203 research outputs found
Genetic and Chemical Modifiers of a CUG Toxicity Model in Drosophila
- Author
- A Ebralidze
- A Guichet
- A Mankodi
- A Mankodi
- A Tomlinson
- Alfred Lewin
- Amparo Garcia-Lopez
- AV Philips
- D Gatfield
- G Begemann
- H Furuya
- H Gu
- H Jiang
- H Li
- Irma Garcia-Alcover
- J Mohler
- JD Rhodes
- JF Desaphy
- JM Houseley
- JW Miller
- K Kobayashi
- KW Marek
- L Machuca-Tzili
- L Monferrer
- Lidon Monferrer
- LP Ranum
- M Bate
- M Fardaei
- M Gomes-Pereira
- M Tettamanti
- M Vicente
- M Vicente-Crespo
- M. Carmen Alvarez-Abril
- Marta Vicente-Crespo
- MD Haro
- Ms Mahadevan
- MZ Garcia-Casado
- OA Sofola
- P Fernandez-Funez
- P Harper
- P Jin
- RD Read
- RN Kanadia
- RN Kanadia
- RN Kanadia
- Ruben D. Artero
- S Paul
- SN Prokopenko
- T Fergestad
- T Kurihara
- TH Ho
- V Bharathi
- W Dansithong
- W Fischer
- WR Mathews
- WS Neckameyer
- X Lin
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2008
- Field of study
Non-coding CUG repeat expansions interfere with the activity of human Muscleblind-like (MBNL) proteins contributing to myotonic dystrophy 1 (DM1). To understand this toxic RNA gain-of-function mechanism we developed a Drosophila model expressing 60 pure and 480 interrupted CUG repeats in the context of a non-translatable RNA. These flies reproduced aspects of the DM1 pathology, most notably nuclear accumulation of CUG transcripts, muscle degeneration, splicing misregulation, and diminished Muscleblind function in vivo. Reduced Muscleblind activity was evident from the sensitivity of CUG-induced phenotypes to a decrease in muscleblind genetic dosage and rescue by MBNL1 expression, and further supported by the co-localization of Muscleblind and CUG repeat RNA in ribonuclear foci. Targeted expression of CUG repeats to the developing eye and brain mushroom bodies was toxic leading to rough eyes and semilethality, respectively. These phenotypes were utilized to identify genetic and chemical modifiers of the CUG-induced toxicity. 15 genetic modifiers of the rough eye phenotype were isolated. These genes identify putative cellular processes unknown to be altered by CUG repeat RNA, and they include mRNA export factor Aly, apoptosis inhibitor Thread, chromatin remodelling factor Nurf-38, and extracellular matrix structural component Viking. Ten chemical compounds suppressed the semilethal phenotype. These compounds significantly improved viability of CUG expressing flies and included non-steroidal anti-inflammatory agents (ketoprofen), muscarinic, cholinergic and histamine receptor inhibitors (orphenadrine), and drugs that can affect sodium and calcium metabolism such as clenbuterol and spironolactone. These findings provide new insights into the DM1 phenotype, and suggest novel candidates for DM1 treatments
Measurement of the cross-section of high transverse momentum vector bosons reconstructed as single jets and studies of jet substructure in pp collisions at âs = 7 TeV with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Abulaitia Y
- Acharya BS
- Adamczyk L
- Adams DL
- Addy TN
- Adelman J
- Adomeit S
- Adye T
- Agatonovic-Jovin T
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahmadov F
- Aielli G
- Akesson TP
- Akimoto G
- Akimov AV
- Albert J
- Albrand S
- Alconada Verzini MJ
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Alimonti G
- Alio L
- Alison J
- Allbrooke BMM
- Allison LJ
- Allport PP
- Allwood-Spiers SE
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- Anastopoulos C
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- Zhemchugov A
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- Zurzolo G
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2014
- Field of study
This paper presents a measurement of the cross-section for high transverse momentum W and Z bosons produced in pp collisions and decaying to all-hadronic final states. The data used in the analysis were recorded by the ATLAS detector at the CERN Large Hadron Collider at a centre-of-mass energy of âs = 7 TeV;{\rm Te}{\rm V}andcorrespondtoanintegratedluminosityof4.6\;{\rm f}{{{\rm b}}^{-1}}.ThemeasurementisperformedbyreconstructingtheboostedWorZbosonsinsinglejets.ThereconstructedjetmassisusedtoidentifytheWandZbosons,andajetsubstructuremethodbasedonenergyclusterinformationinthejetcentreâofâmassframeisusedtosuppressthelargemultiâjetbackground.ThecrossâsectionforeventswithahadronicallydecayingWorZboson,withtransversemomentum{{p}_{{\rm T}}}\gt 320\;{\rm Ge}{\rm V}andpseudorapidity|\eta |\lt 1.9,ismeasuredtobe{{\sigma }_{W+Z}}=8.5\pm 1.7$ pb and is compared to next-to-leading-order calculations. The selected events are further used to study jet grooming techniques
Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Abreu H
- Acerbi E
- Acharya BS
- Adams DL
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- Adomeit S
- Adragna P
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- Aguilar-Saavedra JA
- Aharrouche M
- Ahlen SP
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- Ahsan M
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- Akesson TPA
- Akimoto G
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- Aleksandrov IN
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2013
- Field of study
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of âs = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pTâ„20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60â€pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2â€{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration
Measurement of the transverse polarization of Î and ÎÂŻ hyperons produced in proton-proton collisions at âs=7ââTeV using the ATLAS detector
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- Zhemchugov A
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- Zurzolo G
- Zwalinski L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/12/2014
- Field of study
The transverse polarization of Î and ÎÂŻ hyperons produced in proton-proton collisions at a center-of-mass energy of 7 TeV is measured. The analysis uses 760ââÎŒbâ1 of minimum bias data collected by the ATLAS detector at the LHC in the year 2010. The measured transverse polarization averaged over Feynman xF from 5Ă10â5 to 0.01 and transverse momentum pT from 0.8 to 15 GeV is â0.010±0.005(stat)±0.004(syst) for Î and 0.002±0.006(stat)±0.004(syst) for ÎÂŻ. It is also measured as a function of xF and pT, but no significant dependence on these variables is observed. Prior to this measurement, the polarization was measured at fixed-target experiments with center-of-mass energies up to about 40 GeV. The ATLAS results are compatible with the extrapolation of a fit from previous measurements to the xF range covered by this measurement
Measurements of normalized differential cross sections for ttÌ production in pp collisions at â(s)=7ââTeV using the ATLAS detector
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- Yurkewicz A
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zaman A
- Zambito S
- Zanello L
- Zanzi D
- Zaytsev A
- Zeitnitz C
- Zeman M
- Zemla A
- Zengel K
- Zenin O
- Zenis T
- Zerwas D
- Zhang D
- Zhang F
- Zhang H
- Zhang J
- Zhang L
- Zhang X
- Zhang Z
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou L
- Zhou N
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zitoun R
- Zobernig G
- Zoccoli A
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2014
- Field of study
Measurements of normalized differential cross sections for top-quark pair production are presented as a function of the top-quark transverse momentum, and of the mass, transverse momentum, and rapidity of the tÂŻt system, in protonâproton collisions at a center-of-mass energy of âs=7ââTeV. The data set corresponds to an integrated luminosity of 4.6ââfbâ1, recorded in 2011 with the ATLAS detector at the CERN Large Hadron Collider. Events are selected in the lepton+jets channel, requiring exactly one lepton and at least four jets with at least one of the jets tagged as originating from a b-quark. The measured spectra are corrected for detector efficiency and resolution effects and are compared to several Monte Carlo simulations and theory calculations. The results are in fair agreement with the predictions in a wide kinematic range. Nevertheless, data distributions are softer than predicted for higher values of the mass of the tÂŻt system and of the top-quark transverse momentum. The measurements can also discriminate among different sets of parton distribution functions
Measurements of Higgs boson production and couplings in the four-lepton channel in pp collisions at center-of-mass energies of 7 and 8 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
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- Zanzi D
