of CP violation is addressed in detail, including the cases of explicit CP violation and spontaneous CP violation. We present a detailed study of weak basis invariants which are odd under CP. A careful study of spontaneous CP violation is presented, including an analysis of the conditions which have to be satisfied in order for a vacuum to violate CP. We present minimal models of CP violation where the vacuum phase is sufficient to generate a complex CKM matrix, which is at present a requirement for any realistic model of spontaneous CP violation.Comment: v3: 180 pages, 506 references, new chapter 7 with recent LHC results; referee comments taken into account; submitted to Physics Report

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Profibrotic role of endoglin is dependent on its intracellular domain

2 p.Peer reviewe