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- Zhemchugov A
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- Zimine NI
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- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/08/2014
- Field of study
The final ATLAS Run 1 measurements of Higgs boson production and couplings in the decay channel HâZZâââ+âââ'+â'â, where â,ââČ=e or ÎŒ, are presented. These measurements were performed using pp collision data corresponding to integrated luminosities of 4.5 and 20.3ââfbâ1 at center-of-mass energies of 7 and 8 TeV, respectively, recorded with the ATLAS detector at the LHC. The HâZZââ4â signal is observed with a significance of 8.1 standard deviations, with an expectation of 6.2 standard deviations, at mH=125.36ââGeV, the combined ATLAS measurement of the Higgs boson mass from the Hâγγ and HâZZââ4â channels. The production rate relative to the Standard Model expectation, the signal strength, is measured in four different production categories in the HâZZââ4â channel. The measured signal strength, at this mass, and with all categories combined, is 1.44+0.40â0.33. The signal strength for Higgs boson production in gluon fusion or in association with ttÂŻ or bbÂŻ pairs is found to be 1.7+0.5â0.4, while the signal strength for vector-boson fusion combined with WH/ZH associated production is found to be 0.3+1.6â0.9
Search for nonpointing and delayed photons in the diphoton and missing transverse momentum final state in 8 TeV pp collisions at the LHC using the ATLAS detector
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- Yen AL
- Yildirim E
- Yildiz HD
- Yilmaz M
- Yoosoofmiya R
- Yorita K
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- Yoshihara K
- Young C
- Young CJS
- Youssef S
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- Yu J
- Yu J
- Yu JM
- Yuan L
- Yurkewicz A
- Yusuff I
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zaman A
- Zambito S
- Zanello L
- Zanzi D
- Zeitnitz C
- Zeman M
- Zemla A
- Zengel K
- Zenin O
- Zenis T
- Zerwas D
- Zhang D
- Zhang F
- Zhang H
- Zhang J
- Zhang L
- Zhang R
- Zhang X
- Zhang Z
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou L
- Zhou N
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zobernig G
- Zoccoli A
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2014
- Field of study
A search has been performed, using the full 20.3ââfbâ1 data sample of 8 TeV proton-proton collisions collected in 2012 with the ATLAS detector at the LHC, for photons originating from a displaced vertex due to the decay of a neutral long-lived particle into a photon and an invisible particle. The analysis investigates the diphoton plus missing transverse momentum final state, and is therefore most sensitive to pair production of long-lived particles. The analysis technique exploits the capabilities of the ATLAS electromagnetic calorimeter to make precise measurements of the flight direction, as well as the time of flight, of photons. No excess is observed over the Standard Model predictions for background. Exclusion limits are set within the context of gauge mediated supersymmetry breaking models, with the lightest neutralino being the next-to-lightest supersymmetric particle and decaying into a photon and gravitino with a lifetime in the range from 250 ps to about 100 ns
Determination of the ratio of b-quark fragmentation fractions fs/fd in pp collisions at âs = 7 TeV with the ATLAS Detector
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adam ER
- Adamczyk L
- Adams DL
- Adelman J
- Adomeit S
- Adye T
- Affolder AA
- Agatonovic-Jovin T
- Agricola J
- Aguilar-Saavedra JA
- Ahlen SP
- Ahmadov F
- Aielli G
- Akerstedt H
- Akesson TPA
- Akimov AV
- Alberghi GL
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexopoulos T
- Alhroob M
- Alimonti G
- Alio L
- Alison J
- Alkire SP
- Allbrooke BMM
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Altheimer A
- Alviggi MG
- Amadio BT
- Amako K
- Amelung C
- Amidei D
- Amorim A
- Amoroso S
- Amram N
- Amundsen G
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anders JK
- Anderson KJ
- Andreazza A
- Andrei V
- Angelidakis S
- Angelozzi I
- Anger P
- Angerami A
- Anghinolfi F
- Anisenkov AV
- Anjos N
- Annovi A
- Antonelli M
- Antonov A
- Antos J
- Anulli F
- Aoki M
- Arabidze G
- Arai Y
- Aranda CP
- Araque JP
- Arce ATH
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Arik M
- Armadans RC
- Armbruster AJ
- Arnaez O
- Arnal V
- Arnold H
- Arratia M
- Arslan O
- Artamonov A
- Artoni G
- Asai S
- Asbah N
- Ashkenazi A
- Asman B
- Asquith L
- Assamagan K
- Astalos R
- Atkinson M
- Atlay NB
- Augsten K
- Aurousseau M
- Avolio G
- Axen B
- Ayoub MK
- Azuelos G
- Baak MA
- Baas AE
- Baca MJ
- Bacci C
- Bachacou H
- Bachas K
- Backes M
- Backhaus M
- Bagiacchi P
- Bagnaia P
- Bai Y
- Bain T
- Baines JT
- Baker OK
- Baldin EM
- Balek P
- Balestri T
- Balli F
- Banas E
- Banerjee S
- Bannoura AAE
- Bansil HS
- Barajas CAC
- Barak L
- Barberio EL
- Barberis D
- Barbero M
- Barillari T
- Barisonzi M
- Barklow T
- Barlow N
- Barnes SL
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- Zhemchugov A
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- Zivkovic L
- Zobernig G
- Zoccoli A
- Zurzolo G
- Zwalinski L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2015
- Field of study
With an integrated luminosity of 2.47ââfbâ1 recorded by the ATLAS experiment at the LHC, the exclusive decays B 0sâJ/ÏÏ and B0dâJ/ÏK*0 of B mesons produced in pp collisions at âs=7ââTeV are used to determine the ratio of fragmentation fractions fs/fd. From the observed B0sâJ/ÏÏ and B0dâJ/ÏK*0 yields, the quantity (fs/fd)[B(B0sâJ/ÏÏ)/B(B 0dâJ/ÏK*0)] is measured to be 0.199±0.004(stat)±0.008(syst). Using a recent theory prediction for [B(B0sâJ/ÏÏ)/B(B0dâJ/ÏK*0)] yields (fs/fd)=0.240±0.004(stat)±0.010(syst)±0.017(th). This result is based on a new approach that provides a significant improvement of the world average
Measurement of the inelastic proton-proton cross section at âs=13 TeV with the ATLAS detector at the LHC
- Author
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- Aad G
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- Zwalinski L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2015
- Field of study
This Letter presents a measurement of the inelastic proton-proton cross section using 60ââÎŒb â1 of pp collisions at a center-of-mass energy âs of 13 TeV with the ATLAS detector at the LHC. Inelastic interactions are selected using rings of plastic scintillators in the forward region (2.0710 â6 , where M X is the larger invariant mass of the two hadronic systems separated by the largest rapidity gap in the event. In this Ο range the scintillators are highly efficient. For diffractive events this corresponds to cases where at least one proton dissociates to a system with M X >13ââGeV . The measured cross section is compared with a range of theoretical predictions. When extrapolated to the full phase space, a cross section of 78.1±2.9ââmb is measured, consistent with the inelastic cross section increasing with center-of-mass energy
Searches for Higgs boson pair production in the hhâbbÏÏ, γγWWâ, γγbb, bbbb channels with the ATLAS detector
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- Zalieckas J
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- Zhemchugov A
- Zhong J
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- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
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- Zinonos Z
- Zinser M
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- Zivkovic L
- Zobernig G
- Zoccoli A
- Zurzolo G
- Zwalinski L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2015
- Field of study
Searches for both resonant and nonresonant Higgs boson pair production are performed in the hhâbbÏÏ, γγWWâ final states using 20.3ââfbâ1 of pp collision data at a center-of-mass energy of 8 TeV recorded with the ATLAS detector at the Large Hadron Collider. No evidence of their production is observed and 95% confidence-level upper limits on the production cross sections are set. These results are then combined with the published results of the hhâγγbb, bbbb analyses. An upper limit of 0.69 (0.47) pb on the nonresonant hh production is observed (expected), corresponding to 70 (48) times the SM ggâhh cross section. For production via narrow resonances, cross-section limits of hh production from a heavy Higgs boson decay are set as a function of the heavy Higgs boson mass. The observed (expected) limits range from 2.1 (1.1) pb at 260 GeV to 0.011 (0.018) pb at 1000 GeV. These results are interpreted in the context of two simplified scenarios of the Minimal Supersymmetric Standard Model
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